Low dose ketoconazole is an effective and a relatively safe alternative in the treatment of hirsutism

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volumn 36, Issue 4, 1996, Pages 487-489

  Işik, Ahmet Zeki ^a   Gökmen, Oya ^a,b   Zeyneloǧlu, Hulusi B ^a   Şenoz, Selim ^a   Zorlu, C Gürkan ^a,c  

^a ZEKAI TAHIR BURAK WOMEN S HEALTH EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b IVF ET Unit   (Turkey)

^c NONE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOLE DERIVATIVE; KETOCONAZOLE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLICULAR PHASE; HIRSUTISM; HUMAN; MASTALGIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS;

EID: 0029803451     PISSN: 00048666     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1479-828x.1996.tb02202.x     Document Type: Article

References (16)

1. Feldman D. Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis. Endoc Rev. 1985; 7: 409-420.
2. Schurmayer T, Nieschlag E. Effects of ketoconazole and other imidazole fungicides on testosterone biosynthesis. Acta Endocrinol (Copenh.) 1984; 105: 275-280.
3. Denis L, Chaban M, Mahler C. Clinical applications of ketoconazole in prostatic cancer. Prog Clin Biol Res 1985; 185A: 319-326.
4. Holland FJ, Fishman L, Bailey JD, Fazekas ATA. Ketoconazole in the management of precocious puberty not responsive to LHRH-analogue therapy. N Engl J Med 1985; 312: 1023-1028.
5. Sonino N, Boscaro M, Merola G, Mantero F. Prolonged treatment of Cushing's disease by ketoconazole. J Clin Endocrinol Metab 1983; 57: 732-736.
6. Martikainen H, Heikkinen J, Ruokonen A, Kaupila A. Hormonal and clinical effects of ketoconazole in hirsute women. J Clin Endocrinol Metab 1988; 987-992.
7. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961; 21: 1440-1447.
8. Adams J, Polson DW, Abdulwahid N et al. Multifollicular ovaries: Clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet 1985; 2: 1375-1378.
9. Gal M, Orly J, Barr I, Algur N, Boldes R, Diamant YZ. Low dose ketoconazole attenuates serum androgen levels in patients with polycystic ovary syndrome and inhibits ovarian steroidogenesis in vitro. Fertil Steril 1994; 61: 823-832.
10. Feldman D. Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis. Endocrin Rev 1986; 7: 409-420.
11. Sonino N. The use of ketoconazole as an inhibitor of steroid production. N Eng J Med 1987; 317: 812-818.
12. DiMattina M, Maronian N, Ashby H, Loriaux DL, Albertson BD. Fertil Steril 1988; 49: 62-65.
13. Akalin S. Effects of ketoconazole in hirsute women. Acta Endocrinol 1991; 124: 19-22.
14. Venturoli S, Fabbri R, Prato LD et al. Keotonazole therapy for women with acne and/or hirsutism. J Clin Endocrinol Metabol 1990; 71: 335-339.
15. Sonino N, Scaroni C, Biason A, Boscaro M, Mantero F. Low-dose ketoconazole treatment in hirsute women. J Endocrinol Invest 1990; 13: 35-40.
16. De Pedrint P, Tomaselli A, Spano G, Montemurro G. Clinical and hormonal effects of ketoconazole in hirsutism in women. Int J Tiss Reac 1988; 3: 193-198.