메뉴 건너뛰기




Volumn 47, Issue , 1996, Pages 211-250

Therapeutic applications of cytokines for immunostimulation and immunosuppression: An update

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

EID: 0029803178     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-8998-8_6     Document Type: Review
Times cited : (2)

References (256)
  • 1
    • 0026441413 scopus 로고
    • Clinical applications of cytokines for immunostimulation and immunosuppression
    • B. Lee and T. L. Ciardelli: Clinical applications of cytokines for immunostimulation and immunosuppression. Prog. in Drug Res. 39, 167 (1992).
    • (1992) Prog. in Drug Res. , vol.39 , pp. 167
    • Lee, B.1    Ciardelli, T.L.2
  • 2
    • 0029558511 scopus 로고
    • Immune-mediated side-effects of cytokines in humans
    • T. Vail and J. Descotes: Immune-mediated side-effects of cytokines in humans. Toxicology 105, 31 (1995).
    • (1995) Toxicology , vol.105 , pp. 31
    • Vail, T.1    Descotes, J.2
  • 3
    • 0028963091 scopus 로고
    • Hematopoietic reconstruction: New approaches
    • M.A.S. Moore: Hematopoietic reconstruction: New approaches. Clin. Cancer Res. 1, 3 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 3
    • Moore, M.A.S.1
  • 4
    • 0028574887 scopus 로고
    • The present and future of hematopoietic cytokines in clinical practice
    • Dayt
    • M.J. George:The present and future of hematopoietic cytokines in clinical practice. Stem Cells (Dayt) 12 S1., 249 (1994).
    • (1994) Stem Cells , vol.12 , Issue.S1 , pp. 249
    • George, M.J.1
  • 5
    • 0028420784 scopus 로고
    • Biotherapy in hematology:The next decade
    • P.J. Quesenberry: Biotherapy in hematology:The next decade. Rev. Invest. Clin. Apr. S., 8 (1994).
    • (1994) Rev. Invest. Clin. , vol.APR. S. , pp. 8
    • Quesenberry, P.J.1
  • 6
    • 0028040189 scopus 로고
    • Clinical application of cytokines for cancer treatment
    • F. Takaku: Clinical application of cytokines for cancer treatment. Oncology 51, 123 (1994).
    • (1994) Oncology , vol.51 , pp. 123
    • Takaku, F.1
  • 7
    • 0027445381 scopus 로고
    • Hematopoietic cytokines: From biology and pathophysiology to clinical application
    • R. Mertelsmann: Hematopoietic cytokines: from biology and pathophysiology to clinical application. Leukemia 7 S2, 168 (1993).
    • (1993) Leukemia , vol.7 , Issue.S2 , pp. 168
    • Mertelsmann, R.1
  • 8
    • 0025772135 scopus 로고
    • High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy
    • G.M. Clore, P.T. Wingfield and A.M. Gronenborn: High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. Biochemistry 30, 2315 (1991).
    • (1991) Biochemistry , vol.30 , pp. 2315
    • Clore, G.M.1    Wingfield, P.T.2    Gronenborn, A.M.3
  • 9
    • 0026524055 scopus 로고
    • Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression
    • K. Ye, K.C. Koch, B.D. Clark and C.A. Dinarello: Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression. Immunology 75, 427 (1992).
    • (1992) Immunology , vol.75 , pp. 427
    • Ye, K.1    Koch, K.C.2    Clark, B.D.3    Dinarello, C.A.4
  • 10
    • 2342570705 scopus 로고
    • Interleukin-1 alpha: Results of a phase one toxicity and immunomodulatory trial
    • J. Smith, W. Urba, R. Steis, J. Janik et al.: Interleukin-1 alpha: Results of a phase one toxicity and immunomodulatory trial. Am. Soc. Clin. Oncol. 9, 717 (1990).
    • (1990) Am. Soc. Clin. Oncol. , vol.9 , pp. 717
    • Smith, J.1    Urba, W.2    Steis, R.3    Janik, J.4
  • 12
    • 0027916179 scopus 로고
    • The role of interleukin-1 in disease
    • C.A. Dinarello and S.M. Wolff: The role of interleukin-1 in disease. N. Engl. J. Med. 325, 106 (1993).
    • (1993) N. Engl. J. Med. , vol.325 , pp. 106
    • Dinarello, C.A.1    Wolff, S.M.2
  • 13
    • 0028675659 scopus 로고
    • The interleukin-1 family:10 years of discovery
    • C.A. Dinarello: The interleukin-1 family:10 years of discovery. FASEB J. 8, 1314 (1994).
    • (1994) FASEB J. , vol.8 , pp. 1314
    • Dinarello, C.A.1
  • 15
    • 0027937755 scopus 로고
    • Phase II trial of recombinant interleukin-1 beta in patients with metastatic renal cell carcinoma
    • B.G. Redman, Y. Abubakr, T. Chou et al: Phase II trial of recombinant interleukin-1 beta in patients with metastatic renal cell carcinoma. J. Immunother. Emphasis Tumor Immunol. 16, 211 (1994).
    • (1994) J. Immunother. Emphasis Tumor Immunol. , vol.16 , pp. 211
    • Redman, B.G.1    Abubakr, Y.2    Chou, T.3
  • 16
    • 0028831364 scopus 로고
    • Phase I trial of escalating doses of interleukin-1β in combination with a fixed dose of interleukin-2
    • P.L. Triozzi, J.A. Kim, E.W. Martin et al: Phase I trial of escalating doses of interleukin-1β in combination with a fixed dose of interleukin-2. J. Clin. Oncol. 13, 482 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 482
    • Triozzi, P.L.1    Kim, J.A.2    Martin, E.W.3
  • 17
    • 0027261008 scopus 로고
    • Interleukin-1 : Biological effects in human hematopoiesis
    • J. Crown, A. Jakubowski and J. Gabrilove: Interleukin-1 : biological effects in human hematopoiesis. Leuk. Lymphoma 9, 433 (1993).
    • (1993) Leuk. Lymphoma , vol.9 , pp. 433
    • Crown, J.1    Jakubowski, A.2    Gabrilove, J.3
  • 18
    • 0026633556 scopus 로고
    • The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies
    • J.W. Smith 2nd, W.J. Urba, B.D. Curti et al.: The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies. J. Clin. Oncol. 10, 1141 (1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1141
    • Smith II, J.W.1    Urba, W.J.2    Curti, B.D.3
  • 19
    • 0028169280 scopus 로고
    • Interleukin-1 alpha administered after autologous transplantation
    • D. Weisdorf, E. Katsanis, C. Verfaillie et al.: Interleukin-1 alpha administered after autologous transplantation. Blood 84, 2044 (1994).
    • (1994) Blood , vol.84 , pp. 2044
    • Weisdorf, D.1    Katsanis, E.2    Verfaillie, C.3
  • 20
    • 0028051245 scopus 로고
    • Blocking interleukin-1 receptors
    • C.A. Dinarello: Blocking interleukin-1 receptors. Int. J. Clin. Lab. Res. 24, 61 (1994).
    • (1994) Int. J. Clin. Lab. Res. , vol.24 , pp. 61
    • Dinarello, C.A.1
  • 21
    • 10344242544 scopus 로고
    • Interleukin-1 antagonism in inflammatory disease
    • W.P. Arend: Interleukin-1 antagonism in inflammatory disease. Lancet 16, 155 (1993).
    • (1993) Lancet , vol.16 , pp. 155
    • Arend, W.P.1
  • 22
    • 0010993926 scopus 로고
    • Biological role of the IL-1 receptor type II as defined by monoclonal antibody
    • P. Ghiara, D. Armellini, G. Scapigliati et al.: Biological role of the IL-1 receptor type II as defined by monoclonal antibody. Cytokine 3, 1423 (1991).
    • (1991) Cytokine , vol.3 , pp. 1423
    • Ghiara, P.1    Armellini, D.2    Scapigliati, G.3
  • 23
    • 0027349463 scopus 로고
    • Pharmacokinetic parameters and biodistribution of soluble cytokine receptors
    • C.A. Jacobs, M.P. Beckman, K. Mohler et al.: Pharmacokinetic parameters and biodistribution of soluble cytokine receptors. Internat. Rev. Exp. Path. 34, 123 (1993).
    • (1993) Internat. Rev. Exp. Path. , vol.34 , pp. 123
    • Jacobs, C.A.1    Beckman, M.P.2    Mohler, K.3
  • 24
    • 0025021471 scopus 로고
    • Primary structure and functional expression from complementary DNA of a human interleukin-1 antagonist
    • S.P. Eisenberg, R.J. Evans, W.P. Arend et al.: Primary structure and functional expression from complementary DNA of a human interleukin-1 antagonist. Nature 25, 341 (1990).
    • (1990) Nature , vol.25 , pp. 341
    • Eisenberg, S.P.1    Evans, R.J.2    Arend, W.P.3
  • 25
    • 0025713953 scopus 로고
    • Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
    • C.H. Hannum, C.J. Wilcox, W.P. Arend et al.: Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343, 336 (1990).
    • (1990) Nature , vol.343 , pp. 336
    • Hannum, C.H.1    Wilcox, C.J.2    Arend, W.P.3
  • 26
    • 0026928357 scopus 로고
    • Pharmacokinetics, safety, and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans
    • E.V. Granowitz, R. Porat, J.W. Mier et al.: Pharmacokinetics, safety, and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. Cytokine 4, 353 (1992).
    • (1992) Cytokine , vol.4 , pp. 353
    • Granowitz, E.V.1    Porat, R.2    Mier, J.W.3
  • 27
    • 0027229622 scopus 로고
    • Potential agonist action of the interleukin-1 receptor antagonist protein: Implications for the treatment of women
    • M.D. Mitchell, S.S. Edwin, R.M. Silver and R.J. Romero: Potential agonist action of the interleukin-1 receptor antagonist protein: implications for the treatment of women. J. Clin. Endocrin. Metab. 76, 1386 (1993).
    • (1993) J. Clin. Endocrin. Metab. , vol.76 , pp. 1386
    • Mitchell, M.D.1    Edwin, S.S.2    Silver, R.M.3    Romero, R.J.4
  • 28
    • 0028086480 scopus 로고
    • Recombinant human interleukin-1 receptor antagonist in the treatment of steroid resistant graft-versus-host disease
    • J.H. Antin, H.J. Weinstein, E.C. Guinan et al.: Recombinant human interleukin-1 receptor antagonist in the treatment of steroid resistant graft-versus-host disease. Blood 84, 1342 (1994).
    • (1994) Blood , vol.84 , pp. 1342
    • Antin, J.H.1    Weinstein, H.J.2    Guinan, E.C.3
  • 29
    • 0028305204 scopus 로고
    • Sepsis Therapy Trial
    • E. Abraham and T.A. Raffin: Sepsis Therapy Trial. JAMA 271, 1876 (1994).
    • (1994) JAMA , vol.271 , pp. 1876
    • Abraham, E.1    Raffin, T.A.2
  • 30
    • 0028239555 scopus 로고
    • Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome
    • C.J. Fisher, J.A. Dhainaut, S.M. Opal et al.: Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome. JAMA 271, 1836 (1994).
    • (1994) JAMA , vol.271 , pp. 1836
    • Fisher, C.J.1    Dhainaut, J.A.2    Opal, S.M.3
  • 31
    • 0029009910 scopus 로고
    • Molecular cloning and characterization of a second subunit of the interleukin-1 receptor
    • S.A. Greenfeld, P. Nunes, L. Kwee et al.: Molecular cloning and characterization of a second subunit of the interleukin-1 receptor. J. Biol. Chem. 270, 13757 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 13757
    • Greenfeld, S.A.1    Nunes, P.2    Kwee, L.3
  • 32
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact and implications
    • K.A. Smith: Interleukin-2: Inception, impact and implications. Science 240, 1169 (1988).
    • (1988) Science , vol.240 , pp. 1169
    • Smith, K.A.1
  • 34
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • T. Taniguchi and Y. Minami: The IL-2/IL-2 receptor system: a current overview. Cell 73, 5 (1993).
    • (1993) Cell , vol.73 , pp. 5
    • Taniguchi, T.1    Minami, Y.2
  • 35
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • J.N. Ihle: Cytokine receptor signalling. Nature 377, 591 (1995).
    • (1995) Nature , vol.377 , pp. 591
    • Ihle, J.N.1
  • 36
    • 0028171065 scopus 로고
    • c Chains with Jak1 and Jak3: Implications for XSCID and XCID
    • c Chains with Jak1 and Jak3: Implications for XSCID and XCID. Science 266, 1042 (1994).
    • (1994) Science , vol.266 , pp. 1042
    • Russell, S.M.1    Johnston, J.A.2    Noguchi, M.3
  • 37
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    • B.A. Witthuhn, O. Silvennoinen, O. Miura et al.: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370, 153 (1994).
    • (1994) Nature , vol.370 , pp. 153
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3
  • 38
    • 0027993022 scopus 로고
    • Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits
    • T. Miyazaki, A. Kawahara, H. Fujii et al.: Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits. Science 266, 1045 (1994).
    • (1994) Science , vol.266 , pp. 1045
    • Miyazaki, T.1    Kawahara, A.2    Fujii, H.3
  • 39
    • 0027328343 scopus 로고
    • The Alphas, Betas, and Kinases of Cytokine Receptor Complexes
    • N. Stahl and G.D. Yancopoulos: The Alphas, Betas, and Kinases of Cytokine Receptor Complexes. Cell 74, 587 (1993).
    • (1993) Cell , vol.74 , pp. 587
    • Stahl, N.1    Yancopoulos, G.D.2
  • 40
    • 10344246732 scopus 로고    scopus 로고
    • Management of Metastatic Renal Cell Carcinoma: Chemotherapy. Hormonal Therapy and Interferons
    • N.J. Vogelzang, P.T. Scardino, W.U. Shipley and D.S. Coffey (eds). Williams & Wilkins, Baltimore
    • S.M. Gorsch and M.S. Ernstoff: Management of Metastatic Renal Cell Carcinoma: Chemotherapy. Hormonal Therapy and Interferons. In: Comprehensive Textbook of Genitourinary Oncology. N.J. Vogelzang, P.T. Scardino, W.U. Shipley and D.S. Coffey (eds). Williams & Wilkins, Baltimore (1996).
    • (1996) Comprehensive Textbook of Genitourinary Oncology
    • Gorsch, S.M.1    Ernstoff, M.S.2
  • 42
    • 0027980190 scopus 로고
    • Interleukin-2: Solid tumor therapy
    • M.H. Oppenheim and M.T. Lotze: Interleukin-2: Solid tumor therapy. Oncology 57, 154 (1994).
    • (1994) Oncology , vol.57 , pp. 154
    • Oppenheim, M.H.1    Lotze, M.T.2
  • 43
    • 0028945004 scopus 로고
    • High-dose interleukin-2 in the therapy of metastatic renal-cell carcinoma
    • D.R. Parkinson and M. Sznol: High-dose interleukin-2 in the therapy of metastatic renal-cell carcinoma. Seminars in Oncology 22, 61 (1995).
    • (1995) Seminars in Oncology , vol.22 , pp. 61
    • Parkinson, D.R.1    Sznol, M.2
  • 44
    • 0028828093 scopus 로고
    • Immunotherapy for renal cell carcinoma: The era of interleukin-2-based treatment
    • S.S. Taneja, W. Pierce, R. Figlin and A. Belldegrun: Immunotherapy for renal cell carcinoma: the era of interleukin-2-based treatment. Urology 45, 911 (1995).
    • (1995) Urology , vol.45 , pp. 911
    • Taneja, S.S.1    Pierce, W.2    Figlin, R.3    Belldegrun, A.4
  • 45
    • 0028303671 scopus 로고
    • Recombinant interleukin-2 in cancer: Basic and clinical aspects
    • L.T. Vlasveld and E.M. Rankin: Recombinant interleukin-2 in cancer: basic and clinical aspects. Cancer Treatment Reviews 20, 275 (1994).
    • (1994) Cancer Treatment Reviews , vol.20 , pp. 275
    • Vlasveld, L.T.1    Rankin, E.M.2
  • 46
    • 0028915161 scopus 로고
    • Renal cell carcinoma and interleukin-2: A review
    • J. Wagstaff, J.W. Baars, G.-J. Wolbink et al.: Renal cell carcinoma and interleukin-2: A review. Eur. J. Cancer 31A, 401 (1995).
    • (1995) Eur. J. Cancer , vol.31 A , pp. 401
    • Wagstaff, J.1    Baars, J.W.2    Wolbink, G.-J.3
  • 47
    • 0029200217 scopus 로고
    • Perspectives of cytokine treatment in malignant skin tumors
    • C. Garbe: Perspectives of cytokine treatment in malignant skin tumors. Recent Results Cancer Res. 139, 349 (1995).
    • (1995) Recent Results Cancer Res. , vol.139 , pp. 349
    • Garbe, C.1
  • 48
    • 0027522021 scopus 로고
    • Interleukin-2, a review of its pharmacological properties and therapeutic use in patients with cancer
    • R. Whittington and D. Faulds: Interleukin-2, a review of its pharmacological properties and therapeutic use in patients with cancer. Drugs 46, 446 (1993).
    • (1993) Drugs , vol.46 , pp. 446
    • Whittington, R.1    Faulds, D.2
  • 49
    • 0022349817 scopus 로고
    • Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 in patients with metastatic cancer
    • S.A. Rosenberg, M.T. Lotze, L.M. Muul et al.: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 in patients with metastatic cancer. N. Eng. J. Med. 313, 1485 (1985).
    • (1985) N. Eng. J. Med. , vol.313 , pp. 1485
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3
  • 50
    • 0022501035 scopus 로고
    • Lymphokine activated killer (LAK) cells: Analysis of progenitors and effectors
    • J.R. Ortaldo, A. Mason and R. Overton: Lymphokine activated killer (LAK) cells: analysis of progenitors and effectors. J. Exp. Med. 164, 1193 (1986).
    • (1986) J. Exp. Med. , vol.164 , pp. 1193
    • Ortaldo, J.R.1    Mason, A.2    Overton, R.3
  • 51
    • 0028287292 scopus 로고
    • Interleukin 2 Receptor γ Chain Expression on Resting and Activated Lymphoid Cells
    • T. Nakarai, M.J. Robertson, M. Streuli et al.: Interleukin 2 Receptor γ Chain Expression on Resting and Activated Lymphoid Cells. J. Exp. Med. 180, 241 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 241
    • Nakarai, T.1    Robertson, M.J.2    Streuli, M.3
  • 52
    • 0025289835 scopus 로고
    • Functional Consequences of Interleukin-2 Receptor Expression on Resting Human Lymphocytes
    • M. Caligiuri, A. Zmiudzinas, T.J. Manley et al.: Functional Consequences of Interleukin-2 Receptor Expression on Resting Human Lymphocytes. J. Exp. Med. 171, 1509 (1990).
    • (1990) J. Exp. Med. , vol.171 , pp. 1509
    • Caligiuri, M.1    Zmiudzinas, A.2    Manley, T.J.3
  • 53
    • 0027529476 scopus 로고
    • Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer
    • S.A. Rosenberg, M.T. Lotze, J.C. Yang et al.: Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J. Natl. Cancer Inst. 85, 622 (1993).
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 622
    • Rosenberg, S.A.1    Lotze, M.T.2    Yang, J.C.3
  • 54
    • 0025768477 scopus 로고
    • Randomized study of interleukin-2 (IL-2) vs IL-2 plus lymphokine-activated killer cells for the treatment of melanoma and renal cell cancer
    • M.J. Koretz, D.H. Lawson, M. York et al.: Randomized study of interleukin-2 (IL-2) vs IL-2 plus lymphokine-activated killer cells for the treatment of melanoma and renal cell cancer. Arch. Surg. 726, 898 (1991).
    • (1991) Arch. Surg. , vol.726 , pp. 898
    • Koretz, M.J.1    Lawson, D.H.2    York, M.3
  • 55
    • 0026719536 scopus 로고
    • Continuous infusion of recombinant interleukin-2 with or without autologous lymphokine activated killer cells for the treatment of advanced renal cell carcinoma
    • P.A. Palmer, J. Vinke, P. Evers et al.: Continuous infusion of recombinant interleukin-2 with or without autologous lymphokine activated killer cells for the treatment of advanced renal cell carcinoma. Eur. J. Cancer 28A, 1038 (1992).
    • (1992) Eur. J. Cancer , vol.28 A , pp. 1038
    • Palmer, P.A.1    Vinke, J.2    Evers, P.3
  • 56
    • 0030030641 scopus 로고    scopus 로고
    • Evaluation of interleukin-2 administered by continuous infusion in patients with metastatic melanoma
    • S. Legha , M.A. Gianan, C. Plager et al.: Evaluation of interleukin-2 administered by continuous infusion in patients with metastatic melanoma. Cancer 77, 89 (1996).
    • (1996) Cancer , vol.77 , pp. 89
    • Legha, S.1    Gianan, M.A.2    Plager, C.3
  • 57
    • 0029090362 scopus 로고
    • Phase III randomized trial of interleukin-2 with or without lymphokine activated killer cells in the treatment of patients with advanced renal cell carcinoma
    • T.M. Law, R.J. Motzer, M. Madhu et al.: Phase III randomized trial of interleukin-2 with or without lymphokine activated killer cells in the treatment of patients with advanced renal cell carcinoma. Cancer 76, 824 (1995).
    • (1995) Cancer , vol.76 , pp. 824
    • Law, T.M.1    Motzer, R.J.2    Madhu, M.3
  • 58
    • 0024580003 scopus 로고
    • Tumor localization of adoptively transferred Indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma
    • B. Fisher, B.S. Packard, E.J. Read et al.: Tumor localization of adoptively transferred Indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma. J. Clin. Oncol. 7, 250 (1989).
    • (1989) J. Clin. Oncol. , vol.7 , pp. 250
    • Fisher, B.1    Packard, B.S.2    Read, E.J.3
  • 59
    • 0025726545 scopus 로고
    • Human autologous tumor-specific T-cells in malignant melanoma
    • C.D. Platsoucas: Human autologous tumor-specific T-cells in malignant melanoma. Metastasis Rev. 10, 151 (1991).
    • (1991) Metastasis Rev. , vol.10 , pp. 151
    • Platsoucas, C.D.1
  • 60
    • 0028917991 scopus 로고
    • Cellular therapy: Scientific rationale and clinical results in the treatment of metastatic renal cell carcinoma
    • W.C. Pierce, A. Belldegrun and R.A. Figlin: Cellular therapy: scientific rationale and clinical results in the treatment of metastatic renal cell carcinoma. Semin. Oncol, 22, 74 (1995).
    • (1995) Semin. Oncol , vol.22 , pp. 74
    • Pierce, W.C.1    Belldegrun, A.2    Figlin, R.A.3
  • 61
    • 0027770020 scopus 로고
    • Treatment with pentoxifylline and ciprofloxacin reduces the toxicity of high-dose interleukin-2 and lymphokine-activated killer cells
    • J.A. Thompson, M.C. Benyunes, J.A. Bianco and A. Fefer: Treatment with pentoxifylline and ciprofloxacin reduces the toxicity of high-dose interleukin-2 and lymphokine-activated killer cells. Semin. Oncol. 20, 46 (1993).
    • (1993) Semin. Oncol. , vol.20 , pp. 46
    • Thompson, J.A.1    Benyunes, M.C.2    Bianco, J.A.3    Fefer, A.4
  • 62
    • 0029055509 scopus 로고
    • The effects of pentoxifylline on interleukin-2 toxicity in patients with metastatic renal cell carcinoma
    • J.A. Anderson, T.M. Woodcock, J.I. Harty et al.:The effects of pentoxifylline on interleukin-2 toxicity in patients with metastatic renal cell carcinoma. Eur. J. Cancer 31A, 714 (1995).
    • (1995) Eur. J. Cancer , vol.31 A , pp. 714
    • Anderson, J.A.1    Woodcock, T.M.2    Harty, J.I.3
  • 63
    • 0025635950 scopus 로고
    • The influence of autologous lymphokine activated killer cell infusions on the toxicity and antitumor effect of repetitive cycles of interleukin-2
    • M.R. Albertini, J.A. Sosman, J.A. Hank et al.:The influence of autologous lymphokine activated killer cell infusions on the toxicity and antitumor effect of repetitive cycles of interleukin-2. Cancer 66, 2457 (1990).
    • (1990) Cancer , vol.66 , pp. 2457
    • Albertini, M.R.1    Sosman, J.A.2    Hank, J.A.3
  • 64
    • 0028106484 scopus 로고
    • Randomized comparison of high-dose and low-dose intravenous interleukin-2 for therapy of metastatic renal cell carcinoma, an interim report
    • J.C. Yang, S.X. Topalian, D. Parkinson et al.: Randomized comparison of high-dose and low-dose intravenous interleukin-2 for therapy of metastatic renal cell carcinoma, an interim report. J. Clin. Oncol. 12, 1572 (1994).
    • (1994) J. Clin. Oncol. , vol.12 , pp. 1572
    • Yang, J.C.1    Topalian, S.X.2    Parkinson, D.3
  • 65
    • 0028147594 scopus 로고
    • Prognostic factors of the clinical response to subcutaneous immunotherapy with interleukin-2 alone in patients with metastatic renal cell carcinoma
    • P. Lissoni, S. Barni, A. Ardizzoia et al.: Prognostic factors of the clinical response to subcutaneous immunotherapy with interleukin-2 alone in patients with metastatic renal cell carcinoma. Oncology 51, 59 (1994).
    • (1994) Oncology , vol.51 , pp. 59
    • Lissoni, P.1    Barni, S.2    Ardizzoia, A.3
  • 66
    • 0027972544 scopus 로고
    • Phase II study of intermittent continuous infusion of low-dose recombinant interleukin-2 in advanced melanoma and renal cell cancer
    • L.T. VLasveld, S. Horenblas, A. Hekman et al.: Phase II study of intermittent continuous infusion of low-dose recombinant interleukin-2 in advanced melanoma and renal cell cancer. Ann. Oncol. 5, 179 (1994).
    • (1994) Ann. Oncol. , vol.5 , pp. 179
    • Vlasveld, L.T.1    Horenblas, S.2    Hekman, A.3
  • 67
    • 0025081439 scopus 로고
    • Subcutaneous recombinant interleukin-2 in a dose escalating regimen in patients with metastatic renal cell adenocarcinoma
    • R.P. Whitehead, D. Ward, L. Hemingway et al.: Subcutaneous recombinant interleukin-2 in a dose escalating regimen in patients with metastatic renal cell adenocarcinoma. Cancer Res. 50, 6708 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 6708
    • Whitehead, R.P.1    Ward, D.2    Hemingway, L.3
  • 68
    • 0026718336 scopus 로고
    • Phase II study of subcutaneous interleukin-2 in unselected patients with advanced renal cell cancer on an outpatient basis
    • D.T. Sleifer, R.A. Janssen, J. Buter et al.: Phase II study of subcutaneous interleukin-2 in unselected patients with advanced renal cell cancer on an outpatient basis. J. Clin. Oncol. 10, 1119 (1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1119
    • Sleifer, D.T.1    Janssen, R.A.2    Buter, J.3
  • 69
    • 0028045103 scopus 로고
    • Local interleukin-2 therapy for cancer, and its effector induction mechanisms
    • S. Sone and T. Ogura: Local interleukin-2 therapy for cancer, and its effector induction mechanisms. Oncology 51, 170 (1994).
    • (1994) Oncology , vol.51 , pp. 170
    • Sone, S.1    Ogura, T.2
  • 70
    • 0028332155 scopus 로고
    • Effects of route and formulation on clinical pharmacokinetics of interleukin-2
    • P.M. Anderson and M.A. Sorenson: Effects of route and formulation on clinical pharmacokinetics of interleukin-2. Clin. Pharmacokinet. 27, 19 (1994).
    • (1994) Clin. Pharmacokinet. , vol.27 , pp. 19
    • Anderson, P.M.1    Sorenson, M.A.2
  • 71
    • 0026664243 scopus 로고
    • Depot characteristics and biodistribution of interleukin-2 liposomes: Importance of route of administration
    • P.M. Anderson, E. Katsanis, S.F. Sencer et al.: Depot characteristics and biodistribution of interleukin-2 liposomes: importance of route of administration. J. Immunother. 12, 19 (1992).
    • (1992) J. Immunother. , vol.12 , pp. 19
    • Anderson, P.M.1    Katsanis, E.2    Sencer, S.F.3
  • 72
    • 0026061242 scopus 로고
    • A phase I study including pharmacokinetics of polyethylene glycol conjugated interleukin-2
    • F.J. Meyers, C. Paradise, S.A. Scudder et al.: A phase I study including pharmacokinetics of polyethylene glycol conjugated interleukin-2. Clinical Pharmacol. and Therap. 49, 307 (1991).
    • (1991) Clinical Pharmacol. and Therap. , vol.49 , pp. 307
    • Meyers, F.J.1    Paradise, C.2    Scudder, S.A.3
  • 73
    • 0028134983 scopus 로고
    • An anti-IL-2 antibody increases serum halflife and improves anti-tumor efficacy of human recombinant interleukin-2
    • L.P. Courtney, J.L. Phelps and L.M. Karavodin: An anti-IL-2 antibody increases serum halflife and improves anti-tumor efficacy of human recombinant interleukin-2. Immunopharmacology. 28, 223 (1994).
    • (1994) Immunopharmacology. , vol.28 , pp. 223
    • Courtney, L.P.1    Phelps, J.L.2    Karavodin, L.M.3
  • 75
    • 85084722411 scopus 로고
    • Combination immunotherapy for non-small cell lung cancer-results with interleukin-2 and TNFa
    • Y.C. Yang, L. Owen-Schaub, A. Mendiguren-Rodriquez et al.: Combination immunotherapy for non-small cell lung cancer-results with interleukin-2 and TNFa. J. Thorac. Cardiovasc. Surg. 79, 8 (1990).
    • (1990) J. Thorac. Cardiovasc. Surg. , vol.79 , pp. 8
    • Yang, Y.C.1    Owen-Schaub, L.2    Mendiguren-Rodriquez, A.3
  • 76
    • 0029188227 scopus 로고
    • Interleukin-2-based immunotherapy and chemoimmunotherapy in metastatic melanoma
    • U. Keilholz, C. Scheibenbogen, P. Brossart et al.: Interleukin-2-based immunotherapy and chemoimmunotherapy in metastatic melanoma. Recent Results Cane. Res. 139, 383 (1995).
    • (1995) Recent Results Cane. Res. , vol.139 , pp. 383
    • Keilholz, U.1    Scheibenbogen, C.2    Brossart, P.3
  • 77
    • 0023697540 scopus 로고
    • Combining chemotherapy with biological response modifiers in the treatment of cancer
    • M.S. Mitchell: Combining chemotherapy with biological response modifiers in the treatment of cancer. J. Natl. Cancer Inst. 80, 1445 (1988).
    • (1988) J. Natl. Cancer Inst. , vol.80 , pp. 1445
    • Mitchell, M.S.1
  • 78
    • 0028594033 scopus 로고
    • Combination of chemotherapy with interleukin-2 and interferon-alpha for the treatment of advanced melanoma
    • A.C. Buzaid and S.S. Legha: Combination of chemotherapy with interleukin-2 and interferon-alpha for the treatment of advanced melanoma. Seminars in Oncol. 27, 23 (1994).
    • (1994) Seminars in Oncol. , vol.27 , pp. 23
    • Buzaid, A.C.1    Legha, S.S.2
  • 79
    • 0028908324 scopus 로고
    • Paracrine cytokine adjuvants in cancer immunotherapy
    • D.M. Pardoll: Paracrine cytokine adjuvants in cancer immunotherapy, Annu. Rev. Immunol. 13, 399 (1995).
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 399
    • Pardoll, D.M.1
  • 80
    • 0028813149 scopus 로고
    • Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen
    • J. Triesman, P. Hwu, S. Minamoto, G.E. Shafer et al.: Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen. Blood 85, 139 (1995).
    • (1995) Blood , vol.85 , pp. 139
    • Triesman, J.1    Hwu, P.2    Minamoto, S.3    Shafer, G.E.4
  • 81
    • 0029156407 scopus 로고
    • Clinical protocol: Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer
    • P.A. Cassileth, E. Podack, K. Sridhar et al.: Clinical protocol: Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer. Human Gene Ther. 6, 369 (1995).
    • (1995) Human Gene Ther. , vol.6 , pp. 369
    • Cassileth, P.A.1    Podack, E.2    Sridhar, K.3
  • 82
    • 0027032428 scopus 로고
    • A pilot study of immunization with IL-2 secreting allogeneic HLA-A2 matched renal cell carcinoma cells in patients with advanced renal cell carcinoma
    • B. Gansbacher: A pilot study of immunization with IL-2 secreting allogeneic HLA-A2 matched renal cell carcinoma cells in patients with advanced renal cell carcinoma. Human Gene Therapy 3, 691 (1992).
    • (1992) Human Gene Therapy , vol.3 , pp. 691
    • Gansbacher, B.1
  • 83
    • 9444251670 scopus 로고
    • Clinical Protocols
    • Clinical Protocols. Cancer Gene Ther. 7, 289 (1994).
    • (1994) Cancer Gene Ther. , vol.7 , pp. 289
  • 85
    • 0028912032 scopus 로고
    • Increases in CD4T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection
    • J.A. Kovacs, M. Basler, R.J. Dewar et al.: Increases in CD4T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. N. Engl. J. Med. 332, 567 (1995).
    • (1995) N. Engl. J. Med. , vol.332 , pp. 567
    • Kovacs, J.A.1    Basler, M.2    Dewar, R.J.3
  • 86
    • 0028840964 scopus 로고
    • Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity
    • Z.P. Bernstein, M.M. Porter, M. Gould et al.: Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity. Blood 86, 3287 (1995).
    • (1995) Blood , vol.86 , pp. 3287
    • Bernstein, Z.P.1    Porter, M.M.2    Gould, M.3
  • 87
    • 0028607282 scopus 로고
    • Interleukin-2: Full circle in a decade
    • R.G. Hewitt: Interleukin-2: Full circle in a decade. Infect. in Med. July 490 (1994).
    • (1994) Infect. in Med. , vol.JULY , pp. 490
    • Hewitt, R.G.1
  • 89
    • 0020081969 scopus 로고
    • Identification of a T cell derived B-cell growth factor distinct from IL-2
    • M. Howard, J. Farrar, M. Hilfiker et al.: Identification of a T cell derived B-cell growth factor distinct from IL-2. J. Exp. Med. 755, 914 (1982).
    • (1982) J. Exp. Med. , vol.755 , pp. 914
    • Howard, M.1    Farrar, J.2    Hilfiker, M.3
  • 91
    • 10344228371 scopus 로고
    • Human interleukin 4: Its agonistic and antagonistic effects on B lymphocytes and its receptor
    • S. Romagnani, A.K. Abbas (eds). Raven Press: New York
    • J. Banchereau, T. Defrance, J.P. Galizzi et al.: Human interleukin 4: Its agonistic and antagonistic effects on B lymphocytes and its receptor. In Cytokines: Basic Principles and Clinical Applications. S. Romagnani, A.K. Abbas (eds). Raven Press: New York 1990, 177-187.
    • (1990) Cytokines: Basic Principles and Clinical Applications , pp. 177-187
    • Banchereau, J.1    Defrance, T.2    Galizzi, J.P.3
  • 92
    • 9244246438 scopus 로고    scopus 로고
    • Role of IL-4 in the antitumor response
    • H. Spits (ed). CRC Press: Boca Raton, 19XX
    • M.T. Lotze: Role of IL-4 in the antitumor response. In IL-4 Structure and Function. H. Spits (ed). CRC Press: Boca Raton, 19XX.
    • IL-4 Structure and Function
    • Lotze, M.T.1
  • 93
    • 0023764082 scopus 로고
    • IL-4 regulates differentiation and proliferation of human precursor B cells
    • F.M. Hofman, M. Brock, C.R. Taylor et al.: IL-4 regulates differentiation and proliferation of human precursor B cells. J. Immunol. 141, 1185 (1988).
    • (1988) J. Immunol. , vol.141 , pp. 1185
    • Hofman, F.M.1    Brock, M.2    Taylor, C.R.3
  • 94
    • 0023884382 scopus 로고
    • Resting B lymphocytes can be triggered directly through the CDW40(Gp50) antigen
    • J. Gordon, M.J. Millsum, G.R. Guy et al.: Resting B lymphocytes can be triggered directly through the CDW40(Gp50) antigen. J. Immunol. 140, 1425 (1988).
    • (1988) J. Immunol. , vol.140 , pp. 1425
    • Gordon, J.1    Millsum, M.J.2    Guy, G.R.3
  • 95
    • 0021680253 scopus 로고
    • Increased expression of Ia antigen on resting B cells: A new role for B cell growth factor
    • R. Noelle, P.H. Karmmer, J. Ohara et al.: Increased expression of Ia antigen on resting B cells: a new role for B cell growth factor. Proc. Natl. Acad. Sci. USA 81, 6149 (1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 6149
    • Noelle, R.1    Karmmer, P.H.2    Ohara, J.3
  • 96
    • 0023933655 scopus 로고
    • Differential regulation of IgG1 and IgE synthesis by interleukin 4
    • C.M. Snapper, F.D. Finkelman, W.E. Paul: Differential regulation of IgG1 and IgE synthesis by interleukin 4. J. Exp. Med. 767, 183 (1988).
    • (1988) J. Exp. Med. , vol.767 , pp. 183
    • Snapper, C.M.1    Finkelman, F.D.2    Paul, W.E.3
  • 97
    • 0023683372 scopus 로고
    • Recombinant interleukin 4 [RIL-4] inhibits interleukin-2 induced activation of peripheral blood lymphocytes
    • X. Han, K. Hoh, C.M. Balch et al.: Recombinant interleukin 4 [RIL-4] inhibits interleukin-2 induced activation of peripheral blood lymphocytes. Lympho. Res. 7, 227 (1988).
    • (1988) Lympho. Res. , vol.7 , pp. 227
    • Han, X.1    Hoh, K.2    Balch, C.M.3
  • 98
    • 0023747688 scopus 로고
    • Interleukin 4 inhibits interleukin 2 mediated induction of human lymphokine activated killer cells, but not the generation of antigen specific cytotoxic T lymphocytes in mixed leukocyte cultures
    • H. Spits, H. Yssel, X. Paliard et al.: Interleukin 4 inhibits interleukin 2 mediated induction of human lymphokine activated killer cells, but not the generation of antigen specific cytotoxic T lymphocytes in mixed leukocyte cultures. J. Immunol. 141, 29 (1988).
    • (1988) J. Immunol. , vol.141 , pp. 29
    • Spits, H.1    Yssel, H.2    Paliard, X.3
  • 99
    • 0024513519 scopus 로고
    • Developmental control of lymphokine gene expression in fetal thymocytes during T cell ontogeny
    • S.R. Carding, E.J. Jenkinson, R. Kingston et al.: Developmental control of lymphokine gene expression in fetal thymocytes during T cell ontogeny. Proc. Natl. Acad. Sci. USA 86, 2242 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2242
    • Carding, S.R.1    Jenkinson, E.J.2    Kingston, R.3
  • 100
    • 0023601776 scopus 로고
    • Interferon gamma is produced by activated immature mouse thymocytes and reverses the interleukin 4-induced proliferation of immature thymocytes
    • J. Ransom, M. Fischer, T. Mosmann et al.: Interferon gamma is produced by activated immature mouse thymocytes and reverses the interleukin 4-induced proliferation of immature thymocytes. J. Immunol. 139, 4102 (1987).
    • (1987) J. Immunol. , vol.139 , pp. 4102
    • Ransom, J.1    Fischer, M.2    Mosmann, T.3
  • 101
    • 0025274499 scopus 로고
    • Soluble CD23 (FcE) and interleukin 1 synergistically induce early human thymocyte maturation
    • M.D. Mossalayi, J.C. Lecron, A.H. Dalloul, et al Soluble CD23 (FcE) and interleukin 1 synergistically induce early human thymocyte maturation. J. Exp. Med. 171, 959 (1990).
    • (1990) J. Exp. Med. , vol.171 , pp. 959
    • Mossalayi, M.D.1    Lecron, J.C.2    Dalloul, A.H.3
  • 102
    • 0023133192 scopus 로고
    • B cell stimulatory factor I (interleukin 4) is a potent costimulant for normal resting T lymphocytes
    • J. Hu-Li, E.M. Sherach, J. Mizuguchi et al.: B cell stimulatory factor I (interleukin 4) is a potent costimulant for normal resting T lymphocytes. J. Exp. Med. 165, 157 (1987).
    • (1987) J. Exp. Med. , vol.165 , pp. 157
    • Hu-Li, J.1    Sherach, E.M.2    Mizuguchi, J.3
  • 103
    • 10344221186 scopus 로고    scopus 로고
    • Anti-proliferative effect of IL-4 in B chronic lymphocytic leukemia
    • in press (ref from Spits)
    • H. Luo, M. Rubio, G. Biron et al.: Anti-proliferative effect of IL-4 in B chronic lymphocytic leukemia. J. Immunol. in press (ref from Spits).
    • J. Immunol.
    • Luo, H.1    Rubio, M.2    Biron, G.3
  • 104
    • 0025119692 scopus 로고
    • Low doses of IL-4 injected perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently non-immunogenic tumors and induce a tumor-specific immune memory
    • M. Bosco, M. Giovarelli , M. Forni et al.: Low doses of IL-4 injected perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently non-immunogenic tumors and induce a tumor-specific immune memory. J. Immunol. 145, 3136 (1990).
    • (1990) J. Immunol. , vol.145 , pp. 3136
    • Bosco, M.1    Giovarelli, M.2    Forni, M.3
  • 105
    • 0024502120 scopus 로고
    • Murine interleukin 4 displays potent anti-tumor activity in vivo
    • R.I. Tepper, P.K. Pattengale and P. Leder: Murine interleukin 4 displays potent anti-tumor activity in vivo. Cell 57, 503 (1989).
    • (1989) Cell , vol.57 , pp. 503
    • Tepper, R.I.1    Pattengale, P.K.2    Leder, P.3
  • 106
    • 0025095664 scopus 로고
    • Interleukin 2 production by tumor cells bypasses T helper function in the generation of an anti-tumor response
    • E.R. Fearon, D.M. Pardoll, T. Itanya et al.: Interleukin 2 production by tumor cells bypasses T helper function in the generation of an anti-tumor response. Cell 60, 397 (1990).
    • (1990) Cell , vol.60 , pp. 397
    • Fearon, E.R.1    Pardoll, D.M.2    Itanya, T.3
  • 107
    • 0025604195 scopus 로고
    • Retroviral vector-mediated gamma interferon gene transfer into tumor cells generates potent and long lasting anti-tumor immunity
    • B. Gansbacher, R. Bannerji, B. Daniels et al.: Retroviral vector-mediated gamma interferon gene transfer into tumor cells generates potent and long lasting anti-tumor immunity. Cancer Res. 50, 7820 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 7820
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3
  • 108
    • 0024210868 scopus 로고
    • Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes for human autologous melanoma
    • Y. Kawakami, S.A. Rosenberg and M.T. Lotze: Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes for human autologous melanoma. J. Exp. Med. 768, 2183 (1988).
    • (1988) J. Exp. Med. , vol.768 , pp. 2183
    • Kawakami, Y.1    Rosenberg, S.A.2    Lotze, M.T.3
  • 109
    • 0026696410 scopus 로고
    • Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections - A phase I dose toxicity trial
    • M.H. Gilleece, J.H. Scarffe, A. Ghosh et al.: Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections - a phase I dose toxicity trial. Brit. J. Cancer 66, 204 (1992).
    • (1992) Brit. J. Cancer , vol.66 , pp. 204
    • Gilleece, M.H.1    Scarffe, J.H.2    Ghosh, A.3
  • 110
    • 0025232833 scopus 로고
    • Effects of interleukin 4 on the in vitro growth of human lymphoid and plasma cell neoplasms
    • C.W. Taylor, T.M. Grogan and S.E. Salmon: Effects of interleukin 4 on the in vitro growth of human lymphoid and plasma cell neoplasms. Blood 75, 1114 (1990).
    • (1990) Blood , vol.75 , pp. 1114
    • Taylor, C.W.1    Grogan, T.M.2    Salmon, S.E.3
  • 111
    • 0026049122 scopus 로고
    • Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin 6 expression
    • F. Herrman, M. Andreeft H.J. Gruss et al.: Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin 6 expression. Blood 78, 2070 (1991).
    • (1991) Blood , vol.78 , pp. 2070
    • Herrman, F.1    Andreeft, M.2    Gruss, H.J.3
  • 112
    • 0026569539 scopus 로고
    • Antiproliferative effects of interleukin 4 on freshly isolated non-Hodgkin malignant B-lymphoma cells
    • T. Defrance, A.C. Fluckiger, J.-F. Rossi et al.: Antiproliferative effects of interleukin 4 on freshly isolated non-Hodgkin malignant B-lymphoma cells. Blood 79, 990 (1992).
    • (1992) Blood , vol.79 , pp. 990
    • Defrance, T.1    Fluckiger, A.C.2    Rossi, J.-F.3
  • 113
    • 0026602154 scopus 로고
    • Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6
    • T.E. Tanner and G. Tosato: Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6. Blood 79, 452 (1992).
    • (1992) Blood , vol.79 , pp. 452
    • Tanner, T.E.1    Tosato, G.2
  • 114
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • J. Van Snick: Interleukin-6: An overview. Annu. Rev. Immunol. 5, 253 (1990).
    • (1990) Annu. Rev. Immunol. , vol.5 , pp. 253
    • Van Snick, J.1
  • 116
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 [BSF-2/IFNb2] receptor
    • K. Yamasaki, T. Taga, Y. Hirata et al.: Cloning and expression of the human interleukin-6 [BSF-2/IFNb2] receptor. Science 241, 825 (1988).
    • (1988) Science , vol.241 , pp. 825
    • Yamasaki, K.1    Taga, T.2    Hirata, Y.3
  • 117
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer gp130
    • T. Taga, M. Hibi, Y. Hirata et al.: Interleukin-6 triggers the association of its receptor with a possible signal transducer gp130. Cell 58, 573 (1989).
    • (1989) Cell , vol.58 , pp. 573
    • Taga, T.1    Hibi, M.2    Hirata, Y.3
  • 118
    • 0024446495 scopus 로고
    • Interleukin-6 is a potent thrombopoietic factor in vivo in mice
    • T. Ishibashi, H. Kimura, Y. Shikama et al.: Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood 74, 1241 (1989).
    • (1989) Blood , vol.74 , pp. 1241
    • Ishibashi, T.1    Kimura, H.2    Shikama, Y.3
  • 119
    • 0027461967 scopus 로고
    • Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies
    • J. Weber, J.C. Yang, S.L. Topalian et al.: Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J. Clin. Oncol. 11, 499 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 499
    • Weber, J.1    Yang, J.C.2    Topalian, S.L.3
  • 120
    • 0024502002 scopus 로고
    • Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSG
    • D. Caracciolo, S.C. Clark and G. Rovera: Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSG. Blood 73, 666 (1989).
    • (1989) Blood , vol.73 , pp. 666
    • Caracciolo, D.1    Clark, S.C.2    Rovera, G.3
  • 121
    • 0004847262 scopus 로고
    • Phase IA/IB trial of rhIL-6 in patients with refractory malignancy: Hematologic and immunologic effects
    • T. Olencki, G.T. Budd, S. Murthy et al.: Phase IA/IB trial of rhIL-6 in patients with refractory malignancy: hematologic and immunologic effects. Blood Suppl 1, 89a (1992).
    • (1992) Blood , vol.1 SUPPL
    • Olencki, T.1    Budd, G.T.2    Murthy, S.3
  • 122
    • 0025321245 scopus 로고
    • In vivo administration of recombinant interleukin-6 mediates tumor regression in mice
    • J.J. Mulé, J.K. McIntosh, D.M. Jablons et al.: In vivo administration of recombinant interleukin-6 mediates tumor regression in mice. J. Exp. Med. 171, 629 (1990).
    • (1990) J. Exp. Med. , vol.171 , pp. 629
    • Mulé, J.J.1    McIntosh, J.K.2    Jablons, D.M.3
  • 123
    • 0026485358 scopus 로고
    • Clinical applications of IL-6 in cancer therapy
    • J.J. Mulé, S.G. Marcus, J.C. Yang et al.: Clinical applications of IL-6 in cancer therapy. Res. Immunol. 143, 777 (1992).
    • (1992) Res. Immunol. , vol.143 , pp. 777
    • Mulé, J.J.1    Marcus, S.G.2    Yang, J.C.3
  • 124
    • 0026772066 scopus 로고
    • IL-6 gene transfection into 3LL tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells
    • A. Porgator, E. Tzehoval, A. Katz et al.: IL-6 gene transfection into 3LL tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. Cancer Res. 52, 3679 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 3679
    • Porgator, A.1    Tzehoval, E.2    Katz, A.3
  • 125
    • 0028153776 scopus 로고
    • Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: Induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity
    • C. Scheid, R. Young, R. McDermott et al.: Immune function of patients receiving recombinant human interleukin-6 (IL-6) in a phase I clinical study: induction of C-reactive protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity. Cancer Immunol. Immunother. 38, 119 (1994).
    • (1994) Cancer Immunol. Immunother. , vol.38 , pp. 119
    • Scheid, C.1    Young, R.2    McDermott, R.3
  • 126
    • 0026637522 scopus 로고
    • Production of natural killer cell activity-augmenting factor (interleukin-6) by human epiphyseal chondrocytes
    • J. Malejczyk, M. Malejczyk, A. Urbanski and T.A. Luger: Production of natural killer cell activity-augmenting factor (interleukin-6) by human epiphyseal chondrocytes. Arthritis Rheum. 35, 706 (1992).
    • (1992) Arthritis Rheum. , vol.35 , pp. 706
    • Malejczyk, J.1    Malejczyk, M.2    Urbanski, A.3    Luger, T.A.4
  • 127
    • 0028933658 scopus 로고
    • Establishment of a novel myeloma cell line KPMM2 canying t(3;14)(q21;q32), which proliferates specifically in response to interleukin-6 through an autocrine mechanism
    • H. Goto, C. Shimazaki, T. Tatsumi et al.: Establishment of a novel myeloma cell line KPMM2 canying t(3;14)(q21;q32), which proliferates specifically in response to interleukin-6 through an autocrine mechanism. Leukemia 9, 711 (1995).
    • (1995) Leukemia , vol.9 , pp. 711
    • Goto, H.1    Shimazaki, C.2    Tatsumi, T.3
  • 128
    • 0028267592 scopus 로고
    • High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma
    • O.F. Ballester, L.C. Moscinski, G.H. Lyman et al.: High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood 83, 1903 (1994).
    • (1994) Blood , vol.83 , pp. 1903
    • Ballester, O.F.1    Moscinski, L.C.2    Lyman, G.H.3
  • 129
    • 0025990509 scopus 로고
    • Interferon-gamma interrupts autocrine growth mediated by endogenous interleukin-6 in renal-cell carcinoma
    • H.J. Gruss, M.A. Brach, R.H. Mertelsmann and F. Herrmann: Interferon-gamma interrupts autocrine growth mediated by endogenous interleukin-6 in renal-cell carcinoma. International J. Cancer 71, 770 (1991).
    • (1991) International J. Cancer , vol.71 , pp. 770
    • Gruss, H.J.1    Brach, M.A.2    Mertelsmann, R.H.3    Herrmann, F.4
  • 130
    • 0028243588 scopus 로고
    • Inhibition of CT-26 murine adenocarcinoma growth in the rectum of mice treated with recombinant human interleukin-6
    • M. Rabau, H. Kashtan, S. Baron et al.: Inhibition of CT-26 murine adenocarcinoma growth in the rectum of mice treated with recombinant human interleukin-6. J. Immunother. Emphasis Tumor. Immunol. 15, 257 (1994).
    • (1994) J. Immunother. Emphasis Tumor. Immunol. , vol.15 , pp. 257
    • Rabau, M.1    Kashtan, H.2    Baron, S.3
  • 131
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis inhibitory factor (IL-10) to Epstein-Barr virus gene BCRF1
    • K.W. Moore, P. Vieira, D.F. Florentine et al.: Homology of cytokine synthesis inhibitory factor (IL-10) to Epstein-Barr virus gene BCRF1. Science 248, 1230 (1990).
    • (1990) Science , vol.248 , pp. 1230
    • Moore, K.W.1    Vieira, P.2    Florentine, D.F.3
  • 132
    • 0029148581 scopus 로고
    • Crystal structure of interleukin-10 reveals an interferon gamma-like fold
    • M.R. Walter and T.L. Nagabhushan: Crystal structure of interleukin-10 reveals an interferon gamma-like fold. Biochemistry 34, 12118 (1995).
    • (1995) Biochemistry , vol.34 , pp. 12118
    • Walter, M.R.1    Nagabhushan, T.L.2
  • 133
    • 0029644946 scopus 로고
    • Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma
    • A. Zdanov, C. Schalk-Hihi, A. Gustchina et al.: Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure 3, 591 (1995).
    • (1995) Structure , vol.3 , pp. 591
    • Zdanov, A.1    Schalk-Hihi, C.2    Gustchina, A.3
  • 134
    • 10344220118 scopus 로고
    • Expression cloning of the human IL-10 receptor
    • Y. Lui, S.H. Wei, A.S. Ho et al.: Expression cloning of the human IL-10 receptor. J. Immunol. 15, 1821 (1994).
    • (1994) J. Immunol. , vol.15 , pp. 1821
    • Lui, Y.1    Wei, S.H.2    Ho, A.S.3
  • 136
    • 0026570853 scopus 로고
    • IL-10 inhibits T-cell proliferation and IL-2 production
    • K. Taga and G. Tosato: IL-10 inhibits T-cell proliferation and IL-2 production. J. Immunol. 748, 1143 (1992).
    • (1992) J. Immunol. , vol.748 , pp. 1143
    • Taga, K.1    Tosato, G.2
  • 137
    • 0026094306 scopus 로고
    • Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • M. de Waal, R.J. Abrams, B. Bennet et al.: Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174, 1209 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 1209
    • De Waal, M.1    Abrams, R.J.2    Bennet, B.3
  • 138
    • 0029017121 scopus 로고
    • The functional characterization of interleukin-10 receptor expression on human natural killer cells
    • W.E. Carson, M.J. Lindemann, R. Baiocchi et al.: The functional characterization of interleukin-10 receptor expression on human natural killer cells. Blood 85, 3577 (1995).
    • (1995) Blood , vol.85 , pp. 3577
    • Carson, W.E.1    Lindemann, M.J.2    Baiocchi, R.3
  • 139
    • 0029070119 scopus 로고
    • A randomized, controlled trial of IL-10 in humans
    • A.E. Chernoff, E.V. Granowitz, L. Shapiro et al.: A randomized, controlled trial of IL-10 in humans. J. Immunol. 154, 5492 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5492
    • Chernoff, A.E.1    Granowitz, E.V.2    Shapiro, L.3
  • 140
    • 0028908520 scopus 로고
    • Antitumor effects of interleukin-12 (IL-12): Applications for the immunotherapy and gene therapy of cancer
    • H. Tahara and M.T. Lotze: Antitumor effects of interleukin-12 (IL-12): applications for the immunotherapy and gene therapy of cancer. Gene Therapy 2, 96 (1995).
    • (1995) Gene Therapy , vol.2 , pp. 96
    • Tahara, H.1    Lotze, M.T.2
  • 141
    • 0028139174 scopus 로고
    • The role of interleukin 12 in the immune response, disease and therapy
    • G. Trinchieri and P. Scott: The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 15 , 460 (1994).
    • (1994) Immunol. Today , vol.15 , pp. 460
    • Trinchieri, G.1    Scott, P.2
  • 142
    • 0029122962 scopus 로고
    • Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease
    • F.D. Finkelman: Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease. J. Exp. Med. 182, 279 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 279
    • Finkelman, F.D.1
  • 143
    • 0029031029 scopus 로고
    • Activation of γδT cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12
    • M.J. Skeen and H.K. Ziegler: Activation of γδT cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J. Immunol. 154, 5832 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5832
    • Skeen, M.J.1    Ziegler, H.K.2
  • 144
    • 0028510360 scopus 로고
    • Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide
    • R.T. Gazzinelli, S. Hayashi, M. Wysocka et al.: Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide. J. Eukaryotic Microbiol. 41, 9S (1994).
    • (1994) J. Eukaryotic Microbiol. , vol.41
    • Gazzinelli, R.T.1    Hayashi, S.2    Wysocka, M.3
  • 145
    • 0028132982 scopus 로고
    • Interteukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis-infected human monocytes
    • M. Denis: Interteukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis-infected human monocytes. Cellular Immunol. 756, 529 (1994).
    • (1994) Cellular Immunol. , vol.756 , pp. 529
    • Denis, M.1
  • 146
    • 0027963161 scopus 로고
    • Recombinant IL-12 administration induces tumor regression in association with IFN-α production
    • C.L. Nastala, H.D. Edington, T.G. McKinney et al.: Recombinant IL-12 administration induces tumor regression in association with IFN-α production. J. Immunol. 153, 1697 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 1697
    • Nastala, C.L.1    Edington, H.D.2    McKinney, T.G.3
  • 147
    • 0028982517 scopus 로고
    • Th1 and Th2 subsets: Paradigms lost
    • A. Kelso: Th1 and Th2 subsets: paradigms lost. Immunol. Today 16, 374 (1995).
    • (1995) Immunol. Today , vol.16 , pp. 374
    • Kelso, A.1
  • 148
    • 0028931469 scopus 로고
    • IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ
    • T.A. Wynn, D. Jankovic, S. Hieny et al.: IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154, 3999 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 3999
    • Wynn, T.A.1    Jankovic, D.2    Hieny, S.3
  • 149
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor a production
    • A. D'Andrea, X. Ma, M. Aste-Amezaga et al.: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor a production. J. Exp. Med. 181, 537 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 537
    • D'Andrea, A.1    Ma, X.2    Aste-Amezaga, M.3
  • 150
    • 0029042649 scopus 로고
    • IL-12 enhances vaccine-induced immunity to Schisotoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia
    • T. A. Wynn, D. Kankovic, S. Hieny et al.: IL-12 enhances vaccine-induced immunity to Schisotoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J. Immunol. 154, 4701 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 4701
    • Wynn, T.A.1    Kankovic, D.2    Hieny, S.3
  • 151
    • 0029062597 scopus 로고
    • IL-12 at the crossroads
    • S.S. Hall: IL-12 at the crossroads. Science 268, 1432 (1995).
    • (1995) Science , vol.268 , pp. 1432
    • Hall, S.S.1
  • 152
    • 0028910222 scopus 로고
    • Interleukin-12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differntial use of Janus family tyrosine kinases by 11-2 and IL-12
    • C.M. Bacon, D.W. McVicar, J.R. Ortaldo et al.: Interleukin-12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differntial use of Janus family tyrosine kinases by 11-2 and IL-12. J. Exp. Med. 181, 399 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 399
    • Bacon, C.M.1    McVicar, D.W.2    Ortaldo, J.R.3
  • 153
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • K.H. Grabstein, J. Eisenman, K. Shanebeck et al.: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264, 965 (1994).
    • (1994) Science , vol.264 , pp. 965
    • Grabstein, K.H.1    Eisenman, J.2    Shanebeck, K.3
  • 154
    • 0028221433 scopus 로고
    • Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    • J.G. Giri, M. Ahdieh, J. Eisenmann et al.: Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13, 2822 (1994).
    • (1994) EMBO J. , vol.13 , pp. 2822
    • Giri, J.G.1    Ahdieh, M.2    Eisenmann, J.3
  • 155
    • 0029099146 scopus 로고
    • Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    • J. Giri, S. Kumaki, M. Ahdieh et al.: Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 14, 3654 (1995).
    • (1995) EMBO J. , vol.14 , pp. 3654
    • Giri, J.1    Kumaki, S.2    Ahdieh, M.3
  • 156
    • 0028798403 scopus 로고
    • IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation
    • R.J. Armitage, B.M. Macduff, J. Eisenman et al.: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 15, 483 (1995).
    • (1995) J. Immunol. , vol.15 , pp. 483
    • Armitage, R.J.1    Macduff, B.M.2    Eisenman, J.3
  • 157
    • 0028910341 scopus 로고
    • Interleukin-15 and the growth of tumor derived activated T-cells
    • W.M. Lewko, T.L. Smith, D.J. Bowman et al.: Interleukin-15 and the growth of tumor derived activated T-cells. Cancer Biother. 10, 13 (1995).
    • (1995) Cancer Biother. , vol.10 , pp. 13
    • Lewko, W.M.1    Smith, T.L.2    Bowman, D.J.3
  • 158
    • 0028829105 scopus 로고
    • Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2
    • W. Munger, S.Q. DeJoy, R. Jeyaseelan Sr. et al.: Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2. Cellular Immunol. 165, 289 (1995).
    • (1995) Cellular Immunol. , vol.165 , pp. 289
    • Munger, W.1    DeJoy, S.Q.2    Jeyaseelan Sr., R.3
  • 159
    • 0029098563 scopus 로고
    • Interleukin-15: A novel anabolic cytokine for skeletal muscle
    • L.S. Quinn, K.L. Haugk and K.H. Grabstein: Interleukin-15: A novel anabolic cytokine for skeletal muscle. Endocrinology 126, 3669 (1995).
    • (1995) Endocrinology , vol.126 , pp. 3669
    • Quinn, L.S.1    Haugk, K.L.2    Grabstein, K.H.3
  • 160
    • 0010621993 scopus 로고
    • Interferons
    • J.F. Holland et al. (eds). Lea & Feabiger: Philadelphia
    • E.C. Borden: Interferons. In: Cancer Medicine. J.F. Holland et al. (eds). 1993. Lea & Feabiger: Philadelphia.
    • (1993) Cancer Medicine
    • Borden, E.C.1
  • 161
    • 0001913587 scopus 로고
    • Interferons: An overview of their biological and biochemical properties
    • L.M. Pfeffer (ed). CRC Press, Inc: Boca Raton
    • S.E. Grossberg: Interferons: an overview of their biological and biochemical properties. In Mechanism of Interferon Actions, L.M. Pfeffer (ed). 1987. CRC Press, Inc: Boca Raton, p. 137.
    • (1987) Mechanism of Interferon Actions , pp. 137
    • Grossberg, S.E.1
  • 162
    • 0019853949 scopus 로고
    • Evidence that types I and II interferons have different receptors
    • A.A. Branca and C. Baglioni: Evidence that types I and II interferons have different receptors. Nature 294, 768 (1981).
    • (1981) Nature , vol.294 , pp. 768
    • Branca, A.A.1    Baglioni, C.2
  • 163
    • 0023685684 scopus 로고
    • Molecular cloning and expression of the human interferon-g receptor
    • M. Aguet, Z. Dembic and G. Merlin: Molecular cloning and expression of the human interferon-g receptor. Cell 55, 273 (1988).
    • (1988) Cell , vol.55 , pp. 273
    • Aguet, M.1    Dembic, Z.2    Merlin, G.3
  • 164
    • 0027214809 scopus 로고
    • The biology and biochemistry of interferon-gamma and its receptor
    • R.D. Schreiber and M.A. Farrar: The biology and biochemistry of interferon-gamma and its receptor. Gastroenterol. Jpn. 4, 88 (1993).
    • (1993) Gastroenterol. Jpn. , vol.4 , pp. 88
    • Schreiber, R.D.1    Farrar, M.A.2
  • 165
    • 0019434576 scopus 로고
    • Activation of mouse macrophages for tumor cell killing. Quantitave analysis of interactions between lymphokine and lipopolysaccharide
    • J.L. Pace and S.W. Russell: Activation of mouse macrophages for tumor cell killing. Quantitave analysis of interactions between lymphokine and lipopolysaccharide. J. Immunol. 126, 1863 (1981).
    • (1981) J. Immunol. , vol.126 , pp. 1863
    • Pace, J.L.1    Russell, S.W.2
  • 166
    • 0039410139 scopus 로고
    • Influence of antimouse interferon serum on the growth and metastasis of tumor cells persistently infected by virus and of human prostatic tumors in athymic mice
    • L. Reid, N. Minato, I. Gresser et al.: Influence of antimouse interferon serum on the growth and metastasis of tumor cells persistently infected by virus and of human prostatic tumors in athymic mice. Proc. Natl. Acad. Sci. 78, 1171 (1981).
    • (1981) Proc. Natl. Acad. Sci. , vol.78 , pp. 1171
    • Reid, L.1    Minato, N.2    Gresser, I.3
  • 167
    • 0021070204 scopus 로고
    • Injection of mice with antibody to interferon enhances the growth of murine transplantable tumors
    • I. Gresser, F. Belardelli, C. Maury et al.: Injection of mice with antibody to interferon enhances the growth of murine transplantable tumors. J. Exp. Med. 158, 2095 (1983).
    • (1983) J. Exp. Med. , vol.158 , pp. 2095
    • Gresser, I.1    Belardelli, F.2    Maury, C.3
  • 168
    • 0021078845 scopus 로고
    • Effects of recombinant interferon-alpha on immune function in cancer patients
    • A.E. Maluish: Effects of recombinant interferon-alpha on immune function in cancer patients. J. Biol. Response Mod. 2, 470 (1983).
    • (1983) J. Biol. Response Mod. , vol.2 , pp. 470
    • Maluish, A.E.1
  • 169
    • 0020450948 scopus 로고
    • Interferon-dependent induction of mRNA for the major histocompatability antigens in human fibroblasts and lymphoblastoid cell lines
    • M. Fellous, U. Nir, D. Wallach et al.: Interferon-dependent induction of mRNA for the major histocompatability antigens in human fibroblasts and lymphoblastoid cell lines. Proc. Natl. Acad. Sci. 79, 3082, 1982.
    • (1982) Proc. Natl. Acad. Sci. , vol.79 , pp. 3082
    • Fellous, M.1    Nir, U.2    Wallach, D.3
  • 170
    • 0026673760 scopus 로고
    • Effect of rIFN-gamma on antibody-mediated cytotoxicity via human monocyte IgG Fc receptor II (CD32)
    • R.C. van Schie, H.G. Verstraten, W.J. Tax et al.: Effect of rIFN-gamma on antibody-mediated cytotoxicity via human monocyte IgG Fc receptor II (CD32). Scand. J. Immunol. 36, 385 (1992).
    • (1992) Scand. J. Immunol. , vol.36 , pp. 385
    • Van Schie, R.C.1    Verstraten, H.G.2    Tax, W.J.3
  • 171
    • 0027057265 scopus 로고
    • IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10
    • A.A. te Velde, R. de Waal Malefijt, R.J. Huijbens et al.: IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10. J. Immunol. 149, 4048 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 4048
    • Te Velde, A.A.1    De Waal Malefijt, R.2    Huijbens, R.J.3
  • 172
    • 0027406416 scopus 로고
    • Enhancement of the antibody-dependent cellular cytotoxicity of human peripheral blood lymphocytes with interleukin-2 and interferon alpha
    • W.M. Vuist, M.J. Visseren, M. Otsen et al.: Enhancement of the antibody-dependent cellular cytotoxicity of human peripheral blood lymphocytes with interleukin-2 and interferon alpha. Cancer Immunol. Immunother. 36, 163 (1993).
    • (1993) Cancer Immunol. Immunother. , vol.36 , pp. 163
    • Vuist, W.M.1    Visseren, M.J.2    Otsen, M.3
  • 173
    • 0027522959 scopus 로고
    • Improvement of Superoxide production in monocytes from patients with chronic granulomatous disease by recombinant cytokines
    • V. Jendrossek, A.M. Peters, S. Buth et al.: Improvement of Superoxide production in monocytes from patients with chronic granulomatous disease by recombinant cytokines. Blood 81, 2131 (1993).
    • (1993) Blood , vol.81 , pp. 2131
    • Jendrossek, V.1    Peters, A.M.2    Buth, S.3
  • 174
    • 0027158409 scopus 로고
    • Costimulatory signals are required for optimal proliferation of human natural killer cells
    • M.J. Robertson, T.J. Manley, C. Donahue et al.: Costimulatory signals are required for optimal proliferation of human natural killer cells. J. Immunol. 150, 1705 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 1705
    • Robertson, M.J.1    Manley, T.J.2    Donahue, C.3
  • 175
    • 0025639142 scopus 로고
    • Biology and clinical relevance of human natural killer cells
    • M.J. Robertson and J. Ritz: Biology and clinical relevance of human natural killer cells. Blood 76, 2421 (1990).
    • (1990) Blood , vol.76 , pp. 2421
    • Robertson, M.J.1    Ritz, J.2
  • 176
    • 0011956359 scopus 로고
    • Principles of Tumor Immunity: Biology of Cellular Immune Responses
    • V.T. Devita, S. Hellman, S.A. Rosenberg (eds). J. B. Lippincott: New York
    • J.R. Wunderlich and R.J. Hodes: Principles of Tumor Immunity: Biology of Cellular Immune Responses, in: Biologic Therapy of Cancer, V.T. Devita, S. Hellman, S.A. Rosenberg (eds). 1991. J. B. Lippincott: New York. p. 14.
    • (1991) Biologic Therapy of Cancer , pp. 14
    • Wunderlich, J.R.1    Hodes, R.J.2
  • 177
    • 0018886078 scopus 로고
    • Mode regulation of natural killer cell activity by intereferon
    • N. Minato, L. Reid, H. Cantor et al.: Mode regulation of natural killer cell activity by intereferon. J. Exp. Med. 152, 124 (1980).
    • (1980) J. Exp. Med. , vol.152 , pp. 124
    • Minato, N.1    Reid, L.2    Cantor, H.3
  • 178
    • 0026668049 scopus 로고
    • Natural killer cell activity against cultured melanoma cells: A dye-reduction technique with studies on augmented activity by interferon subtypes
    • C. Losinno, B.D. Wines, T.G. Johns et al.: Natural killer cell activity against cultured melanoma cells: a dye-reduction technique with studies on augmented activity by interferon subtypes. Nat. Immun. 11, 215 (1992).
    • (1992) Nat. Immun. , vol.11 , pp. 215
    • Losinno, C.1    Wines, B.D.2    Johns, T.G.3
  • 179
    • 0018143273 scopus 로고
    • Enhanced NK cell activity in mice injected with interferon and interferon inducers
    • M.A. Giedlund, H. Orn and H. Wigzell: Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature 273, 759 (1987).
    • (1987) Nature , vol.273 , pp. 759
    • Giedlund, M.A.1    Orn, H.2    Wigzell, H.3
  • 180
    • 0019261703 scopus 로고
    • Cellular Interactions in the augmentation of human NK activity by interferon
    • E. Saksela, T. Timonen and K. Cantell: Cellular Interactions in the augmentation of human NK activity by interferon. Ann. N.Y. Acad. Sci. 350, 102 (1980).
    • (1980) Ann. N.Y. Acad. Sci. , vol.350 , pp. 102
    • Saksela, E.1    Timonen, T.2    Cantell, K.3
  • 181
    • 0019349313 scopus 로고
    • Interferon-mediated protection of normal and tumor target cells against lysis by mouse natural killer cells
    • R.M. Welsh, K. Karre, M. Hansson et al: Interferon-mediated protection of normal and tumor target cells against lysis by mouse natural killer cells. J. Immunol. 1, 219 (1981).
    • (1981) J. Immunol. , vol.1 , pp. 219
    • Welsh, R.M.1    Karre, K.2    Hansson, M.3
  • 182
    • 0027415223 scopus 로고
    • Effects of interferons and cytokines on melanoma cells
    • C. Garbe and K. Krasagakis: Effects of interferons and cytokines on melanoma cells. J. Invest. Derm. 100, 239S (1993).
    • (1993) J. Invest. Derm. , vol.100
    • Garbe, C.1    Krasagakis, K.2
  • 183
    • 0027262562 scopus 로고
    • Direct and indirect effects of human interferon alpha on renal cell carcinoma: A new in vitro assay system for evaluating cytokine-mediated antitumor effects
    • H. Matsuyama, S. Yoshihiro, Y. Ohmoto et al.: Direct and indirect effects of human interferon alpha on renal cell carcinoma: a new in vitro assay system for evaluating cytokine-mediated antitumor effects. Cancer Immunol. Immunother. 37, 84 (1993).
    • (1993) Cancer Immunol. Immunother. , vol.37 , pp. 84
    • Matsuyama, H.1    Yoshihiro, S.2    Ohmoto, Y.3
  • 184
    • 0027530151 scopus 로고
    • Combination treatment of 2-chlorodeoxyadenosine and type I interferon on hairy cell leukemia-like cells: Cytotoxic effect and MHC-unrestricted killer cell regulation
    • Z. Reiter, S. Tomson, O.N. Ozes et al.: Combination treatment of 2-chlorodeoxyadenosine and type I interferon on hairy cell leukemia-like cells: cytotoxic effect and MHC-unrestricted killer cell regulation. Blood 81, 1699 (1993).
    • (1993) Blood , vol.81 , pp. 1699
    • Reiter, Z.1    Tomson, S.2    Ozes, O.N.3
  • 185
    • 0027396813 scopus 로고
    • Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase
    • E.F. Meurs, J. Galabru, G.N. Barber et al.: Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. 90, 232 (1993).
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 232
    • Meurs, E.F.1    Galabru, J.2    Barber, G.N.3
  • 186
    • 0026649586 scopus 로고
    • Lack of expression of tumor-suppressor genes in human malignant glioma cell lines
    • R. Godbout, J. Miyakoshi, K.D. Dobler et al.: Lack of expression of tumor-suppressor genes in human malignant glioma cell lines. Oncogene 7, 1879 (1992).
    • (1992) Oncogene , vol.7 , pp. 1879
    • Godbout, R.1    Miyakoshi, J.2    Dobler, K.D.3
  • 187
    • 0027175376 scopus 로고
    • Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers
    • O.I. Olopade, D.L. Buchhagen, K. Malik et al.: Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res. 55 (Suppl. 10), 2410 (1993).
    • (1993) Cancer Res. , vol.55 , Issue.10 SUPPL. , pp. 2410
    • Olopade, O.I.1    Buchhagen, D.L.2    Malik, K.3
  • 188
    • 0027447248 scopus 로고
    • Dynamic test with recombinant interferon-alpha-2b: Effect on 90K and other tumour-associated antigens in cancer patients without evidence of disease
    • C. Natoli, C. Garufi, N. Tinari et al.: Dynamic test with recombinant interferon-alpha-2b: effect on 90K and other tumour-associated antigens in cancer patients without evidence of disease. Br. J. Cancer 67, 564 (1993).
    • (1993) Br. J. Cancer , vol.67 , pp. 564
    • Natoli, C.1    Garufi, C.2    Tinari, N.3
  • 189
    • 0027416637 scopus 로고
    • Induction of the intercellular adhesion molecule (ICAM-1) on squamous cell carcinoma by interferon gamma
    • R.L. Scher, W.M. Koch and W.J. Richtsmeier: Induction of the intercellular adhesion molecule (ICAM-1) on squamous cell carcinoma by interferon gamma. Arch. Otolaryngol. Head Neck Surg. 119, 432 (1993).
    • (1993) Arch. Otolaryngol. Head Neck Surg. , vol.119 , pp. 432
    • Scher, R.L.1    Koch, W.M.2    Richtsmeier, W.J.3
  • 190
    • 0027460864 scopus 로고
    • Differential regulation of carcinoembryonic antigen and biliary glycoprotein by gamma-interferon
    • H. Takahashi, Y. Okai, R.J. Paxton et al.: Differential regulation of carcinoembryonic antigen and biliary glycoprotein by gamma-interferon. Cancer Res. 53, 1612 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 1612
    • Takahashi, H.1    Okai, Y.2    Paxton, R.J.3
  • 191
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
    • N. Weidner, J.P. Semple, W.R. Welch et al.: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med. 324, 1 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 192
    • 0027043136 scopus 로고
    • Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma
    • N. Weidner, J. Folkman, F. Dozza et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma [see comments]. J. Natl. Cancer Inst. 84, 1875 (1992).
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1875
    • Weidner, N.1    Folkman, J.2    Dozza, F.3
  • 193
    • 0026735235 scopus 로고
    • Inhibition of tumor-induced angiogenesis by the administration of recombinant interferon-gamma followed by a synthetic lipid-A subunit analogue (GLA-60)
    • I. Saiki, K. Sato, Y.C. Yoo et al.: Inhibition of tumor-induced angiogenesis by the administration of recombinant interferon-gamma followed by a synthetic lipid-A subunit analogue (GLA-60). Intl. J. Cancer 57, 641 (1992).
    • (1992) Intl. J. Cancer , vol.57 , pp. 641
    • Saiki, I.1    Sato, K.2    Yoo, Y.C.3
  • 195
    • 0025324547 scopus 로고
    • Treatment of hemangiomatosis with recombinant interferon alfa
    • C.W. White: Treatment of hemangiomatosis with recombinant interferon alfa. Semin. Hematol. 27, 15 (1990).
    • (1990) Semin. Hematol. , vol.27 , pp. 15
    • White, C.W.1
  • 196
    • 0026028219 scopus 로고
    • Differential effects of interferon gamma and alpha on in vitro model of angiogenesis
    • R.K. Maheshwari, V. Srikantan, D. Bhartiya et al.: Differential effects of interferon gamma and alpha on in vitro model of angiogenesis. J. Cell. Physiol. 146, 164 (1991).
    • (1991) J. Cell. Physiol. , vol.146 , pp. 164
    • Maheshwari, R.K.1    Srikantan, V.2    Bhartiya, D.3
  • 197
    • 0026348814 scopus 로고
    • Angiogenesis and its inhibition: Potential new therapies in oncology and non-neoplastic diseases
    • D.C. Billington: Angiogenesis and its inhibition: potential new therapies in oncology and non-neoplastic diseases. Drug Des. Discov. 8, 3 (1991).
    • (1991) Drug Des. Discov. , vol.8 , pp. 3
    • Billington, D.C.1
  • 198
    • 0021345092 scopus 로고
    • Alpha interferon for the induction of remission in hairy-cell leukemia
    • J.R. Quesada, J. Reuben, J.T. Manning et al.: Alpha interferon for the induction of remission in hairy-cell leukemia. N. Engl. J. Med. 310, 15 (1984).
    • (1984) N. Engl. J. Med. , vol.310 , pp. 15
    • Quesada, J.R.1    Reuben, J.2    Manning, J.T.3
  • 199
    • 0023607974 scopus 로고
    • Hairy cells possess more interferon receptors than other lymphoid cell types
    • R. Dadmarz, T. Evans, D. Secher et al.: Hairy cells possess more interferon receptors than other lymphoid cell types. Leukemia 1, 357 (1987).
    • (1987) Leukemia , vol.1 , pp. 357
    • Dadmarz, R.1    Evans, T.2    Secher, D.3
  • 200
    • 0023550124 scopus 로고
    • Effect of alpha-2-interferon on hairy cells and cell lines. A role for type I interferon receptors and RNA synthesis
    • J.D. Scharzmeier, M. Schwabe, L. Wagner et al.: Effect of alpha-2-interferon on hairy cells and cell lines. A role for type I interferon receptors and RNA synthesis. Leukemia 1, 361 (1987).
    • (1987) Leukemia , vol.1 , pp. 361
    • Scharzmeier, J.D.1    Schwabe, M.2    Wagner, L.3
  • 201
    • 0023196529 scopus 로고
    • Clinical investigation of human alpha interferon in chronic myelogenous leukemia
    • M. Talpaz, H.M. Kantarjain, K.B. McCerdie et al.: Clinical investigation of human alpha interferon in chronic myelogenous leukemia. Blood 69, 1280, (1987).
    • (1987) Blood , vol.69 , pp. 1280
    • Talpaz, M.1    Kantarjain, H.M.2    McCerdie, K.B.3
  • 202
    • 0023611741 scopus 로고
    • Therapy of chronic myelogenous leukemia with recombinant interferon-gamma
    • R. Kurzrock, M. Talpaz, H.M. Kantarjain et al.: Therapy of chronic myelogenous leukemia with recombinant interferon-gamma. Blood 70, 943 (1987).
    • (1987) Blood , vol.70 , pp. 943
    • Kurzrock, R.1    Talpaz, M.2    Kantarjain, H.M.3
  • 203
    • 0021878220 scopus 로고
    • Down regulation of peripheral blood cell interferon receptors in chronic myelogenous leukemia patients undergoing human interferon (HuIFN) therapy
    • B. Maxwell, M. Talpaz and J.U. Gutterman: Down regulation of peripheral blood cell interferon receptors in chronic myelogenous leukemia patients undergoing human interferon (HuIFN) therapy. Intl. J. Cancer. 56, 23 (1985).
    • (1985) Intl. J. Cancer. , vol.56 , pp. 23
    • Maxwell, B.1    Talpaz, M.2    Gutterman, J.U.3
  • 204
    • 0022489309 scopus 로고
    • In vitro sensitivity and resistance of chronic myelogenous leukemia cells to alpha interferon: Correlation with receptor binding and induction of 2′5′ oligoadenylate synthetase
    • M. Rosenblum, B. Maxwell, M. Talpaz et al.: In vitro sensitivity and resistance of chronic myelogenous leukemia cells to alpha interferon: Correlation with receptor binding and induction of 2′5′ oligoadenylate synthetase. Cancer Res. 46, 4848 (1986).
    • (1986) Cancer Res. , vol.46 , pp. 4848
    • Rosenblum, M.1    Maxwell, B.2    Talpaz, M.3
  • 205
    • 0344082058 scopus 로고
    • Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level
    • E. Knight, Jr., E.D. Anton, D. Fahey et al.: Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level. Proc. Natl. Acad. Sci. USA 82, 1151 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 1151
    • Knight Jr., E.1    Anton, E.D.2    Fahey, D.3
  • 206
    • 0020696384 scopus 로고
    • Renal Cell Carcinoma: Antitumor effects of leukocyte interferon
    • J.R. Quesada, D.A. Swanson, A. Trindade et al.: Renal Cell Carcinoma: Antitumor effects of leukocyte interferon. Cancer Res. 43, 940 (1983).
    • (1983) Cancer Res. , vol.43 , pp. 940
    • Quesada, J.R.1    Swanson, D.A.2    Trindade, A.3
  • 207
    • 0021915420 scopus 로고
    • A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: The American Cancer Society Collaborative Trial
    • J.M. Kirkwood, J.E. Harris, R. Vera et al.: A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: The American Cancer Society Collaborative Trial. Cancer Res. 45, 863 (1985).
    • (1985) Cancer Res. , vol.45 , pp. 863
    • Kirkwood, J.M.1    Harris, J.E.2    Vera, R.3
  • 208
    • 0022455717 scopus 로고
    • Phase II study of alpha interferon on renal cell carcinoma
    • T. Umeda and T. Niijima: Phase II study of alpha interferon on renal cell carcinoma. Cancer 58, 1231 (1986).
    • (1986) Cancer , vol.58 , pp. 1231
    • Umeda, T.1    Niijima, T.2
  • 209
    • 0023135868 scopus 로고
    • Recombinant alfa interferon in renal cell carcinoma: A randomised trial of two routes of administration
    • H.B. Muss, J.J. Costanzi, R. Leavitt et al.: Recombinant alfa interferon in renal cell carcinoma: A randomised trial of two routes of administration. J. Clin. Oncol. 5, 286 (1987).
    • (1987) J. Clin. Oncol. , vol.5 , pp. 286
    • Muss, H.B.1    Costanzi, J.J.2    Leavitt, R.3
  • 210
    • 0024243915 scopus 로고
    • Recombinant interferon alfa-2a in metastatic renal cell carcinoma
    • Figlin, R.A., J.B. deKernion, E. Mukamel et al.: Recombinant interferon alfa-2a in metastatic renal cell carcinoma. J. Clin. Oncol. 6, 1604 (1988).
    • (1988) J. Clin. Oncol. , vol.6 , pp. 1604
    • Figlin, R.A.1    DeKernion, J.B.2    Mukamel, E.3
  • 211
    • 0022000861 scopus 로고
    • Phase II study of human lymphoblastoid Interferon in patients with advanced renal carcinoma
    • D. Vugrin, L. Hood, W. Taylor and J. Laslo: Phase II study of human lymphoblastoid Interferon in patients with advanced renal carcinoma. Cancer Treat. Reports 69, 817 (1985).
    • (1985) Cancer Treat. Reports , vol.69 , pp. 817
    • Vugrin, D.1    Hood, L.2    Taylor, W.3    Laslo, J.4
  • 212
    • 0023906447 scopus 로고
    • An evaluation of recombinant leucocyte interferon with aspirin in patients with metastatic renal cell cancer
    • E.T. Creagan, J.C. Buckner, R.G. Hahn et al.: An evaluation of recombinant leucocyte interferon with aspirin in patients with metastatic renal cell cancer. Cancer 61, 1787 (1988).
    • (1988) Cancer , vol.61 , pp. 1787
    • Creagan, E.T.1    Buckner, J.C.2    Hahn, R.G.3
  • 213
    • 0024574011 scopus 로고
    • Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma
    • R.L. Miller, R.G. Stess, J.W. Clark et al.: Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. Cancer Res. 49, 1871 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 1871
    • Miller, R.L.1    Stess, R.G.2    Clark, J.W.3
  • 214
    • 0026598364 scopus 로고
    • Recombinant interferon alpha-2A combined with prednisone in metastatic renal-cell carcinoma: Treatment results, serum interferon levels and the development of antibodies
    • S.D. Fossa, G. Lehne, R. Gunderson et al.: Recombinant interferon alpha-2A combined with prednisone in metastatic renal-cell carcinoma: treatment results, serum interferon levels and the development of antibodies. Intl. J. Cancer 50, 868 (1992).
    • (1992) Intl. J. Cancer , vol.50 , pp. 868
    • Fossa, S.D.1    Lehne, G.2    Gunderson, R.3
  • 216
    • 0023838682 scopus 로고
    • Phase FII study of recombinant interferon gamma in advanced renal cell carcinoma
    • M.B. Garnick, S.D. Reich and B.E.A. Maxwell: Phase FII study of recombinant interferon gamma in advanced renal cell carcinoma. J. Urol. 139, 251 (1988).
    • (1988) J. Urol. , vol.139 , pp. 251
    • Garnick, M.B.1    Reich, S.D.2    Maxwell, B.E.A.3
  • 217
    • 0023156669 scopus 로고
    • Phase II studies of recombinant human interferon gamma in metastatic renal cell carcinoma
    • J.R. Quesada, R. Kurzrock, S.A. Sherwin et al.: Phase II studies of recombinant human interferon gamma in metastatic renal cell carcinoma. J. Biol. Response Mod. 6, 20 (1987).
    • (1987) J. Biol. Response Mod. , vol.6 , pp. 20
    • Quesada, J.R.1    Kurzrock, R.2    Sherwin, S.A.3
  • 218
    • 0022972731 scopus 로고
    • Phase I/II Trial of human recombinant interferon gamma in renal cell carcinoma
    • J.J. Rinehart, L. Malspeis, D. Young et al.: Phase I/II Trial of human recombinant interferon gamma in renal cell carcinoma. J. Biol. Response Mod. 5, 300 (1986).
    • (1986) J. Biol. Response Mod. , vol.5 , pp. 300
    • Rinehart, J.J.1    Malspeis, L.2    Young, D.3
  • 219
    • 0023760276 scopus 로고
    • Recombinant interferon gamma in the treatment of metastatic renal cell carcinoma
    • U. Otto, S. Conrad, A.W. Schneider et al.: Recombinant interferon gamma in the treatment of metastatic renal cell carcinoma. Drug Res. 38, 1658 (1988).
    • (1988) Drug Res. , vol.38 , pp. 1658
    • Otto, U.1    Conrad, S.2    Schneider, A.W.3
  • 220
    • 0024809918 scopus 로고
    • Successful treatment of metastatic renal cell carcinoma with a biologically active dose of recombinant interferon-gamma
    • W. Aulitzky, G. Gastl, W.E. Aulitzky et al.: Successful treatment of metastatic renal cell carcinoma with a biologically active dose of recombinant interferon-gamma. J. Clin. Oncol. 7, 1875 (1989).
    • (1989) J. Clin. Oncol. , vol.7 , pp. 1875
    • Aulitzky, W.1    Gastl, G.2    Aulitzky, W.E.3
  • 221
    • 0025354658 scopus 로고
    • Phase II study of recombinant human interferon-gamma in metastatic renal cell carcinoma
    • U. Bruntsch, P.H. de Mulder, W.W. ten Bokkel Huinink et al.: Phase II study of recombinant human interferon-gamma in metastatic renal cell carcinoma. J. Biol. Response Mod. 9, 335 (1990).
    • (1990) J. Biol. Response Mod. , vol.9 , pp. 335
    • Bruntsch, U.1    De Mulder, P.H.2    Ten Bokkel Huinink, W.W.3
  • 222
    • 0021351766 scopus 로고
    • Synergistic antiviral and antiproliferative activities of E coli derived human alpha, beta and gamma interferons
    • C.W. Czarniecki, C.W. Fennie, D.B. Powers et al.: Synergistic antiviral and antiproliferative activities of E coli derived human alpha, beta and gamma interferons. J. Virol. 49, 490 (1984).
    • (1984) J. Virol. , vol.49 , pp. 490
    • Czarniecki, C.W.1    Fennie, C.W.2    Powers, D.B.3
  • 223
    • 0023737411 scopus 로고
    • A prospective randomized trial of alpha2b interferon/gamma interferon or the combination in advanced metastatic renal cell carcinoma
    • K. Foon, J. Doroshow, E. Bonnem et al.: A prospective randomized trial of alpha2b interferon/gamma interferon or the combination in advanced metastatic renal cell carcinoma. J. Biol. Response Mod. 7, 540 (1988).
    • (1988) J. Biol. Response Mod. , vol.7 , pp. 540
    • Foon, K.1    Doroshow, J.2    Bonnem, E.3
  • 224
    • 0023888150 scopus 로고
    • Recombinant interferon alpha and gamma in combination as treatment for metastatic renal cell carcinoma
    • J.R. Quesada, L. Evans, S.R. Saks et al.: Recombinant interferon alpha and gamma in combination as treatment for metastatic renal cell carcinoma. J. Biol. Response Mod. 7, 234 (1988).
    • (1988) J. Biol. Response Mod. , vol.7 , pp. 234
    • Quesada, J.R.1    Evans, L.2    Saks, S.R.3
  • 225
    • 0025149116 scopus 로고
    • A phase IA trial of sequential administration recombinant DNA-produced interferons: Combination recombinant interferon gamma and recombinant interferon alfa in patients with metastatic renal cell carcinoma
    • M.S. Ernstoff, S. Nair, R.R. Bahnson et al.: A phase IA trial of sequential administration recombinant DNA-produced interferons: combination recombinant interferon gamma and recombinant interferon alfa in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 8, 1637 (1990).
    • (1990) J. Clin. Oncol. , vol.8 , pp. 1637
    • Ernstoff, M.S.1    Nair, S.2    Bahnson, R.R.3
  • 226
    • 0026582149 scopus 로고
    • Immunological effects of treatment with sequential administration of recombinant interferon gamma and alpha in patients with metastatic renal cell carcinoma during a phase I trial
    • M.S. Ernstoff, W. Gooding, S. Nair et al.: Immunological effects of treatment with sequential administration of recombinant interferon gamma and alpha in patients with metastatic renal cell carcinoma during a phase I trial. Cancer Res. 52, 851 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 851
    • Ernstoff, M.S.1    Gooding, W.2    Nair, S.3
  • 227
    • 0025281977 scopus 로고
    • Synergistic effects of vinblastine and recombinant interferon-beta on renal tumor cell lines
    • J.P. Kuebler, G.A. Godette, D.J. Bock et al.: Synergistic effects of vinblastine and recombinant interferon-beta on renal tumor cell lines. J. Interferon Res. 10, 281 (1990).
    • (1990) J. Interferon Res. , vol.10 , pp. 281
    • Kuebler, J.P.1    Godette, G.A.2    Bock, D.J.3
  • 228
    • 0021888642 scopus 로고
    • Treatment of renal cell carcinoma with alpha(human leukocyte) interferon and vinblastine in combination: A phase I-II trial
    • R. A. Figlin, J.B. deKernion, J. Maldazys et al.: Treatment of renal cell carcinoma with alpha(human leukocyte) interferon and vinblastine in combination: A phase I-II trial. Cancer Treat. Reports 69, 263 (1985).
    • (1985) Cancer Treat. Reports , vol.69 , pp. 263
    • Figlin, R.A.1    DeKernion, J.B.2    Maldazys, J.3
  • 229
    • 0023229636 scopus 로고
    • Further experience with recombinant interferon alfa-2a with vinblastine in metastatic renal cell carcinoma: A progress report
    • S.D. Fossa and S.T. de Garis: Further experience with recombinant interferon alfa-2a with vinblastine in metastatic renal cell carcinoma: a progress report. Intl. J. Cancer Suppl 1, 36 (1987).
    • (1987) Intl. J. Cancer , vol.1 SUPPL , pp. 36
    • Fossa, S.D.1    De Garis, S.T.2
  • 230
    • 0024552005 scopus 로고
    • Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma
    • M.R. Sertoli, I. Brunetti, A. Ardizzoni et al.: Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma. Am. J. Clin. Oncol. 12, 43 (1989).
    • (1989) Am. J. Clin. Oncol. , vol.12 , pp. 43
    • Sertoli, M.R.1    Brunetti, I.2    Ardizzoni, A.3
  • 231
    • 0024791554 scopus 로고
    • Recombinant interferon-alpha with or without vinblastine in metastatic renal carcinoma. Results of a randomised phase II study
    • S.D. Fosså, N. Raabe and B. Moe: Recombinant interferon-alpha with or without vinblastine in metastatic renal carcinoma. Results of a randomised phase II study. Br. J. Urol. 64, 468 (1989).
    • (1989) Br. J. Urol. , vol.64 , pp. 468
    • Fosså, S.D.1    Raabe, N.2    Moe, B.3
  • 232
    • 0025322194 scopus 로고
    • Vinblastine and interferon-alpha-2a regimen in the treatment of metastatic renal cell carcinoma
    • S. Palmeri, V. Gebbia, A. Russo et al.: Vinblastine and interferon-alpha-2a regimen in the treatment of metastatic renal cell carcinoma. Tumori 76, 64 (1990).
    • (1990) Tumori , vol.76 , pp. 64
    • Palmeri, S.1    Gebbia, V.2    Russo, A.3
  • 233
    • 0025135524 scopus 로고
    • Interferon-alpha-nl and continuous infusion vinblastine for treatment of advanced renal cell carcinoma
    • D.L. Trump, P.M. Ravdin, E.C. Borden et al.: Interferon-alpha-nl and continuous infusion vinblastine for treatment of advanced renal cell carcinoma. J. Biol. Response Mod. 9, 108 (1990).
    • (1990) J. Biol. Response Mod. , vol.9 , pp. 108
    • Trump, D.L.1    Ravdin, P.M.2    Borden, E.C.3
  • 234
    • 0025072949 scopus 로고
    • Recombinant interferon-alpha 2a and vinblastine in advanced renal cell cancer: A clinical phase I-II study
    • L.P. Kellokumpu and E. Nordman: Recombinant interferon-alpha 2a and vinblastine in advanced renal cell cancer: a clinical phase I-II study. J. Biol. Response Mod. 9, 439 (1990).
    • (1990) J. Biol. Response Mod. , vol.9 , pp. 439
    • Kellokumpu, L.P.1    Nordman, E.2
  • 235
    • 0024410019 scopus 로고
    • Interferon alpha-2a and vinblastine in the treatment of metastatic renal carcinoma
    • M. Rizzo, R. Bartoletti, C. Selli et al.: Interferon alpha-2a and vinblastine in the treatment of metastatic renal carcinoma. Eur. Urol. 16, 271 (1989).
    • (1989) Eur. Urol. , vol.16 , pp. 271
    • Rizzo, M.1    Bartoletti, R.2    Selli, C.3
  • 236
    • 0025254658 scopus 로고
    • Interferon plus vinblastine in renal carcinoma patients who had failed on interferon alone
    • O. Merimsky and S. Chaitchik: Interferon plus vinblastine in renal carcinoma patients who had failed on interferon alone [letter]. Eur. J. Cancer 26, 8 (1990).
    • (1990) Eur. J. Cancer , vol.26 , pp. 8
    • Merimsky, O.1    Chaitchik, S.2
  • 237
    • 0026133415 scopus 로고
    • Does vinblastine add to the potency of alpha interferon in the treatment of renal cell carcinoma?
    • O. Merimsky, B.I. Shnider and S. Chaitchik: Does vinblastine add to the potency of alpha interferon in the treatment of renal cell carcinoma? Mol. Biother. 3, 34 (1991).
    • (1991) Mol. Biother. , vol.3 , pp. 34
    • Merimsky, O.1    Shnider, B.I.2    Chaitchik, S.3
  • 238
    • 0026600592 scopus 로고
    • Phase II study of interferon-alpha and chemotherapy (5-fluorouracil and mitomycin C) in metastatic renal cell cancer
    • A. Sella, C.J. Logothers, K. Fitz et al.: Phase II study of interferon-alpha and chemotherapy (5-fluorouracil and mitomycin C) in metastatic renal cell cancer. J. Urol. 147, 573 (1992).
    • (1992) J. Urol. , vol.147 , pp. 573
    • Sella, A.1    Logothers, C.J.2    Fitz, K.3
  • 239
    • 0026329493 scopus 로고
    • Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma
    • H.J. Konig, W. Gutmann and J. Weissmuller: Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma. J. Cancer Res. Clin. Oncol. 117, S221 (1991).
    • (1991) J. Cancer Res. Clin. Oncol. , vol.117
    • Konig, H.J.1    Gutmann, W.2    Weissmuller, J.3
  • 240
    • 0027189584 scopus 로고
    • Alpha-2B-interferon plus floxuridine in metastatic renal cell carcinoma. A phase I-II study
    • A. Falcone, C. Cianci, S. Ricci et al.: Alpha-2B-interferon plus floxuridine in metastatic renal cell carcinoma. A phase I-II study. Cancer Diag. Treat. Res. 72, 564 (1993).
    • (1993) Cancer Diag. Treat. Res. , vol.72 , pp. 564
    • Falcone, A.1    Cianci, C.2    Ricci, S.3
  • 241
    • 0008509682 scopus 로고
    • Renal Cell Carcinoma
    • V.T. Devita, S. Hellman, S.A. Rosenberg (eds). J.B. Lippincott: New York
    • H.B. Muss: Renal Cell Carcinoma. In: Biologic Therapy of Cancer, V.T. Devita, S. Hellman, S.A. Rosenberg (eds). 1991. J.B. Lippincott: New York. p. 298-309.
    • (1991) Biologic Therapy of Cancer , pp. 298-309
    • Muss, H.B.1
  • 242
    • 0027173443 scopus 로고
    • Interferon alfa-2a in advanced renal cell carcinoma: Treatment results and survival in 159 patients with long-term follow-up
    • L.M. Minasian, R.J. Motzer, L. Gluck et al.: Interferon alfa-2a in advanced renal cell carcinoma: treatment results and survival in 159 patients with long-term follow-up. J. Clin. Oncol. 11, 1368 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 1368
    • Minasian, L.M.1    Motzer, R.J.2    Gluck, L.3
  • 243
    • 0021038111 scopus 로고
    • Effects of cloned human leukocyte interferons in the human tumor stem cell assay
    • S.E. Salmon, B.G. Durie, L. Young et al.: Effects of cloned human leukocyte interferons in the human tumor stem cell assay. J. Clin. Oncol. 1, 217 (1983).
    • (1983) J. Clin. Oncol. , vol.1 , pp. 217
    • Salmon, S.E.1    Durie, B.G.2    Young, L.3
  • 244
    • 0023201497 scopus 로고
    • Evaluation of the anti-tumor activity recombinant human gamma interferon employing human melanoma xenografts in athymic nude mice
    • P.P. Trotta and S.D. Harrison, Jr.: Evaluation of the anti-tumor activity recombinant human gamma interferon employing human melanoma xenografts in athymic nude mice. Cancer Res. 47, 5347 (1987).
    • (1987) Cancer Res. , vol.47 , pp. 5347
    • Trotta, P.P.1    Harrison Jr., S.D.2
  • 245
    • 10344233313 scopus 로고
    • The expression of p97, kd250, DR and beta-2 microglobulin cell surface antigen in cycling melanoma cells in culture
    • M.S. Ernstoff, D. Chee, G. Witman et al.: The expression of p97, kd250, DR and beta-2 microglobulin cell surface antigen in cycling melanoma cells in culture (Abstract). Clin. Res. 32, 345A (1984).
    • (1984) Clin. Res. , vol.32
    • Ernstoff, M.S.1    Chee, D.2    Witman, G.3
  • 246
    • 0022379919 scopus 로고
    • Melanoma: Therapeutic options with recombinant interferons
    • J.M. Kirkwood and M.S. Ernstoff: Melanoma: therapeutic options with recombinant interferons Semin. Oncol. 12, 7 (1985).
    • (1985) Semin. Oncol. , vol.12 , pp. 7
    • Kirkwood, J.M.1    Ernstoff, M.S.2
  • 247
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alpha-2b adjuvant therapy of high risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST1684
    • J.M. Kirkwood, M.H. Stawderman, M.S. Ernstoff et al.: Interferon alpha-2b adjuvant therapy of high risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST1684. J. Clin. Oncol. 14, 7 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , pp. 7
    • Kirkwood, J.M.1    Stawderman, M.H.2    Ernstoff, M.S.3
  • 248
    • 0022371461 scopus 로고
    • Identity of tumour necrosis factor and the macrophage-secreted factor 'cachectin'
    • B. Beutler, D. Greenwald, J.D. Hulmes et al: Identity of tumour necrosis factor and the macrophage-secreted factor 'cachectin'. Nature 316, 552 (1985).
    • (1985) Nature , vol.316 , pp. 552
    • Beutler, B.1    Greenwald, D.2    Hulmes, J.D.3
  • 249
    • 0027420579 scopus 로고
    • Tumor necrosis factor: An updated review of its biology
    • K.J. Tracey and A. Cerami: Tumor necrosis factor: an updated review of its biology. Crit .Care Med. 21 (10 Suppl), S415 (1993).
    • (1993) Crit .Care Med. , vol.21 , Issue.10 SUPPL.
    • Tracey, K.J.1    Cerami, A.2
  • 250
    • 0025879415 scopus 로고
    • Tumour necrosis factor (cachectin) and other cytokines in septic shock: A review of the literature
    • A.S. Dofferhoff, E. Vellenga, P.C. Limburg et al.: Tumour necrosis factor (cachectin) and other cytokines in septic shock: a review of the literature. Nether. J. Med. 39, 45 (1991).
    • (1991) Nether. J. Med. , vol.39 , pp. 45
    • Dofferhoff, A.S.1    Vellenga, E.2    Limburg, P.C.3
  • 251
    • 0025003076 scopus 로고
    • Metabolic responses to cachectin/TNF. A brief review
    • K.J. Tracey and A. Cerami: Metabolic responses to cachectin/TNF. A brief review. Ann. NY. Acad. Sci. 587, 325 (1990).
    • (1990) Ann. NY. Acad. Sci. , vol.587 , pp. 325
    • Tracey, K.J.1    Cerami, A.2
  • 252
    • 0026717674 scopus 로고
    • The pathophysiology of tumor necrosis factor
    • P. Vassalli: The pathophysiology of tumor necrosis factor. Ann. Rev. Immunol. 10, 411 (1992).
    • (1992) Ann. Rev. Immunol. , vol.10 , pp. 411
    • Vassalli, P.1
  • 254
    • 0028947776 scopus 로고
    • Cytokines and evolution: In vitro effects of IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta on an ancestral type of stress response
    • E. Ottaviani, E. Caselgrandi and C. Franceschi : Cytokines and evolution: in vitro effects of IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta on an ancestral type of stress response. Biochem. Biophys. Res. Commun. 207, 288 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.207 , pp. 288
    • Ottaviani, E.1    Caselgrandi, E.2    Franceschi, C.3
  • 255
    • 0028332581 scopus 로고
    • CD8+ T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2, IFN-gamma and TNF-beta
    • D. Adamthwaite and M.A. Cooley : CD8+ T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2, IFN-gamma and TNF-beta. Immunol. 81, 253 (1994).
    • (1994) Immunol. , vol.81 , pp. 253
    • Adamthwaite, D.1    Cooley, M.A.2
  • 256
    • 0027513978 scopus 로고
    • Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens
    • C. Jassoy, T. Harrer, T. Rosenthal et al.: Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens. J. Virol. 67, 2844 (1993).
    • (1993) J. Virol. , vol.67 , pp. 2844
    • Jassoy, C.1    Harrer, T.2    Rosenthal, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.