In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis

Journal of Neuroradiology

Volumn 23, Issue 2, 1996, Pages 49-55

  Tourbah, A ^a,b   Stievenart, J L ^a,c   Iba Zizen, M T ^a   Zannoli, G ^d   Lyon Caen, O ^b   Cabanis, E A ^a  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c BEAUJON HOSPITAL   (France)

^d GE HEALTHCARE   (France)

Author keywords

multiple sclerosis; normal appearing white matter; proton magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; INOSITOL; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTON NUCLEAR MAGNETIC RESONANCE; WHITE MATTER;

ADULT; ANALYSIS OF VARIANCE; ASPARTIC ACID; BRAIN; BRAIN DISEASES; CHOLINE; CLINICAL TRIALS; CREATINE; DISCRIMINANT ANALYSIS; HUMANS; IMAGE ENHANCEMENT; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY; MIDDLE AGED; MULTIPLE SCLEROSIS; PROTONS;

EID: 0029803030     PISSN: 01509861     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Young IR, Hall AS, Pallis CA, Legg N, Bydder G, Steiner R. Magnetic resonance imaging of the brain in multiple sclerosis. Lancet 1981; 11: 1063-6
2. Paty DW. Multiple Sclerosis with an Emphasis on MR imaging. Curr Neur 1991; 11: 169-98.
3. McDonald WI, Miller DH, Barnes D. The Pathological evolution of multiple sclerosis Neuropathol Appl Neurobiol 1992; 18: 319-34.
4. Jacobs L, Munschauer FE, Kaba SE. Clinical and magnetic resonance imaging in optic neuritis. Neurology 1991; 41: 15-9
5. Frederiksen JL, Laesson HB, Ottovay E, Stigsby B, Olesen J. Acute optic neuritis with normal visual acuity; comparision of symptoms and signs with psychophysiological, electrophysiological and magnetic resonance imaging data. Acta Ophtalmol (Copenh) 1991; 69: 357-66.
6. Christiansen P, Frederiksen JL, Henriksen O, Larsson HB. Gd-TPA-enhanced lesions in the brain of patients with acute optic neuritis. Acta Neurol Scand 1992; 85: 141-6
7. Martinelli V, Comi G, Filippi M, Poggi A, Colombo B, Rodegher M, Scotti G, Triulzi F, Canal N Paraclinical tests in acute-onset optic neuritis: basal data and results of a short follow-up Acta Neurol Scand 1991; 84: 231-6.
8. Frahm J, Bruhn H, Gyngell ML, Merbolt KD, Hänicke KD, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes; initial applications to human brain in vivo Magn Reson Med 1989; 9 79-93.
9. Frahm J, Michaelis T, Merboldt KD, Bruhn H, Gyngell ML, Hänicke W. Improvement in localized proton NMR spectroscopy of human brain, water suppression, short echo times and 1 ml resolutions. J Magn Reson 1990; 90: 464-73.
10. Richards TL. Proton MR spectroscopy in multiple sclerosis, value in establishing diagnosis, monitoring progression and evaluating therapy AM J Roentgenol 1991, 157: 1073-8.
11. Larsson HB, Christiansen P, Jensen M, Frederiksen J, Heltberg A, Olesen J, Henriksen O Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med 1991, 22: 23-31.
12. Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP. Proton magnetic resonance spectroscoptc imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992, 31: 235-41.
13. Grossman R, Lenkinsky RE, Ramer KN, Gonzales-Scarano F, Cohen JA. MR proton spectroscopy in multiple sclerosis. AJNR 1992; 13: 1535-43.
14. Koopmans RA, Li DKB, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products. Lancet 1993; 341: 631-2.
15. Davie CA, Hawkins CP, Barker GJ, Brennan P, Tofts S, Miller DH, McDonald WI. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994; 117: 49-58.
16. Arnold DL, Ries GT, Matthews PM, Francis GS, Collins DL, Wolfson C, Antel JP. Use of magnetic resonance spectroscopy for moitoring disease progresion in multiple sclerosis. Ann Neurol 1994; 36: 76-82.
17. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GA, Johnson KA, Sibley WA, Silberberg DH, Tourtelotte WW New diagnostic criteria for multiple sclerosis guidlines for research protocols. Ann Neurol 1983; 13: 227-31.
18. Klose U In vivo proton spectroscopy in presence of eddy currents. MRM 1990; 14: 1-30.
19. Morrison DF. Multivariate stastitical methods. Singapore, 1978, McGraw-Hill.
20. Howe FA, Maxwell RJ, Saunders DE, Brown MM, Griffiths JR. Proton spectroscopy in vivo. Magnetic Resonance Quaterly 1993, 9: 31-59.
21. Van Hecke P, Marchai G, Johannik K, Demaerel P, Wilms G, Carton H, Baert AL. Human brain proton localized NMR spectroscopy in multiple sclerosis. Magnetic Resonance in Medicine 1991, 18: 199-206.
22. Bruhn H, Frahm J, Merboldt KD, Hanicke W, Hanefeld F, Christen HJ, Kruse B, Bauer HJ. Multiple sclerosis in children; cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992; 32: 140-50.
23. 1H magnetic spectroscopic imaging Ann Neurol 1994; 36: 157-65.
24. Miller DH, Austin SJ, Conneley A, Youl BD, Gadian DG, McDonald WI Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis (letter). Lancet 1991; 337: 8-9.
25. Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis. Neurology 1991; 41: 1251-6.
26. Miyake M, Kakimoto Y, Soromachi M. A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-alpha-aspartylglutamic acid and beta-citryl-L-giutamic acid and their distribution in the brain and other organs of various species of animals. J Neurochem 1981; 36: 804-10.
27. Zaczek R, Koller K, Cotter R, Heller D, Coyle JT. N-acetyl-aspartylglutamate: an endogenous peptide with high affinity for a brain «glutamate receptor». Proc Natl Acad Sci USA 1983, 80: 1116-9.
28. Koller KJ, Zaczek R, Coyle TJT. N-acetyl-aspartate-glutamate: regional levels in rat brain and the effect of brain lesions as determined by a new HPLC method. J Neurochem 1984; 43: 1136-42.
29. Patel TB, Clark JB. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvment in mitochondrial; cytostolic carbon transport. J Biochem 1979, 184. 539-46.
30. Koopmans RA, Zhu G, Li DKB, Allen PS, Javidan M, Paty DW. In vivo proton MRS in the acute and chronic lesion of multiple sclerosis. Society of Magnetic Resonance in Medicine vol 2 Berkeley, CA 1990; 1205 (Abstract).
31. Coyle JT, Robinson MB, Blakeley RD, Forlini JL. The neurobiology of N-acetyl-aspartate-glutamate. In : Barnard EA, Costa E, eds. Allosteric modulation of amino acid receptors: therapeutic implications. New York 1989: Raven, 319-33.
32. Moffett JR, Namboodiri MAA, Cangro CB, Neale JH. Immunocytochemical localization of N-Acetyl Aspartate in rat brain. Neuroreport 1991, 27: 131-4.
33. Arnold DL. Reversible reduction of N-acetylaspartate after acute central nervous system damage. In Proceedings of the eleventh Annual Meeting of the Society for Magnetic resonance in Medicine I 1992: 643.
34. Birken DL, Olendorf WH. N-acetylaspartic acid: a literature review of compound prominent in 1H-NMR spectroscopic studies of brain (review). Neurosci Biobehav Rev 1989; 13: 23-31
35. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-Acetyl-Aspartate with monoclonal antibodies Neuroscience 1991; 45. 37-45.
36. Unrejak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiuously identifies different neural cell types. J Neurosci 1993, 13 (3): 981-9.
37. Roser W, Hagberg G, Mader I, Brunnschweiler H, Radue EW, Seelig J, Kappos L. Proton MRS of gadolinium-enhancing Ms plaques and metabolic changes in normal appearing white matter. MRM 1995, 33: 811-7.
38. McIlwain H, Bachelard HS. Biochemistry and central nervous system. 5th ed. Edinburgh: Churchill Livingstone 1985: 282-335
39. Brenner ME, Munro PMG, Williams SCR, Bell JD, Barker GJ, Hawkins CP, Landon DN, McDonald WI. The proton NMR spectium in acute EAE: the significance of the change in the cho: Cr ratio. Magn reson Med 1993; 29: 737-45.
40. Brand A, Engelmann J, Leibfritz D. A 13C NMR study of fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells. Biochimie 1992; 74 : 941-8.
41. Zhu G, Allen PS, Koopmans RA, Li DK, Paty DW. A marked elevation of mositol in MS lesions. SMRM 1992; 1: 1948.
42. Lacomis D, Osbakken M, Gross G. Spin-lattice relaxation (T1) times of cerebral white matter in multiple sclerosis. MRM 1986; 3: 194-202.
43. Miller DH, Johnson G, Tofts PS, MacManus D, McDonald WI. Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. MRM 1989; 11: 331-6.
44. Armspach JP, Gounot D, Rumbach L, Chambron J. In vivo determination of multiexponential T2 relaxation in the brain of patients with multiple sclerosis. Magn Reson Imag 1991, 9: 107-13.
45. Barbosa S, Blumhardt LD, Roberts N, Lock T, Edwards RHT. Magnetic resonance relaxation time mapping in multiple sclerosis: normal appearing white matter and the «invisible » lesion load. Magnetic Resonnance Imaging 1994; 12: 33-42.
46. Dousset V, Grossman RI, Ramer KN, Schnall MD, Yound LH, Gonzales-Scaeano F, Lavi E, Cohen JA. Experimental allergic encephalomyelitis and multiple sclerosis : lesion characterization with magnetization transfer imaging. Radiology 1992; 182: 483-91
47. Filippi M, Campi A, Dousset V, Baratti C, Martinelli V, Canal N, Scotti G, Comi G. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995;45:478-82.
48. Forti A, Bydder GM, Hajnal JV, Young IR. Use of diffusion weighted magnetic resonance imaging in multiple sclerosis. Soc Magn Reson Med 1991; 1: 86 (Abstract).
49. Larsson HBW, Thomsen C, Frederiksen J, Stubgaard M, Henriksen O. In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. MRI 1992; 10: 7-12.
50. Arstila AU, Riekkinen P, Rinne UK, Laitinen L Studies on the pathogenesis of multiple sclerosis. Eur Neurol 1973; 9: 1-20.
51. Allen IV, McKeown SR A histological, histochemical and biochemical study of macroscopically normal white matter in multiple sclerosis. J Neurol Sci 1979; 41: 81-91.
52. Hirsh HE, Parks ME. A thiol proteinase highly elevated in and around the plaques of multiple sclerosis. J Neurochem 1979; 32: 505-13.
53. Allen IV, Glovei G, Anderson R. Abnormalities in the macroscopically normal white matter in cases of mild or spinal multiple sclerosis (MS). Acta Neuropathol (Berl) 1981 , (suppl VII). 167-78
54. Newcombe J, Woodroofe MN, Cuzner ML. Distribution of glial fibrillary acidic protein in gliosed human white matter. J Neurochem 1986; 47. 1713-9.