Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein

Parasite Immunology

Volumn 18, Issue 10, 1996, Pages 527-533

  Baker, D A ^a   Drakeley, C J ^a   Ong, C S L ^b   Lulat, A G M I ^c   Greenwood, B M ^a,c   Targett, G A T ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c MRC Laboratories Fajara   (Gambia)

Author keywords

Humoral immunity; P. falciparum gametocyte; Pfs16; Sporozoite invasion

Indexed keywords

MALARIA VACCINE; MONOCLONAL ANTIBODY; OUTER MEMBRANE PROTEIN; SYNTHETIC PEPTIDE;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GAMBIA; GAMETOCYTE; HUMAN; HUMORAL IMMUNITY; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PAPUA NEW GUINEA; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; SPOROZOITE;

PLASMODIUM FALCIPARUM;

EID: 0029802720     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1996.d01-17.x     Document Type: Article

References (18)

1. Baker D.A., Daramola O., McCrossan M.V., Harmer J. & Targett G.A.T. (1994) Subcellular localization of pfs16, a Plasmodium falciparum gametocyte antigen. Parasitology, 108, 129-137
2. Baker D.A., Thompson J., Daramola O.O., Carlton J.M.R. & Targett G.A.T. (1995) Sexual-stage-specific RNA expression of a new Plasmodium falciparum gene detected by in situ hybridisation. Molecular and Biochemical Parasitology, 72, 193-201
3. Bruce M.C., Baker D.A., Alano P., Rogers N.C., Graves P.M., Targett G.A.T. & Carter R. (1990) Sequence coding for a sexual stage specific protein of Plasmodium falciparum. Nucleic Acids Research, 18, 3637
4. Eisenberg D., Schwarz E., Komaromy M. & Wall R. (1984) Analysis of membrane and surface protein sequences with the hydrophobie moment plot. Journal of Molecular Biology, 179, 125-142
5. Graves P.M., Doubrovsky A. & Beckers P. (1991) Antibody responses to Plasmodium falciparum gametocyte antigens during and after malaria attacks in school children from Madang, Papua New Guinea. Parasite Immunology, 13, 291-299
6. Harte P.G., Rogers N.C. & Targett G.A.T. (1985) The role of T cells in preventing transmission of rodent malaria. Immunology, 56, 1-7
7. Kaslow D.C. (1993) Transmission-blocking immunity against malaria and other vector-borne diseases. Current Opinion in Immunology, 5, 557-565
8. Moelans I.M.D., Meis J.F.G.M., Kocken C.H.M., Konings R.N.H. & Schoenmakers J.G.G. (1991a) A novel protein antigen of the malaria parasite Plasmodium falciparum, located on the surface of gametes and sporozoites. Molecular and Biochemical Parasitology, 45, 193-204
9. Moelans I.M.D., Klassen C.H.W., Kaslow D.C., Konings R.N.H. & Schoenmakers J.G.G. (1991b) Minimal variation in Pfs16, a novel protein located in the membrane of gametes and sporozoites of Plasmodium falciparum. Molecular and Biochemical Parasitology, 46, 311-314
10. Moelans I.I.M.D. & Schoenmakers J.G.G. (1992) Crossreactive antigens between life cycle stages of Plasmodium falciparum. Parasitology Todays, 8, 118-123
11. Moelans I.I.M.D., Cohen J., Marchard M. et al. (1995) Induction of Plasmodium falciparum sporozoite-neutralizing antibodies upon vaccination with recombinant Pfs 16 protein produced in yeast. Molecular and Biochemical Parasitology, 72, 179-192
12. Muller H.M., Reckmann I., Hollingdale M.R., Bujard H., Robson, K.J.H. & Crisanti A. (1993) Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes. EMBO Journal, 12, 2881-2889
13. Nudelman S., Rénia L., Charoenvit Y., Yuan L., Miltgen F., Beaudoin R.L. & Mazier D. (1989) Dual action of anti-sporozoite antibodies in vitro. The Journal of Immunology, 143, 996-1000
14. Peins J.S.M., Premawansa Ranawaka M.B.R., Udagama P.V. et al., (1988) Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium virax malaria. Americal Journal of Tropical Medicine and Hygiene, 39, 26-32
15. Rawlings D.J., Fujioka H., Fried M., Keister D.B., Aikawa M. & Kaslow D.C. (1992) α-Tubulin II is a male-specific protein in Plasmodium falciparum. Molecular and Biochemical Parasitology, 56, 239-250
16. Robson K.J.H., Hall J.R.S., Jennings M.W. et al. (1988) A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature, 355, 79-82
17. Rodriquez, R.O., Moreno A., Guzman F., Calvo M. & Patarroyo M.E. (1990) Studies in owl monkeys leading to the development of a synthetic vaccine against the asexual blood stages of Plasmodium falciparum. American Journal of Tropical Medicine & Hygiene, 43, 339-354
18. Roeffen W., Mulder B., Teelen K. et al. (1996) Association between anti-Pfs 48/45 reactivity and P. falciparum transmission-blocking activity in sera from Cameroon. Parasite Immunology 18, 103-109