Improvement in the therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus fludarabine

Radiation Research

Volumn 146, Issue 5, 1996, Pages 548-553

  Grégoire, Vincent ^a,b   Hunter, Nancy R ^a   Brock, William A ^a   Hittelman, Walter N ^a   Plunkett, William ^a   Milas, Luka ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

FLUDARABINE; INDOMETACIN; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; CONTRACTURE; CONTROLLED STUDY; HAIR LOSS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOSENSITIZATION; SARCOMA; SKIN EXFOLIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; INDOMETHACIN; MALE; MICE; MICE, INBRED C3H; PROSTAGLANDIN ANTAGONISTS; SARCOMA, EXPERIMENTAL; VIDARABINE;

ANIMALIA; MURINAE;

EID: 0029802384     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579555     Document Type: Article

References (20)

1. H. R. Withers, Biologic basis of radiation therapy. In Principles and Practice of Radiation Oncology, 2nd ed. (C. A. Perez and L. W. Brady, Eds.), pp. 67-98. J. B. Lippincott, Philadelphia, 1992.
2. W. Plunkett, S. Chubb, L. Alexander and J. A. Montgomery, Comparison of the toxicity and metabolism of 9-β-D-arabinofuranosyl-2-fluoroadenine and 9-β-D-arabinofuranosyladenine in human lymphoblastoid cells. Cancer Res. 40, 2349-2355 (1980).
3. P. Huang, S. Chubb and W. Plunkett, Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenosine: A mechanism for cytotoxicity. J. Biol. Chem. 265, 16617-16625 (1990).
4. R. V. Jayanth and W. N. Hittelman, 9-β-D-arabinofuranosyl-2-fluroadenine (F-ara-A) inhibits both the fast and slow components of chromosome repair. In Radiation Research: A Twentieth-Century Perspective, Vol. 1 (J. D. Chapman, W. C. Dewey and G. F. Whitmore, Eds.), p. 411. Academic Press, San Diego, 1991. [Abstract]
5. V. Gregoire, N. Hunter, L. Milas, W. A. Brock, W. Plunkett and W. N. Hittelman, Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine. Cancer Res. 54, 468-474 (1994).
6. V. Grégoire, N. Hunter, W. A. Brock, L. Milas, W. Plunkett and W. N. Hittelman, Fludarabine improves the therapeutic ratio of radiotherapy in mouse tumors after single dose irradiation. Int. J. Radiat. Oncol. Biol. Phys. 30, 363-371 (1994).
7. V. Grégoire, N. T. Van, W. A. Brock, L. Milas, W. Plunkett and W. N. Hittelman, The role of fludarabine-induced apoptosis and cell cycle synchronization in enhanced murine tumor radiation response in vivo. Cancer Res. 54, 6201-6209 (1994).
8. V. Grégoire, A. C. C. Ruifrok, R. E. Price, W. A. Brock, W. N. Hittelman, W. K. Plunkett and K. K. Ang, Effect of intra-peritoneal fludarabine administration on rat spinal cord tolerance to fractionated irradiations. Radiother. Oncol. 36, 50-55 (1995).
9. Y. F. Furuta, E. R. Hall, S. Sanduja, T. Barkley and L. Milas, Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin. Cancer Res. 48, 3002-3007 (1988).
10. Y. Furuta, N. Hunter, T. Barkley, E. Hall and L. Milas, Increase in radioresponse of murine tumors by treatment with indomethacin. Cancer Res. 48, 3008-3013 (1988).
11. L. Milas, Y. Furuta, N. Hunter, I. Nishiguchi and S. Runkel, Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence. Cancer Res. 50, 4473-4477 (1990).
12. L. Milas, H. Ito, T. Nakayama and N. Hunter, Improvement in therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus misonidazole. Cancer Res. 51, 3639-3642 (1991).
13. I. Nishiguchi, Y. Furuta, N. Hunter, D. Murray and L. Milas, Increase in radioresponse of hematopoietic tissues in mice by indomethacin. Radiat. Res. 122, 188-192 (1990).
14. J. P. Volpe, N. Hunter, I. Basic and L. Milas, Metastatic properties of murine sarcomas and carcinomas. I. Positive correlation with lung colonization and lack of correlation with s.c. tumor take. Clin. Exp. Metastasis 3, 281-294 (1985).
15. L. Milas, N. Hunter, K. Mason and H. R. Withers, Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes. Cancer Res. 34, 61-71 (1974).
16. N. R. Lynch, M. Castes, M. Astoin and J. C. Salomon, Mechanism of inhibition of tumor growth by aspirin and indomethacin. Br. J. Cancer 38, 503-512 (1978).
17. K. Masuda, K. Matsuura, H. R. Withers and N. Hunter, Response of previously irradiated mouse skin to a second course of irradiation: early skin reaction and skin shrinkage. Int. J. Radiat. Oncol. Biol. Phys. 12, 1645-1651 (1986).
18. A. C. C. Ruifrok, K. A. Mason, N. Hunter and H. D. Thames, Changes in the radiation sensitivity of mouse skin during fractionated and prolonged treatments. Radiat. Res. 139, 334-343 (1994).
19. H. B. Stone, Leg contracture in mice: An assay of normal tissue response. Int. J. Radiat. Oncol. Biol. Phys. 10, 1053-1061 (1984).
20. E. H. Porter, The statistics of dose/cure relationship for irradiated tumours. Part I. Br. J. Radiol. 53, 210-227 (1980).