Supraphysiological serum relaxin concentration during pregnancy achieved by in-vitro fertilization is strongly correlated to the number of growing follicles in the treatment cycle

Human Reproduction

Volumn 11, Issue 9, 1996, Pages 2036-2040

  Kristiansson, Per ^a,b,c   Svärdsudd, Kurt ^b   Von Schoultz, Bo ^a   Wramsby, Håkan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c Skonsmons VC   (Sweden)

Author keywords

Follicles; In vitro fertilization; Oocytes; Pregnancy; Relaxin

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; PROGESTERONE; RELAXIN;

ARTICLE; BLOOD SAMPLING; ESTRADIOL BLOOD LEVEL; FEMALE; FERTILIZATION IN VITRO; FIRST TRIMESTER PREGNANCY; FOLLICULAR PHASE; GESTATION PERIOD; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; LUTEAL PHASE; MULTIPLE PREGNANCY; NORMAL HUMAN; OVARY; OVARY FOLLICLE DEVELOPMENT; PREGNANCY; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY;

EID: 0029802291     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.humrep.a019539     Document Type: Article

References (25)

1. Arthur, I.D., Anthony, F.W., Adams, S. and Thomas, E.J. (1996) Serum relaxin and the major endometrial secretory proteins in in-vitro fertilization and down-regulated hormone-supported and natural cycle frozen embryo transfer. Hum. Reprod., 11, 88-91.
2. Bell, R.J., Healy, D.L., Sutton, B. et al. (1989) Relaxin levels in antenatal patients following in vitro fertilisation. Fertil. Steril., 52, 85-87.
3. Blankenship, T., Stewart, D.R., Benirschke, K. et al. (1994) Immunocytochemical localization of nonluteal ovarian relaxin. J. Reprod. Med., 39, 235-240.
4. Bryant-Greenwood, G.D. and Schwabe, C. (1994) Human relaxins: chemistry and biology. Endocr. Rev., 15, 5-26.
5. Csemiczky, G., Hagenfeldt, K. and Wramsby, H. (1994) Selection of ovarian stimulation protocol is related to IVF treatment outcome in women 35 years of age and older. J. Assist. Reprod. Genet., 11, 474-477.
6. Eddie, L.W., Cameron, I.T., Leeton, J.F. et al. (1990) Ovarian relaxin is not essential for dilatation of cervix. Lancet, 336, 243.
7. Emmi, A.M., Skurnick, J., Goldsmith, L.T. et al. (1991) Ovarian control of pituitary hormone secretion in early human pregnancy. J. Clin. Endocrinol. Metab., 72, 1359-1363.
8. Haning, R.V., Steinetz, B. and Weiss, G. (1985) Elevated serum relaxin levels in multiple pregnancy after menotropin treatment. Obstet. Gynecol., 66, 42-45.
9. Johnson, M.R., Okokon, E., Collins, W.P. et al. (1991a) The effect of human chorionic gonadotropin and pregnancy on the circulating level of relaxin. J. Clin. Endocrinol. Metab., 72, 1042-1047.
10. Johnson, M.R., Wren, M.E., Abdalla, H. et al. (1991b) Relaxin levels in ovum donation pregnancies. Fertil. Steril., 56, 59-61.
11. Johnson, M.R., Abbas, A.A., Allman, A.C.J. et al. (1994a) The regulation of plasma relaxin levels during human pregnancy. J. Endocrinol., 142, 261-265.
12. Johnson, M.R., Abbas, A.A., Irvine, R. et al. (1994b) The regulation of corpus luteum function. Hum. Reprod., 9, 41-48.
13. Khan-Dawood, F.S., Goldsmith, L.T., Weiss, G. and Dawood, M.Y. (1989) Human corpus luteum secretion of relaxin, oxytocin and progesterone. J. Clin. Endocrinol. Metab., 68, 627-631.
14. Kristiansson, P., Svärdsudd, K. and von Schoultz, B. (1996) Serum relaxin, symphyseal pain and back pain during pregnancy. Am. J. Obstet. Gynecol., in press.
15. Ljubica, V.B., Morton, M. and Bryant-Greenwood, G.D. (1995) Relaxin gene expression in human reproductive tissues by in situ hybridization. J. Clin. Endocrinol. Metab., 80, 130-137.
16. Lucas, C., Bald, L.N., Martin, M.C. et al. (1989) An enzyme-linked immunosorbent assay to study human relaxin in human pregnancy and in pregnant rhesus monkeys. J. Endocrinol., 120, 449-457.
17. Lynch, L., Berkowitz, R.L., Weiss, G. et al. (1995) The effect of multifetal pregnancy reduction on serum relaxin. Obstet. Gynecol., 85, 756-759.
18. MacLennan, A.M., Nicolson, R., Green, R.C. and Bath, M. (1986) Serum relaxin and pelvic pain of pregnancy. Lancet, ii, 243-245.
19. Stewart, D.R., Celniker, A.C., Taylor, C.A. et al. (1990) Relaxin in the peri-implantation period. J. Clin. Endocrinol. Metab., 70, 1771-1773.
20. Stoelk, E., Chegini, N., Lei, Z.M. et al. (1991) Immunocytochemical localization of relaxin in human corpora lutea: cellular and subcellular distribution and dependence on reproductive state. Biol. Reprod., 44, 1140-1147.
21. Udén, A. and Lindhagen, T. (1988) Inguinal hernia in patients with congenital dislocation of the hip. A sign of general connective tissue disorder. Acta Orthop. Scand., 59, 667-668.
22. Weiss, G., O'Byrne, E.M. and Steinetz, B.G. (1976) Relaxin: a product of the human corpus luteum of pregnancy. Science, 194, 948-949.
23. Weiss, G., O'Byrne, E.M., Hochman, J.A. et al. (1977) Secretion of progesterone and relaxin by the human corpus luteum at midpregnancy and at term. Obstet. Gynecol., 5, 679-681.
24. Weiss, G., Goldsmith, L.T., Sachdev, R. et al. (1993) Elevated first trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery. Obstet. Gynecol., 82, 821-828.
25. Winslow, J.W., Shih, A., Bourell, J.H. et al. (1992) Human seminal relaxin is a product of the same gene as human luteal relaxin. Endocrinology, 130, 2660-2668.