Autoradiographical and immunohistochemical analysis of receptor in the central nervous system

Histochemical Journal

Volumn 28, Issue 11, 1996, Pages 729-745

  Chabot, Jean Guy ^a   Kar, Satyabrata ^a   Quirion, Rémi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR;

AUTORADIOGRAPHY; CENTRAL NERVOUS SYSTEM; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0029801973     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02272147     Document Type: Review

References (142)

1. ALLEN, S. J., DAWBARN, D., ECKFORD, S. D., WILCOCK, G. K., ASHCROFT, M., COLEBROOK, S. M., FEENEY, R. & MACGOWAN, S. H. (1994) Cloning of a non-catalytic form of human trkB and distribution of mRNA for trkB in human brain. Neuroscience 60, 825-34.
2. AOKI, C., JOH, T. H. & PICKEL, V. M. (1987) Ultrastructural localization of β-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain. Brain Res. 437, 264-82.
3. APPEL, N. M., MATHEWS, S. A., STORTI, G. M. & KUHAR, M. J. (1991) Storage phosphors as an alternative to photographic emulsion for recording and quantifying autoradiograms. Soc. Neurosci. Abst. 17, 373.
4. ARITA, N., HAYAKAWA, T., IZUMOTO, S., TAKI, T., OHNISKI, T., YAMAMOTO, H., BITOH, S. & MOGAMI, H. (1989) Epidermal growth factor in human glioma. J. Neurosurg. 70, 916-19.
5. ARVIDSSON, U., DADO, R. J., RIEDL, M., LEE, S. H., LAW, P. Y., LOH, H. H., ELDE, R. & WESSENDORF, M. W. (1995) δ-opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J. Neurosci. 15, 1215-35.
6. ATWEH, S. F. & KUHAR, M. J. (1977a) Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla. Brain Res. 124, 53-67.
7. ATWEH, S. F. & KUHAR, M. J. (1977b) Autoradiographic localization of opiate receptors in rat brain. II. The brain stem. Brain Res. 129, 1-12.
8. ATWEH, S. F. & KUHAR, M. J. (1977c) Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res. 134, 393-405.
9. 2 receptors in the rat brain. Eur. J. Pharmacol. 217, 173-84.
10. AUBERT, I., ROWE, W., MEANEY, M. J., GAUTHIER, S. & QUIRION, R. (1995) Cholinergic markers in aged cognitively impaired Long-Evans rats. Neuroscience, 67, 277-92.
11. AUBERT, I., CECYRE, D., GAUTHIER, S. & QUIRION, R. (1996) Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors in the rat brain. J. Comp. Neurol. 369, 31-55.
12. BALDINO, F., CHESSELET, M. F. & LEWIS, M. E. (1989) High resolution in situ hybridization histochemistry. Meth. Enzymol. 168, 761-78.
13. BARD, J. A., WALKER, M. W., BRANCHEK, T. A. & WEINSHANK, R. L. (1995) Cloning and functional expression of a human Y4 receptor subtype for pancreatic polypeptide, neuropeptide Y and peptide YY. J. Biol. Chem. 270, 26762-5.
14. BEAUDET, A. (1993) Autoradiographic localization of receptors at the electron microscopic level. In Receptor Autoradiography: Principles and Practice (edited by WHARTON, J. & POLAK, J. M.) pp. 135-58. Oxford: Oxford University Press.
15. BERNARD, V., NORMAND, E. & BLOCH, B. (1992) Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes. J. Neurosci. 12, 3591-600.
16. BIRECREE, E., WHETSELL, W. O., STOSCHECK, C., KING, L. E. & NANNEY, L. B. (1988) Immunoreactive epidermal growth factor receptor in neuritic plaques from patients with Alzheimer's disease. Exp. Neurol. 47, 549-60.
17. BIRECREE, E., KING, L. E. & NANNEY, L. B. (1991) Epidermal growth factor and its receptor in the developing human nervous system. Dev. Brain Res. 60, 145-54.
18. BOUCHARD, P., ROMAN, F., JUNIEN, J.-L. & QUIRION, R. (1996) Autoradiographic evidence for the modulation of in vivo sigma receptor labeling by neuropeptide Y and calcitonin gene-related peptide in the mouse brain. J. Pharmacol. Exp. Ther. 276, 223-30.
19. BUCKLEY, N. J., BONNER, T. I. & BRANN, M. R. (1988) Localization of a family of muscarinic receptor mRNAs in rat brain. J. Neurosci. 8, 4646-52.
20. CHABOT, J.-G., KAR, S. & QUIRION, R. (1993) Ontogenic profile of epidermal growth factor receptors in rat brain. In Receptors in the Developing Nervous System. Vol. 1. Growth and hormones (edited by ZAGON, I. S. & MCLAUGHIN, P. J.) pp. 83-97. London: Chapman & Hall.
21. CHABOT, J.-G., TONG, Y., SHEN, S.-H., O'DOWD, B. F., GEORGE, S. R. & QUIRION, R. (1995) Ontogeny of the expression of the mu opioid receptor gene in rat brain: an in situ hybridization study. Soc. Neurosci. Abstr. 21, 1357.
22. CHAN-PALAY, V., ALLEN, Y. S., LANG, W., HAESLER, U. & POLAK, J. M. (1985) Cytology and distribution in normal human cerebral cortex of neurons immunoreactive with antisera against neuropeptide Y. J. Comp. Neurol. 238, 382-9.
23. CHEN, J. F. & WEISS, B. (1991) Ontogenic expression of D2 dopamine receptor mRNA in rat corpus striatum. Dev. Brain Res. 63, 95-104.
24. CHRONWALL, B. M., DIMAGGIO, D. A., MASSARI, V. J., PICKEL, V. M., RUGGIERO, D. A. & O'DONOHUE, T. L. (1985) The anatomy of neuropeptide Y containing neurons in rat brain. Neurosience 15, 1159-81.
25. CIMINO, M., MARINI, P., FORNASARI, D., CATTABENI, F. & CLEMENTI, F. (1992) Distribution of nicotinic receptors in Cynomolgus monkey brain and ganglia: localization of α3 subunit mRNA, α-bungarotoxin and nicotine binding sites. Neuroscience 51, 77-86.
26. COMPTON, D. R., BAGLEY, R. B., KATZEN, J. S. & MARTIN, B. R. (1987) (+)- and (-)-N-allylnormetazocine binding sites in mouse brain: in vitro and in vivo characterization and regional distribution. Life Sci. 40, 2195-206.
27. DE LACALLE, S., LIM, C., SOBREVIELA, T., MUFSON, E. J., HERSH, L. & SAPER, C. B. (1994) Cholinergic innervation in the human hippocampus formation including the entorhinal cortex. J. Comp. Neurol. 345, 321-44.
28. DELFS, J. M., KONG, H., MESTEK, A., CHEN, Y., YU, L., REISINE, T. & CHESSELET, M.-F. (1994) Expression of μ opoid receptor mRNA in rat brain: an in situ hybridization study at the single cell level. J. Comp. Neurol. 345, 46-68.
29. 8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J. Pharmacol. Exp. Ther. 254, 123-8.
30. DENNIS, T., FOURNIER, A., GUARD, S., ST. PIERRE, S. & QUIRION, R. (1991) Calcitonin gene-related peptide (hCGRPα) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences. Brain Res. 539, 59-66.
31. DEQUIDT, M. E., & EMSON, P. C. (1986a) Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. I. Radioimmunoassay and chromatographic characterisation. Neuroscience 18, 527-43.
32. DEQUIDT, M. E. & EMSON, P. C. (1986b) Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. II. Immunohistochemical analysis. Neuroscience 18, 545-618.
33. 2 radioligands. J. Pharmacol. Exp. Ther. 272, 673-80.
34. 2 receptor radioligands. Synapse 22, 139-58.
35. FLORES, G., BARBEAU, D., QUIRION, R. & SRIVASTAVA, L. (1996) Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus. J. Neurosci. 16, 2020-6.
36. FONSECA, M. I., AGUILAR, J. S., SKORUPA, A. F. & KLEIN, W. L. (1991) Cellular mapping of m2 muscarinic receptor in rat olfactory bulb using an antiserum raised against a cytoplasmic loop peptide. Brain Res. 563, 163-70.
37. FKOST, J. J. & WAGNER, H. N. (1990) Quantitative Image: Neuroreceptors, Neurotransmitters and Enzymes. New York: Raven Press.
38. GERFEN, C. R. (1991) Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain. Brain Res. 556, 165-70.
39. GOLDSTEIN, A. & NAIDU, A. (1989) Multiple opioid receptors: ligand selectivity and binding sites signatures. Mol. Pharmacol. 36, 265-72.
40. GOMEZ-PINILLA, F., KNAUER, D. J. & NIETO-SAMPEDRO, M. (1988) Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization. Brain Res. 438, 385-90.
41. GRUNDEMAR, L., WAHLESTEDT, C. & REIS, D. J. (1991) Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem. J. Pharmacol. Exp. Ther. 258, 633-8.
42. HARRISON, P. J., BARTON, A. J. L., NAJLERAHIM, A., MCDONALD, B. & PEARSON, R. C. A. (1991) Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry. Mol. Brain Res. 9, 15-21.
43. HERKENHAM, M. & PERT, C. B. (1982) Light microscopic localization of brain opiate receptor: a general autoradiographic method which preserves tissue quality. J. Neurosci, 2, 1129-49.
44. HILL, J. A., ZOLI, M., BOURGEOIS, J.-P. & CHANGEUX, J.-P. (1993) Immunocytochemical localization of a neuronal nicotinic receptor: the β2-subunit. J. Neurosci. 13, 1551-68.
45. 1c receptor mRNA in adult rat brain. FEBS Lett. 247, 453-62.
46. HOLTZMAN, D. M., LI, Y., PARADA, L. F., KINSMAN, S., CHEN, C.-K., VALLETA, J. S., ZHOU, J., LONG, J. B. & WOBLEY, W. C. (1992) P140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9, 465-78.
47. 1 receptor mRNA in the human brain: an in situ hybridization study. NeuroReport, 7, 1053-6.
48. JIN, H., OKSENBERG, D., ASKENAZI, A., PEROUTKA, S., DUNCAN, A. M. V., ROZMAHEL, R., YANG, Y., MENGOD, G., PALACIOS, J. M. & O'DOWD, B. (1992) Identification and characterization of the human 5-hydroxytryptamine 1B receptor. J. Biol. Chem. 267, 5735-8.
49. 125I]insulin receptor binding sites in developing and adult rat brain. J. Comp. Neurol. 333, 375-97.
50. KEEN, M. & MACDERMOT, J. (1993) Analysis of receptors by radioligand binding. In Receptor Autoradiography: Principles and Practice (edited by WHARTON, J. & POLAK, J. M.) pp. 23-55. Oxford: Oxford University Press.
51. KUHAR, M. J. (1993) Background to receptor mapping and future trends. In Receptor Autoradioraphy: Principles and Practice (edited by WHARTON, J. & POLAK, J. M.) pp. 13-22. Oxford: Oxford University Press.
52. KUHAR, M. J. & YAMAMURA, H. I. (1975) Autoradiographic localization of the muscarinic receptor in rat brain. Nature 253, 560-1.
53. KUHAR, M. J. & YAMAMURA, H. I. (1976) Localization of cholinergic muscarinic receptors in rat brain by light microscope radioautography. Brain Res. 110, 229-43.
54. KUHAR, M. J., TAYLOR, M., WOSLEY, J. K., HULME, E. C. & BIRDSALL, N. J. M. (1981) Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography. Brain Res. 112, 497-512.
55. KUHAR, M. J., DESOUZA, E. B. & UNNERSTALL, J. R. (1986) Neurotransmitter receptor mapping by autoradiography and other methods. Annu. Rev. Neurosci. 9, 27-59.
56. LAPCHAK, P. A., ARAUJO, D. M., QUIRION, R. & BEAUDET, A. (1991) Immunoautoradiographic localization of interleukin-2 like immunoreactivity and interleukin-2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience 44, 173-84.
57. LEE, C. M., CAMPBELL, N. J., WILLIAMS, B. J. & IVERSEN, L. L. (1986) Multiple tackykinin binding sites in peripheral tissues and in brain. Eur. J. Pharmacol. 130, 209-17.
58. LE JEUNE, H., CHABOT, J.-G., ROWE, W., MEANEY, M. & QUIRION, R. (1995) In situ hybridization studies of the expression of muscarinic receptor sub-type mRNA in aged memory-impaired and unimpaired Long Evans rats. Soc. Neurosci. Abst. 21, 2041.
59. LE MOINE, C., NORMAND, E., GUITTENY, A. F., FOUQUE, B., TEOULE, R. & BLOCH, B. (1990) Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc. Natl. Acad. Sci. USA 87, 230-4.
60. LESAUTEUR, L., MALIARTCHOUK, S., LE JEUNE, H., QUIRION, R. & SARAGOVI, H. U. (1996) Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody. J. Neurosci. 16, 1308-16.
61. LEVEY, A. I., STORMANN, T. M. & BRANN, M. R. (1990) Bacterial expression of human muscarinic receptor fusion proteins and generation of subtype-specific antisera. FEBS Lett. 275, 65-9.
62. LEWIS, M. E. & BALDINO, F. (1990) Probes for in situ hybridization histochemistry. In In situ hybridization (edited by CHESSELET, M. F.) pp. 1-21. Boca Raton: CRC Press.
63. LEWIS, M. E., SHERMAN, T. G. & WATSON, S. J. (1985) In situ hybridization histochemistry with synthetic oligonucleotides: strategies and methods. Peptides 6, 75-87.
64. LI, M., YASUDA, R. P., WALL, S. J., WELLSTEIN, A. & WOLFE, B. B. (1991) Distribution of m2 muscarinic receptors in rat brain using antisera selective for m2 receptors. Mol. Pharmacol. 40, 28-35.
65. MANIATIS, T., FRITSCH, E. F. & SAMBROOK, J. (1982) Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory.
66. MANSOUR, A. & WATSON, S. J. (1993) Anatomical distribution of opioid receptors in mammalians: an overview. In Handbook of Experimental Pharmacology, Vol 104/I. Opioids I (edited by HERZ, A.) pp. 79-105. New York: Springer-Verlag.
67. MANSOUR, A., KHACHATURIAN, H., LEWIS, M. E., AKIL, H. & WATSON, S. J. (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci. 7, 2445-64.
68. 2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J. Neurosci. 10, 2587-600.
69. MANSOUR, A., THOMPSON, R. C., AKIL, H. & WATSON, S. J. (1993) δ opioid receptor mRNA distribution in the brain: comparison to 5-receptor binding and proenkephalin mRNA. J. Chem. Neuroanat. 6, 351-62.
70. 1 opioid receptors. Regul. Pept. 54, 177-8.
71. 1 receptor mRNA distribution in the rat CNS: comparison to K receptor binding and prodynorphin mRNA. Mol. Cell. Neurosci. 5, 124-44.
72. MANSOUR, A., FOX, C. A., THOMPSON, R. C., AKIL, H. & WATSON, S. J. (1994c) μ-opioid receptor mRNA expression in the rat CNS: comparison to μ-receptor binding. Brain Res. 643, 245-65.
73. MANSOUR, A., FOX, C. A., AKIL, H. & WATSON, S. J. (1995a) Opioid-receptor mRNA expression in rat CNS: anatomical and functional implications. Trends Neurosci. 18, 22-9.
74. MANSOUR, A., FOX, C. A., BURKE, S., AKIL, H. & WATSON, S. J. (1995b) Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS. J. Chem. Neuroanat. 8, 283-305.
75. 1b serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc. Natl. Acad. Sci. USA 89, 3020-4.
76. 125I]Bolton-Hunter neuropeptide Y binding sites in the forebrain of various mammalian species. Brain Res. 419, 403-7.
77. MARTINOFF, R., CHEN, E.-Y., POLLER, E. H., SLADEK, J. R., MUFSON, E. J. & KORDOWER, J. H. (1994) Trk-immunoreactivity in the forebrain of young and aged non-human primates. Soc. Neurosci. Abstr. 20, 41.
78. 2 dopamine receptor mRNA in rat brain. Proc. Natl. Acad. Sci. USA 86, 7625-8.
79. MENGOD, G. & VILARÓ, M. T. (1993) Analysis of receptor expression by in situ hybridization histochemistry. In Receptor Autoradiography: Principles and Practice (edited by WHARTON, J. & POLAK, J. M.) pp. 159-70. Oxford: Oxford University Press.
80. 2 receptor in the rat brain by in situ hybridization histochemistry. Proc. Natl. Acad. Sci. USA 86, 8560-1.
81. 1c receptor mRNA in the rodent examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35, 577-91.
82. 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res. 524, 139-43.
83. MENGOD, G., VILARÓ, M. T., NIZNIK, H. B., SUNAHARA, R. K., SEEMAN, P., O'DOWD, B. F. & PALACIOS, J. M. (1991) Visualization of a dopamine D1 receptor mRNA in human and rat brain. Mol. Brain Res. 10, 185-91.
84. MENGOD, G., VILARÓ, M. T., LANDWEHRMEYER, G. B., MARTINEZ-MIR, M. I., NIZNlK, H. B., SUNAHARA, R. K., SEEMAN, P., O'DOWD, B. F., PROBST, A. & PALACIOS, J. M. (1992) Visualization of dopamine D1, D2, and D3 receptor mRNAs in human and rat brain. Neurochem. Int. 20, suppl. 33S-43S.
85. 1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc. Natl. Acad. Sci. USA 86, 6793-7.
86. A/benzodiazepine receptor (α subunit) mRNA in rat brain. J. Neurochem. 51, 1651-4.
87. MRZLJAK, L., LEVEY, A. I. & GOLDMAN-RAKIC, P.S. (1993) Association of ml and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission. Proc. Natl. Acad. Sci. USA 90, 5194-8.
88. NAJLERAHIM, A., BARON, A. J. L., HARRISON, T. J., HEFFERNAN, J. & PEARSON, R. C. A. (1989) Messenger RNA encoding the D2 dopamine receptor detected by in situ hybridization histochemistry in rat brain. FEBS Lett. 255, 335-9.
89. OCRANT, I., VALENTINOm K. L. ENG, L. F., HINTZ, R. L., WILSON, D. M. & ROSENFELD, R. G. (1988) Structural and immunohistochemical characterization of insulin-like growth factor 1 and II receptors in the murine central nervous system. Endocrinology 123, 1021-34.
90. O'DONOHUE, T. L., CHRONWALL, B. M., PRUSS, R. M., MEZEY, E., KISS, J. Z., EIDEN, L. E., MASSARI, V. J., TESSEL, R. E., PICKEL, V. M., DIMAGGIO, D. A., HOTCHKISS, A. J., CROWLEY, W. R. & ZUKOWSKA-GROJEC, Z. (1985) Neuropeptide Y and peptide YY neuronal and endocrine systems. Peptides 6, 755-68.
91. PALACIOS, J. M., NIEHOFF, D. L. & KUHAR, M. J. (1981) Receptor autoradiography with tritium sensitive film: potential for computerized densitometry. Neurosci. Lett. 24, 111-16.
92. PALAClOS, J. M., MENGOD, G., SARASA, M., VILARÓ, M. T., WIEDHERHOLD, K. H., BODDEKE, H. W. C. M., ALVAREZ, F. J., CHINAGLIA, G. & PROBST, A. (1990) Cholinergic receptors in the rat and human brain. Microscopic visualization. Prog. Brain Res. 84, 343-53.
93. PASTERNAK, G. W. (1986) Multiple μ opiate receptors: biochemical and pharmacological evidence for multiplicity. Biochem. Pharmacol. 35, 361-4.
94. PELLEGRINI-GIAMPIETRO, D. E., BENNETT, M. V. L. & ZUKIN, R. S. (1991) Differential expression of three glutamate receptor genes in developing rat brain: an in situ hybridization study. Proc. Natl. Acad. Sci. USA 88, 4157-61.
95. PLATA-SALAMAN, C. R. (1991) Epidermal growth factor and the nervous system. Peptides 12, 653-63.
96. 1A receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12, 440-53.
97. QUIRION, R. & GAUDREAU, P. (1985) Strategies in neuropeptide receptor binding research. Neurosci. Biobehav. Res. 9, 413-20.
98. QUIRION, R. & RICHARD, J. (1987) Differential effects of selective lesions of cholinergic and dopaminergic neurons in serotonin-type 1 receptors in rat brain. Synapse 1, 124-30.
99. QUIRION, R., HAMMER, R. P., HERKENHAM, M. & PERT, C. B. (1981) Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film. Proc. Natl. Acad. Sci. USA 78, 5881-5.
100. QUIRION, R., RICHARD, J. & DAM, T. V. (1985) Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex. Brain Res. 333, 345-6.
101. QUIRION, R., ROBITAILLE, Y., MARTIAL, J., CHABOT, J.-G., LEMOINE, P., PILAPIL, C. & DALPÉ, M. (1987) Human brain receptor autoradiography using whole hemisphere sections: a general method that minimizes tissue artefacts. Synapse 1, 446-54.
102. QUIRION, R., DALPE, M., LEMOINE, P. & ROBITAILLE, Y. (1988) Whole hemisphere human brain receptor autoradiography and brain banking methodology. In Raceptor Localization: Ligand Autoradiography (edited by LESLIE, F. M. & ALTAR, L. A.), pp. 163-76. New York: Alan R. Liss, Inc.
103. 3H]acetylcholine muscarinic receptors in mammalian brain. Apparent labelling of an M2-like receptor sub-type. Neuroscience 29, 271-89.
104. QUIRION, R., DAM, T.-V., SARRIEAU, A. & ROSTÈNE, W. (1989b) Receptor autoradiography in neuropeptide research. In Brain Imaging: Techniques and Applications (edited by SHARIF, N. A. & LEWIS, M. E.) pp. 77-94. New York: John Wiley & Sons.
105. QUIRION, R., KAR, S., CHABOT, J-G. & DUMONT, Y. (1993) Neuropeptide and growth factor receptor autoradiography. In Receptor Autoradiography: Principles and Practice (edited by WHARTON, J. & POLAK, J. M.) pp. 257-79. Oxford: Oxford University Press.
106. A/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies. J. Cell Biol. 41, 1-12.
107. 3H]-propylbenzilylcholine mustard and its distribution in the forebrain. Brain Res. Rev. 1, 141-66.
108. SARGENT, P. B., PIKE, S. H., NADEL, D. B. & LINDSTROM, J. M. (1989) Nicotinic acetylcholine receptor-like molecules in the retina retinotectal pathway and optic tectum of the frog. J. Neursci. 9, 565-73.
109. SCHRÖDER, H., ZILLES, K., LUITEN, P. G. M. & STROSBERG, A. D. (1990) Immunocytochemical visualization of muscarinic cholinoceptors in the human cerebral cortex. Brain Res. 514, 249-58.
110. A γ-aminobutyrate receptor. Proc. Natl. Acad. Sci. USA 85, 7815-19.
111. SHARIF, N. A. (1996) Quantitative Autoradiographic Methods. In Brain Mapping: The Methods (edited by TOGA, A. W. & MAZZIOTA, J. C.), pp. 115-44. New York: Academic Press.
112. SHARIF, N. A. & HUGHES, J. (1989) Discrete mapping of brain mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptors. Peptides 10, 499-522.
113. SNYDER, S. H. (1983) Molecular aspects of neurotransmitter receptors: an overview. In Handbook of Psychopharmacology (edited by IVERSEN, L. L., IVERSEN, S. D. & SNYDER, S. H.) pp. 1-12. New York: Plenum Press.
114. 3) as a target for neuroleptics. Nature 347, 146-51.
115. STEININGER, T. L., WAINER, B. H., KLEIN, R., BARBACID, M. & PALFREY, H. C. (1993) High affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain. Brain Res. 612, 330-5.
116. STERNBERGER, L. A. (1986) Immunocytochemistry. 4th edn. New York: John Wiley & Sons.
117. 3H]-mesobilirubinogen. J. Histochem. Cytochem. 14, 274-86.
118. 1 receptor autoradiography. Soc. Neurosci. Abst. 19, 727.
119. 1 receptor in human embryonic kidney 293 cells: ligand binding characteristics, in situ hybridization and receptor autoradiography. Mol. Brain Res. 34, 303-8.
120. TRILLER, A., CLUZEAUD, F., PFEIFFER, F., BETZ, H. & KORN, H. (1985) Distribution of glycine receptors at central synapses: an immuno-electron microscopy study. J. Cell Biol. 191, 683-8.
121. 3H]-Ultrafilm: application to multiple benzodiazepine receptors. J. Neurosci. Meth. 6, 59-73.
122. VAN DER ZEE, E. A., MATSUYAMA, T., STROSBERG, A. D., TRABER, J. & LUITEN, P. G. M. (1989) Demonstration of muscarinic acetylcholine receptor-like immunoreactivity in the rat forebrain and upper brainstem. Histochemistry 92, 475-85.
123. VILARÓ, M. T., PALACIOS, J. M. & MENGOD, G. (1990) Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci. Lett. 114, 154-9.
124. VILARÓ, M. T., WIEDERHOLD, K. H., PALACIOS, J. M. & MENGOD, G. (1991) Muscarinic cholinergic receptors in the rat caudate-putamen and olfactory tubercle belong predominantly to the m4 class: in situ hybridization and receptor autoradiography evidence. Neuroscience 40, 159-67.
125. VILARÓ, M. T., WIEDERHOLD, K. H., PALACIOS, J. M. & MENGOD, G. (1992) Muscarinic M2 receptor mRNA expression and receptor binding in cholinergic and non-cholinergic cells in the rat brain: a correlative study using in situ hybridization histochemistry and receptor autoradiography. Neuroscience 47, 367-93.
126. VILARÓ, M. T., MENGOD, G., PALACIOS, G. & PALACIOS, J. M. (1993) Receptor distribution in the human and animal hippocampus: focus on muscarinic acetylcholine receptors. Hippocampus 3, 149-56.
127. VILARÓ, M. T., PALACIOS, J. M. & MENGOD, G. (1994) Multiplicity of muscarinic autoreceptor subtypes? Comparison of the distribution of cholinergic cells and cells containing mRNA for five subtypes of muscarinic receptors in the rat brain. Mol. Brain. Res. 21, 30-46.
128. VOIGT, M. M., LAURIE, D. J., SEEBURG, P. H. & BACH, A. (1991) Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine 1B receptor. EMBO J. 10, 4017-23.
129. WADA, E., WADA, K., BOULTER, J., DENERIS, E., HEINEMANN, S., PATRICK, J. & SWANSON, L. W. (1989) Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J. Comp. Neurol. 284, 314-35.
130. WADA, E., MCKINNON, D., HEINEMANN, S., PATRICK, J. & SWANSON, L. W. (1990) The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor family (α5) in the rat central nervous system. Brain Res. 526, 45-53.
131. 1 neuropeptide Y receptor are essential for ligand binding. J. Biol. Chem. 269, 2863-9.
132. 2 receptor mRNA in rat brain. FEBS Lett. 253, 207-13.
133. WEINER, D. M., LEVEY, A. I., SUNAHARA, R. K., NIZNIK, H. B., O'DOWD, B. F., SEEMAN, P. & BRANN, M. R. (1991) D1 and D2 dopamine receptor mRNA in rat brain. Proc. Natl. Acad. Sci. USA 88, 1859-63.
134. 3H]haloperidol to sigma receptors in the mouse brain. J. Chem. Neuroanat. 3, 347-54.
135. WERNER, M. H., NANNEY, L. B., STOSCHECK, C. M. & KING, L. E. (1988) Localization of immunoreactive epidermal growth factor in human nervous system. J. Histochem. Cytochem. 36, 81-6.
136. WHARTON, J. & POLAK, J. M. (1993) Receptor Autoradiography: Principles and Practice. Oxford: Oxford University Press.
137. WHARTON, J., GORDON, L., BYRNE, J., HERZOG, H., SELBI, L. A., NOORE, K., SULLIVAN, M. H. F., ELDER, M. G., MOSCOSO, G., TAYLOR, K. M., SHINE, J. & POLAK, J. M. (1992) Expression of the human neuropeptide tyrosine Y1 receptor. Proc. Natl. Acad. Sci. USA 90, 687-91.
138. 1 and Y2 receptor subtypes in human and rat brain. Brain Res. 631, 27-38.
139. WOLOZIN, B. L. & PASTERNAK, G. W. (1981) Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc. Natl. Acad. Sci. USA 78, 6181-5.
140. YAMAMURA, H. I., ENNAM, J. J. & KUHAR, M. J. (1978) Neutransmitter receptor binding. New York: Raven Press.
141. 3H] opioid receptor labelling in mounted tissue sections of rat brain. Brain. Res. 179, 255-70.
142. ZIMPRICH, A., BACHER, B. & HOLLT, V. (1994) Cloning and expression of an isoform of the rmu opioid receptor (rmuOR1B). Regul. Pept. 54, 347-8.