Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus

European Journal of Pediatrics

Volumn 155, Issue 10, 1996, Pages 885-889

  Saukkonen, T ^a   Savilahti, E ^a   Madacsy L ^b   Arato A ^b   Korner A ^b   Barkai, L ^c   Sarnesto, A ^a   Akerblom H K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c Postgraduate Medical University   (Hungary)

Author keywords

Bovine serum albumin antibodies; Cow's milk antibodies; Hungary; IDDM; Lactoglobulin antibodies

Indexed keywords

BETA LACTOGLOBULIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; OVALBUMIN;

ADOLESCENT; ANTIBODY TITER; ARTICLE; CHILD; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUNGARY; IMMUNOBLOTTING; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MILK; PRIORITY JOURNAL;

EID: 0029801627     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02282839     Document Type: Article

References (19)

1. Dahlquist GG, Blom LG, Persson L-A, Sandström AIM, Wall SGI (1990) Dietary factors and the risk of developing insulin dependent diabetes in childhood. BMJ 300: 1302-1306
2. Dahlquist G, Savilahti E, Landin-Olsson M (1992) An increased level of antibodies to β-lactoglobulin is a risk determinant for early-onset type-1 (in sulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia 35: 980-984
3. Eastham EJ, Lichauco T, Grady MI, Walker WA (1978) Antigenicity of infant formulas: Role of immature intestine on protein permeability. J Pediatr 93: 561-564
4. Gerstein HC (1994) Cow's milk exposure and type I diabetes mellitus - a critical overview of the clinical literature. Diabetes Care 17: 13-19
5. Gruskay FL, Cooke RE (1955) The gastrointestinal absorption of unaltered protein in normal infants and in infants recovering from diarhhea. Pediatrics 16: 763-768
6. Holm S, Andersson Y, Gothefors L, Lindberg T (1992) Increased protein absorption after acute gastroenteritis in children. Acta Paediatr 81: 585-588
7. Husby S, Oxelius V-A, Teisner B, Jensenius JC, Svehag S-E (1985) Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. Int Arch Allergy Appl Immunol 77: 416-422
8. Jalonen T, Isolauri E, Heyman M, Crain-Denoyelle A-M, Sillanaukee P, Koivula T (1991) Increased β-lactoglobulin absorption during rotavirus enteritis in infants: Relationship to sugar permeability. Pediatr Res 30: 290-293
9. Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Åkerblom HK, Dosch HM (1992) A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327: 302-307
10. Korenblat PE, Rothberg RM, Minden P, Farr RS (1968) Immune responses of human adults after oral and parenteral exposure to bovine serum albumin. J Allergy 41: 226-235
11. Muir A, Schatz D (1993) Antigen-specific immunotherapy: oral tolerance and subcutaneous immunization in the treatment of insulin-dependent dia3 betes. Diabetes Metab Rev 9: 279-287
12. Saukkonen T, Savilahti E, Vaarala O, Virtala E, Tuomilehto J, Åkerblom HK, Childhood Diabetes in Finland Study Group (1994) Children with newly diagnosed insulin-dependent diabetes mellitus have increased levels of antibodies to bovine serum albumin but not to ovalbumin. Diabetes Care 17: 970-976
13. Savilahti E, Åkerblom HK, Tainio V-M, Koskimies S (1988) Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 7: 137-140
14. Savilahti E, Saukkonen TT, Virtala ET, Tuomilehto J, Åkerblom HK, Childhood Diabetes in Finland Study Group (1993) Increased levels of cow's milk and β-lactoglobulin antibodies in young children with newly diagnosed IDDM. Diabetes Care 16: 984-989
15. Sheehy MJ (1992) HLA and insulin-dependent diabetes - a protective perspective. Diabetes 41: 123-129
16. Soltész G, Jeges S, Dahlquist G, Hungarian Childhood Diabetes Epidemiology Study Group (1994) Non-genetic risk determinants for type 1 (insulin-dependent) diabetes mellitus in childhood. Acta Paediatr 83: 730-735
17. Verge CF, Howard NJ, Irwig L, Simpson JM, Mackerras D, Silink M (1994) Environmental factors in childhood IDDM - a population-based, case-control study. Diabetes Care 17: 1381-1389
18. Virtanen SM, Räsänen L, Ylönen K, Aro A, Clayton D, Langholz B, Pitkäniemi J, Savilahti E, Lounamaa R, Tuomilehto J, Åkerblom HK, Childhood Diabetes in Finland Study Group (1993) Early introduction of dairy products associated with increased risk for insulin-dependent diabetes mellitus in Finnish children. Diabetes 42: 1786-1789
19. Virtanen SM, Saukkonen T, Savilahti E, Ylonen K, Rasanen L, Aro A, Knip M, Tuomilehto J, Åkerblom HK, Childhood Diabetes in Finland Study Group (1994) Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Diabetologia 37: 381-387