β-carotene treatment of cervical intraepithelial neoplasia: A phase II study

Cancer Epidemiology Biomarkers and Prevention

Volumn 5, Issue 11, 1996, Pages 929-932

  Manetta, Alberto ^a,d   Schubbert, Toni ^a   Chapman, Julia ^a   Schell, Michael J ^a   Peng, Yei Mei ^c   Liao, Shu Yuan ^b   Meyskens Jr , Frank J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; RETINOL;

ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; COLPOSCOPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HUMAN; HUMAN TISSUE; NUTRIENT; ORAL DRUG ADMINISTRATION; PAPANICOLAOU TEST; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY; VAGINA MUCOSA; VITAMIN BLOOD LEVEL;

ANTIOXIDANTS; BETA CAROTENE; CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; HUMANS; MUCOUS MEMBRANE; UTERINE CERVICAL NEOPLASMS; VAGINA;

EID: 0029801127     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Wylie-Rosett, J. A., Romney, S. L., Slage, S., Wasseniheil-Smoller, S., Miller, G. L., Palan, P. R., Lucido, D. L., and Duttagupta, C. Influence of vitamin A on cervical dysplasia and carcinoma in situ. Nutr. Cancer, 6: 47-49, 1984.
2. Herrero, R., Potischman, N., Brinton, L. A., Reeves, W. C., Brenes, M. M., Tenorio, F., deBritton, R. C., and Gaitan, E. A case-control study of nutrient status and invasive cervical cancer. I. Dietary Indicators. Am. J. Epidemiol., 134: 1335-1346, 1991.
3. Potischman, N., Herrero, R., Brinton, L. A., Reeves, W. C., Staccwicz-Sapuntzakis, M., Jones, C. J., Brenes, M. M., Tenorio, F., deBritton, R. C., and Gaitan, E. A case-control study of nutrient status and invasive cervical cancer. II. Serologic indicators. Am. J. Epidemiol., 134: 1347-1355, 1991.
4. Batieha, A. M., Armenian, H. K., Norkus, E. P., Morris, J. S., Spate, V. E., and Comstock, G. W. Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol., Biomarkers & Prev., 2: 335-339, 1993.
5. Koch, H. F. Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid. J. Maxillofac. Surg., 6: 59-63, 1978.
6. Garewal, H. A. S., Meyskens, F., Jr., Killen, D., Reeves, D., Kiersch, T. A., Elletson, H., Strosberg, A., King, D., and Steinbraun, K. Response of oral leukoplakia to β-carotene. J. Clin. Oncol., 8: 1715-1720, 1990.
7. Meyskens, F. L., Jr., Graham, V., Chvapil, M., Dorr, R. T., Alberts, D. S., and Surwit, E. A. A phase I trial of β-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J. Natl. Cancer Inst., 71: 921-925, 1983.
8. Surwit, E. A., Gramah, V., Droegemueller, W., Alberts, D., Chvapil, M., Dorr, R. T., Davis, J. R., and Meyskens, F. L. Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions. Am. J. Obstet. Gynecol., 143: 821-823, 1982.
9. Peng, Y. S., Peng, Y. M., McGee, D. L., and Alberts, D. S. Carotenoids, tocopherols and retinoids in human buccal mucosal cells: intra-and interindividual variability and storage stability. Am. J. Clin. Nutr., 59: 636-643, 1994.
10. Palan, P. R., Mikhail, M. S., Basu, J., and Romney, S. L. β carotene levels in exfoliated cervicovaginal epithelial cells in cervical intraepithelial neoplasia and cervical cancer. J. Obstet. Gynecol., 167: 1899-1903, 1992.
11. DeVet, H. C. W., Knipschild, P. G., Willebrand, D., et al. The effect of β-carotene on the regression and progression of cervical dysplasia: a clinical experiment. J. Clin. Epidemiol., 44: 273-283, 1991.
12. Scott, R. B., and Ballard, L. A. Problems of cervical biopsies. Ann. NY Acad. Sci., 1997: 767-781, 1962.
13. Lerch, V., Okagaki, T., Austin, J. H., Kevorkian, A. Y., and Young, P. A. Cytologic findings in the progression of anaplasia (dysplasia) to carcinoma in situ: a progress report. Acta Cytol., 7: 183-186, 1963.
14. Richart, R. M., and Barron, B. A. A follow-up study of patients with cervical dysplasia. Am. J. Obstet. Gynecol., 105: 383-393, 1969.