Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp.

Journal of Antibiotics

Volumn 49, Issue 10, 1996, Pages 1014-1021

  Bryans, Justin ^a   Charlton, Peter ^a   Chicarelli Robinson, Inês ^a   Collins, Mark ^a   Faint, Richard ^a   Latham, Chris ^a   Shaw, Ian ^a   Trew, Sally ^a  

^a Cantab Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOLYTIC AGENT; PIPERAZINEDIONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; XR 330; XR 334;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FERMENTATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STREPTOMYCES; THROMBUS;

EID: 0029801041     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.1014     Document Type: Article

References (19)

1. KRISHNAMURTI, C. & B. M. ALVING: Plasminogen activator inhibitor type 1: biochemistry and evidence for modulation of fibrinolysis in vivo. Seminars in Thrombosis and Haemostasis 18: 67-80, 1992
2. HUBER, R. & R. W. CARRELL: Implications of the three-dimensional structure of alpha l-antitrypsin for the structure and function of serpins. Biochemistry 28: 8951-8966, 1989
3. NY, T.; M. SAWDEY, D. LAWRENCE, J. L. MILLAN & D. J. LOSKUTOFF: Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor. Proc. Natl. Acad. Sci. U.S.A. 83: 6776-6780, 1986
4. LINDAHL, T. L.; P. I. OHLSSON & B. WIMAN: The mechanism of the reaction between human plasminogen-activator inhibitor 1 and tissue plasminogen activator. Biochem. J. 265: 109-113, 1990
5. ERICKSON, L. A.; G. J. FICI, J. E. LUND, T. P. BOYLE, H. G. POLITES & K. R. MAROTTI: Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene. Nature 346: 74-76, 1990
6. DAWSON, S. & A. HENNEY: The status of PAI-1 as a risk factor for arterial and thrombotic disease: a review. Atherosclerosis 95: 105-117, 1992
7. COLLINS, M. A. D.; M. I. CHICARELLI-ROBINSON, J. S. BRYANS, S. J. BROCCHINI, C. J. LATHAM & J. R. SHAW (Xenova Limited): Pharmaceutically active diketopiperazines. WO 94/04512, March 3, 1994
8. GERBER, N. N.: Phenazines, phenoxazinones, and dioxopiperazines from Streptomyces thioluteus. J. Org. Chem. 32: 4055-4059, 1967
9. SHIN, C.; M. HAYAKAWA, H. KATO, K. MIKANI & J. YOSHIMURA: α,β-Unsaturated carboxylic acid derivatives. 18. Syntheses of geometric isomers of 3,6-dibenzylidene-and 3-p-anisylidene-6-benzylidene-2, 5-piperazinediones. J. Chem. Soc. Perkin Trans. 1: 419-421, 1980
10. SHIN, C.; Y. SATO, M. HAYAKAWA, M. KONDO & J. YOSHIMURA: α,β-Unsaturated carboxylic acid derivatives. 20. N-Methylation of α-dehydroamino acid ester and its cyclic dipeptide from various routes, Heterocycles 16: 1573-1578, 1981
11. POJER, P. M.: Mild catalytic hydrogenation of carbon-carbon multiple bonds. Chemistry and Industry: 177-178, 1986
12. YOKOI, T.; L. M. YANG, T. YOKOI, R. Y. WU & K. H. LEE: Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. J. Antibiotics 41: 494-501, 1988
13. WILLIAMS, S. T.; M. GOODFELLOW, E. M. H. WELLINGTON, J. C. VICKERS, G. ALDERSON, P. H. A. SNEATH, M. J. SACKIN & A. M. MORTIMER: A probalitity matrix for identification of streptomycetes. J. Gen. Microbiol. 129: 1815-1830, 1983
14. WILLIAMS, S. T.; M. GOODFELLOW, G. ALDERSON, E. M. H. WELLINGTON, P. H. A. SNEATH & M. J. SACKIN: Numerical classification of Streptomyces and related genera. J. Gen. Microbiol. 129: 1743-1813, 1983
15. DECLERK, P. J.; I. JUHAN-VAGUE, J. FELEZ & B. WIMAN: Pathophysiology of fibrinolysis. Journal of Internal Medicine 236: 425-432, 1994
16. LEVI, M.; B. J. BIEMOND, A. J. VAN ZONNEVELD, J. W. TEN GATE & H. PANNEKOEK: Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis. Circulation 85: 305-312, 1992
17. ABRAHAMSSON, T.; P. BJÖRQUIST, J. DEINUM, J. EHNEBOM, M. HULANDER, A, LEGNEHED, C. MATSSON, V. NERME, A. WESTIN-ERIKSSON & B. AKERBLOM: An antibody fragment against PAI-1 inhibits PAI-1 activity and stimulates fibrinolysis in vitro and in vivo. Fibrinolysis 8 (Suppl. 2): 55-56, 1994
18. CHARLTON, P.; R. FAINT, F. BENT, J. BRYANS, I. CHICARELLI-ROBINSON, I. MACKIE, S. MACHIN & P. BEVAN: Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thombosis and Haemostasis 75: 808-815, 1996
19. NILSSON, K.; S. ROSÉN & P. FRIBERGER: A new kit for the determination of tissue plasminogen activator and its inhibitor in blood. Fibrinolysis 1: 163-168, 1987