Inhibition of human eosinophil chemotaxis in vitro by the anti-allergic agent emedastine difumarate

Immunopharmacology and Immunotoxicology

Volumn 18, Issue 4, 1996, Pages 587-595

  El Shazly, A E ^a   Masuyama, K ^a   Samejima, Y ^a   Eura, M ^a   Ishikawa, T ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EMEDASTINE; MEPYRAMINE; THROMBOCYTE ACTIVATING FACTOR;

ADULT; ARTICLE; CHEMOTAXIS; EOSINOPHIL; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0029800681     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979609052755     Document Type: Article

References (16)

1. Fukuda, T., Morimoto, Y., Iemura, R., Kawashima, T., Tsukamoto, G, and Ito, K., Effect of 1- (2-ethoxyethyl) -2- (4-methyl-1-homopiperazinyl)-benzimidazole difumarate (KB-2413), a new antiallergic, on chemical mediators., Arzneim-Forsch/Drug Res., 34: 801, 1984.
2. Fleisch, J. H., Rinkema, L. E., Haisch, K. D. and Whitesitt, C. A., Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzinidazole difumarate, a potent histamine receptor antagonist, Agents Actions, 20: 40, 1987.
3. Fukuda, T., Saito, T., Tajima,S., Shimohara,K. and Ito, k., Antiallergic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl) benzimidazole difumarate (KB-2413), Arzneim-Forsch./ Drug Res., 7:805, 1984.
4. Fukuda, T., Saito, T. and Ito, k., Anti asthmatic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1- homopiperazinyl) benzimidazole difumarate (KB-2413), a new antiallergic, Arzneimittel-Forsch./Drug Res., 7:811, 1984.
5. Nishimura, N., Ito, K., Tomioka, H. and Yoshida, S., Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413, Immunopharmacology and Immunotoxicology., 1 9: 511, 1987.
6. Hansel, T.T., Pound, J. D., Pilling, D., Kitas, G. D., Salmon, M., Gentle, T. A., Lee,S. S. and Thompson, R. A., Purification of human blood eosinophils by negative selection using immunomagnetic beads, J. Immunol. Methods.,122: 97, 1998.
7. Gleich, G. J., Flavahan, N.A, Fujisawa, T. and Vanhoutt, P. M.,The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperactivity, J. Allergy clin. Immunol.,81:776, 1988.
8. Venge, P., Hakansson, L., Peterson, C. G. B., Eosinophils activation in allergic disease, Int. Arch. Allergy Appl. Immunol., 82: 333, 1987.
9. Fukuda, T. and Gleich, G. J.,Heterogeneity of human eosinophils, J. Allergy Clin. Immunol., 83: 369, 1989.
10. Benveniste, J., Henson, P. M. and Cochrane, C. G., Leukocyte-dependent histamine release from rabbit platelets; the role of IgE, Basophils and a platelet activating factor, J. Exp. Med., 136: 1356,1972.
11. Chignard, M., LeCouedic, J. P., Vargafting, B. B. and Benveniste, J., Platelet-activating factor (PAF-Acether) secretion from platelets: effect of aggregating agents, Br. J. Haematol., 46: 455, 1980.
12. Betz, S. J. and Henson, P. M, Production and release of platelet-activating factor (PAF); dissociation from degranulation and Superoxide production in the human neutrophil, J. Immunol., 125:2756, 1980.
13. Mencia-Huerta, J. M. and Benveniste, J, Platelet-activating factor and macrophages I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes, Eur. J. Immunol.,9: 409, 1997.
14. Lee, T. C., Lenihan, D. J., Malone, B., Roddy, L. L. and Wasserman, S. I., Increased biosynthesis of platelet-activating factor in activated human eosinophils, J. Biol. Chemist., 259: 5526, 1984.
15. Wardlaw, A. J., Moqbel, R., Cromwell, O. and Kay, A. B., Platelet activating factor. A potent chemotactic and chemokinetic factor for human eosinophils, J. Clin. Invest., 78: 1701, 1986.
16. Bokoh, G. M., Chemoattractant signaling and leukocyte activation, Blood., 86: 1649, 1995