Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity

Neurochemical Research

Volumn 21, Issue 9, 1996, Pages 1005-1012

  Ben Yoseph, Oded ^a,c   Boxer, Peter A ^b   Ross, Brian D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

glutathione pathway; hydrogen peroxide; microdialysis; oxidative stress; Pentose phosphate pathway; primary cerebrocortical cultures

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE;

ARTICLE; BRAIN METABOLISM; GLUCOSE METABOLISM; GLYCOLYSIS; IRON CHELATION; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PUTAMEN;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CARBON ISOTOPES; CAUDATE NUCLEUS; CELLS, CULTURED; CEREBRAL CORTEX; DEFEROXAMINE; DEUTERIUM; DIZOCILPINE MALEATE; FETUS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HYDROGEN PEROXIDE; IRON; KAINIC ACID; KINETICS; N-METHYLASPARTATE; NEUROGLIA; NEURONS; PENTOSE PHOSPHATE PATHWAY; PUTAMEN; QUINOXALINES; RATS;

EID: 0029800421     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532410     Document Type: Article

References (30)

1. Baquer, N. Z., Hothersall, J. S., and McLean, P. 1988. Function and regulation of the pentose phosphate pathway in brain. Vol. 29, pages 265-289, in Horecker, B. L. and Stadtman, E. R. (eds), Current Topics in Cellular Regulation.
2. Baquer, N. Z., Hothersall, J. S., McLean, P., and Greenbaum, A. L. 1977. Aspects of carbohydrate metabolism in developing brain. Develop. Med. Child Neurol. 19:81-104.
3. Zubairu, S., Hothersall, J. S., El-Hassan, A., McLean, P., and Greenbaum, L. 1983. Alternative pathways of glucose utilization in brain: Changes in the pattern of glucose utilization and of the response of the pentose phosphate pathway to 5-hydroxytryptamine. J. Neurochem. 41:76-83.
4. Coleman, M. Y., and Allen, N. 1978. The hexose monophosphate pathway in ethylnitrosourea induced tumors of the nervous system. J. Neurochem. 30:83-90.
5. Hothersall, J. S., Baquer, N. Z., Greenbaum, A. L., and McLean, P. 1979. Alternative pathways of glucose utilization in brain. Changes in the pattern of glucose utilization in brain during development and the effect of phenazine methosulfate on the integration of metabolic routes. Arch. Biochem. Biophys. 198:478-492.
6. Loreck, D. J., Galarraga, J., Van der Feen, J., Phang, J. M., Smith, B. H., and Cummins, C. J. 1987. Regulation of the pentose phosphate pathway in human astrocytes and gliomas. Metab. Brain Disease 2:31-46.
7. Appel, S. H., and Parrot, B. L. 1970. Hexosemonophosphate pathway in synapses. J. Neurochern. 17:1619-1626.
8. Tabakoff, B., Groskopt, W., Anderson, R., and Alivisatos, S. G. A. 1974. Biogenic aldehyde metabolism, relation to pentose shunt in brain. Biochem. Pharmacol. 23:1710-1719.
9. Baquer, N. Z., McLean, P., and Greenbaum, A. L. 1975. Systems relationships and the control of metabolism pathways in developing brain. Pages 109-132, in Hommes, F. A., and Van den Berg, C. J., (eds), Normal and Pathological Development of Energy Metabolism, Academic Press, London.
10. Hothersall, J. S., Greenbaum, A. L., and McLean, P. 1982. The functional significance of the pentose phosphate pathway in synaptosomes: Protection against peroxidative damage by catecolamines and oxidants. J. Neurochem. 39:1325-1332.
11. Brin, M. 1966. Erythrocyte as a biopsy tissue for functional evaluation of thiamine adequacy. J. Am. Med. Assoc. 187:762-766.
12. Herken, H., Lange, K., and Kolbe, H. 1969. Brain disorders induced by pharmacological blockade of the pentose phosphate pathway. Biochim. Biophys. Res. Commun. 36:93-100.
13. Gaitonde, M. K., Evison, E., and Evans, G. M. 1983. The rate of utilization of glucose via hexosemonophosphate shunt in brain. J. Neurochem. 41:1253-1260.
14. Embree, L. J., and Dreyfus, P. M. 1963. Blood transketolase determinations in nutritional disorders of the nervous system. Trans. Am. Neurol. Assoc. 88:36-42.
15. 14C]glucose labeled in the 1, 2 or 6 position. Am. J. Physiol. 248: C170-C176.
16. 14C]glucose. Neuroscience 24:877-883.
17. 14C]glucose. J. Neurochem. 59:1430-1436.
18. 2) glucose. Biochem. J. 302:31-38.
19. Ben-Yoseph, O., Kingsley, P. B., Camp, D. M., Robinson, T. E., and Ross, B. D. 1994. Measurement of pentose phosphate pathway activity by microdialysis in vivo and in a single incubation in vitro. Neurosci. Protocols. 94-060-02-01-13.
20. Ben-Yoseph, O., Ross, B. D., Camp, D. M. and Robinson, T. E. 1995. Dynamic measurements of cerebral pentose phosphate pathway activity in vivo. J. Neurochem. 64:1336-1342.
21. Rose, K., Goldberg, M. P., and Choi, D. W. 1993. Cytotoxicity in murine cortical culture. Pages 46-60, in Tyson, C. A., and Frazier, J. M. (eds.), In Vitro Biological Methods, Academic Press, San Diego, California.
22. Koh, J. Y., and Choi, D. W. 1987. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Meth. 149:279-293.
23. Boxer, P. A., Ben-Yoseph, O., Levy, J. and Ross, B. D. 1995. Role of the glutathione pathway in the detoxification of hydrogen peroxide in culture neurons. Soc. Neurosci. Abstr. 21:99.20.
24. Coyle, J. and, Puttfarcken, P. 1993. Oxidative stress, glutamate and neurodegenerative disorders. Science 262:689-695.
25. Chaudiere, J., Wilhelmsen, E. C., and Tappel, A. L. 1984. Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptants. J. Biol. Chem. 259:1043-1050.
26. Bondy, S. G., and Lebel, C. P. 1993. The relationship between excitotoxicity and oxidative stress in the central nervous system. Free Rad. Biol. Med. 14:633-642.
27. Hostetler, K. Y., and Landau, B. R. 1967. Estimation of the pentose cycle contribution to glucose metabolism in tissue in vivo. Biochemistry 6:2961-2964.
28. Ben-Yoseph, O., Boxer, P. A., and Ross, B. D. 1994. Oxidative stress in the CNS: Monitoring the metabolic response using the pentose phosphate pathway: Dev. Neurosci. 16:328-336.
29. +: Implication for neurodegeneration. J. Neurochem 63:584-591.
30. Kish, S. J., Morito, C., and Hornykiewicz O. 1985. Glutathione peroxidase in Parkinson's disease brain. Neurosci. Lett. 58:343-346.