The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients

Journal of Periodontology

Volumn 67, Issue 11, 1996, Pages 1201-1205

  Cebeci, Irfan ^a,c   Kantarci, Alpdoǧan ^a   Firatli, Erhan ^a   Çarin, Mahmut ^b   Tuncer, Özen ^d  

^a ISTANBUL UNIVERSITY   (Turkey)

^b Faculty of Medicine

^c Ozer Sok Ogretmenler   (Turkey)

^d NONE

Author keywords

cyclosporine; kidney transplantation; verapamil gingiva hyperplasia

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; PREDNISOLONE; VERAPAMIL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GINGIVA HYPERPLASIA; GRAFT REJECTION; HUMAN; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PREVALENCE;

EID: 0029800275     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1996.67.11.1201     Document Type: Article

References (38)

1. Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporine-A: A new antilymphocytic agent. Agent Actions 1976;6:468-475.
2. Sommer G, Ferguson RM. Mismatched living, related donor renal transplantation: A prospective, randomized study. Surgery 1985;98: 267.
3. Canadian Multicenter Transplant Study Group. A randomized clinical trial of cyclosporine in cadaveric renal transplantation: Analysis at three years. N Engl J Med 1986;314:1219.
4. Chao JJ, Schmidt GM, Niland JC. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. N Engl J Med 1993;329: 1225.
5. Faulds D, Goa KL, Benfield P. Cyclosporine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 1993;45:953-1040.
6. Shaw LM. Advances in cyclosporine pharmacy, measurement, and therapeutic monitoring. Clin Chem 1989;35:1299-1308.
7. Rateitschak-Plüss EM, Hefti A, Lörtscher R, Thiel G. Initial observation that cyclosporine-A induces gingival enlargement in man. J Clin Periodontol 1983;10:237-246.
8. Hassell TM, Hefti AF. Drug-induced gingival overgrowth: Old problem, new problem. Crit Rev Oral Biol Med 1991;2:103-107.
9. Lederman D, Lumerman H, Reuben S, Freedman PD. Gingival hyperplasia associated with nifedipine therapy. Report of a case. Oral Surg Oral Med Oral Pathol 1984;57:620-622.
10. Giustiniani S, Robustelli DC, Marieni M. Hyperplastic gingivitis during diltiazem therapy. Int J Cardiol 1987;15:247-249.
11. Pernu HE, Oikarinen K, Hietanen J, Knuuttila M. Verapamil-induced gingival overgrowth: A clinical, histologic, and biochemic approach. J Oral Pathol Med 1989;18:422-425.
12. Slavin J, Taylor J. Cyclosporine, nifedipine, and gingival hyperplasia. Lancet 1987;2(8561):739.
13. Thomason JM, Seymour RA, Rice N. The prevalence and severity of cyclosporine and nifedipine-induced gingival overgrowth. J Clin Periodontol 1993;20:37-40.
14. Thomason JM, Seymour RA, Ellis JS, et al. Iatrogenic gingival overgrowth in cardiac transplantation. J Periodontol 1995;66:742-746.
15. Bokenkamp A, Bohnhorst B, Beier C, Albers N, Offner G, Brodehl J. Nifedipine aggravates cyclosporine A-induced gingival hyperplasia. Pediatr Nephrol 1994;8:181-185.
16. O'Valle F, Mesa F, Aneiros J, et al. Gingival overgrowth induced by nifedipine and cyclosporine A. Clinical and morphometric study with image analysis. J Clin Periodontol 1995;22:591-597.
17. King GN, Fullinfaw R, Higgins TJ, Walker RG, Francis DMA, Wiesenfeld D. Gingival hyperplasia in renal allograft recipients receiving cyclosporine-A and calcium antagonists. J Clin Periodontol 1993;20:286-293.
18. Dawidson I, Rooth P. Improvement of cadaver renal transplantation outcomes with verapamil: A review. Am J Med 1991;90:37-41.
19. Weir MR. Therapeutic benefits of calcium channel blockers in cyclosporine-treated organ transplant recipients: Blood pressure control and immunosuppression. Am J Med 1991;90:32-36.
20. McMillen MA, Baumgarten WK, Schaefer HC, et al. The effect of verapamil on cellular uptake, organ distribution, and pharmacology of cyclosporine. Transplantation 1987;44:395-401.
21. Weir MW, Peppler R, Gomolka D, Handwerger B. Additive inhibition of afferent and efferent immunological responses of human peripheral blood mononuclear cells by verapamil and cyclosporine. Transplantation 1991;51:851-857.
22. Cucchi G, Giustiniani S, Robustelli F. Gingival hyperplasia caused by verapamil. G Ital Cardiol 1985;15:556-557.
23. Smith M, Glenert U. Gingivhyerplasi forarsaget af behadling med verapamil. Tandlaegebladet 1987;91:849.
24. Margolin RE, Glazer HS, Lesh MF. Drug-induced gingival hyperplasia. Gen Dent 1994;42:344-345.
25. Miller CS, Damm DD. Incidence of verapamil-induced gingival hyperplasia in a dental population. J Periodontol 1992;63:453-456.
26. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135.
27. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551.
28. Seymour RA, Smith DG, Turnbull DN. The effect of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. J Clin Periodontol 1985;12:413-419.
29. Seymour RA, Smith DG. The effect of a plaque control programme on the incidence and severity of cyclosporine-induced gingival changes. J Clin Periodontol 1991;18:107-110.
30. Somacarrera ML, Hernandez JA, Moskow BS. Factors related to the incidence and severity of cyclosporine-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994;65: 671-675.
31. Nery EB, Edson RG, Lee KK, Pruthi VK, Watson J. Prevalence of nifedipine-induced gingival hyperplasia. J Periodontol 1995;66: 572-578.
32. Tyldesley WR, Rotter E. Gingival hyperplasia induced by cyclosporine-A. Br Dent J 1984;157:305-309.
33. McGaw T, Lam S, Scales J. Cyclosporine-induced gingival overgrowth: Correlation with dental plaque scores, gingivitis scores, and cyclosporine levels in serum and saliva. Oral Surg Oral Med Oral Pathol 1987;64:293-297.
34. Bullon P, Machuca G, Martinez-Sahuguillo A, Rios JV, Rojas J, Lacalle JR. Clinical assessment of gingival hyperplasia in patients treated with nifedipine. J Clin Periodontol 1994;21:256-259.
35. Somacarrera ML, Hernandez JA, Moskow BS. Localization of gingival overgrowth in heart transplant patients undergoing cyclosporine therapy. J Periodontol 1994;65:666-670.
36. Daley TD, Wysocki GP, May C. Clinical and pharmacological correlations in cyclosporine-induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1986;62:417-421.
37. Seymour RA, Smith DG, Rogers SR. The comparative effects of azathioprine and cyclosporine on some gingival health parameters of renal transplant patient. A longitudinal study. J Clin Periodontol 1987;14:610-613.
38. Hefti AF, Eshenaur AE, Hassell TM, Stone C. Gingival overgrowth in cyclosporine A-treated multiple sclerosis patients. J Periodontol 1994;65:744-749.