Insect cell bioreactors

Cytotechnology

Volumn 20, Issue 1-3, 1996, Pages 173-189

  Agathos, Spiros N ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

bioreactors; insect cells; parameters; production

Indexed keywords

EID: 0029800225     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00350398     Document Type: Review

References (86)

1. Agathos SN (1993) The future of cell culture engineering. In: Goosen MFA, Daugulis AJ & Faulkner P (eds) Insect Cell Culture Engineering, pp. 221-240. Marcel Dekker, New York.
2. Agathos SN (1994) Large scale insect cell production. In: Maramorosch K & McIntosh AH (eds) Insect Cell Biotechnology, pp. 89-103. CRC Press, Roca Raton.
3. Agathos SN, Jeong Y-H & Venkat K (1990) Growth kinetics of free and immobilized insect cell cultures. Ann. N.Y. Acad. Sci. 589: 372-398.
4. Al Rubeai M, Kioukia N & Emery AN (1994) Monitoring of insect-baculovirus culture processes by flow cytometry. Presented at Cell Culture Engineering IV, Engineering Foundation Conferences, San Diego, CA 7-12 March 1994 (Abstract WE3, Cell Culture Engineering IV Program and Abstracts, p. 86).
5. Archambault J, Robert J & Tom RL (1994) Culture of immobilized insect cells. Bioprocess Eng. 11: 189-197.
6. Barkhem T, Carlsson B, Danielsson A, Norinder U, Frieberg H & Öhman L (1992) Production in a 100 liter stirred tank reactor of functional full length human thyroid receptor b1 in Sf-9 insect cells using a recombinant baculovirus. In: Vlak JM, Schlaeger E-J & Bernard AR (eds) Baculovirus and Recombinant Protein Production Processes, pp. 235-246. Editiones Roche, Basel.
7. Bédart C, Jolicoeur M, Jardin B, Tom R, Serret S & Kamen A (1994a) Insect cell density in bioreactor cultures can be estimated from on-line measurements of optical density. Biotechnol. Techniques 8: 605-610.
8. Bédart C, Kamen A, Tom R & Massie B (1994b) Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures. Cytotechnology 15: 129-138.
9. Bonarius HPJ, de Gooijer CD, Tramper J & Schmid G (1995) Determination of the respiration quotient in mammalian cell culture in bicarbonate buffered media. Biotechnol. Bioeng. 45: 524-535.
10. Caron AW, Archambault J & Massie B (1990) High-level recombinant protein production in bioreactors using the baculovirus-insect cell expression system. Biotechnol. Bioeng. 36: 1133-1140.
11. Caron AW, Tom RL, Kamen AA & Massie B (1994) Baculovirus expression system scaleup by perfusion of high-density Sf-9 cell cultures. Biotechnol. Bioeng. 43: 881-891.
12. Chalmers JJ (1994) Cells and bubbles in sparged bioreactors. Cytotechnology 15: 311-320.
13. Chung IS, Taticek RA & Shuler ML (1993) Production of human alkaline phosphatase, a secreted glycosylated protein, from a baculovirus expression system and the attachment-dependent cell line Trichoplusia ni BTI-Tn 5B1-4 using a split-flow, airlift bioreactor. Biotechnol. Progress 9: 675-678.
14. de Gooijer CD, van Lier FLJ, van den End EJ, Vlak JM & Tramper J (1989) A model for baculovirus production with continuous insect cell cultures. Appl. Microbiol. Biotechnol. 30: 497-501.
15. Depinto W & Familetti PC (1994) Increased expression of recombinant proteins from baculovirus infected cultures using Tn-5B1-4 (High Five) insect cells. In Vitro 30: 722 (Presented at the 1994 Cell and Tissue Culture Congress, Research Triangle Park, NC, 4-7 June 1994).
16. Deutschmann SM & Jäger V (1994) Optimization of the growth conditions of Sf-21 insect cells for high-density perfusion culture in stirred-tank bioreactors. Enzyme Microb. Technol. 16: 1133-1140.
17. Eberhard U & Schügerl K (1987) Investigations of reactors for insect cell culture. Develop. Biol. Standard. 66: 325-330.
18. Fleischaker RJ & Sinskey AJ (1981) Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12: 193-197.
19. Goldblum S, Bae Y-K, Hink WF & Chalmers J (1990) Protective effect of methylcellulose and other polymers on insect cells subjected to laminar shear stress. Biotechnol. Progress 6: 383-390.
20. Graf H & Schügerl K (1991) Influence of the reciprocating movement on the performance of a membrane aeration system in insect cell cultures. Biotechnol. Techniques 5: 91-94.
21. Guillame JM, Soria HM, Couteault N, Hurwitz DR, Multon MC & Crespo A (1992) Insect cell fermentation scale-up for recombinant protein production. In: Vlak JM, Schlaeger E-J & Bernard AR (eds) Baculovirus and Recombinant Protein Production Processes, pp. 255-261. Editiones Roche, Basel.
22. Hensler WT & Agathos SN (1994) Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells. Cytotechnology 15: 177-186.
23. Hensler W, Singh V & Agathos SN (1994) Sf9 insect cell growth and β-galactosidase production in serum and serum-free media. Ann. N.Y. Acad. Sci. 745: 149-166.
24. Hink WF (1982) Production of Autographa californica nuclear polyhedrosis virus in cells from large-scale suspension cultures. In: Kurstak E (ed.) Microbial and Viral Pesticides, pp. 493-506. Marcel Dekker, New York.
25. Hink WF & Strauss EM (1976) Growth of Trichoplusia ni (TN-368) cells in suspension culture. In: Kurstak E & Maramorosch K (eds) Invertebrate Tissue Culture, pp. 297-300. Academic Press, New York.
26. Hink WF & Strauss EM (1980) Semi-continuous culture of the TN-368 cell line in fermenters with virus production in harvested cells. In: Kurstak E, Maramorosch K & Dübendorfer A (eds) Invertebrate Systems In Vitro, pp 27-33. Elsevier-North Holland Biomedical Press, Amserdam.
27. Jäger V (1996) Perfusion culture of insect cells. This volume.
28. Jain D, Ramasubramanyan K, Gould S, Lenny A, Candelore M, Tola M, Strader C, Alves K, Cuca G, Tung JS, Hunt G, Junker B, Buckland BC & Silberklang M (1991) Large-scale recombinant protein production using the insect cell-baculovirus expression vector system: antistasin and β-adrenergic receptor. In: Spier RE, Griffiths JB & Meignier B (eds.) Production of Biologicals from Animal Cells in Culture, pp. 345-350. Butterworth-Heinemann, Oxford.
29. Junker BH, Hunt G, Burgess B, Aunins J & Buckland BC (1994) Modified microbial fermenter performance in animal cell culture and its implications for flexible fermenter design. Bioprocess Eng. 11: 57-63.
30. Kamen AA, Tom RL, Caron AW, Chavarie C, Massie B & Archambault J (1991) Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnol. Bioeng. 38: 619-628.
31. Kamen AA & Tom R (1994) Mass spectroscopy determination of insect cell respiration rates in culture and production processes. In: Spier RE, Griffiths JB & Berthold W (eds) Animal Cell Technology. Products of Today, Prospects for Tomorrow (12th Meeting of the European Society for Animal Cell Culture Technology) pp. 345-350. Butterworth-Heinemann, Oxford.
32. Kim K & Familetti PC (1994) Optimal culture conditions for the production of recombinant proteins from baculovirus infected cells. In Vitro 30: 722 (Presented at the 1994 Cell and Tissue Culture Congress, Research Triangle Park, NC, 4-7 June 1994).
33. King GA, Daugulis AJ, Faulkner P, Bayly D & Goosen MFA (1988) Growth of baculovirus-infected insect cells in microcapsules to a high cell and virus density. Biotechnol. Lett 10: 683-688.
34. King G, Kuzio J, Daugulis A, Faulkner P, Allen B, Wu J & Goosen MFA (1991) Assessment of virus production and chloramphenicol acetyl transferase expression by insect cells in serum-free and serum-supplemented media using a temperature-sensitive baculovirus. Biotechnol. Bioeng. 38: 1091-1099.
35. King GA, Daugulis AJ, Faulkner P & Goosen MFA (1992) Recombinant β-galactosidase production in serum-free medium in a 14-L airlift bioreactor. Biotechnol. Progr. 8: 567-571.
36. Kioukia N, Nienow AW, Emery AN & Al-Rubeai M (1995) Physiological and environmental factors affecting the growth of insect cells and infection with baculovirus. J. Biotechnol. 38: 243-251.
37. Klöppinger M, Fertig G, Fraune E & Miltenburger HG (1990) Multistage production of Autographa California nuclear polyhedrosis virus in insect cell cultures. Cytotechnology 4: 271-278.
38. Klöppinger M, Fertig G, Fraune E & Miltenburger HG (1991) High cell density perfusion culture of insect cells for production of baculovirus and recombinant protein. In: Spier RE, Griffiths JB & Meignier B (eds) Production of Biologicals from Animal Cells in Culture (10th Meeting of the European Society for Animal Cell Culture Technology) pp. 470-476. Butterworth-Heinemann, Oxford.
39. Kompier R, Tramper J & Vlak JM (1988) A continuous process for production of baculovirus using insect-cell cultures. Biotechnol. Lett. 10: 849-854.
40. Kompier R, Kislev N, Segal I & Kadouri A (1991) Use of a stationary bed reactor and serum-free medium for the production of recombinant protein in insect cells. Enzyme Microb. Technol. 13: 822-827.
41. Konstantinov KB, Pambayun R, Matanguihan R, Yoshida T, Perusich CM & Hu W-S (1992) On-line monitoring of hybridoma cell growth using a laser turbidity sensor. Biotechnol. Bioeng. 40: 1337-1342.
42. Kool M, Vondken JW, van Lier FLJ, Tramper J & Vlak JM (1991) Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties. Virology 183: 739-746.
43. Lazarte EJ, Tossin P-F & Nicolau C (1992) Optimization of the production of full-length rCD4 in baculovirus-infected Sf9 cells. Biotechnol. Bioeng. 40: 214-217.
44. Licari P & Bailey JE (1991) Factors influencing recombinant protein yields in an insect cell - baculovirus system: multiplicity of infection and intracellular protein degradation. Biotechnol. Bioeng. 37: 238-246.
45. Licari P & Bailey JE (1992) Modeling the population dynamics of baculovirus-infected insect cells: optimizing infection stategies for enhanced recombinant protein yields. Biotechnol. Bioeng. 39: 432-441.
46. Lindsay DA & Betenbaugh MJ (1992) Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells. Biotechnol. Bioeng. 39: 614-618.
47. Maiorella B, Inlow D, Shauger A & Harano D (1988) Large-scale insect cell culture for recombinant protein production. Bio/Technol. 6: 1406-1410.
48. Miltenburger HG & David P (1980) Mass production of insect cells in suspension. Devel. Biol. Standard. 46: 183-186.
49. Murhammer DW & Goochee CF (1988) Scaleup of insect cell cultures: protective effects of Pluronic F-68. Bio/Technol. 6: 1411-1418.
50. Neutra R, Levi B-Z & Shoham Y (1992) Optimization of protein production by the baculovirus expression vector system in shake flasks. Appl. Microbiol. Biotechnol. 37: 74-78.
51. Ogonah O, Shuler ML & Granados RR (1991) Protein production (β-galactosidase) from a baculovirus vector hi Spodoptera frugiperda and Trichoplusia ra cells in suspension culture. Biotechnol. Lett. 13: 265-270.
52. Papoutsakis ET (1991) Media additives for protecting freely suspended animal cells against agitation and aeration damage. Trends Biotechnol. 9: 316-324.
53. Reuveny S, Kemp CW, Eppstein L & Shiloach J (1992) Carbohydrate metabolism in insect cell cultures during cell growth and recombinant protein production. Ann. N.Y. Acad. Sci. 665: 220-237.
54. Reuveny S, Kim YJ, Kemp CW & Shiloach J (1993a) Production of recombinant proteins in high-density insect cell cultures. Biotechnol. Bioeng. 42: 235-239.
55. Reuveny S, Kim YJ, Kemp CW & Shiloach J (1993b) Effect of temperature and oxygen on cell growth and recombinant protein production in insect cell cultures. Appl. Microbiol. Biotechnol. 38: 619-623.
56. Rhodes M, Gardiner S & Broad D (1991) Scaleup of animal cell suspension culture. In: Ho CS and Wang DIC (eds.) Animal Cell Bioreactors, pp. 253-268. Butterworth-Heinemann, Boston.
57. Schlaeger E-J, Foggetta M, Vonach JM & Christensen K (1993) SF-1, a low cost culture medium for the production of recombinant proteins in baculovirus infected insect cells. Biotechnol. Techniques 7: 183-188.
58. Schlaeger E-J, Wippler J & Foggetta M (1994) Scale-up of baculovirus expressed recombinant proteins using the High Five insect cell line. Presented at Cell Culture Engineering IV, Engineering Foundation Conferences, San Diego, CA 7-12 March 1994 (Abstract WE2, Cell Culture Engineering IV Program and Abstracts, p. 85).
59. Schopf B, Howaldt MW & Bailey JE (1990) DNA distribution and respiratory activity of Spodoptera frugiperda populations infected with wild-type and recombinant Autographa California nuclear polyhedrosis virus. J. Biotechnol. 15: 169-186.
60. Scott RI, Blanchard JH & Ferguson CHR (1992) Effects of oxygen on recombinant protein production by suspension cultures of Sf9 insect cells. Enzyme Microb. Technol. 14: 798-804.
61. Shuler ML, Cho T, Wickham T, Ogonah O, Kool M, Hammer DA, Granados RR & Wood HA (1990) Bioreactor development for production of viral pesticides or heterologous proteins in insect cell cultures. Ann. N.Y. Acad. Sci. 589: 399-422.
62. Streett DA & Hink WF (1978) Oxygen consumption of TN 368 cell line infected with AcNPV. J. Invertebr. Pathol. 31: 112-122.
63. Tramper J, Williams JB, Joustra D & Vlak JM (1986) Shear sensitivity of insect cells in suspension. Enzyme Microb. Technol. 8: 33-36.
64. Tramper J, de Gooijer KD & Vlak JM (1993) Scale-up considerations and bioreactor development for animal cell cultivation. In: Goosen MFA, Daugulis AJ & Faulkner P (eds) Insect Cell Culture Engineering, pp. 139-177. Marcel Dekker, New York.
65. van Lier FLJ, van den End EJ, de Gooijer CD, Vlak JM & Tramper J (1990) Continuous production of baculovirus in a cascade of insect-cell reactors. Appl. Microbiol. Biotechnol. 33: 43-47.
66. van Lier FLJ, van der Meijs WCJ, Grobben NA, Olie RA, Vlak JM & Tramper J (1992) Continuous β-galactosidase production with a recombinant baculovirus insect-cell system in bioreactors. J. Biotechnol. 22: 291-298.
67. Vaughn JL (1976) The production of nuclear polyhedrosis virus in large-volume cell cultures. J. Invertebr. Pathol. 28: 233-237.
68. Wang M-Y, Kwong S & Bentley WE (1993a) Effects of oxygen/glucose/glutamine feeding in insect cell baculovirus protein expression: a study on epoxide hydrolase production. Biotechnol. Progr. 9: 355-371.
69. Wang M-Y, Vakharia V & Bentley WE ( 1993b) Expresion of epoxide hydrolase in insect cells: a focus on the infected cell. Biotechnol. Bioeng. 42: 240-246.
70. Wang MY, Valler M, Pulliam TR & Bentley WE (1995) Elicitation of protease activity in Spodoptera frugiperda cell cultures. Presented at the 209th American Chemical Society National Meeting, Anaheim, CA 2-6 April 1995 (Abstract BIOT 120).
71. Weiss SA & Vaughn JL (1986) Cell culture methods for large-scale propagation of baculoviruses. In: Granados RR and Frederici BA (eds) The Biology of Baculoviruses, Vol. 2 Practical Applications for Insect Control, pp. 64-87. CRC Press, Boca Raton.
72. Weiss SA, Smith GC, Kalter SS & Vaughn JL (1981) Improved method for the production of insect cell cultures in large volume. In Vitro 17: 495-502.
73. Weiss SA, Orr T, Smith GC, Kalter SS, Vaughn JL & Dougherty EM (1982) Quantitative measurement of oxygen consumption in insect cell culture infected with polyhedrosis virus. Biotechnol. Bioeng. 24: 1145-1154.
74. Weiss SA, DeGiovanni A, Godwin G & Kohler J (1988) Large scale cultivation of insect cells. In: Roberts DW and Granados RR (eds) Conference on Biotechnology Biological Pesticides and Novel Plant-Pest Resistance for Insect Pest Management, Boyce Thompson Institute for Plant Research, Cornell University, July 18-20, 1988, pp. 22-30 Cornell University Press, Ithaca, NY.
75. Weiss SA, Belisle BW, DeGiovanni A, Godwin G, Kohler J & Summers MD (1989) Continuous cell lines as substrates for biologicals. Devel. Biol. Standard. 70: 272-279.
76. Wickham TJ, Davis T, Granados RR, Hammer DA. Shuler ML & Wood HA (1991) Baculovirus defective interfering particles are responsible for variations in recombinant protein production as a function of multiplicity of infection. Biotechnol. Lett 13: 483-488.
77. Wickham TJ, Davis T, Granados RR, Shuler ML & Wood HA (1992) Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnol. Progress 8: 391-396.
78. Wickham TJ & Nemerow GR (1993) Optimization of growth methods and recombinant protein production in BTI-TN-5B1-4 insect cells using the baculovirus expression vector. Biotechnol. Progress 9: 25-30.
79. Wong TKK, Nielsen LK, Greenfield PF & Reid S (1994) Relationship between oxygen uptake rate and time of infection of Sf9 insect cells infected with a recombinant baculovirus. Cytotechnology 15: 157-167.
80. Wood HA, Johnston LB & Burand JP (1982) Inhibition of Autographs californica nuclear polyhedrosis virus replication in high-density Trichoplusia ni cell cultures. Virology 119: 245-254.
81. Wu J, King G, Daugulis AJ, Faulkner P, Bone DH & Goosen, MFA (1989) Engineering aspects of insect cell suspension culture: a review. Appl. Microbiol. Biotechnol. 32: 249-255.
82. Wu JY & Goosen MFA (1996) Insect cell immobilization. This volume.
83. Zhang J, Kalogerakis N, Behie LA & Iatrou K (1993) A two-stage bioreactor system for the production of recombinant proteins using a genetically engineered baculovirus/insect cell system. Biotechnol. Bioeng. 42: 357-366.
84. Zhang J, Kalogerakis N & Behie LA (1994a) Optimization of the physicochemical parameters for the culture of Bombyx mori insect cells used in recombinant protein production. J. Biotechnol. 33: 249-258.
85. Zhang J, Kalogerakis N, Behie LA & Iatrou K (1994b) Optimum infection conditions for recombinant protein production in insect cell (Bm5) suspension culture. Biotechnol. Progr. 10: 636-643.
86. Zhou W & Hu W-S (1994) On-line characterization of a hybridoma cell culture. Biotechnol. Bioeng. 44: 170-177.