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0025075422
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Vaccine-induced escape mutants of hepatitis B virus
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3
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0029034319
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Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA
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Carman WF, Korula J, Wallace L, MacPhee R, Mimms L, Decker R: Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet 1995, 345:1406-1407.
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4
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0028946153
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A unique insertion in the S gene of surface antigen-negative hepatitis B virus Chinese carriers
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0024427902
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Mutation preventing formation of hepatitis HB e antigen in chronic hepatitis B virus infection
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Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC: Mutation preventing formation of hepatitis HB e antigen in chronic hepatitis B virus infection. Lancet 1989, ii:588-591.
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0028222146
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Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal
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Lok ASF, Akarca V, Greene S: Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci USA 1994, 91:4077-4081.
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0028859465
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Emergence of precore TAG mutation during hepatitis B e seroconversion and its dependence on pregenomic base pairing between nucleotide 1858 and 1896
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Lindh M, Furuta Y, Vahlne A, Norkrans G, Horal P: Emergence of precore TAG mutation during hepatitis B e seroconversion and its dependence on pregenomic base pairing between nucleotide 1858 and 1896. J Infect Dis 1995, 172:1343-1347.
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8
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0001765014
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Hepatitis B e antigen negative chronic hepatitis B: From clinical recognition to pathogenesis and treatment
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Hadziyannis SJ: Hepatitis B e antigen negative chronic hepatitis B: from clinical recognition to pathogenesis and treatment. Viral Hep Rev 1995, 1:7-36.
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Hadziyannis, S.J.1
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9
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0025874036
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Association of a pre-core genome variant of hepatitis B virus with fulminant hepatitis
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Carman WF, Fagan EA, Hadzyiannis S, Karayiannis P, Tassopoulos NC, Williams R, Thomas HC: Association of a pre-core genome variant of hepatitis B virus with fulminant hepatitis. Hepatology 1991, 14:219-222.
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Carman, W.F.1
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Thomas, H.C.7
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10
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0028783359
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X gene and precore region mutations in the hepatitis B virus genome in persons positive for antibody to hepatitis B e antigen: Comparison between asymptomatic 'healthy' carriers and patients with severe chronic active hepatitis
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Fukuda R, Xuanthanh N, Ishimura N, Ishihara S, Chowdhury A, Kohge N, Akagi S, Watanabe M, Fukumoto S: X gene and precore region mutations in the hepatitis B virus genome in persons positive for antibody to hepatitis B e antigen: comparison between asymptomatic 'healthy' carriers and patients with severe chronic active hepatitis. J Infect Dis 1995, 172:1191-1197. Of 28 patients, with a pre-core stop codon mutation, 17 out of 19 who were asymptomatic and had low replication levels of HBV had an X gene mutation, but none out of nine symptomatic patients with high HBV replication levels had an X gene mutation. An interesting study although dual mutations may be an exception rather than the rule?
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11
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0028843059
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Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis
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Sato S, Suzuki K, Akahane Y, Akamatsu K, Yunomura K, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995, 122:241-248.
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12
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0028877912
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Detection of hepatitis B virus precore TAG mutant by an amplification-created restriction type method
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Lindh M, Furuta Y, Ljunggren KK, Norkans G, Horal P: Detection of hepatitis B virus precore TAG mutant by an amplification-created restriction type method. J Infect Dis 1995, 171:194-197.
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13
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Hadziyannis S, Bramou T, Makris A, Moussoulis G, Zignego L, Papaioannou C: Interferon-alpha 2b treatment of HBeAg negative/serum HBV DNA positive chronic hepatitis type B. J Hepatol 1990, 11(suppl 1):S133-S136.
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14
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0028915795
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Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia
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Thursz MR, Kwiatkowski D, Allsopp CEM, Greenwood BM, Thomas HC, Hill AVS: Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 1995, 332:1065-1069. HLA-DRB1* 1302 was found in 26.6% of 218 children (under 10 years of age) with transient HBV compared with 16.2% of 185 children with persistent HBV, and in 25.6% of 195 adults with transient HBV compared with 7.5% of 40 adults with persistent HBV.
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15
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0028918747
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Cost-effectiveness of interferon-alpha 2b treatment for hepatitis B e antigen-positive chronic hepatitis B
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Wong JB, Koff RS, Tine F, Pauker SG: Cost-effectiveness of interferon-alpha 2b treatment for hepatitis B e antigen-positive chronic hepatitis B. Ann Intern Med 1995, 122:664-675. With therapy 45.6% cleared HBeAg and 7.7% cleared HBsAg compared with 9.1% and 1.7% clearing HBeAg and HBsAg, respectively, without therapy. Life expectancy increased by 3.1 years with quality adjusted life years increasing by 3.4 years.
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16
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0029031381
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Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2′,3′-dideoxy-3′-thiacytidine
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Severini A, Liu XY, Wilson JS, Tyrrell DLJ: Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2′,3′-dideoxy-3′-thiacytidine. Antimicrob Agents Chemother 1995, 39:1430-1435.
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17
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0029591574
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A preliminary trial of lamivudine for chronic hepatitis B infection
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Dienstag JL, Perrillo RP, Schiff ER, Bartholomew M, Vicary C, Rubin M: A preliminary trial of lamivudine for chronic hepatitis B infection. N Engl J Med 1995, 333:1657-1661. In 32 chronic HBV patients lamivudine reduced HBV DNA after 12 weeks of treatment. In most cases HBV DNA levels increased again, although 19% had prolonged HBV DNA suppression and normalization of ALT and 12% cleared HBeAg. After 36 weeks of 300 mg of lamivudine, 18% cleared HBeAg.
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Dienstag, J.L.1
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18
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0029994971
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Viral dynamics in hepatitis B infection
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Nowak MA, Bonhoeffer S, Hill AM, Boehme R, Thomas HC, McDade H: Viral dynamics in hepatitis B infection. Proc Natl Acad Sci USA 1996, 93:4398-4402.
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Nowak, M.A.1
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Thomas, H.C.5
McDade, H.6
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19
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0028897933
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Adenine arabinoside 5′ monophosphate in patients with chronic hepatitis B: Comparison of the efficacy in patients with high and low viral replication
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Marcellin P, Pouteau M, Loriot MA, Boyer N, Desgos F, Cales P, Bettan L, Bacq Y, Coppere H, Grange JD et al.: Adenine arabinoside 5′ monophosphate in patients with chronic hepatitis B: comparison of the efficacy in patients with high and low viral replication. Gut 1995, 36:422-426.
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Gut
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Bacq, Y.8
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20
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0028817865
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Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
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McKenzie R, Fried MW, Sallie R, Conjeevaram H, Di Biscegli AM, Park Y, Savarese B, Kleiner B, Tsokos M, Luciano C et al.: Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. N Engl J Med 1995, 333:1099-1105.
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McKenzie, R.1
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Park, Y.6
Savarese, B.7
Kleiner, B.8
Tsokos, M.9
Luciano, C.10
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21
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0028861575
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Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluro-1-b-d-arabinofuranosyl)-5-idouracil in human liver cells
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Cui L, Yoon S, Schinazi R, Sommadossi JP: Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluro-1-b-d-arabinofuranosyl)-5-idouracil in human liver cells. J Clin Invest 1995, 95:555-563.
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Cui, L.1
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22
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0030179646
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A double blind placebo controlled study to assess the effect of famciclovir on viral replication in patients with chronic hepatitis B virus infection
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Main J, Brown JL, Howels C, Galassini R, Crossley M, Karayiannis P, Georgiou P, Atkinson G, Thomas HC: A double blind placebo controlled study to assess the effect of famciclovir on viral replication in patients with chronic hepatitis B virus infection. J Viral Hepatitis 1996, 3:211-215.
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J Viral Hepatitis
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Main, J.1
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Karayiannis, P.6
Georgiou, P.7
Atkinson, G.8
Thomas, H.C.9
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23
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0028843353
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Inhibition of duck hepatitis B virus DNA replication by anti-viral chemotherapy with ganciclovir-nalidixic acid
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Wang YL, Luscombe C, Bowden S, Shaw T, Locarnini S: Inhibition of duck hepatitis B virus DNA replication by anti-viral chemotherapy with ganciclovir-nalidixic acid. Antimicrob Agents Chemother 1995, 39:556-558.
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Wang, Y.L.1
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Locarnini, S.5
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24
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0030061482
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Ganciclovir treatment of hepatitis B infection in liver transplant recipients
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Gish RG, Lau JY, Brooks L, Fang JW, Steady SL, Imperial JC, Kennedy RG, Esquivel CO, Keeffe GB: Ganciclovir treatment of hepatitis B infection in liver transplant recipients. Hepatology 1996, 23:1-7.
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Gish, R.G.1
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25
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0028897690
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Distinguishing acute from symptomatic chronic hepatitis C virus (HCV) infection by site-directed serology of the HCV structural proteins
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Zhang ZX, Chen M, Sonnerborg A, Weiland O, Sallberg M: Distinguishing acute from symptomatic chronic hepatitis C virus (HCV) infection by site-directed serology of the HCV structural proteins. J Infect Dis 1995, 171:1356-1359.
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Zhang, Z.X.1
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Sallberg, M.5
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26
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0029156655
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Randomised trial; comparing 3 different regimens of alpha-2b-interferon in chronic hepatitis C
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Chemello L, Bonetti P, Cavalletto L, Talato F, Donadon V, Casarin P, Belussi F, Frezza M, Noventa F, Pontisso P et al.: Randomised trial; comparing 3 different regimens of alpha-2b-interferon in chronic hepatitis C. Hepatology 1995, 22:700-706.
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Hepatology
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Chemello, L.1
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Pontisso, P.10
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27
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0029054011
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A comparison of three interferon-alpha 2b regimens for the long term treatment of chronic non-A, non-B hepatitis
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Poynard T, Bedossa P, Chevallier M, Mathurin P, Lemonnier C, Trepo C, Couzigou P, Payen JL, Sajus M, Costa JM et al.: A comparison of three interferon-alpha 2b regimens for the long term treatment of chronic non-A, non-B hepatitis. N Engl J Med 1995, 332:1457-1462.
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N Engl J Med
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Poynard, T.1
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Trepo, C.6
Couzigou, P.7
Payen, J.L.8
Sajus, M.9
Costa, J.M.10
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28
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0028895543
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Serial assays of hepatitis C virus RNA in serum for predicting response of interferon alpha therapy
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Hino K, Okuda M, Konishi T, Ishiko H, Okita K: Serial assays of hepatitis C virus RNA in serum for predicting response of interferon alpha therapy. Dig Dis Sci 1995, 40:14-20.
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Dig Dis Sci
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Hino, K.1
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Okita, K.5
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29
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0028934559
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Chronic hepatitis C virus infections: Predictive value of genotype and level of viraemia on disease progression and response to interferon-alpha
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Booth JCL, Foster GR, Kumar U, Gallassini R, Goldin RD, Brown JL, Thomas HC: Chronic hepatitis C virus infections: predictive value of genotype and level of viraemia on disease progression and response to interferon-alpha. Gut 1995, 36:427-432
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Gut
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Booth, J.C.L.1
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Gallassini, R.4
Goldin, R.D.5
Brown, J.L.6
Thomas, H.C.7
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30
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15844399125
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A pilot study of corticosteroids priming for lymphoblastoid interferon alfa in patients with chronic hepatitis C
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Chayama K, Tsubuta A, Kobayashi M, Hashimoto M, Miyano Y, Koike H, Kobayashi M, Koida I, Arase Y, Saitoh S et al.: A pilot study of corticosteroids priming for lymphoblastoid interferon alfa in patients with chronic hepatitis C. Hepatology 1996, 23:953-957.
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Hepatology
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Chayama, K.1
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Hashimoto, M.4
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Koike, H.6
Kobayashi, M.7
Koida, I.8
Arase, Y.9
Saitoh, S.10
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31
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0028919926
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Hepatitic hepatitis C virus RNa as a predictor of long term response to interferon alpha therapy
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Shindo M, Arai K, Sokawa Y, Okuno T: Hepatitic hepatitis C virus RNA as a predictor of long term response to interferon alpha therapy. Ann Intern Med 1995, 122:586-591.
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Ann Intern Med
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Shindo, M.1
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32
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0028876371
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Randomised trial of effect of interferon alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis
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Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, Shiomi S, Seki S, Kobayashi K, Otani S: Randomised trial of effect of interferon alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 1995, 346:1051-1055. In this study 45 out of 90 patients with cirrhotic chronic hepatitis C were treated with IFN for 24 weeks and followed up for 2-7 years. A total of 4% of IFN-treated patients developed HCC and 38% of non-IFN, symptomatic treated patients developed HCC.
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Lancet
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Nishiguchi, S.1
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33
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0028950183
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HCV-associated liver cancer without cirrhosis
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Demitri MS, Poussin K, Baccarini P, Pontisso P, Derrico A, Simon N, Grigioni W, Alberti A, Beaugrand M, Pisi E et al.: HCV-associated liver cancer without cirrhosis. Lancet 1995, 345:413-415.
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Lancet
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Demitri, M.S.1
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34
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0029161576
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Comparison of full length sequencies of interferon sensitive and resistant hepatitic C virus 1b
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Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C: Comparison of full length sequencies of interferon sensitive and resistant hepatitic C virus 1b. J Clin Invest 1995, 96:224-230. In determining that the IFN sensitivity region is at the NS5A region, around codon 2218, the specific nature of these mutations might make it possible to predict the prognostic effects of IFN therapy.
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J Clin Invest
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Enomoto, N.1
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35
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0028823771
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Treatment of chronic type B and C hepatitis with interferon alfa: An economic evaluation
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Dusheiko G, Roberts JA: Treatment of chronic type B and C hepatitis with interferon alfa: an economic evaluation. Hepatology 1995, 22:1863-1873.
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Hepatology
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Dusheiko, G.1
Roberts, J.A.2
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36
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0028825313
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Ribavarin as therapy for chronic hepatitis - A randomised double blind, placebo-controlled trial
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Di-Bisceglie AM, Conjeevaram HS, Fried MW, Sallie R, Park Y, Yurdaydin C, Swam M, Klein DE, Mahaney K, Hoofnagle JH, Wright D: Ribavarin as therapy for chronic hepatitis - a randomised double blind, placebo-controlled trial. Ann Intern Med 1995, 123:897-903. Ribavarin was given to 29 patients for 12 months in a double-blind randomized placebo-controlled study, transaminase levels fell to normal or nearly normal in 35% of patients, but a sustained biochemical response was seen in only 7% of them.
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Ann Intern Med
, vol.123
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Di-Bisceglie, A.M.1
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37
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Ribavarin treatment for patients with chronic hepatitis C: Results of a placebo-controlled study
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in press
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Dusheiko G, Main J, Thomas HC, Reichard O, Lee C, Dhillon A, Rassam S, Fryden A, Reesink H, Bassendine M et al.: Ribavarin treatment for patients with chronic hepatitis C: results of a placebo-controlled study. J Hepatol 1996, in press.
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J Hepatol
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Dusheiko, G.1
Main, J.2
Thomas, H.C.3
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