Quantitation of proliferation-associated markers Ag-NOR and Ki-67 does not contribute to the prediction of lymph node metastases in squamous cell carcinoma of the vulva

Human Pathology

Volumn 27, Issue 8, 1996, Pages 807-811

  Emanuels, Arleen G ^a   Burger, Matthé P M ^b   Hollema, Harry ^b   Koudstaal, Jan ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b NONE

Author keywords

Ag NOR; Ki 67; metastasis; proliferation; vulvar carcinoma

Indexed keywords

TUMOR MARKER;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CHROMOSOME NOR; FEMALE; HUMAN; HUMAN TISSUE; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; METASTASIS; MITOSIS; PREDICTION; PROGNOSIS; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; VULVA CARCINOMA;

EID: 0029799802     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90453-0     Document Type: Article

References (44)

1. Burger MPM, Hollema H, Emanuels AG, et al: The importance of the groin node status for the survival of T1 and T2 vulvar carcinoma patients. Gynecol Oncol 57, 327-334, 1995
2. Burke TW, Stringer CA, Gershenson DM, et al: Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva. Gynecol Oncol 38:328-332, 1990
3. Thomas GM, Dembo AJ, Bryson SCP, et al: Changing concepts in the management of vulvar cancer. Gynecol Oncol 42:9-21, 1991
4. Homesly HD, Bundy BN, Sedlis A, et al: Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a gynecologic oncology group study). Gynecol Oncol 49:279-283, 1993
5. Sedlis A, Homesly H, Bundy B, et al: Positive groin lymph nodes in superficial sqamous cell vulvar cancer: A gynecologic oncology group study. Am J Obstet Gynecol 156:1159-1164, 1987
6. Atamdede F, Hoogerland D: Regional lymph node recurrence following local excision for microinvasive vulvar carcinoma. Gynecol Oncol 34:125-128, 1989
7. Kunishio K, Ohmoto T, Matsuhisa T, et al: The significance of nucleolar organizer region (AgNOR) score in predicting meningioma recurrence. Cancer 73:2200-2205, 1994
8. Kuratsu SH, Aozasa K, Myoui A, et al: Prognostic significance of argyrophilic nucleolar organizer staining in soft-tissue sarcomas. Int J Cancer 48:211-214, 1991
9. Pich A, Marmont F, Chiusa L, et al: Argyrophilic nucleolar organizer region counts and prognosis in multiple myeloma. Br J Haematol 82:681-688, 1992
10. Ruschoff J: Prognostic significance of nucleolar organizing regions (NORs) in carcinomas of the sigmoid colon and rectum. Pathol Res Pract 186:85-91, 1990
11. Gasparini G, Boracchi P, Verderio P, et al: Cell kinetics in human breast cancer: Comparison between the prognostic value of the cytofluorimetric S-phase fraction and that of the antibodies to Ki-67 ans PCNA antigens detected by immunocytochemistry. Int J Cancer 57:822-829, 1994
12. Railo MS, Nordling S, von Boguslawsky K, et al: Prognostic value of Ki-67 immunolabelling in primary operable breast cancer. Br J Cancer 68:579-583, 1993
13. Ueda TM, Aozasa K, Tsujimoto M, et al: Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer 63:1607-1611, 1989
14. Aubele M, Auer G, Jutting U, et al: Prognostic value of quantitatively measured AgNors in ductal mammary carcinoma. Anal Quant Cytol Histol 16:211-218, 1994
15. Trerè D, Cancellieri A, Perrone A, et al: Ag-NOR protein distribution correlates with patient survival in stage I endometrial adenocarcinoma. Virchows Archiv [A] Pathol Anat 421:203-207, 1992
16. Hansen AB, Bjerregaard B, Ovesen H, et al: AgNOR counts and histological grade in stage pTa bladder tumours: Reproducibility and relation to recurrence pattern. Histopathology 20:257-262, 1992
17. Scagliotti GV, Micela M, Gubetta L, et al: Prognostic significance of Ki67 labelling in resected non small cell lung cancer. Eur J Cancer 29A:363-365, 1993
18. Magno WB, Hirschfield L, Bhuiya T, et al: Correlation of proliferative index (PCNA reactivity and Ki-67 reactivity) in primary breast carcinoma with hormone status, lymph node status, and disease-free survival. Conn Med 56:667-669, 1992
19. Gerdes J, Lemke H, Baisch H, et al: Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715, 1984
20. Key G, Becker MHG, Duchrow M, et al: New Ki-67 equivalent murine monoclonal antibodies (MIB 1-3) prepared against recombinant parts of the Ki-67 antigen. Anal Cell Pathol 4:181, 1992 (abstr)
21. Gambini C, Casazza S, Borgiani L: Counting the nucleolar organizer region associated proteins is a prognostic clue of malignant melanoma. Arch Dermatol 128:487-490, 1992
22. Martin H, Hufnagl P, Beil M, et al: Nucleolar organizer region-associated proteins in cancer cells: Quantitative investigations on gliomas, meningiomas, urinary bladder carcinomas and pleural lesions. Anal Quant Cytol Histol 14:312-319, 1991
23. Emanuels A, Hollema H, Koudstaal J: Autoclave heating: An alternative method for microwaving? Eur J Morphology 32:337-340, 1994
24. Baak JPA, Oort J: A manual of morphometry in diagnostic pathology. Berlin Heidelberg, Springer-Verlag, 1983
25. Howell WM, Black DA: Controlled silverstaining of nucleolus organizer regions with a protective colloidal developer: A 1-step method. Experientia 36:1014, 1980 (abstr)
26. Emmers R: De Agnor-kleuring een kwantitatief: en kwalitatief onderzoek. Histotechniek 9:109-115, 1990
27. Eskelinen MJ, Lipponen PK, Collan Y, et al: The role of nucleolar organiser regions as prognostic factors in breast cancer. Eur J Cancer 27:989-992, 1991
28. Sacks NP, Robertson JF, Ellis IO, et al: Silver-stained nucleolar organiser region counts are of no prognostic value in primary breast cancer. Eur J Surg Oncol 18:98-102, 1992
29. Charpin CT, Andrac L, Vacharet H, et al: Multiparametric evaluation (SAMBA) of growth fraction (monoclonal Ki67) in breast carcinoma tissue sections. Cancer Res 48:4368-4374, 1988
30. Veronese SM, Gambacorta M: Detection of Ki-67 proiferation rate in breast cancer. AmJ Clin Pathol 95:30-34, 1991
31. Veronese SML, Gambacorta M, Gottardi O, et al: Proliferation index as a prognostic marker in breast cancer. Cancer 71:3926-3931, 1993
32. Stumpp J, Dietl J, Simon W, et al: Growth fraction in breast carcinoma determined by Ki-67 immunostaining: Correlation with pathological and clinical variables. Gynecol Obstet Invest 33:47-50, 1992
33. Wintzer HO, Zipfel I, Schulte-Mönting J, et al: Ki-67 immunostaining in human breast tumors and its relationship to prognosis. Cancer 67:421-428, 1991
34. Vielh PH, Chevillard S, Mosseri V, et al: Ki67 index and S-phase fraction in human breast carcinomas: Comparison and correlations with prognostic factors. Am J Clin Pathol 94:681-686, 1990
35. Marchetti EN, Querzoli P, Marzola A, et al: Assessment of proliferative rate of breast cancer by Ki-67 monoclonal antibody. Mod Pathol 3:31-35, 1990
36. Evans AT, Blessing K, Orrell JM, et al: Mitotic indices, anti-PCNA immunostaining, and AgNORs in thick cutaneous melanomas displaying paradoxical behaviour. J Pathol 168:15-22, 1992
37. Griffiths AP, Cross D, Kingston RE, et al: Flow cytometry and AgNORs in benign, borderline, and malignant mucinous and serous tumours of the ovary. Int J Gynecol Pathol 12:307-314, 1993
38. Suzuki T, Takano Y, Kida Y, et al: Silver-binding argyrophilic nucleolar organizer regions (AgNOR) in gall-bladder cancer: Correlations with malignant grading and prognosis. Acta Pathol Jpn 43:36-43, 1993
39. Kobayashi I, Matsuo K, Ishibashi Y, et al: The proliferative activity in dysplasia and carcinoma in situ of the uterine cervix analyzed by proliferating cell nuclear antigen immunostaining and silver-binding argyrophilic nucleolar organizer region staining. HUM PATHOL 25:198-202, 1994
40. Yamaguchi A, TsukiokaY, Kurosaka Y, et al: Prognostic value of nucleolar organizer regions in endoscopically biopsied tissues of colorectal cancers. Oncology 50:121-126, 1993
41. Morita M, Kuwano H, Matsuda H, et al: Prognostic significance of argyrophilic nucleolar organizer regions in esophageal carcinoma. Cancer Res 51:5339-5341, 1991
42. Yang AH, Wang TY, Liu HC: Comparative study of the prognostic value of nuclear grade and silver-binding nucleolar organizer region in renal cell carcinomas. J Pathol 166:157-161, 1992
43. Shepherd NA, Richman PI, EnglandJ: Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations. J Pathol 155:213-219, 1988
44. Soyer HP: Ki 67 immunostaining in melanocytic skin tumors: Correlation with histologic parameters. J Cutan Pathol 18:264-272, 1991