Penetration of Clindamycin and Metronidazole into Inflamed Appendiceal Tissue

European Journal of Surgery

Volumn 162, Issue 8, 1996, Pages 633-635

  Levy, Yeheskel ^a,b   Berger, Stephen A ^c   Gorea, Alfred ^c   Shnaker, Ali ^a,b   Orda, Ruben ^a,b  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Antibiotics and appendicitis; Antibiotics in appendiceal tissue; Tissue penetration of antibiotics

Indexed keywords

CLINDAMYCIN; GENTAMICIN; METRONIDAZOLE;

ACUTE APPENDICITIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG TISSUE LEVEL; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL;

ADULT; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; APPENDICITIS; APPENDIX; CLINDAMYCIN; DRUG THERAPY, COMBINATION; FEMALE; GENTAMICINS; HUMANS; MALE; METRONIDAZOLE; PROSPECTIVE STUDIES;

EID: 0029799231     PISSN: 11024151     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bennet JV, Brodie JL, Brenner EJ, Kirby WMM. Simplified accurate method for antibiotic assay of clinical specimens. Appl Microbiol 1966; 14: 170-177.
2. Bergamini TM, Polk HC, Jr. Pharmacodynamics of antibiotic penetration of tissue and surgical prophylaxis. Surg Gynecol Obstet 1989; 168: 283-289.
3. Berger SA, Barza M, Leslie SW, Raciti A, Kazarian KK, Kane A. Penetration of clindamycin into the human appendix. Arch Surg 1978; 113: 1094-1095.
4. Berne TV, Appleman MD, Chenella FC, Yellin AE, Gill MA, Heseltine PNR. Surgically treated gangrenous or perforated appendicitis. A comparison of aztreonam and clindamycin versus gentamicin and clindamycin. Ann Surg 1987; 205: 133-137.
5. Canadian Metronidazole-Clindamycin Study Group Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intraabdominal infection. Surgery 1983; 93: 221-229.
6. Eklund A, Tunewall TG. Prevention of postoperative wound infection after appendectomy by local application of tinidazole: double-blind study. World J Surg 1987; 11: 263-266.
7. Gorbach SL. Antimicrobial prophylaxis for appendectomy and colorectal surgery. Rev Infect Dis 1991; 13 (Suppl 10): 815-820.
8. Greenall MJ, Bakran A, Pickford IR et al. A double-blind trial of a single intravenous dose of metronidazole as prophylaxis following appendicectomy. Br J Surg 1979; 66: 428-429.
9. Lau WY, Fan ST, Yiu TF, Wong SH. Prophylaxis of postappendicectomy sepsis by metronidazole and ampicillin; a randomized, prospective and double-blind trial. Br J Surg 1983; 70: 155-157.
10. Lau WY, Fan ST, Chu KW et al. Cefoxitin versus gentamicin and metronidazole in prevention of post-appendectomy sepsis: a randomized, prospective trial. J Antimicrob Chemother 1986; 18: 613-619.
11. Leigh DA, Simmons K, Norman E. Bacterial flora of the appendix fossa in appendicitis and postoperative wound infection. J Clin Pathol 1974; 27: 997-1000.
12. Nguyen B, Raynor S, Thompson JS. Selective versus routine antibiotic use in acute appendicitis. Am Surg 1992; 58: 280-283.
13. O'Rourke MGE, Wynne JM, Morahan RJ et al. Prophylactic antibiotics in appendicectomy: a prospective double-blind randomised study. Aust NZ J Surg 1984; 54: 535-541.
14. Ralph ED, Kirby WMM. Bioassay of metronidazole with either anaerobic or aerobic incubation. J Infec Dis 1975; 132: 387-391.
15. Sherlock DJ, Ward A, Holl-Allan R. Combined preoperative antibiotic therapy and intra-operative topical povidone iodine; reduction of wound sepsis following emergency appendectomy. Arch Surg 1984; 119: 909-911.
16. Stones HH. Metronidazole in the treatment of surgical infections. Surgery 1983; 93: 230-234.
17. Sutter VL, Finegold SM. Susceptibility of anaerobic bacteria to 23 antimicrobial agents. Antimicrob Agents Chemother 1976; 10: 736-752.
18. Tanner WA, Ali AE, Collins PG et al. Single dose intrarectal metronidazole as prophylaxis against wound infection following emergency appendectomy. Br J Surg 1980; 67: 809-810.
19. Wilson RG, Taylor EW, Lindsay G et al. A comparative study of cefotetan and metronidazole alone to prevent infection after appendectomy. Surg Gynecol Obstet 1987; 164: 447-451.