The interaction between MCI-196 and bile acids or other biological substances - Comparison with cholestyramine

Japanese Pharmacology and Therapeutics

Volumn 24, Issue SUPPL. 4, 1996, Pages 127-132

  Shimada, Hiroshi ^a   Mitsuka, Masayuki ^a   Umezu, Kohei ^a  

^a MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Bile acid; Cholestyramine; Free fatty acid; Hypolipidemic drugs; MCI I96

Indexed keywords

COLESTILAN; COLESTYRAMINE;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE; ARTICLE; BILE ACID METABOLISM; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; ELECTROSTATIC PRECIPITATION; HYPOLIPEMIA; MICELLE; NONHUMAN; RECEPTOR AFFINITY;

EID: 0029798559     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Shepherd J : Mechanism of action of bile acid sequestrants and other lipid-lowering drugs. Cardiology 76 (Suppl 1) : 65-74, 1989
2. Johns WH, Bates TR : Quantification of the binding tendencies of cholestyramine 1 ; Effect of structure and added electrolytes on the binding of unconjugated and conjugated bile-salt anions. J Pharma Sci 58 : 179-183, 1969
3. Mansbach CM et al : Isolation and properties of the mixed lipid micelles present in intestinal content during fat digestion in man. J Clin Invest 56 : 781-791, 1975
4. De Simone R et al : New microporous cholestyramine analog for treatment of hypercholesterolemia. J Pharma Sci 67 : 1695-1698, 1978
5. Wilson FA : Intestinal transport of bile acids. Am J Physiol 241 : G 83-G 92, 1981
6. Hofmann AF et al : Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acid in man ; Cholic acid in healthy man. J Clin Invest 71 : 1003-1022, 1983
7. Johns WH, Bates TR : Quantification of the binding tendencies of cholestyramine 2 ; Mechanism of interaction with bile salt and fatty acid salt anions. J Pharma Sci 59 : 329-333, 1970
8. Zhu XX, St-Pierre LE : Polymeric sorbents for bile acid 1 ; Comparison between cholestyramine and colestipol. J Pharma Sci 81 : 65-69, 1992