Xanthine oxidase activity is not increased in the colonic mucosa of ulcerative colitis

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 5, 1996, Pages 737-741

  Reynolds, P D ^a   Rhenius, S T ^a   Hunter, J O ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYSTINE; SUPEROXIDE; URIC ACID; XANTHINE OXIDASE;

ARTICLE; BIOPSY; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0029798350     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1996.57199000.x     Document Type: Article

References (23)

1. Blake DR, Merry P, Usworth, J, et al. Hypoxic-reperfusion injury in the inflamed human joint. Lancet 1989; i: 289-93.
2. Davies GR, Simmonds NJ, Stevens TRJ, et al. Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut 1992; 33: 1467-72.
3. Simmonds NJ, Allen RE, Stevens TRJ, et al. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology 1992; 103: 186-96.
4. Keshavarzian A, Sedghj S, Kanofsky J, et al. Excessive production of reactive oxygen metabolites by inflamed colon: analysis by chemiluminescence probe. Gastroenterology 1992; 103: 177-85.
5. Ahnfelt-Rønne I, Nielsen OH, Christensen A, et al. Clinical evidence supporting the radical scavenger mechanism of 5 aminosalicylic acid. Gastroenterology 1990; 98: 1162-9.
6. Sedghi S, Keshavarzian A, Klamut M, et al. Elevated breath ethane levels in active ulcerative colitis: evidence for excessive lipid peroxidation. Am J Gastroenterol 1994; 89(12): 2217-21.
7. McCord JM. Human disease, free radicals, and the oxidant/ antioxidant balance. Clin Biochem 1993; 26: 351-7.
8. Simmonds NJ, Rampton DS. Inflammatory bowel disease - a radical view. Gut 1993; 34: 865-8.
9. Freidl HP, Till GO, Ryan US, Ward PA. Mediator induced activation of xanthine oxidase in endothelial cells. FASEB J 1989; 3: 2512-8.
10. Sturzaker HG, Hawley PR. Collagenase activity in rectal and colonic biopsies. Proc R Soc Med 1975; 68: 33.
11. Siems WG, Grune T, Werner A, et al. Protective influence of oxypurinol on the trinitrobenzene sulfonic acid (TNB) model of inflammatory bowel disease in rats. Cell Mol Biol 1992; 38(2): 189-99.
12. Levin KE, Pemberton JH, Phillips SF, Zinsmeister AR, Pezim ME. Effect of a xanthine oxidase inhibitor in patients with pouchitis after ilea pouch anal anastomosis. Gut 1990; 31: A1168. (Abstract.)
13. - generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest 190; 85: 739-45.
14. Reed DJ, Babson JR, Beatty PW, et al. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathion disulfide, and related thiols and disulfides. Anal Biochem 1980; 106: 55-62.
15. Akerboom TPM, Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Meth Enzymol 1981; 77: 373-82.
16. Sakuma R, Nishina T, Kitamura M. Deproteinizing methods evaluated for determination of uric acid in serum by reversed-phase liquid chromatography with ultraviolet detection. Clin Chem 1987; 33(8): 1427-30.
17. Terada LS, Leff JA, Repine JE. Measurement of xanthine oxidase in biological tissues. Meth Enzymol 190; 186: 651-6.
18. Lowry OH, Rosenborough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265.
19. Sedghi S, Fields JZ, Klamut M, et al. Increased production of luminol enhanced chemiluminescence by the inflamed colonic mucosa in patients with ulcerative colitis. Gut 1993; 34: 1191-7.
20. Fukahori M, Ichimori K, Ishida H, Nakagawa H, Okino H. Nitric oxide reversibly suppresses xanthine oxidase activity. Free Radic Res 1994; 21(4): 203-12.
21. Rinaldo JE, Clark M, Parinello J, Shepherd VL. Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma stimulated macrophages. Am J Respir Cell Mol Biol 1994; 11(5): 625-30.
22. Hassoun PM, Yu FS, Zulueta JJ, White AC, Lanzillo JJ. Effect of nitric oxide and cell redox status on the regulation of endothelial cell xanthine dehydrogenase. Am J Physiol 1995; 268(5 Part 1): L809-17.
23. Middleton SJ, Shorthouse M, Hunter JO. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993; 341: 465-6.