Effects of halothane, isoflurane, enflurane, and sevoflurane on the monosynaptic reflex response in the isolated spinal cord of newborn rats

Japanese Journal of Anesthesiology

Volumn 45, Issue 7, 1996, Pages 829-836

  Tsutahara, Sho ^a   Furumido, Hitoshi ^a   Ohta, Yoshihiro ^a   Harasawa, Katsumi ^a   Yamamura, Takeyasu ^a   Kemmotsu, Osamu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENFLURANE; HALOTHANE; ISOFLURANE; SEVOFLURANE;

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; GAS CHROMATOGRAPHY; MINIMUM LUNG ALVEOLUS CONCENTRATION; MONOSYNAPTIC REFLEX; NEWBORN; NONHUMAN; RAT; SPINAL CORD;

ANESTHETICS, INHALATION; ANIMALS; ANIMALS, NEWBORN; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENFLURANE; ETHERS; HALOTHANE; ISOFLURANE; METHYL ETHERS; RATS; RATS, WISTAR; REFLEX, MONOSYNAPTIC; SPINAL CORD;

EID: 0029797484     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Quasha AL, Eger EI, Tinker JH: Determination and applications of MAC. Anesthesiology 53: 315, 1980
2. Rampil I, Mason P, Singh H: Anesthetic potency (MAC) is independent of telencephalic structures in the rat. Anesthesiology 78: 707, 1993
3. Antognini J, Schwartz K: Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 79: 1244, 1993
4. Collins JG, Kendig JJ, Mason P: Anesthetic actions within the spinal cord: Contributions to the state of general anesthesia. Trends Neurosci 18: 540, 1995
5. Lin L-H, Chen L, Haris R: Enflurane inhibits NMDA, AMPA, and kainate-induced currents in Xenopus oocytes expressing mouse and human brain mRNA. FASEB J 7: 479, 1993
6. Tanelian D, Kosek P, Mody I, et al: The role of the GABAA receptor/chloride channel complex in anesthesia. Anesthesiology 78: 757, 1993
7. Franks N, Lieb W: Selective action of volatile general anesthetics at molecular and cellular levels. Br J Anaesth 71: 65, 1993
8. Franks N, Lieb W: Molecular and cellular mechanisms of general anaesthesia. Nature 367: 607, 1994
9. Jewett B, Tarasiuk A, Gibbs L, et al: Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology 77: 1148, 1992
10. Kendig J, Kodde A, Gibbs L, et al: Correlates of anesthetic properties in isolated spinal cord: Cyclobutanes. Eur J Pharmacol 264: 427, 1994
11. Savola M, Woodley S, Maze M, et al: Isoflurane and an alpha2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Anesthesiology 75: 489, 1991
12. Evans R, Evans S, Pook P, et al: A comparison of excitatory ammo acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat. Br J Pharmacol 91: 531, 1987
13. Jahr C, Yoshioka K: Ia afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonized by kynurenate. J Physiol 370: 515, 1986
14. Long S, Smith D, Siarey R, et al: Effect of 6-cyano-2, 3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. Br J Pharmacol 100: 850, 1990
15. Woodley SJ, Kendig JJ: Substance P and NMDA receptors mediate a slow nociceptive ventral root potential in neonatal rat spinal cord. Brain Res 559: 17, 1991
16. el-Beheiry H, Puil E: Anaesthetic depression of excitatory synaptic transmission in neocortex. Exp Brain Res 77: 87, 1989
17. Taheri S, Halsey MJ, Liu J, et al: What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs ? Anesth Analg 72: 627, 1991
18. A receptor in anesthesia: Isoflurane. Anesthesiology 81: A1477, 1994
19. Otsuka M, Yanagisawa M: Effect of a tachykinin antagonist on a nociceptive reflex in the isolated spinal cord-tail preparation of the newborn rat. J Physiol 395: 255, 1988
20. Yanagisawa M, Murakoshi T, Tamai S, et al: Tail-pinch method in vitro and the effects of some antinociceptive compounds. Eur J Pharmacol 106: 231, 1985
21. Weight F, Aguayo L, White G, et al: GABA-and glutamate-gated ion channels as molecular sites of alcohol and anesthetic action, GABAergic Synaptic Transmission. Edited by Concas BG. New York, Raven Press, 1992, p335
22. MacIver M, Kendig J: Enflurane-induced burst discharge of hippocampal CA1 neurones is blocked by the NMDA receptor antagonist APV. Br J Anaesth 62: 301, 1989