Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment: A randomized controlled trial

JAMA

Volumn 276, Issue 12, 1996, Pages 972-977

  Smack, David Phillips ^a,b,d   Harrington, Allan C ^a   Dunn, Cary ^a   Howard, Robin S ^a   Szkutnik, Albert J ^a   Krivda, Steven J ^a   Caldwell, James B ^a   James, William D ^a,c  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b WOMACK ARMY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACITRACIN; PETROLATUM;

ADULT; ARTICLE; CLINICAL TRIAL; CONTACT DERMATITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN SURGERY; TOPICAL DRUG ADMINISTRATION; WOUND INFECTION;

EID: 0029797019     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.276.12.972     Document Type: Article

References (42)

1. Hinman CD, Maibach HI. Effect of air exposure and occlusion on experimental human skin wounds. Nature. 1963;200:377.
2. Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293-294.
3. Winter GD. Epidermal regeneration studies in the domestic pig. In Maibach HI, Rouge DT, eds. Epidermal Wound Healing. Chicago, Ill: Yearbook Medical Publishers; 1972:71-112.
4. Leyden JJ, Bartelt NM. Comparison of topical antibiotic ointments, a wound protectant, and antiseptics for the treatment of human blister wounds contaminated with Staphylococcus aureus. J Fam Pract. 1987;24:601-604.
5. Leyden JJ, Sulzberger MB, Topical antibiotics and minor skin trauma. Am Fam Physician. 1981; 23:121-125.
6. Geronemus RG, Mertz PM, Eaglstein WH. Wound healing: the effects of topical antimicrobial agents. Arch Dermatol. 1979;115:1311-1314.
7. Eaglstein WH. Effect of occlusive dressing on wound healing. Clin Dermatol. 1984;2:107-111.
8. Falanga V, Zitelli JA, Eaglstein WH. Wound healing. J Am Acad Dermatol. 1988;19:559-562.
9. Hirschmann JV. Topical antibiotics in dermatology. Arch Dermatol. 1988;124:1691-1700.
10. Pollack SV. Wound healing: a review, II: environmental factors affecting wound healing. J Dermatol Surg Oncol. 1979;5:477-481.
11. Watcher M, Wheeland R. The role of topical antibiotics in the healing of full thickness wounds. J Dermatol Surg Oncol. 1989;15:1188-1195.
12. Anderson V. Over-the-counter topical antibiotic products: data on safety and efficacy. Int J Dermatol. 1976;15:1-118.
13. Winton GB, Salasche SJ. Wound dressings for dermatologic surgery. J Am Acad Dermatol. 1985; 13:1026-1044.
14. Reed BR, Clark RAF. Cutaneous tissue repair: practical implications of current knowledge, II. J Am Acad Dermatol. 1985;13:919-941.
15. Haas AF, Grekin RC. Antibiotic prophylaxis in dermatologic surgery. J Am Acad Dermatol. 1995; 32:155-176.
16. Moy JA, Caldwell-Brown D, Lin AN, et al. Mupirocin-resistant Staphylococcus aureus after long-term treatment of patients with epidermolysis bullosa. J Am Acad Dermatol. 1990;22:893-895.
17. Shanson DC. Antibiotic-resistant Staphylococcus aureus. J Hasp Infect. 1981;2:11-36.
18. Livingston DH, Cryer HG, Miller FB, et al. A randomized prospective study of topical antimicrobial agents on skin grafts after thermal injury. Plast Reconstr Surg. 1990;86:1059-1064.
19. Pirila V, Forstrom L, Rouhunkoski S. Twelve years of sensitization to neomycin in Finland. Acta. Dermatol Venereal 1967;47:419-425.
20. Fraki JE, Peltonen L, Hopsu-Havu VK Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Contact Dermatitis. 1979;5:97-100.
21. Marks JG, Belsito DV, Deleo VA, et al. North American contact dermatitis group standard tray patch test results (1992 to 1994). Am J Contact Dermatitis. 1995;6:160-165.
22. Fisher AA. Adverse reactions to bacitracin, polymyxin and gentamicin sulfate. Cutis. 1983;32: 510-513.
23. Van Ketel WG. Polymyxin B sulfate and bacitracin. Contact Dermatitis News Lett. 1974;15:445.
24. Schechter JR, Wilkinson RD, Carpio JD. Anaphylaxis following the use of bacitracin ointment. Arch Dermatol. 1984;120:909-911.
25. Comaish JS, Cunliffe WJ. Absorption of drugs from various ulcers: a cause of anaphylaxis. Br J Clin Pract. 1967;21:97.
26. Roupe G, Strennegard O. Anaphylactic shock elicited by topical administration of bacitracin. Arch Dermatol. 1969;100:450-452.
27. Vale MA, Connolly A, Epstein AM, et al. Bacitracin induced anaphylaxis. Arch Dermatol. 1978; 114:800.
28. Phillips TJ, Rogers GS, Kanj LF. Bacitracin anaphylaxis. J Geriatr Dermatol. 1995;3:83-85.
29. Knowles SR, Shear NH. Anaphylaxis from bacitracin and polymyxin B (Polysporin) ointment. Int J Dermatol. 1995;34:572-573.
30. Farley M, Pak H, Carregal V, et al. Bacitracin anaphylaxis. Am J Contact Derm. 1995;6:28-32.
31. Kelly DR, Nilo ER, Berggren RB. Deafness after topical neomycin wound irrigation. N Engl J Med. 1969;280:1338-1339.
32. Zar JH. Biostatistical Analysis. 2nd ed. Engle-wood Cliffs, NJ: Prentice-Hall International Inc; 1984:378-379.
33. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic Research: Principles and Quantitative Methods. New York, NY: Van Nostrand Reinhold Co; 1982:296-307.
34. Bennett RG, ed. Fundamentals of Cutaneous Surgery. St. Louis, Mo: Mosby-Yearbook Inc; 1988: 141-143.
35. Sebben JE. Sterile technique and the prevention of wound infection in office surgery - part II. J Dermatol Surg Oncol. 1989;15:38-48.
36. Scherbenske JM, Winton GB, James WD. Acute pseudomonas infection of the external ear (malignant external otitis). J Dermatol Surg Oncol. 1988; 14:165-169.
37. Bjorkner B, Moller H. Bacitracin: a cutaneous allergen and histamine liberator. Acta Dermatol Venereol. 1973;53:487-492.
38. Gette MT, Marks JG, Maloney ME. Frequency of postoperative allergic contact dermatitis to topical antibiotics. Arch Dermatol. 1992;128:365-367.
39. Eaglstein WH, Mertz PM. 'Inert' vehicles do affect wound healing. J Invest Dermatol. 1980;74: 90-91.
40. Mertz PM, Hebda PA, Eaglstein WH. A porcine model for evaluating epidermal wound healing. In: Tumbleson ME, ed. Swine in Biomedical Research, vol 1. New York, NY: Plenum Publishing Corp; 1986:291-302.
41. Lineaweaver W, Howard R, Soucy D, et al. Topical antimicrobial toxicity. Arch Surg. 1985;120: 267-270.
42. Tur E, Bolton L, Constantine BE. Topical hydrogen peroxide treatment of ischemic ulcers in the guinea pig: blood recruitment in multiple skin sites. J Am Acad Dermatol. 1995;33:217-221.