(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: A high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity

Journal of Medicinal Chemistry

Volumn 39, Issue 19, 1996, Pages 3837-3841

  Daines, Robert A ^a   Chambers, Pamela A ^a   Foley, James J ^a   Griswold, Don E ^a   Kingsbury, William D ^a   Martin, Lenox D ^a   Schmidt, Dulcie B ^a   Sham, Kelvin K C ^a   Sarau, Henry M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [6 [[(2,6 DICHLOROPHENYL)THIO]METHYL] 3 (2 PHENYLETHOXY) 2 PYRIDINYL] 2 PROPENOIC ACID; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; SB 201146; SB 209247; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOUSE; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION; OTITIS; SKIN INFLAMMATION; STRUCTURE ACTIVITY RELATION; TOPICAL DRUG ADMINISTRATION;

ACRYLATES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; CALCIUM; CYTOPLASMIC GRANULES; HUMANS; LEUKOTRIENE B4; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NEUTROPHILS; OTITIS; PYRIDINES; RECEPTORS, LEUKOTRIENE B4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029796864     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960248s     Document Type: Article

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