Uptake of 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene in melanin-containing tissues

Pharmacology and Toxicology

Volumn 79, Issue 2, 1996, Pages 92-99

  Roberto, Amilcar ^a   Larsson, Bengt S ^a,c   Tjälve, Hans ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BENZO[A]PYRENE; MELANIN; POLYCYCLIC AROMATIC HYDROCARBON;

ALBINISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG UPTAKE; EYE; FEMALE; HAIR FOLLICLE; IN VITRO STUDY; ISOTOPE LABELING; MALE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RISK FACTOR; WHOLE BODY AUTORADIOGRAPHY;

EID: 0029796305     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1996.tb00248.x     Document Type: Article

References (53)

1. Agarwal, R., E. E. Medrano, I. U. Khan, J. J. Nordlund & H. Mukhtar: Metabolism of benzo(a)pyrene by human melanocytes in culture. Carcinogenesis 1991, 12, 1963-1966.
2. Albert, D. M., C. A. Puliafito, A. B. Fulton, N. L. Robinson, Z. N. Zakov, T. P. Dryja, A. B. Smith, E. Egan & S. S. Leffingwell: Increased incidence of choroidal malignant melanoma occurring in a single population of chemical workers. Amer. J. Ophthalmol. 1980, 89, 323-337.
3. Armstrong, B. K., J. C. McNulty, L. J. Levitt, K. A. Williams & M. S. T. Hobbs: Mortality in gold and coal miners in Western Australia with special reference to lung cancer. Brit. J. Ind. Med. 1979, 36, 199-205.
4. Appelgren, L.- E.: Sites of steroid hormone formation. Autoradiographic studies using labelled precursors. Acta physiol. scand. 1967, 301, Suppl. 42-51.
5. Austin, D. F. & P. J. Reynolds: Occupation and malignant melanoma of the skin. Recent Results Cancer Res. 1986, 102, 98-107.
6. Austin, D. F., M. A. Snyder, P. J. Reynolds, M. W. Biggs & H. A. Stubbs: Malignant melanoma among employees of Lawrence Livermore National Laboratory. Lancet 1981, 2, 712-716.
7. Bahn, A. K., I. Rosenwaike, N. Herrmann, P. Groven, J. Stellman & K. O'Leary: Melanoma after exposure to PCB'S. New. Engl. J. Med. 1976, 19, 450-450.
8. Barthel, E.: Erhöhte Mortalität an Öophaguskrebs, Magenkrebs und Hautmelanom bei Pestizid-exponierten Schädlingsbekämpfern in der DDR. Arch. Geschwulstforsch. 1985, 55, 481-488.
9. Bell, C. M. J., C. M. Jenkinson, T. J. Murrels, R. G. Skeet & J. D. Everall: Aetiological factors in cutaneous malignant melanomas seen at a UK skin clinic. J. Epidemiol. Community Health 1987, 41, 306-311.
10. Berenblum, I.: The carcinogenic action of 9,10-dimethyl-1,2-benzanthracene on the skin and subcutaneous tissues of the mouse, rabbit, rat, and guinea pig. J. Natl. Cancer Inst. 1949, 10, 167-174.
11. 3H-imidazol[4,5-f]quinoline-2-amines in mice. Cancer Res. 1985, 45, 1351-1356.
12. Berkelhammer, J., R. W. Oxenhandler, R. R. J. r. Hook & J. M. Hennessy: Development of a new melanoma model in C57BL/6 mice. Cancer Res. 1982, 42, 3157-3163.
13. Brandt, I., J.-Å. Gustafsson & J. Rafter: Distribution of the carcinogenic tryptophan pyrolysis product Trp-P-1 in control, 9-hydroxyellipticine and β-naphthoflavone pretreated mice. Carcinogenesis 1983, 4, 1291-1296.
14. Brandt, L. B. Kowalski, J.-Å. Gustafsson & J. Rafter: Tissue localization of the carcinogenic glutamic acid pyrolysis product GLU-P-I in control and β-naphthoflavonc-treated mice and rats. Carcinogenesis 1989, 10, 1529-1533.
15. DiGiovanni, J. & M. R. Juchau: Biotransformation and bioactivation of 7,12-dimethylbenz[a]anthracene (7,12-DMBA). Drug. Metab. Rev. 1980, 11, 61-101.
16. D'Argy, R., G. O. Sperber, B. S. Larsson & S. Ullberg: Computer-assisted quantification and image processing of whole-body autoradiograms. J. Pharmacol. Metho. 1990, 24, 165-181.
17. Edcomb, J. H. & J. Mitchelich: Melanomas of the skin of guinea-pigs following the application of a solution of 9,10 Dimethyl-1,2 benzanthracene in benzene. Acta-Unio Internationalis Contra Cancrum 1963, 19, 706-707.
18. Epstein, H. H., W. L. Epstein & T. Nakai: Production of melanomas from DMBA induced "blue nevi" in hairless mice with ultraviolet light. J. Natl. Cancer Inst. 1967, 38, 19-30.
19. Evans, R. D., A. W. Kopf, R. A. Lew, D. S. Rigel, R. S. Bart, R. J. Friedman & J. K. Rivers: Risk factors for the development of malignant melanoma I: Review of case-control studies. J. Dermatol. Surg. Oncol. 1988, 14, 393-408.
20. Goerttler, K., H. Loehrke, J. Schweizer & B. Hesse: Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian Golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetra-decanoylphorbol-13-acetate. Cancer Res. 1980, 40, 155-161.
21. Hallberg, E.: Metabolism and toxicity of xenobiotics in the adrenal cortex, with particular reference to 7,12-dimethylbenz(a)anthracene. J. Biochem. Toxicol. 1990, 5, 71-90.
22. Heldaas, S. S., A. A. Andersen & S. Langård: Incidence of cancer among vinyl chloride and polyvinyl chloride workers: further evidence for an association with malignant melanoma. Brit. J. Ind. Med. 1987, 44, 278-280.
23. Heldaas, S. S., S. L. Langord & A. Andersen: Incidence of cancer among vinyl chloride and polyvinyl chloride workers. Brit. J. Ind. Med. 1984, 41, 25-30.
24. Holmberg, B., P. Westerholm, R. Maasing, L. Kestrup, K. Gumaelius, L. Holmlund & A. Englund: Retrospective cohort study of two plants in the Swedish rubber industry. Scand. J. Work Environ. Healt 1983, 9 Suppl 2, 59-68.
25. Husain, Z., M. A. Pathak, T. Flotte & M. M. Wick: Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenza(a)anthracene application and ultraviolet. Cancer Res. 1991, 51, 4964-4970.
26. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans; Polynuclear Aromatic Compounds Part 4, Bitumens, Coal-tars and Derived Products. Shale-oils and Soots. 1985, 35, 83-218.
27. Iglesias, R. & S. Salinas: Transplantable melanotic tumors induced in AxC rats by a single feeding of DMBA. J. Invest. Dermatol. 1970, 54, 89.
28. Ioannides C. & D. V. Parke: The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab. Rev. 1990, 22, 1-85.
29. 14C in vitro. Biochem. Pharmacol. 1967, 16, 2449-2451.
30. Koh, H. K., B. E. Kligler & R. A. Lew: Sunlight and cutaneous malignant melanoma: Evidence and against causation. Photochem. Photobiol. 1990, 51, 765-799.
31. Larsson, B., A. Oskarssoll & H. Tjälve: Binding of paraquat and diquat on melanin. Exp. Eye Res. 1977, 25, 353-359.
32. Larsson, B. S., H. Tjälve, P. Larsson, A. Roberto, I. Brandt & K. Bergman: Retention of carcinogens in pigmented tissues due to melanin affinity. Abstract, Second Meeting of the European Society for Pigment Cell Research. 1989, pp 64. . Uppsala, Sweden.
33. Larsson, P., B. S. Larsson & H. Tjälve: Binding of aflatoxin BI to melanin. Food Chem. Toxicol. 1988, 26, 579-586.
34. Larsson B. S.: Interaction between chemicals and melanin. Melanomia Res. 1993, 6, 127-133.
35. MacKie, R. M. & T. Aitchison: Severe sunburn and subsequent risk of primary cutaneous malignant melanoma in Scotland. Br. J. Cancer 1982, 46, 955-960.
36. Magnani, C., D. Coggon, C. Osmond & E. D. Acheson: Occupation and five cancers: A case-control study using death certificates. Br. J. Ind. Med. 1987, 44, 769-776.
37. McLaughlin, J. K., H. S. R. Malker, W. J. Blot, J. L. E. Ericsson, G. Gemne & J. F. Fraumeni Jr: Malignant melanoma in the printing industry. Am. J. Ind. Med. 1988, 13, 301-304.
38. Nelemans, P. J., A. L. M. Verbeek & F. H. J. Rampen: Nonsolar factors in melanoma risk. Clin. Dermatol. 1992, 10, 51-63.
39. O'Berg, M. T., C. A. Burke, J. L. Chen, J. Walrath, S. Pell & C. R. Gallie: Cancer incidence and mortality in the DuPont Company: An update. J. Occup. Med. 1987, 29, 245-252.
40. Otto, S., C. Marcus, C. Pidgeon & C. Jefcoate: A novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism. Endocrinology 1991, 129 (2), 970-981.
41. Pawlowski, A., H. F. Haberman & I. A. Menon: Skin melanoma induced by 7,12-dimethylbenzanthracene in albino guinea pigs and its similarities to skin melanoma of humans. Cancer Res. 1980, 40, 3652-3660.
42. Pell, S., M. T. O'Berg & B. W. Karrh: Cancer epidemiologic surveillance in the DuPont Company. J. Occup. Med. 1978, 20, 725-740.
43. Persky, B., C. C. Huerta & M. J. C. Hendrix: Morphological charactherization of cellular and extracellular components of 7,12 dimethylbenz[a]anthracene induced melanoma tumours. Brit. J. Exp. Pathol. 1987, 68, 493-499.
44. Powell, G. M., T. J. Parry & C. G. Curtis: An enterogastric circulation. Biochem. Soc. Trans. 1978, 6, 141-143.
45. Quevedo, W. C. J., R. D. Fleischmann, J. Dyckman, K. Jimbow & T. C. Bienieki: Ultrastructural observations on DMBA-induced dermal hyperpigmentation and nevus-like tumors in the Mongolian gerbil. Proc. Soc. Exp. Biol. Med. 1980, 163, 461-468.
46. Sama, S. R., T. R. Martin, L. K. Davis & D. Kriebel: Cancer incidence among Massachusetts firefighters, 1982-1986. Amer. J. Ind. Med. 1990, 18, 47-54.
47. Schweizer, J., H. Loehrke & K. Goerttler: Benzoyl peroxide promotes the formation of melanotic tumours in the skin of 7,12-dimethylbenz(a)anthracene-initiated Syrian golden hamsters. Carcinogenesis 1987, 8, 479-482.
48. Seidel, H. J.: The effect of dimethylbenz[a]anthracene on murine hematopoiesis. Z. Krebsforsch. 1977, 89, 221-229.
49. Shichi, H., S. A. Atlas & D. V. Nebert: Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: possible significance of the drug metabolizing enzyme system for the retinal pigmented epithelium-choroid. Exp. Eye Res. 1975, 21, 557-567.
50. Shore, P. A., B. B. Brodic, & C. A. M. Hoghem: The gastric secretion of drugs: a pH partition hypothesis. J. Pharmacol. Exp. Therap. 1957, 119, 361-369.
51. Takizawa, H., S. Sato, H. Kitajima, S. Konishi, K. Iwata & Y. Hayashi: Mouse skin melanoma induced in two stage chemical carcinogenesis with 7,12-dimethylbenz(a)anthracene and croton oil. Carcinogenesis 1985, 6, 921-923.
52. Thomas, T. L. & P. Decoufle: Mortality among workers employed in the pharmaceutical industry: A preliminary investigation. J. Occup. Med. 1979, 21, 619-623.
53. Ullberg, S., B. Larsson & H. Tjälve: Autoradiography. In: Biologic applications of radiotracers. Ed.: H. J. Glenn. CRC Press, Boca Raton, Florida USA 1982, 56-108.