Signal transduction: Specificity of growth factors explained by parallel distributed processing

Medical Hypotheses

Volumn 47, Issue 3, 1996, Pages 249-255

  Schamel, W W A ^a,c   Dick, T P ^b  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Max Planck lnstitut F Immunbiologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PROTEIN TYROSINE KINASE;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMAN; HYPOTHESIS; MODEL; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0029796238     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(96)90088-2     Document Type: Article

References (25)

1. Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem 1988; 57: 443-478.
2. Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203-212.
3. Leevers S J, Marshall C J. MAP kinase regulation - the oncogene connection. Trends Cell Biol 1992; 2: 283-286.
4. Levitzki A. Signal-transduction therapy. A novel approach to disease managment. Eur J Biochem 1994; 226: 1-13.
5. Huff K, End D, Guroff G. Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to EGF. J Cell Biol 1981; 88: 189-198.
6. Tischler A S, Greene L A. Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells. Nature 1975; 258: 341-342.
7. Chao M V. Growth factor signaling: where is the specificity? Cell 1992; 68: 995-997.
8. Rabin S J, Cleghon V, Kaplan D R. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 1993; 13: 2203-2213.
9. Muroya K, Hattori S, Nakamura S. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21 Ras in rat pheochromocytoma PC12 cells. Oncogene 1992; 7: 277-281.
10. Heasley L E, Johnson G L. The β PDGF receptor induces neuronal differentiation of PC12 cells. Mol Biol Cell 1992; 3: 545-553.
11. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 1992; 288: 351-355.
12. Traverse S, Seedorf K, Paterson H, et al. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 1994; 4: 694-701.
13. Cowley S, Paterson H, Kemp P, Marshall C J. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994; 77: 841-852.
14. Hopfield J J. Neuronal networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci USA 1982; 79: 2554-2558.
15. Bray D. Intracellular signalling as a parallel distributed process. J Theor Biol 1990; 143: 215-231.
16. Rumelhart DE, McClelland JL. Parallel Distributed Processing. Explorations in the Microstructure of Cognition. Cambridge MA: MIT Press, 1988.
17. Kauffman S A. Antichaos and adaptation. Scientific American 1991; 8: 78-84.
18. Suen K L, Bustelo X R, Pawson T, Barbacid M. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol Cell Biol 1993; 13: 5500-5512.
19. Bray D, Bourret R B, Simon M I. Computer simulation of the phosphorylation cascade controlling bacterial chemotaxis. Mol Biol Cell 1993; 4: 469-482.
20. Ales-Martinez J E, Warner G L, Scott D W. Immunglobulins D and M mediate signals that are qualitatively different in B cells with an immature phenotype. Proc Natl Acad Sci USA 1988; 85: 6919-6923.
21. Tisch R, Roifman C M, Hozumi N. Functional differences between immunglobulins M and D expressed on the surface of an immature B-cell line. Proc Natl Acad Sci USA 1988; 85: 6914-6918.
22. Kim K M, Reth M. The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM. J Exp Med 1995; 181: 1005-1014.
23. Songyang Z, Shoelson S E, Chaudhuri M, et al. SH2 domains recognize specific phosphopeptide sequences. Cell 1993; 72: 767-778.
24. Songyang Z, Carraway K L, Eck M J, et al. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 1995; 373: 536-539.
25. Ball S S, Mah V H, Miller P L . SENEX: a computer-based representation of cellular signal transduction processes in the central nervous system. Comput Appl Biosci 1991; 7: 175-187.