Evaluation of the brain uptake properties of [1-11C]labeled hexanoate in anesthetized cats by means of positron emission tomography

Annals of Nuclear Medicine

Volumn 10, Issue 3, 1996, Pages 361-366

  Sakiyama, Yojiro ^a   Ishiwata, Kiichi ^a   Ishii, Kenji ^a   Oda, Keiichi ^a   Toyama, Hinako ^a   Ishii, Shin Ichi ^a   Nakayama, Hitomi ^a   Sato, Akio ^a   Senda, Michio ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

brain; cats; fatty acid; hexanoate; PET

Indexed keywords

CARBON 11; HEXANOIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; BRAIN SCINTISCANNING; CAT; CONTROLLED STUDY; FATTY ACID METABOLISM; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION;

EID: 0029795792     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03164748     Document Type: Article

References (15)

1. Storch-Becker A, Kaiser KP, Feinendegen LE. Cardiac nuclear medicine: positron emission tomography in clinical medicine. Eur J Nucl Med 13: 648-652, 1988.
2. Jacobson HG. Application of positron emission tomography in the heart. J Am Med Assoc 259: 2438-2445, 1988.
3. Sokoloff L. Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc 40: 2311-2316, 1981.
4. Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF. Brain metabolism during fasting. J Clin Invest 46: 1589-1595, 1967.
5. Beattie DS, Basford RE. Brain mitochondria - III. Fatty acid oxidation by bovine brain mitochondria. J Neurochem 12: 103-111, 1965.
6. 14C]glucose labeled in the 1, 2, oroposition. Am J Physiol 248: C170-C176, 1985.
7. Cremer JE, Teal HM, Heath DF, Cavanagh JB. The influence of portocaval anastomosis on the metabolism of labeled octanoate, butyrate and leucine in rat brain. J Neurochem 28: 215-222, 1974.
8. 14C]octanoate: a fast functional marker of brain activity. Brain Res 335: 326-329, 1985.
9. 11C]hexanoate in the mouse: the effect of hypoxia, starvation and substrate competition. Ann Nucl Med 10: 265-270, 1996.
10. Oldendorf WH. Carrier-mediated blood-brain barrier trans-port of short-chain monocarboxylic organic acids. Am J Physiol 224: 1450-1453, 1973.
11. 11C]hexanoate as a PET tracer of fatty acid metabolism. Ann Nucl Med 9: 51-57, 1995.
12. 11C]hexanoate. Appl Radiat Isot 46: 1035-1037, 1995.
13. Watanabe M, Uchida H, Okada K, Shimizu K, Satoh E, Yoshikawa T, et al. A high resolution PET for animal studies. IEEE Trans Med Imag 11: 577-580, 1992.
14. Shields AF, Graham MM, Kozawa SM, Kozell LB, Link JM, Swenson ER, et al. Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. J Nucl Med 33: 581-586, 1992.
15. 11C]octanoate in rats: Pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism. Ann Nucl Med 9: 137-142, 1995.