Histologic studies of brain microemboli in humans and dogs after cardiopulmonary bypass

Echocardiography

Volumn 13, Issue 5, 1996, Pages 559-566

  Brown, William R ^a   Moody, Dixon M ^a   Challa, Venkata R ^a   Stump, David A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

animal models; brain damage; brain microemboli; histologic studies; microspheres; neuropsychological deficits

Indexed keywords

ALKALINE PHOSPHATASE; ALUMINUM; LIPID; MICROSPHERE; SILICON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; CARDIOPULMONARY BYPASS; DOG; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICROEMBOLISM; NONHUMAN; PRIORITY JOURNAL;

EID: 0029795656     PISSN: 07422822     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8175.1996.tb00936.x     Document Type: Article

References (28)

1. Yates PO, Cassie AB, Dark JF, et al: The detection of antifoam emboli following perfusion with a heart-lung machine. Lancet 1959;1:130.
2. Penry JK, Cordell AR, Johnston FR, et al: Cerebral embolism by Antifoam A in a bubble oxygenator system: An experimental and clinical study. Surgery 1960;47:784-794.
3. Thomassen RW, Howbert JP, Winn DF, et al: The occurrence and characterization of emboli associated with the use of a silicone antifoaming agent. J Thorac Cardiovasc Surg 1961; 41:611-622.
4. Ghatak NR, Sinneberg RJ, deBlois GG: Cerebral fat embolism following cardiac surgery. Stroke 1983;14:619-621.
5. Miller JA, Fonkalsrud EW, Latta HL, et al: Fat embolism associated with extracorporeal circulation and blood transfusion. Surgery 1962;51: 448-451.
6. Shaw PJ, Bates D, Cartlidge NEF, et al: Neurologic and neuropsychological morbidity following major surgery: comparison of coronary artery bypass and peripheral vascular surgery. Stroke 1987;18:700-707.
7. Aris A, Solanes H, Camará ML, et al: Arterial line filtration during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1986;91:526-533.
8. Smith PLC, Treasure T, Newman SP, et al: Cerebral consequences of cardiopulmonary bypass. Lancet 1986;1:823-825.
9. Sotaniemi KA, Mononen H, Hokkanen TE: Long term cerebral outcome after open-heart surgery. A five year neuropsychological follow-up study. Stroke 1986;17:410-416.
10. Åberg T, Ronquist G, Tyden H, et al: Adverse effects on the brain in cardiac operations as assessed by biochemical, psychometric, and radiologic methods. J Thorac Cardiovasc Surg 1984;87:99-105.
11. Steinberg GK, DeLaPaz R, Mitchell RS, et al: Magnetic resonance imaging and CSF enzymes as sensitive indicators of subclinical cerebral injury following open-heart valve replacement surgery. (Abstract) Stroke 1992;23:161.
12. Stump DA, Stein CS, Tegeler CH, et al: Validity and reliability of an ultrasound device for detecting carotid emboli. J Neuroimaging 1991;1:18-22.
13. Padayachee TS, Parsons S, Theobold R, et al: The detection of microemboli in the middle cerebral artery during cardiopulmonary bypass: A transcranial Doppler ultrasound investigation using membrane and bubble oxygenators. Ann Thorac Surg 1987;44:298-302.
14. Blauth CI, Smith PL, Arnold JV, et al: Influence of oxygenator type on the prevalence and extent of microembolic retinal ischemia during cardiopulmonary bypass: assessment by digital image analysis. J Thorac Cardiovasc Surg 1990;99:61-69.
15. Moody DM, Bell MA, Challa VR, et al: Brain microemboli during cardiac surgery or aortography. Ann Neurol 1990;28:477-486.
16. Stump DA, Tegeler CH, Rogers AT, et al: Neuropsychological deficits are associated with the number of emboli detected during cardiac surgery. (Abstract) Stroke 1993;24:509.
17. Williams IM, Merrilees NCR, Robinson PM: Microembolism and the visual system. Part II: The consequence of embolism in the microcirculation of nervous tissue, especially that comprising the visual system. Proc Austral Assoc Neurol 1975;12:179-184.
18. Williams IM: Retinal vascular occlusions in open heart surgery. Br J Ophthal 1975;59:81-91.
19. Bell MA, Scarrow WG: Staining for microvascular alkaline phosphatase in thick celloidin sections of nervous tissue: morphometric and pathological applications. Microvasc Res 1984; 27:189-203.
20. Bell MA, Moody DM, Challa VR, et al: Birefringence as a feature of cerebral microvascular dilatations after cardiopulmonary bypass. Neuroradiology 1991;33(Suppl):443-445.
21. Challa VR, Moody DM, Troost BT: Brain embolic phenomena associated with cardiopulmonary bypass. J Neurol Sci 1993;117:224-231.
22. Williams IM, Stephens JF, Richardson EP Jr, et al: Brain and retinal microemboli during cardiac surgery. (Letter) Ann Neurol 1991;30: 736-737.
23. Kurusz M, Butler BD: Emboli events and cardiopulmonary bypass. In Gravlee GP, Davis RF, Utley JR (eds): Cardiopulmonary Bypass: Principles and Practice. Williams & Wilkins, Baltimore, MD, 1993, pp. 267-290.
24. Vogler C, Sotelo-Avila C, Lagunoff D, et al: Aluminum-containing emboli in infants treated with extracorporeal membrane oxygenation. N Engl J Med 1988;319:75-79.
25. Braun PR, L'Hommedieu BD, Klinedinst WJ: Aluminum contamination by heat exchangers during cardiopulmonary bypass. Proc Am Acad Cardiovasc Perfusion 1988;9:69-71.
26. Brown WR, Moody DM, Mills SA, et al: Surrogate tissues for detecting brain microemboli after cardiopulmonary bypass. Perfusion 1994;9: 389-392.
27. Prough DS, Rogers AT, Stump DA, et al: Hypercarbia depresses cerebral oxygen consumption during cardiopulmonary bypass. Stroke 1990;21:1162-1166.
28. Harris DNF, Bailey SM, Smith PLC, et al: Brain swelling in first hour after coronary artery bypass surgery. (Abstract) Lancet 1993; 342:586-587.