B lymphocyte development and transcription regulation in vivo

Advances in Immunology

Volumn 63, Issue , 1996, Pages 197-268

  Opstelten, Davina ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; B LYMPHOCYTE ACTIVATION; CHROMATIN STRUCTURE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; IMMUNOHISTOCHEMISTRY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

EID: 0029795482     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (308)

1. Abboud, C. N. (1995) Human bone marrow microvascular endothelial cells: elusive cells with unique structural and functional properties. Exp. Hematol. 23, 1-3. [Editorial]
2. Adams, B., Dorfler, P., Aguzzi, A., Kozmik, Z., Urbanek, P., Maurer Fogy, I., and Busslinger, M. (1992) Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6, 1589-1607.
3. Ahmad, L. A., and Bainton, D. F. (1986) Presence of alkaline-phosphatase-positive reticulum cells in fetal liver and bone marrow of mice and their absence in yolk sac. Exp. Hematol. 14, 705-709.
4. Alkema, M. J., van der Lugt, N. M., Bobeldijk, R. C, Berns, A., and van Lohuizen, M. (1995) Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature 374, 724-727.
5. Allen, J. D., Harris, A. W., Bath, M. L., Strasser, A., Scollay, R., and Adams, J. M. (1995) Perturbed development of T and B cells in mice expressing an Hlx homeobox transgene. J. Immunol. 154, 1531-1542.
6. Allen, J. D., Lints, T., Jenkins, N. A., Copeland, N. G., Strasser, A., Harvey, R. P., and Adams, J. (1991) Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis. Genes Dev. 5, 509-520.
7. Anderson, K. L., McKercher, S. L., Henkel, G., Maki, R. A., and Torbett, B. E. (1995) Hematopoietic cells from PU.1 knockout mice engraft SCID mice. 9th International Congress of Immunology, Abstract No. 4177, The Conference Organizers, San Francisco, CA.
8. Asano, M., and Gruss, P. (1992) Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev. 39, 29-39.
9. Badiani, P., Corbella, P., Kioussis, D., Marvel, J., and Weston, K. (1994) Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 8, 770-782.
10. Baeuerle, P. A., and Henkel, T. (1994) Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12, 141-179.
11. Bain, G., Maandag, E. C, Izon, D. J., Amsen, D., Kruisbeek, A. M., Weintraub, B. C, Krop, I., Schlissel, M. S., Feeney, A. J., van Roon, M., et al. (1994) E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements [see comments J. Cell 79, 885-892.
12. Baker, S. J., and Reddy, E. P. (1995) B cell differentiation: Role of E2A and Pax5/ BSAP transcription factors. Oncogene 11, 413-426.
13. Barberis, A., Widenhorn, K., Vitelli, L., and Busslinger, M. (1990) A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 4, 849-859.
14. Barinaga, M. (1994) Knockout mice: Round two [news; comment] [published erratum appears in Science 265(5174):855 J. Science. 265, 26-28.
15. Batten, S. J., and Osmond, D. G. (1984) The localization of B lymphocytes in mouse bone marrow: Radioautographic studies after in vivo perfusion of radiolabeled anti-IgM antibody. J. Immunol. Methods 72, 381-399.
16. Baxevanis, A. D., and Landsman, D. (1995) The HMG-1 box protein family: Classification and functional relationships. Nucleic Acids. Res. 23, 1604-1613.
17. Beelman, C. A., and Parker, R. (1995) Degradation of mRNA in eukaryotes. Cell 81, 179-183
18. Ben Yehuda, A., Szabo, P., Dyall, R.,and Weksler, M. E. (1994) Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution. Proc. Nad. Acad. Sci. U.S.A. 91, 11988-11992.
19. Ben Yehuda, A., Szabo, P., and Weksler, M. E. (1994) Age-associated changes in the B-cell repertoire: Effect of age on RAG-1 gene expression in murine bone marrow. Immunol. Lett. 40, 287-289.
20. Billips, L. G., Nunez, C. A., Bertrand, F. E., Stankovic, A. K., Gartland, G. L., Burrows, P. D., and Cooper, M. D. (1995) Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD 19 in B cell progenitors. J. Exp. Med. 182, 973-982.
21. Bleiberg, I., Ricciardone, M. D., Reddi, H. A., and McCarthy, K. F. (1987) New bone formation and bone marrow differentiation induced in rats by extracellular bone matrix implantation: Effect of local preirradiation on the process. Exp. Hematol. 15,309-315.
22. Bolen, J. B. (1995) Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Opin. Immunol. 7, 306-311.
23. Bories, J.-C, Willerford, D. M., Grevin, D., Davidson, L., Camus, A., Martin, P., Stehelin, D., and Alt, F. W. (1995) Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 377, 635-638.
24. Borrow, J., Goddard, A. D., Sheer, D., and Solomon, E. (1990) Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249, 1577-1580.
25. Boudreau, N., Myers, C., and Bissell, M. J. (1995) From laminin to lamin: Regulation of tissue-specific gene expression by the ECM. Trends Cell Biol. 5, 1-4.
26. Brandon, E. P., Idzerda, R. L., and McKnight, G. S. (1995) Targeting the mouse genome: A compendium of knockouts (part I). Curr. Biol. 5, 625-634.
27. Brandon, E. P., Idzerda, R. L., and McKnight, G. S. (1995) Targeting the mouse genome: A compendium of knockouts (part II). Curr. Biol. 5, 758-765.
28. Brandon, E. P., Idzerda, R. L., and McKnight, G. S. (1995) Targeting the mouse genome: A compendium of knockouts (part III). Curr. Biol. 5, 873-881.
29. Buratowski, S. (1994) The basics of basal transcription by RNA polymerase II. Cell 77, 1-3.
30. Busslinger, M., and Urbanek, P. (1995) The role of BSAP (pax-5) in B-cell development. Curr. Opin. Genet. Dev. 5, 595-601.
31. Capecchi, M. R. (1994) Targeted gene replacement. Sci. Am. 270, 52-59.
32. Carrasco, D., Ryseck, R. P., and Bravo, R. (1993) Expression of relB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting cells. Development 118, 1221-1231.
33. Carrasco, D., Weih, F., and Bravo, R. (1994) Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development 120, 2991-3004.
34. Castigli, E., Alt, F. W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A. K., and Geha, R. S. (1994) CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. U.S.A. 91,12135-12139.
35. Chang, K. S., Fan, Y. H., Andreeff, M., Liu, J., and Mu, Z. M. (1995) The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood 85, 3646-3653
36. Chen, J., Lansford, R., Stewart, V., Young, F., and Alt, F. W. (1993) RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. U.S.A. 90, 4528-4532.
37. Chen, J., Ma, A., Young, F., and Alt, F. W. (1994) IL-2 receptor alpha chain expression during early B lymphocyte differentiation. Int. Immunol. 6, 1265-1268.
38. Chen, J., Shinkai, Y., Young, F., and Alt, F. W. (1994) Probing immune functions in RAG-deficient mice. Curr. Opin. Immunol. 6, 313-319.
39. Clark, R., Strasser, J., McCabe, S., Robbins, K., and Jardieu, P. (1993) Insulin-like growth factor-1 stimulation of lymphopoiesis. J. Clin. Invest. 92, 540-548.
40. Copp, A. J. (1995) Death before birth: Clues from gene knockouts and mutations. Trends Genet. 11, 87-93.
41. Corcoran, L. M., Karvelas, M., Nossal, G. J. V., Ye, Z. S., Jacks, T., and Baltimore, D. (1993) Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 7, 570-582.
42. Coutinho, A. (1993) Lymphocyte survival and V-region repertoire selection. Immunol. Today 14, 38-40.
43. Cumano, A., Dieterlen-Lievre, F., and Godin, I. (1995) Detection of B and T cell precursors in mouse embryos, prior to the establishment of circulation. 9th International Congress of Immunology, Abstract No. 1623, The Conference Organizers, San Francisco, CA.
44. Cumano, A., Furlonger, C., and Paige, C. J. (1993) Differentiation and characterization of B-cell precursors detected in the 7yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage. Proc. Natl. Acad. Sci. U.S.A. 90, 6429-6433.
45. Cumano, A., Kee, B. L., Ramsden, D. A., Marshall, A., Paige, C. J., and Wu, G. E. (1994) Development of B lymphocytes from lymphoid committed and uncommitted progenitors. Immunol. Rev. 137, 5-33.
46. Cumano, A., and Paige, C. J. (1992) Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation. EMBO J. 11, 593-601.
47. Curtis, D., Lehmann, R., and Zamore, P. D. (1995) Translational regulation in development. Cell 81, 171-178
48. de The, H., Chomienne, C., Lanotte, M., Degos, L., and Dejean, A. (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 347, 558-561.
49. Dejbakhsh Jones, S., Okazaki, H., and Strober, S. (1995) Similar rates of production of T and B lymphocytes in the bone marrow. J. Exp. Med. 181, 2201-2211.
50. Deldar, A., Lewis, H., and Weiss, L. (1985) Bone lining cells and hematopoiesis: An electron microscopic study of canine bone marrow. Anat. Rec. 213, 187-201.
51. Deryugina, E. I., Ratnikov, B. I., Bourdon, M. A., and Muller Sieburg, C. E. (1994) Clonal analysis of primary marrow stroma: Functional homogeneity in support of lymphoid and myeloid cell lines and identification of positive and negative regulators. Exp. Hematol. 22, 910-918.
52. Desiderio, S. (1995) Transcription factors controlling B-cell development. Curr. Biol. 5, 605-608.
53. Dong C, Willerford D., Graeff R. M., Lee H. C, Alt F., and Cooper M. D. (1995) Structure/function studies of BP-3, a CD38 relative. 9th International Congress of Immunology, Abstract No 1589, The Conference Organizers, San Francisco, CA.
54. Dorshkind, K. (1994) Transcriptional control points during lymphopoiesis. Cell 79, 751-753. [comment]
55. Ehlich, A., and Kuppers, R. (1995) Analysis of immunoglobulin gene rearrangements in single B cells. Curr. Opin. Immunol. 7, 281-284.
56. Ehlich, A., Martin, V., Muller, W., and Rajewsky, K. (1994) Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4, 573-583.
57. Eisenbeis, C. F., Singh, H., and Storb, U. (1995) Pip, a novel IRF family member, is a lymphoid-speeific, PU. 1-dependent transcriptional activator. Genes Dev. 9,1377-1387.
58. Engel, P., Zhou, L. J., Ord, D. C, Sato, S., Koller, B., and Tedder, T. F. (1995) Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3, 39-50.
59. Era, T., Nishikawa, S., Sudo, T., Wang, F. H., Ogawa, M., Kunisada, T., and Hayashi, S. (1994) How B-precursor cells are driven to cycle. Immunol. Rev. 137, 35-51.
60. Ess, K. C, Whitaker, T. L., Cost, G. J., Witte, D. P., Hutton, J. J., and Aronow, B. J. (1995) A central role for a single c-Myb binding site in a thymic locus control region. Mol. Cell. Biol. 15, 5707-5715.
61. Fagioli, M., Alcalay, M., Pandolfi, P. P., Venturini, L., Mencarelli, A., Simeone, A., Acampora, D., Grignani, F., and Pelicci, P. G. (1992) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms. Oncogene 7, 1083-1091.
62. Felten, D. L., Felten, S. Y., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowki, J. A., and Livnat, S. (1987) Noradrenergic sympathetic neural interactions with the immune system: Stnicture and function. Immunol. Rev. 100, 225-260.
63. Felten, D. L., Felten, S. Y., Carlson, S. L., Olschowka, J. A., and Livnat, S. (1985) Noradrenergic and peptidergic innervation of lymphoid tissue. J. Immunol. 135,755s-765s.
64. Felten, S. Y., Felten, D. L., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowka, J. A., and Livnat, S. (1988) Noradrenergic sympathetic innervation of lymphoid organs. Prog. Allergy 43, 14-36.
65. Freitas, A. A., and Rocha, B. B. (1993) Lymphocyte lifespans: Homeostasis, selection and competition [see comments J. Immunol. Today 14, 25-29.
66. Fujita, K., Imoto, S., Phuchareon, J., and Tokuhisa, T. (1994) c-fos and jun gene expression in murine precursor B lymphocytes developed in the interleukin-7dependent bone marrow cell culture. Immunobiology 190, 13-22.
67. Fujita, K., Miki, N., Mojica, M. P., Takao, S., Phuchareon, J., Nishikawa, S., Sudo, T., and Tokuhisa, T. (1993) B cell development is perturbed in bone marrow from c-fos/v-jun doubly transgenic mice. Int. Immunol. 5, 227-230.
68. Galli Taliadoros, L. A., Sedgwick, J. D., Wood, S. A., and Korner, H. (1995) Gene knock-out technology: A methodological overview for the interested novice. J. Immunol. Methods 181, 1-15.
69. Galson, D. L., Hensold, J. O., Bishop, T. R., Schalling, M., D'Andrea, A. D., Jones, C., Auron, P. E., and Housman, D. E. (1993) Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi- 1/PU. 1, and is restricted in expression to hematopoietic cells and the testis. Mol. Cell. Biol. 13, 2929-2941.
70. Georgopoulos, K., Bigby, M., Wang, J. H., Molnar, A., Wu, P., Winandy, S., and Sharpe, A. (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79, 143-156.
71. Georgopoulos, K., Moore, D. D., and Derfler, B. (1992) Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258, 808-812.
72. Gibson, L. F., Piktel, D., and Landreth, K. S. (1993) Insulin-like growth factor-1 potentiates expansion of interleukin-7-dependent pro-B cells. Blood 82, 3005-3011.
73. Godin, I., Dieterlen Lievre, F., and Cumano, A. (1995) Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus. Proc. Natl. Acad. Sci. U.S.A. 92, 773-777.
74. Godin, I. E., Garcia Porrero, J. A., Coutinho, A., Dieterlen Lievre, F., and Marcos, M. A. (1993) Para-aortic splanchnopleura from early mouse embryos contains Bla cell progenitors. Nature 364, 67-70.
75. Golay, J., Capucci, A., Arsura, M., Castellano, M., Rizzo, V., and Introna, M. (1991) Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells. Blood 77, 149-158.
76. Gordon, M. Y. (1994) Stem cells and the microenvironment in aplastic anaemia. Br. J. Haematol. 86, 190-192.
77. Grabstein, K. H., Waldschmidt, T. J., Finkelman, F. D., Hess, B. W., Alpert, A. R., Boiani, N. E., Namen, A. E., and Morrissey, P. J. (1993) Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J. Exp. Med. 178, 257-264.
78. Grignani, F., Fagioli, M., Alcalay, M., Longo, L., Pandolfl, P. P., Donti, E., Biondi, A., Lo Coco, F., and Pelicci, P. G. (1994) Acute promyelocytic leukemia: From genetics to treatment. Blood. 83, 10-25.
79. Grosschedl, R. (1995) Higher-order nucleoprotein complexes in transcription: Analogies with site-specific recombination. Curr. Opin. Cell Biol. 7, 362-370.
80. Grossi, C. E., Velardi, A., and Cooper, M. D. (1985) Postnatal liver hemopoiesis in mice: Generation of pre-B cells, granulocytes, and erythrocytes in discrete colonies. J. Immunol. 135, 230
81. Gstaiger, M., Knoepfel, L., Georgiev, O., Schaffner, W., and Hovens, C. M. (1995) A B-cell coactivator of octamer-binding transcription factors. Nature 373, 360-362.
82. Gu, H. (1994) Gene targeting and its application to the study of B-cell development. Curr. Opin. Immunol. 6, 308-312.
83. Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Munsterberg, A., and Vivian, N. (1990) A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments J. Nature 346, 245-250.
84. Hagman, J., and Grosschedl, R. (1994) Regulation of gene expression at early stages of B-cell differentiation. Curr. Opin. Immunol. 6, 222-230.
85. Hahm, K., Ernst, P., Lo, K., Kim, G. S., Turck, C., and Smale, S. T. (1994) The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14, 7111-7123.
86. Haider, G., Callaerts, P., and Gehring, W.J. (1995) Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila [see comments J. Science 267,1788-1792.
87. Hamilton, A. M., Lehuen, A., and Kearney, J. F. (1994) Immunofluorescence analysis of B-l cell ontogeny in the mouse. Int. Immunol. 6, 355-361.
88. Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., and Taniguchi, T. (1993) Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 259, 971-974.
89. Harada, H., Takahashi, E., Itoh, S., Harada, K., Hon, T. A., and Taniguchi, T. (1994) Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: Implications for a gene network in the interferon system. Mol. Cell. Biol. 14, 1500-1509.
90. Harada, H., Willison, K., Sakakibara, J., Miyamoto, M., Fujita, T., and Taniguchi, T. (1990) Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell 63, 303-312.
91. Hardy, R. R., Carmack, C. E., Li, Y. S., and Hayakawa, K. (1994) Distinctive developmental origins and specificities of murine CD5+ R cells. Immunol. Rev. 137,91-118.
92. Hardy, R. R., and Hayakawa, K. (1994) CD5 B cells, a fetal B cell lineage. Adv. Immunol. 55, 297-339.
93. Hayakawa, K., Tarlinton, D., and Hardy, R. R. (1994) Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J. Immunol. 152, 4801-4807.
94. Heldin, C. H. (1995) Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.
95. Hendzel, M. J., and Bazett Jones, D. P. (1995) RNA polymerase II transcription and the functional organization of the mammalian cell nucleus. Chromosoma 103,509-516.
96. Hentze, M. W. (1995) Translational regulation: Versatile mechanisms for metabolic and developmental control. Curr. Opin. Cell Biol. 7, 393-398.
97. Hermans, M. H., Hartsuiker, H., and Opstelten, D. (1989) An in situ study of Blymphocytopoiesis in rat bone marrow. Topographical arrangement of terminal deoxynucleotidyl transferase-positive cells and pre-B cells. J. Immunol. 142, 67-73.
98. Hermans, M. H., and Opstelten, D. (1991) In situ visualization of hemopoietic cell subsets and stromal elements in rat and mouse bone marrow by immunostaining of frozen sections. J. Histochem. Cytochem. 39, 1627-1634.
99. Hermans, M. H., Wubbena, A., Kroese, F. G., Hunt, S. V., Cowan, R., and Opstelten, D. (1992) The extent of clonal structure in different lymphoid organs. J. Exp. Med. 175, 1255-1269.
100. Hill, C. S., and Treisman, R. (1995) Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80, 199-211.
101. Himmelmann A., Thevenin C, Harrison K., and Kehrl J.H. (1995) A critical PU.l site is located immediately upstream of the major transcription start sites of Bruton's tyrosine kinase gene. 9th International Congress of Immunology, Abstract No 1609, The Conference Organizers, San Francisco, CA.
102. Hochstrasser, M. (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7, 215-223.
103. Hodes, R. J. (1995) Molecular alterations in the aging immune s y s t e m. J. Exp. Med. 182, 1-3. [Comment]
104. Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z. J., Zhang, D. E., and Tenen, D. G. (1995) PU.l (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol. Cell. Biol. 15, 5830-5845.
105. Hromas, R., Orazi, A., Neiman, R. S., Maki, R., Van Beveran, C., Moore, J., and Klemsz, M. (1993) Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.l. Blood 82, 2998-3004.
106. Hu, E., Mueller, E., Oliviero, S., Papaioannou, V. E., Johnson, R., and Spiegelman, B. M. (1994) Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 13, 3094-3103.
107. Hunter, T. (1995) Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling. Cell 80, 225-236.
108. Huo, L., and Rothstein, T. L. (1995) Receptor-specific induction of individual AP-1 components in B l y m p h o c y t e s. J. Immunol. 154, 3300-3309.
109. Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., and Silvennoinen, O. (1995) Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13, 369-398.
110. Islam, A., Glomski, C., and Henderson, E. S. (1990) Bone lining (endosteal) cells and hematopoiesis: A light microscopic study of normal and pathologic human bone marrow in plastic-embedded sections. Anat. Rec. 227, 300-306.
111. Israel, A. (1995) A role for phosphorylation and degradation in the control of NF-kappa B activity. Trends Genet. 11, 203-205.
112. Jacobs, Y., Xin, X. Q., Dorshkind, K., and Nelson, C. (1994) Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cells. Mol. Cell. Biol. 14, 4087-4096.
113. Jacobsen, K., Miyake, K., Kincade, P. W., and Osmond, D. G. (1992) Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo. J. Exp. Med. 176, 927-935.
114. Jacobsen, K., and Osmond, D. G. (1990) Microenvironmental organization and stromal cell associations of B lymphocyte precursor cells in mouse bone marrow. Eur. J. Immunol. 20, 2395-2404.
115. Jacobsen, K., Tepper, J., and Osmond, D. G. (1990) Early B-lymphocyte precursor cells in mouse bone marrow: Subosteal localization of B220+ cells during postirradiation regeneration. Exp. Hematol. 18, 304-310.
116. Jacobsen, K. A., Prasad, V. S., Sidman, C. L., and Osmond, D. G. (1994) Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of E mumyc transgenic mice. Blood 84, 2784-2794.
117. Jain, J., Nalefski, E. A., McCaffrey, P. G., Johnson, R. S., Spiegelman, B. M., Papaioannou, V., and Rao, A. (1994) Normal peripheral T-cell function in c-Fos-deflcient mice. Mol. Cell. Biol. 14, 1566-1574.
118. Johnson, A. D. (1995) The price of repression. Cell 81, 655-658.
119. Johnson, D. R., and Pober, J. S. (1994) HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Mol. Cell. Biol. 14, 1322-1332.
120. Johnson, R. S., Spiegelman, B. M., and Papaioannou, V. (1992) Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71, 577-586.
121. Jyonouchi, H., and Kincade, P. W. (1983) Changes in B lineage cell population in liver and spleen of normal neonatal m i c e. J. Immunol. 130, 1616-1621.
122. Kaisho, T., Ishikawa, J., Oritani, K., Inazawa, J., Tomizawa, H., Muraoka, O., Ochi, T., and Hirano, T. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proa Natl. Acad. Sci. U.S.A. 91, 5325-5329.
123. Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263, 1612-1615.
124. Kamps, W. A., and Cooper, M. D. (1982) Microenvironmental studies of pre-B and B cell development in human and mouse fetuses. J. Immunol. 129, 526-531.
125. Karasuyama, H., Rolink, A., Shinkai, Y., Young, F., Alt, F. W., and Melchers, F. (1994) The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77, 133-143.
126. Karin, M., and Hunter, T. (1995) Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus. Curr. Biol. 5, 747-756.
127. Kamitz, L. M., and Abraham, R. T. (1995) Cytokine receptor signaling mechanisms. Curr. Opin. Immunol. 7, 320-326.
128. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H. (1994) The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation. Immunity 1, 167-178
129. Kee, B. L., Cumano, A., Iscove, N. N., and Paige, C. J. (1994) Stromal cell independent growth of bipotent B cell-Macrophage precursors from murine fetal liver. Int. Immunol. 6, 401-407.
130. Kee, B. L., and Paige, C. J. (1995) Murine B cell development: Commitment and progression from multipotential progenitors to mature B lymphocytes. Int. Rev. Cytol. 157, 129-179.
131. Kehrl, J. H. (1994) Homeobox genes in hematopoiesis. Crit. Rev. Oncol. Henmtol. 16, 145-156.
132. Kehrl, J. H. (1995) Hematopoietic lineage commitment: Role of transcription factors. Stem Cells 13, 223-241.
133. Kimoto, H., Shirasawa, T., Taniguchi, M., and Takemori, T. (1989) B cell precursors are present in the thymus during early development. Eur. J. Immunol. 19, 97-104.
134. Kimura, T., Nakayama, K., Penninger, J., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilcek, J., Mak, T. W., et al. (1994) Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264, 1921-1924.
135. Kincade, P. W., Medina, K. L., and Smithson, G. (1994) Sex hormones as negative regulators of lymphopoiesis. Immunol. Rev. 137, 119-134.
136. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F., and Rajewsky, K. (1992) A critical role of lambda 5 protein in B cell development. Cell 69, 823-831.
137. Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., and Maki, R. A. (1990) The macrophage and B cell-specific transcription factor PU.l is related to the ets oncogene [see comments J. Cell 61, 113-124.
138. Kobayashi K., Phuchareon J., Tomita Y., Koizumi T., Hatano M., Miyatake S., and Tokuhisa T. (1995) A role of AP-1 in cell cycle progression of B cells stimulated with anti-IgM. 9th International Congress of Immunology, Abstract No. 4162, The Conference Organizers, San Francisco, CA.
139. Koken, M. H. M., Linares-Cruz, C., Quignon, F., Viron, A., Chelbi-Alix, M. K., Sobczak-Thepot, J., Juhlin, L., Degos, L., Calvo, F., and de The, H. (1995) The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene 10, 1315-1324.
140. Koleske, A. J., and Young, R. A. (1995) The RNA polymerase II holoenzyme and its implications for gene regulation. Trends Biochem. Sci. 20, 113-116.
141. Korioth, F., Gieffers, C., Maul, G. G., and Frey, J. (1995) Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. J. Cell Biol. 130, 1-13.
142. Kornberg, R. D., and Lorch, Y. (1995) Interplay between chromatin structure and transcription. Curr. Opin. Cell Biol. 7, 371-375.
143. Kozmik, Z., Sure, U., Ruedi, D., Busslinger, M., and Aguzzi, A. (1995) Deregulated expression of PAX5 in medulloblastoma. Proc. Natl. Acad. Sci. U.S.A. 92, 5709-5713
144. Kozmik, Z., Wang, S., Dorfler, P., Adams, B., and Busslinger, M. (1992) The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 12, 2662-2672.
145. Krumlauf, R. (1994) Hox genes in vertebrate development. Cell 78, 191-201.
146. Lam, K. P., and Stall, A. M. (1994) Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during o n t o g e n y. J. Exp. Med. 180, 507-516.
147. Lam, Y. W., Ammerlaan, W., O, W. S., Kroese, F., and Opstelten, D. (1995) Cell type and differentiation stage-dependent expression of PML domains in rat, detected by monoclonal antibody HIS55. Exp. Cell Res. 221, 344-356.
148. Landreth, K. S., Kincade, P. W., Lee, G., and Medlock, E. S. (1983) Phenotypic and functional characterization of murine B lymphocyte precursors isolated from fetal and adult tissues. J. Immunol. 131, 572-580.
149. Lavau, C., and Dejean, A. (1994) The t(15;17) translocation in acute promyelocytic leukemia. Leukemia 8, 1615-1621.
150. Lavau, C., Marchio, A., Fagioli, M., Jansen, J., Falini, B., Lebon, P., Grosveld, F., Pandolfi, P. P., Pelicci, P. G., and Dejean, A. (1995) The acute promyelocytic leukemia-associated PML gene is induced by interferon. Oncogene 11, 871-876.
151. Lawrence, H. J., and Largman, C. (1992) Homeobox genes in normal hematopoiesis and leukemia. Blood 80, 2445-2453.
152. Lennon, G. G., and Perry, R. P. (1990) The temporal order of appearance of transcripts from unrearranged and rearranged Ig genes in murine fetal liver. J. Immunol. 144, 1983-1987.
153. Lernbecher, T., Kistler, B., and Wirth, T. (1994) Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. EMBO J. 13, 4060-4069.
154. Li, S., and Sedivy, J. M. (1993) Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex. Proc. Natl. Acad. Sci. U.S.A. 90, 9247-9251.
155. Li Y.S., Wasserman R., Hayakawa K., Hardy R.R. (1995) Stages in mouse bone marrow B cell development where germline μ precedes RAG 1/2 expression and where productive Μ downregulates RAG1/2. 9th International Congress of Immunology, Abstract No. 1570, The Conference Organizers, San Francisco, CA.
156. Lichtman, M. A. (1981) The ultrastructure of the hemopoietic environment of the marrow: A review. Exp. Hematol. 9, 391-410.
157. Lin, H., and Grosschedl, R. (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-267.
158. Lin Q., Taniuchi I., Kitamura D., Wang J., Watanabe T., and Cooper M. D. (1995) Analysis of immune system development in aminopeptidase A knockout mice. 9th International Congress of Immunology, Abstract No. 1598, The Conference Organizers, San Francisco, CA.
159. Liou, H. C, Sha, W. C, Scott, M. L., and Baltimore, D. (1994) Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14, 5349-5359.
160. Liu, J. H., Mu, Z. M., and Chang, K. S. (1995) PML suppresses oncogenic transformation of NIH/3T3 cells by activatedneu. J. Exp. Med. 181, 1965-1973.
161. Loffert, D., Schaal, S., Ehlich, A., Hardy, R. R., Zou, Y. R., Muller, W., and Rajewsky, K. (1994) Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137, 135-153.
162. Longo, L., Pandolfi, P. P., Biondi, A., Rambaldi, A., Mencarelli, A., Lo Coco, F., Diverio, D., Pegoraro, L., Avanzi, G., Tabilio, A., et al. (1990) Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias. J. Exp. Med. 172, 1571-1575.
163. Lord, B. I., Testa, N. G., and Hendry, J. H. (1975) The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood 46, 65-72.
164. Lovell-Badge, R. (1995) Living with bad architecture. Nature 376, 725-726.
165. MacLennan, I., and Chan, E. (1993) The dynamic relationship between B-cell populations in adults [see comments J. Immunol. Today 14, 29-34.
166. Macleod, K., Leprince, D., and Stehelin, D. (1995) The ets gene family. Trends Biochem. Sci. 17, 251-256.
167. Marcos, M. A., Godin, I., Cumano, A., Morales, S., Garcia Porrero, J. A., Dieterlen Lievre, F., and Caspar, M. L. (1994) Developmental events from hemopoietic stem cells to B-cell populations and Ig repertoires. Immunol. Rev. 137, 155-171.
168. Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kundig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83-97.
169. Maul, G. G., and Everett, R. D. (1994) The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein I C P O. J. Gen. Virol. 75, 1223-1233.
170. Maul, G. G., Yu, E., Ishov, A. M., and Epstein, A. L. (1995) Nuclear domain 10 (ND10) associated proteins are present in nuclear bodies and redistribute to hundreds of nuclear sites after stress. J. Cell. Biochem. 59, 498-513.
171. Max, E. E., Wakatsuki, Y., Neurath, M. F., and Strober, W. (1995) The role of BSAP in immunoglobulin isotype switching and B-cell proliferation. Curr. Top. Microbiol. Immunol. 194, 449-458.
172. May, G., and Enver, T. (1995) Targeting gene expression to haemopoietic stem cells: A chromatin-dependent upstream element mediates cell type-specific expression of the stem cell antigen CD34. EMBO J. 14, 564-574.
173. McCarthy, J. E., and Kollmus, H. (1995) Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. Trends Biochem. Sci. 20, 191-197.
174. McCarthy, K. F., Wientroub, S., Hale, M., and Reddi, A. H. (1984) Establishment of the hematopoietic microenviranment in the marrow of matrix-induced endochondral bone. Exp. Hetrmtol. 12, 131-138.
175. i75. McKearn, J. P., Baum, C., and Davie, J. M. (1984) Cell surface antigens expressed by subsets of pre-B cells and B cells. J. Immunol. 132, 332-339.
176. McKercher S. R., Anderson K. L., Torbett B. E., Vestal D. J., Henkel G., Paige C, and Maki R. A. (1995) PU.l transcription factor null mutation shows multiple hematopoietic effects. 9th International Congress of Immunology, Abstract No. 4166, The Conference Organizers, San Francisco, CA.
177. Medlock, E. S., Landreth, K. S., and Kincade, P. W. (1984) Putative B lymphocyte lineage precursor cells in early murine embryos. Dev. Comp. Immunol. 8, 877-886.
178. Melchers, F. (1979) Murine embryonic B lymphocyte development in the placenta. Nature. 277, 219-221
179. Melchers, F., and Abramczuk, J. (1980) Murine embryonic blood between day 10 and 13 of gestation as a source of immature precursor B cells. Eur. J. Immunol. 10,763-767.
180. Melchers, F., Haasner, D., Grawunder, U., Kalberer, C., Karasuyama, H., Winkler, T., and Rolink, A. G. (1994) Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12, 209-225.
181. Melchers, F., Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., Ghia, P., and Andersson, J. (1995) Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol. 7, 214-227.
182. Melotti, P., and Calabretta, B. (1994) Ets-2 and c-Myb act independently in regulating expression of the hematopoietic stem cell antigen C D 3 4. J. Biol. Chem. 269, 25303-25309.
183. Melotti, P., Ku, D. H., and Calabretta, B. (1994) Regulation of the expression of the hematopoietic stem cell antigen CD34: Role of c-myb. J. Exp. Med. 179, 1023-1028.
184. Miller, C., Kelsoe, G., and Han, S. (1994) Lack of B7-2 expression in the germinal centers of aged mice. Aging Immunol. Infect. Dis. 5, 249-252.
185. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., and Taniguchi, T. (1988) Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 54, 903-913.
186. Miyamoto, S., Schmitt, M. J., and Verma, I. M. (1994) Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 91, 5056-5060.
187. Modrowski, D., and Marie, P. J. (1993) Cells isolated from the endosteal bone surface of adult rats express differentiated osteoblastic characteristics in vitro. Cell Tissue Res. 271, 499-505.
188. Molnar, A., and Georgopoulos, K. (1994) The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14, 8292-8303.
189. Morales S., Gaspar M. L., Godin I., Dieterlen-Lievre F., Copin S. G., and Marcos M. A. R. (1995) Two early phases of lymphohematopoiesis in the mouse embryo. 9th International Congress of Immunology, Abstract No. 1594, The Conference Organizers, San Francisco, CA.
190. Mu, Z. M., Chin, K. V., Liu, J. H., Lozano, G., and Chang, K. S. (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol. Cell. Biol. 14,6858-6867.
191. Mucenski, M. L., McLain, K., Kier, A. B., Swerdlow, S. H., Schreiner, C. M., Miller, T. A., Pietryga, D. W., Scott, W. J.Jr., and Potter, S. S. (1991) A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65, 677-689.
192. Muller, A. M., Medvinsky, A., Strouboulis, J., Grosveld, F., and Dzierzak, E. (1994) Development of hematopoietic stem cell activity in the mouse embryo. Immunity 1, 291-301.
193. Nagasawa, T., Kikutani, H., and Kishimoto, T. (1994) Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 91,2305-2309.
194. Neish, A. S., Read, M. A., Thanos, D., Pine, R., Maniatis, T., and Collins, T. (1995) Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 15, 2558-2569.
195. Ness, S. A., and Engel, J. D. (1994) Vintage reds and whites: Combinatorial transcription factor utilization in hematopoietic differentiation. Curr. Opin. Genet. Dev. 4,718-724.
196. Neurath, M. F., Max, E. E., and Strober, W. (1995) Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription. Proc. Natl. Acad. Sci. U.S.A. 92, 5336-5340.
197. Neurath, M. F., Strober, W., and Wakatsuki, Y. (1994) The murine Ig3' alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP). J. Immunol. 153, 730-742.
198. Nguyen, H., Mustafa, A., Hiscott, J., and Lin, R. (1995) Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain. Oncogene 11, 537-544.
199. Nielsen, P. J., Wenger, R., Kopf, M., Nitschke, L., and Kohler, G. (1995) Disruption of the mouse CD24 (heat stable antigen) gene. 9th International Congress of Immunology, Abstract No. 1628, The Conference Organizers, San Francisco, CA.
200. Nilsson, S. K., Lieschke, G. J., Garcia Wijnen, C. C, Williams, B., Tzelepis, D., Hodgson, G., Grail, D., Dunn, A. R., and Bertoncello, I. (1995) Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouse. Blood 86, 66-72.
201. Nisitani, S., Tsubata, T., and Honjo, T. (1994) Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. Int. Immunol. 6, 909-916.
202. Nolan, G. P. (1994) NF-AT-AP-1 and Rel-bZIP: Hybrid vigor and binding under the influence. Cell 77, 795-798.
203. Ogasawara, J., Watanabe Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. (1993) Lethal effect of the anti-Fas antibody in mice [published erratum appears in Nature 365(6446):568 J. Nature 364, 806-809.
204. Ogawa, M., Nishikawa, S., Ikuta, K., Yamamura, F., Naito, M., and Takahashi, K. (1988) B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J. 7, 1337-1343.
205. Okabe, T., Watanabe, T., and Kudo, A. (1992) A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreBl gene. Eur. J. Immunol. 22, 37-43.
206. Okada, S., Wang, Z. Q., Grigoriadis, A. E., Wagner, E. F., and von Ruden, T. (1994) Mice lacking c-fos have normal hematopoietic stem cells but exhibit altered B-cell differentiation due to an impaired bone marrow environment. Mol. Cell. Biol. 14, 382-390.
207. Okumura, M., and Thomas, M. L. (1995) Regulation of immune function by protein tyrosine phosphatases. Curr. Opin. Immunol. 7, 312-319.
208. Opstelten, D., and Kwong, A. Y. H. (1996) Lymphocyte dynamics and the application of specific mRNA detection in situ. In: Handbook of Experimental Immunology (Weir, D. M., Herzenberg, L. A., et al. Eds.), 5th ed. Blackwell, London..
209. Orlic, D., Anderson, S., Biesecker, L. G., Sorrentino, B. P., and Bodine, D. M. (1995) Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Proc. Natl. Acad. Sci. U.S.A. 92, 4601-4605.
210. Osmond, D. G. (1985) The ontogeny and organization of the lymphoid system. J. Invest. Dermatol. 85, 2s
211. Osmond, D. G. (1990) B cell development in the bone marrow. Semin. Immunol. 2, 173-180.
212. Osmond, D. G. (1991) Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol. 3, 179-185.
213. Osmond, D. G. (1993) The turnover of B-cell populations [published erratum appears in Immunol Today 14(2):68] [see comments J. Immunol. Today. 14, 34-37.
214. Osmond, D. G., and Batten, S. J. (1984) Genesis of B lymphocytes in the bone marrow: Extravascular and intravascular localization of surface IgM-bearing cells in mouse bone marrow detected by electron-microscope radioautography after in vivo perfusion of 1251 anti-IgM antibody. Am. J. Anat. 170, 349-365.
215. Osmond, D. G., and Hales, P. (1996) Methodology of lymphocyte kinetics. In: Handbook of Experimental Immunology (Weir, D. M., Herzenberg, L. A., et al. Eds.), 5th ed. Blackwell, London.
216. Osmond, D. G., Kim, N., Manoukian, R., Phillips, R. A., Rico Vargas, S. A., and Jacobsen, K. (1992) Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice. Blood 79, 1695-1703.
217. Palacios, R., and Imhof, B. A. (1993) At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro. Proc. Natl. Acad. Set U.S.A. 90, 6581-6585.
218. Palacios, R., and Nishikawa, S. (1992) Developmentally regulated cell surface expression and function of c-kit receptor during lymphocyte ontogeny in the embryo and adult mice. Development 115, 1133-1147.
219. Perrotti, D., Melotti, P., Skorski, T., Casella, I., Peschle, C., and Calabretta, B. (1995) Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: Correlation with negative regulation of CD34 and c-myb promoter activity. Mol. Cell. Biol. 15, 6075-6087.
220. Peschon, J. J., Morrissey, P. J., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B. C., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. (1994) Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960.
221. Pfeffer, K., and Mak, T. W. (1994) Lymphocyte ontogeny and activation in gene targeted mutant mice. Annu. Rev. Immunol. 12, 367-411.
222. Pleiman, C. M., Gimpel, S. D., Park, L. S., Harada, H., Taniguchi, T., and Ziegler, S. F. (1991) Organization of the murine and human interleukin-7 receptor genes: Two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol. Cell. Biol. 11, 3052-3059.
223. Puvion Dutilleul, F., Chelbi Alix, M. K., Koken, M., Quignon, F., Puvion, E., and de The, H. (1995) Adenovirus infection induces rearrangements in the intranuclear distribution of the nuclear body-associated PML protein. Exp. Cell Res. 218, 9-16.
224. Rajewsky, K. (1993) B-cell lifespans in the mouse-why to debate what? [see comments]. Immunol. Today 14, 40-41.
225. Raju, K., Tang, S., Dube, I. D., Kamel Reid, S., Bryce, D. M, and Breitman, M. L. (1993) Characterization and developmental expression of Tlx-1, the murine homolog of HOX11. Meek Dev. 44, 51-64.
226. Ramsden, D. A., Paige, C. J., and Wu, G. E. (1994) Kappa light chain rearrangement in mouse fetal liver, J. Immunol. 153, 1150-1160.
227. Reddi, A. H., and Huggins, C. B. (1975) Formation of bone marrow in fibroblast-transformation ossicles. Proc. Natl. Acad. Sci. U.S.A. 72, 2212-2216.
228. Reis, L. F., Ruffner, H., Stark, G., Aguet, M., and Weissmann, C. (1994) Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J. 13, 4798-4806.
229. Rickert, R. C, Rajewsky, K., and Roes, J. (1995) Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice. Nature 376, 352-355.
230. Rico Vargas, S. A., Weiskopf, B., Nishikawa, S., and Osmond, D. G. (1994) c-kit expression by B cell precursors in mouse bone marrow. Stimulation of B cell genesis by in vivo treatment with anti-c-kit antibody. J. Immunol. 152, 2845-2852.
231. Roberts, C. W., Shutter, J. R., and Korsmeyer, S. J. (1994) Hoxll controls the genesis of the spleen. Nature 368, 747-749.
232. Roberts, C. W., Sonder, A. M., Lumsden, A., and Korsmeyer, S. J. (1995) Development expression of Hoxll and specification of splenic cell fate. Am. J. Pathol. 146, 1089-1101.
233. Roberts, S. G., and Green, M. R. (1995) Transcription. Dichotomous regulators [news; comment J. Nature 375, 105-106.
234. Roberts, V. J., Steenbergen, R., and Murre, C. (1993) Localization of E2A mRNA expression in developing and adult rat tissues. Proc. Natl. Acad. Set. U.S.A. 90, 7583-7587.
235. Roes, J. (1994) Insights into B-cell development by gene targeting, lmmunologist 2, 194-200.
236. Rolink, A., Andersson, J., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., Ten Boekel, E., Winkler, T., and Melchers, F. (1995) B-cell development in mouse and man. lmmunologist 3, 125-128.
237. Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., and Melchers, F. (1994) IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6, 1257-1264.
238. Rolink, A., Haasner, D., Nishikawa, S., and Melchers, F. (1993) Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice. Blood 81,2290-2300.
239. Rolink, A., Karasuyama, H., Haasner, D., Grawunder, U., Martensson, I. L., Kudo, A., and Melchers, F. (1994) Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol. Rev. 137, 185-201.
240. Rosenberg, N., and Kincade, P. W. (1994) B-lineage differentiation in normal and transformed cells and the microenvironment that supports it. Curr. Opin. Immunol. 6,203-211.
241. Rosendaal, M., and Adam, J. (1987) Haemopoietic progenitors in different parts of one femur perform different functions during regeneration. Blood Cells 12, 629-646.
242. Rosette, C., and Karin, M. (1995) Cytoskeletal control of gene expression: Depolymerization of microtubules activates NF-kappa B. J. Cell Biol. 128, 1111-1119.
243. Rosmarin, A. G., Caprio, D., Levy, R., and Simkevich, C. (1995) CD18 (beta -2 leukocyte integrin) promoter requires PU.l transcription factor for myeloid activity. Proc. Natl. Acad. Sci. U.S.A. 92, 801-805.
244. Rossant, J., Vijh, K. M., Grossi, C. E., and Cooper, M. D. (1986) Clonal origin of haematopoietic colonies in the postnatal mouse liver. Nature 319, 507-511.
245. Sauvageau, G., Lansdorp, P. M., Eaves, C. J., Hogge, D. E., Dragowska, W. H., Reid, D. S., Largman, C., Lawrence, H. J., and Humphries, R. K. (1994) Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc. Natl. Acad. Sci. U.S.A. 91, 12223-12227.
246. Scheerlinck, J. P. Y., Corcoran, L. M., and Handman, E. (1995) SCID mice reconstituted with Oct-2-deficient lymphocytes can cure Leishmania major infection and generate normal antigen-specific T cells. Immunol. Lett. 45, 215-217.
247. Schilham, M. W., Oosterwegel, M. A., Moerer, P., Ya, J., de Boer, P. A. J., van de Wetering, M., Verbeek, S., Lamers, W. H., Kruisbeek, A. M., Cumano, A., and Clevers, H. (1996) Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature, 380, 711-714.
248. Schilham, M. W., van Eijk, M., van de Wetering, M., and Clevers, H. C. (1993) The murine Sox-4 protein is encoded on a single exon. Nucleic Acids Res. 21, 2009.
249. Schlissel, M., Voronova, A., and Baltimore, D. (1991) Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5, 1367-1376.
250. Scott, E. W., Simon, M. C, Anastasi, J., and Singh, H. (1994) Requirement of transcription factor PU.l in the development of multiple hematopoietic lineages. Science 265, 1573-1577.
251. Sha, W. C, Liou, H. C, Tuomanen, E. I., and Baltimore, D. (1995) Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell 80, 321-330.
252. Shinjo, F., Hardy, R. R., and Jongstra, J. (1994) Monoclonal anti-lambda 5 antibody FS1 identifies a 130 kDa protein associated with lambda 5 and Vpre-B on the surface of early pre-B cell lines. Int. Immunol. 6, 393-399.
253. Sidman, C. L., Shaffer, D. J., Jacobsen, K., Vargas, S. R., and Osmond, D. G. (1993) Cell populations during tumorigenesis in Eu-myc transgenic mice. Leukemia 7, 887-895.
254. Siebenlist, U., Franzoso, G., and Brown, K. (1994) Structure, regulation and function of NF-kB. Annu. Rev. Cell Biol. 10, 405-455.
255. Simon, J. (1995) Locking in stable states of gene expression: Transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7, 376-385.
256. Singh, H. (1994) Genetic analysis of transcription factors implicated in B lymphocyte development. Immunol. Res. 13, 280-290.
257. Solvason, N., Lehuen, A., and Kearney, J. F. (1991) An embryonic source of Lyl but not conventional B cells. Int. Immunol. 3, 543-550.
258. Stoykova, A., and Gruss, P. (1994) Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J. Neurosci. 14, 1395-1412.
259. Strachan, T., and Read, A. P. (1994) PAX genes. Curr. Opin. Genet. Dev. 4, 427-438.
260. Stuart, E. T., Kioussi, C., and Gruss, P. (1993) Mammalian Pax genes. Annu. Rev. Genet. 27, 219-236.
261. Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi, M., and Yoshida, H. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Set U.S.A. 90, 9125-9129.
262. Sullivan, N. F., Watt, R. A., Delannoy, M. R., Green, C. L., and Spector, D. L. (1986) Colocalization of the myc oncogene protein and small nuclear ribonucleoprotein particles. Cold Spring Harb. Symp. Quant. Biol. 51 Pt 2, 943-947.
263. Sun, X. H. (1994) Constitutive expression of the Idl gene impairs mouse B cell development [see comments J. Cell 79, 893-900.
264. Surh, C. D., and Sprent, J. (1994) T-cell apoptosis detected in situ during positive and negative selection in the thymus [see comments], Nature 372, 100-103.
265. Szostecki, C., Guldner, H. H., Netter, H. J., and Will, H. (1990) Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J. Immunol. 145, 4338-4347.
266. Taichman, R. S., and Emerson, S. G. (1994) Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating f a c t o r. J. Exp. Med. 179, 1677-1682.
267. Takao, S., Sakai, N., Hatano, M., Koizumi, T., Hanioka, K., Ruther, U., and Tokuhisa, T. (1991) IgG response is impaired in H2-c-fos transgenic mice. Int. Immunol. 3,369-375.
268. Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M.S., Aizawa, S., Mak, T. W., and Taniguchi, T. (1994) Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77, 829-839.
269. Tarlinton, D. (1994) B-cell differentiation in the bone marrow and the periphery. Immunol. Rev. 137, 203-229.
270. Tawfic, S., and Ahmed, K. (1994) Growth stimulus-mediated differential translocation of casein kinase 2 to the nuclear matrix. Evidence based on androgen action in the prostate. J. Biol. Chem. 269, 24615-24620.
271. Ten Boekel, E., Melehers, F., and Rolink, A. (1995) The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7,1013-1019.
272. Terns, B., Baldin, V., Dubois, S., Degott, C., Flejou, J. F., Henin, D., and Dejean, A. (1995) PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res. 55, 1590-1597.
273. Thanos, D., and Maniatis, T. (1995) NF-kappa B: A lesson in family values. Cell 80, 529-532.
274. Tjian, R., and Maniatis, T. (1994) Transcriptional activation: a complex puzzle with few easy pieces. Cell 77, 5-8.
275. Tokuhisa T., Hu L., and Imoto S. (1995) A role of c-fos/AP-1 in the development of pre-B cells. 9th International Congress of Immunology, Abstract No. 1615, The Conference Organizers, San Francisco, CA.
276. Tornberg, U. C, and Holmberg, D. (1995) B-la, B-lb and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures. EMBO J. 14, 1680-1689.
277. Trauth, K., Mutschler, B., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Klempnauer, K. H. (1994) Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes. EMBO J. 13, 5994-6005
278. Tsai, F. Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., and Orkin, S. H. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371, 221-226.
279. Ulich, T. R., and del Castillo, J. (1991) The hematopoietic and mature blood cells of the rat: Their morphology and the kinetics of circulating leukocytes in control rats. Exp. Hematol. 19, 639-648.
280. Urbanek, P., Wang, Z. Q., Fetka, I., Wagner, E. F., and Busslinger, M. (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP [see comments J. Cell 79, 901-912.
281. Van de Wetering, M., Oosterwegel, M., van Norren, K., and Clevers, H. (1993) Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J. 12, 3847-3854.
282. Van der Lugt, N. M. T., Domen, J., Linders, K., van Roon, M., Robanus Maandag, E., Te Riele, H., Van der Valk, M., Deschamps, J., Sofroniew, M., van Lohuizen, M., and Berns, A. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto- oncogene. Genes Dev. 8, 757-769.
283. Vassalli, J., and Stutz, A. (1995) Awakening dormant mRNAs. Curr. Biol. 5, 476-479.
284. Vaughan, P. S., Aziz, F., Vanwijnen, A. J., Wu, S. J., Harada, H., Taniguchi, T., Soprano, K. J., Stein, J. L., and Stein, G. S. (1995) Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature 377, 362-365.
285. Viney, J. L. (1994) Transgenic and knockout models for studying diseases of the immune system. Curr. Opin. Genet. Dev. 4, 461-465.
286. Vriz, S., Lemaitre, J. M., Leibovici, M., Thierry, N., and Mechali, M. (1992) Comparative analysis of the intracellular localization of c-Myc, c-Fos, and replicative proteins during cell cycle progression. Mol. Cell. Biol. 12, 3548-3555.
287. Wakatsuki, Y., Neurath, M. F., Max, E. E., and Strober, W. (1994) The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179, 1099-1108.
288. Walther, C., Guenet, J. L., Simon, D., Deutsch, U., Jostes, B., Colliding, M. D., Plachov, D., Balling, R., and Gruss, P. (1991) Pax: A murine multigene family of paired box-containing genes. Genomics 11, 424-434.
289. Wang, Z. Q., Ovitt, C., Grigoriadis, A. E., Mohle Steinlein, U., Ruther, U., and Wagner, E. F. (1992) Bone and haematopoietic defects in mice lacking c-fos. Nature 360, 741-745.
290. Wasylyk, B., Hahn, S. L., and Giovane, A. (1993) The Ets family of transcription factors. Eur. J. Biochem. 211, 7-18.
291. Weih, F., Carrasco, D., and Bravo, R. (1994) Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene 9, 3289-3297.
292. Weih, F., Carrasco, D., Durham, S. K., Barton, D. S., Rizzo, C. A., Ryseck, R. P., Lira, S. A., and Bravo, R. (1995) Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 80, 331-340.
293. Weiss, L. (1983) Bone marrow. In: Histology: Cell and Tissue Biology (Weiss, L., Ed.), 5th ed. Macmillan, New York.
294. Weiss, M. J., and Orkin, S. H. (1995) GATA transcription factors: Key regulators of hematopoiesis. Exp. Hematol. 23, 99-107.
295. Welch, P. A. (1995) Regulation of B cell precursor proliferation by aminopeptidase A. Int. Immunol. 7, 737-746.
296. Willman, C. L., Sever, C. E., Pallavicini, M. G., Harada, H., Tanaka, N., Slovak, M. L., Yamamoto, H., Harada, K., Meeker, T. C, List, A. F., et al. (1993) Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 259, 968-971.
297. Winkler T.H., Grawunder U., Rolink A., and Melchers F. (1995) Shutdown of RAG-1 and RAG-2 gene expression in pre-B cells after expression of a μ-heavy chain-surrogate light chain receptor complex. 9th International Congress of Immunology, Abstract No. 1587, The Conference Organizers, San Francisco, CA.
298. Winkler, T. H., Melchers, F., and Rolink, A. G. (1995) Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Blood 85, 2045-2051.
299. Winkler, T. H., Rolink, A., Melchers, F., and Karasuyama, H. (1995) Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur. J. Immunol. 25, 446-450.
300. Wolffe, A. P. (1994) The transcription of chromatin templates. Curr. Opin. Genet. Dev. 4, 245-254.
301. Wu, X. Y., Miyake, K., Medina, K. L., Kincade, P. W., and Gimble, J. M. (1994) Recognition of murine integrin /31 by a rat anti-stromal cell monoclonal antibody. Hybridoma 13, 409-416.
302. Yamada, G., Ogawa, M., Akagi, K., Miyamoto, H., Nakano, N., Itoh, S., Miyazaki, J., Nishikawa, S., Yamamura, K., and Taniguchi, T. (1991) Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 88, 532-536.
303. Yamamoto, H., Lamphier, M. S., Fujita, T., Taniguchi, T., and Harada, H. (1994) The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain. Oncogene 9, 1423-1428.
304. Yang, Z., Gu, L., Romeo, P. H., Bories, D., Motohashi, H., Yamamoto, M., and Engel, J. D. (1994) Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains. Mol. Cell. Biol. 14,2201-2212.
305. Zelent, A. (1994) Translocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia. Br. J. Haematol. 86, 451-460.
306. Zhuang, Y., Soriano, P., and Weintraub, H. (1994) The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875-884.
307. Zipori, D. (1989) Stromal cells from the bone marrow: Evidence for a restrictive role in regulation of hemopoiesis. Eur. J. Haematol. 42, 225-232.
308. Zubiaga A. M., and Greenberg M. E. (1995) Proliferative defects in mature T cells lacking c-fos. 9th Internationa] Congress of Immunology, Abstract No. 4119, The Conference Organizers, San Francisco, CA.