The human genome contains only two CYP11B (P450c11) genes

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 9, 1996, Pages 3254-3256

  Zhang, Guangren ^a   Miller, Walter L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RENIN; STEROID 11BETA MONOOXYGENASE;

ARTICLE; BLOOD PRESSURE REGULATION; ENZYME ACTIVITY; GENOME; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; RENIN ANGIOTENSIN DISORDER; RENOVASCULAR HYPERTENSION; SOUTHERN BLOTTING; STEROIDOGENESIS;

ALDOSTERONE SYNTHASE; ANIMALS; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CLONING, MOLECULAR; COSMIDS; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA RESTRICTION ENZYMES; GENE LIBRARY; GENOME, HUMAN; HUMANS; ISOENZYMES; POLYMERASE CHAIN REACTION; RATS; SEQUENCE ANALYSIS, DNA; STEROID 11-BETA-HYDROXYLASE;

EID: 0029795413     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.9.3254     Document Type: Article

References (11)

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2. Mornet E, Dupont J, Vitek A, White PC. 1989 Characterization of two genes encoding human steroid 11β-hydroxylase (P45011β). J Biol Chem. 264:20961-20967.
3. Curnow KM, Tusie-Luna M, Pascoe L, et al. 1991 The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol Endocrinol. 5:1513-1522.
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9. Pascoe L, Curnow K, Slutsker L, et al. 1992 Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossover between CYP11B1 and CYP11B2. Proc Natl Acad Sci USA. 89:8372-8331.
10. Lifton R, Dluhy KG, Powers M, Rich GM, Cook S, Ulick S, Lalouel JM. 1992 A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature. 335:262-265.
11. Yabu M, Senda T, Nonaka Y, Matsukawa N, Okamoto M, Fujita H. 1991 Localization of the gene transcripts of 11β-hydroxylase and aldosterone synthase in the rat adrenal cortex by in situ hybridization. Histochemistry. 96:391-394.