Protection against septic shock in mice with SJC13, an azaindolidine derivative that is a cell adhesion molecule inhibitor

Inflammation Research

Volumn 45, Issue 9, 1996, Pages 448-451

  Sakai, A ^a  

^a ZENYAKU KOGYO CO LTD   (Japan)

Author keywords

Azaindolidine derivative; Cell adhesion molecule inhibitor; Mice; Neutrophil; Septic shock

Indexed keywords

ACETIC ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYELOPEROXIDASE; SJC 13; SODIUM [(2,8 DIISOPROPOXYIMIDAZO [1,2A] PYRIDIN 3 YL)METHYLENE]CYANOACETATE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; INTRAVENOUS DRUG ADMINISTRATION; LETHALITY; LEUKOCYTE MIGRATION; LUNG PARENCHYMA; MESSENGER RNA SYNTHESIS; MOUSE; NEUTROPHIL; NONHUMAN; SEPTIC SHOCK; UMBILICAL VEIN;

EID: 0029795387     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02252315     Document Type: Article

References (26)

1. Butcher EC. Cellular and molecular mechanisms that direct leukocyte traffic. Am J Pathol 1990;136:3-11.
2. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033-6.
3. Picker LJ, Butcher EC. Physiological and molecular mechanisms of lymphocyte homing. Am Rev Immunol 1992;10:561-91.
4. Osborn L. Leukocyte adhesion to endothelium in inflammation. Cell 1990;62:3-6.
5. Morrison DC, Ulevitch RJ. The effects of bacterial endotoxins on host mediation system. Am J Pathol 1978;93:526-30.
6. Issekutz AC, Bhimji S. Role of endotoxin in the leukocyte infiltration accompanying Escherichia coli inflammation. Infect Immun 1982;36:558-63.
7. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994;84:2068-101.
8. Barton RW, Rothlein R, Ksiazak J, Kennedy C. The effect of anti-intercellular adhesion molecule-1 on phorbol-ester-induced rabbit lung inflammation. J Immunol 1989;143:1278-82.
9. Mulligan MS, Varani J, Dame MK, Lane CL, Smith CW, Anderson DC, et al. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest 1991;88:1396-406.
10. Gundel RH, Wegner CD, Torcellini CA, Clarke CC, Haynes N, Rothlein R, et al. Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys. J Clin Invest 1991;88:1407-11.
11. Bogen S, Pak J, Garifallou M, Deng X, Muller WA. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med 1994;179:1059-64.
12. Watson SR, Fennie C, Lasky LA. Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera. Nature 1991;349:164-7.
13. Mulligan MS, Watson SR, Fennie C, Ward PA. Protective effects of selectin chimeras in neutrophil-mediated lung injury. J Immunol 1993;151:6410-7.
14. Mulligan MS, Paulson JC, Frees SD, Zheng Z-Li, Loue JB, Ward PA. Protective effects of oligosaccharides in P-selectin-dependent lung injury. Nature 1993;364:149-51.
15. Nelson RM, Cecconio, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 1993;82:3253-8.
16. Rozdzinski E, Jones T, Burnette WN, Burroughs M, Tuomanen E. Antiinflammatory effects in experimental meningitis of prokaryotic peptides that mimic selectins. J Infect Dis 1993;168:1422-8.
17. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987;38:175-94.
18. Xu H, Gonzalo JA, St. Pierre Y, Williams IR, Kupper TS, Cotran RS, et al. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med 1994;180:95-109.
19. Bullard DC, Qin L, Lorenzo I, Quinlin WM, Doyle NA, Bosse R, et al. P-selectin ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J Clin Invest 1995;95:1782-8.
20. Sakai A. Inhibition of endothelial cell adhesion molecule expression with SJC13, an azaindolidine derivative, in vitro. Inflamm Res 1996;45:224-9.
21. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 1984;87:1344-50.
22. Movat HZ, Cybulsky MI, Colditz IG, Chan MKW, Dinarello CA. Acute inflammation in gram-negative infection: endotoxin, interleukin 1, tumor necrosis factor, and neutrophils. FASEB J 1987;46:97-101.
23. Worthen GS, Haslett C, Smedly LA, Rees AJ, Gumbay RS, Henson JE, et al. Lung vascular injury induced by chemotactic factors: enhancement by bacterial endotoxins. FASEB J 1986;45:7-12.
24. Wilson ME. Effects of bacterial endotoxins on neutrophil function. Rev Infec Dis 1985;7:404-19.
25. Redl H, Dinges HP, Buurman WA, van der Linden CJ, Pober JS, Cotran RS, Schlag G. Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic hypovolemic shock in the baboon. Am J Pathol 1991;139:461-6.
26. Munro JM, Pober JS, Cotran RS. Recruitment of neutrophils in the local endotoxin response: association with de novo endothelial expression of endothelial leukocyte adhesion molecule-1. Lab Invest 1991;64:295-9.