Human immunodeficiency virus infection of human cells transplanted to severe combined immunodeficient mice

Advances in Immunology

Volumn 63, Issue , 1996, Pages 79-125

  Mosier, Donald E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; VIRUS DNA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRUS IMMUNITY; VIRUS ISOLATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; XENOGRAFT;

EID: 0029795385     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (288)

1. Abedi, M. R., Christensson, B., Islam, K. B., Hammarstrom, L., and Smith, C. I. (1992). Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells. Eur J Immunol 22, 823-828.
2. Achim, C. L., Miners, D. K., Burrola, P. G., Martin, F. C., and Wiley, C. A. (1993). In vivo model of HIV infection of the human brain. Dev Neurosci 15, 423-432.
3. Achim, C. L., and Wiley, C. A. (1994). In vivo model of HIV infection of the human brain. Adv Neuroimmunol 4, 261-264.
4. Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E., and Trono, D. (1994). Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76, 853-864.
5. Aiken, C, and Trono, D. (1995). Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 69, 5048-5056.
6. Aldrovandi, G., and Zack, J. (1996). Replication and pathogenicity of HIV-1 accessory gene mutants in SCID-hu mice. J Virol 70, 1505-1511.
7. Aldrovandi, G. M., Feuer, G., Gao, L., Jamieson, B., Kristeva, M., Chen, I. S., and Zack, J. A. (1993). The SCID-hu mouse as a model for HIV-1 infection. Nature 363, 732-736.
8. Alegre, M.-L., Peterson, L., Jeyarahah, D., Weiser, M., Bluestone, J., and Thistlethwaite, J. (1994). Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol. 153, 3738-3749.
9. Ambrosino, D. M., Wang, M., Ciamarra, A., Chan, M., Bolon, D. L., Minn, J., Jacobsohn, D. A., and Finberg, R. W. (1994). T cells and natural killer cells regulate human IgG subclass concentrations in SCID mice. Cell Immunol 155, 134-143.
10. Ameisen, J. C, and Capron, A. (1991). Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol Today 12, 102-105.
11. Antonioli, I. M., Baumberger, C, Yerly, S., and Perrin, L. (1995). V3 sequences in primary HIV-1 infection. Aids 9, 11-17.
12. Arthur, L. O., Bess, J. W., Waters, D. J., Pyle, S. W., Kelliher, J. C, Nara, P. L., Krohn, K., Robey, W. G., Langlois, A. J., Gallo, R. C, and Fischinger, P. J. (1989). Challenge of chimpanzees (Pan troglodytes) immunized with human immunodeficiency virus envelope glycoprotein g p l 2 0. J. Virol. 63, 5046-5053.
13. Ascher, M., and Sheppard, H. (1988). AIDS as an immune system activation: A model for pathogenesis. Clin Exp Immunol 73, 1651-1657.
14. Baba, T., Jeong, Y., Penninck, D., Branson, R., Greene, M., and Ruprecht, R. (1995). Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1824.
15. Baier, M., Werner, A., Bannert, N., Metzner, K., and Kurth, R. (1996). HIV suppression by interleukin-16 Nature 378, 563.
16. Balliet, J. W., Kolson, D. L., Eiger, G., Kim, F. M., McGann, K. A., Srinivasan, A., and Collman, R. (1994). Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: Mutational analysis of a primary HIV-1 isolate. Virology 200, 623-631.
17. Bandres, J. C, Shaw, A. S., and Ratner, L. (1995). HIV-1 Nef protein downregulation of CD4 surface expression: Relevance of the Ick binding domain of CD4. Virology 207, 338-341.
18. Barre-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C., Rozenbaum, W., and Montagnier, L. (1983). Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871.
19. Barry, T. S.Jones, D. M., Richter, C. B., and Haynes, B. F. (1991). Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: Differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. J Exp Med 173, 167-180.
20. Bestian, J. M., Janin, A., Zenner, I., Zelus, D., Pruvot, F. R., Dessaint, J. P., and Capron, A. (1995). Biliary duct lesions following zenogeneic liver and peripheral blood lymphocyte grafts in SCID mice. Transplant Proc 27, 1720.
21. Blunt, T., Finnie, N. J., Tacciolo, G. E., Smith, G. C, Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A., and Jackson, S. P. (1995). Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
22. Bonagura, V. R., Cunningham-Rundles, S. L., and Schuval, S. (1992). Dysfunction of natural killer cells in human immunodeficiency virus-infected children with or without Pneumocystis carinii pneumonia. J Pediatr 121, 195-201.
23. Bonyhadi, M. L, Rabin, L., Salimi, S., Brown, D. A., Kosek, J., McCune, J. M., and Kaneshima, H. (1993). HIV induces thymus depletion in vivo. Nature 363, 728-732.
24. Bosma, M., Schuler, W., and Bosma, G. (1988). The scid mouse mutant. Curr Top Microbiol Immunol 137, 197-202.
25. Bou-Habib, D., Rodriquez, G., Oravecz, T., Berman, P., and Norcross, M. (1994). Cryptic nature of envelope V3 region epitope protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization. J Virol 68, 6006-6013.
26. Boyle, M. J., Connors, M., Flanigan, M. E., Geiger, S. P., Ford, H., Jr., Baseler, M., Adelsberger, J., Davey, R. T., Jr., and Lane, H. C. (1995). The human HIV/peripheral blood lymphocyte (PBL)-SCID mouse. A modified human PBL-SCID model for the study of HIV pathogenesis and therapy. J Immunol 154, 6612-6623.
27. Bozzette, S., McCutchan, J., Spector, S., Wright, B., and Richamn, D. (1993). A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing human immunodeficiency virus. J Infect Dis 168, 1374-1379.
28. Burke, A. P., Anderson, D., Benson, W., Turnicky, R., Mannan, P., Liang, Y. H., Smialek, J., and Virmani, R. (1995). Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch Pathol Lab Med 119, 36-41.
29. Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Parren, P. W., Sawyer, L. S., Hendry, R. M., Dunlop, N., Nara, P. L., Lamacchia, M. Garratty, E., Stiehm, E. R., Bryson, Y. J., Cao, Y., Moore, J. P., Ho, D. D., and Barbas, C. F., III. (1994). Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 266, 1024-1027.
30. Calenda, V., and Chermann, J. (1992). The effects of HIV on hematopoiesis. Eur. J Hematol 48, 181-186.
31. Canivet, M., Hoffman, A. D., Hardy, D., Sematinger, J., and Levy, J. A. (1990). Replication of HIV-1 in a wide variety of animal cells following phenotypic mixing with murine retroviruses. Virology 178, 543-551.
32. Castro, B., Barnett, S., Evans, L., Moreau, J., Odehouri, K., and Levy, J. (1990). Biologic heterogeneity of human immunodeficiency virus type 2 (HIV-2) strains. Virology 178, 527-534.
33. Castro, B. A., Cheng-Mayer, C, Evans, L. A., and Levy, J. A. (1988). HIV heterogeneity and viral pathogenesis. Aids 2 (Suppl. 1), S17-27.
34. + cells from infected and uninfected chimpanzees. Cell Immunol 132, 246-255.
35. Cavallo, R., Valente, G., Jemma, C, Gribaudo, G., Landolfo, S., and Cavallo, G. (1994). Presence of murine retroviral sequences in human cell line transplanted in immunosuppressed SCID-mice. Microhiologica 17, 195-202.
36. Cesbron, J. Y., Agut, H., Gosselin, B., Candotti, D., Raphael, M., Puech, F., Grandadam, M., Debre, P. Capron, A., and Autran, B. (1994). SCID-Hu mouse as a model for human lung HIV-1 infection. C R Acad Sci III 317, 669-674.
37. Chang, Y., Cesarman, E., Pessin, M., Lee, F., Culpepper, J., Knowles, D., and Moore, P. (1994). Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 226, 1865-1869.
38. Chapman, L., Folks, T., Salomon, D., Patterson, A., Eggerman, T., and Noguchi, P. (1995). Xenotransplantation and xenogeneic infections. N Engl J Med 333, 1498-1501.
39. Cheng-Mayer, C, and Levy, J. A. (1988). Distinct biological and serological properties of human immunodeficiency viruses from the brain. Ann Neurol 23 Suppl, S58-61.
40. Cheng-Mayer, C, Quiroga, M., Tung, J., Dina, D., and Levy, J. (1990). Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation. J Virol 64, 4390-4398.
41. Cheng-Mayer, C, Seto, D., Tateno, M., and Levy, J. A. (1988). Biologic features of HIV that correlate with virulence in the host. Science 240, 80-82.
42. Chesebro, B., Wehrly, K., Nishio, J., and Perryman, S. (1992). Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison to T cell-tropic isolates: Definition of critical amino acids involved in cell t r o p i s m. J. Virol 66, 6547-6554.
43. Chin, L. T., Ifversen, P., Kristensson, K., Wahren, B., Carlsson, R., and Borrebaeck, C. A. (1994). Human ThO-type T helper-cell clone supports antigen-specific immunoglobulin production in scid/beige-hu mice, Scand J Immunol 40, 529-534.
44. Clerici, M., Shearer, G., Hounsell, E. F., Jameson, B., Habeshaw, J., and Dalgleish, A. G. (1993). Alloactivated cytotoxic T cells recognize the carboxy-terminal domain of human immunodeficiency virus-1 gpl20 envelope glycoprotein. Eur J Immunol 23, 2022-2025.
45. + T cells. Science 270, 1811-1815.
46. Coffin, J. (1995). HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
47. Coffin, J., Haase, A., Levy, J. A., Montagnier, L., Oroszlan, S., Teich, N., Temin, H., Toyoshima, K., Varmus, H., Vogt, P., and Weiss, R. (1986). What to call the AIDS virus? Nature 321, 10. [Letter]
48. Collman, R., Balliet, J. W., Gregory, S. A., Friedman, H., Kolson, D. L., Nathanson, N., and Srinivasan, A. (1992). An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J Virol 66, 7517-7521.
49. + lymphocyte decline and clinical progression in human immunodeficiency virus type-1 infected individuals. J Virol 67, 1772-1777.
50. Cooney, E. L., McElrath, M. J., Corey, L., Hu, S. L., Collier, A. C, Arditti, D., Hoffman, M., Coombs, R. W., Smith, G. E., and Greenberg, P. D. (1993). Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gpl60 protein. Proc Natl Acad Sci USA 90, 1882-1886.
51. Cordonnier, A., Montagnier, L., and Emerman, M. (1989). Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Nature 340, 571-574.
52. Cullen, B. R. (1994). The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology 205, 1-6.
53. Daar, E. S., Moudgil, T., Meyer, R. D., and Ho, D. D. (1991). Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324, 961-964.
54. Dalgleish, A. G. (1993). What is the role of autoimmunity in AIDS? Autoimmunity 15, 237-244.
55. Dalgleish, A. G., Beverley, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F., and Weiss, R. A. (1984). The CD4 (T4) antigen is an essential component of the receptor for the AIDs retrovirus. Nature 312, 763-767.
56. Daniel, M. D., Kirchhoff, F., Czajak, S. C, Sehgal, P. K., and Desrosiers, R. C. (1992). Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941.
57. Deacon, N., Tsykin, A., Solomon, A., Smith, K., Ludford-Menting, M., Hooker, D., McPhee, D., Greenway, A., Ellett, A., Chatfield, C, Lawson, V., Crowe, S., Maerz, A., Sonza, S., Learmont, J., Sullivan, J., Cunningham, A., Dwyer, D., Dowton, D., and Mills, J. (1995). Genomic structure of an attenuated quasispecies of HIV-1 from a blood donor and recipients. Science 270, 988-991.
58. Desrosiers, R. C, Daniel, M. D., Li, Y., and Levy, J. A. (1989). HIV-related Antiviruses of nonhuman primates: Pathogenesis of human immunodeficiency virus infection. AIDS Res Hum Retroviruses 5, 465-473.
59. smmPB14. Nature 345, 636-640.
60. Dickey, W. D., Harley, J. B., and Scofield, R. H. (1994). Human autoantibody production in the severe combined immunodeficiency (scid) mouse. Clin Exp Rheumatol 12,157-161.
61. Dimitrov, D. S., Martin, M. A., Dimitrov, D. S., Willey, R. L., Sato, H., Chang, L. J., Blumenthal, R., and Martin, M. A. (1995). HIV results in the frame. CD4+ cell turnover: Quantitation of human immunodeficiency virus type 1 infection kinetics. Nature 375, 194-195.
62. Dimitrov, D. S., Willey, R. L., Sato, H., Chang, L. J., Blumenthal, R., and Martin, M.A. (1993). Quantitation of human immunodeficiency virus type 1 infection kinetics. J. Virol 67, 2182-2190.
63. Doolittle, R. (1989). Immunodeficiency viruses: The simian-human connection. Nature 339, 338-339.
64. Dorshkind, K., Pollack, S. B., Bosma, M. J., and Phillips, R. A. (1985). Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J Immunol 134, 3798-3801.
65. Du, Z., Lang, S. M., Sasseville, V. G., Lackner, A. A., Ilyinskii, P. O., Daniel, M. D., Jung, J. U., and Desrosiers, R. C. (1995). Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82, 665-674.
66. Duchosal, M. A., Eming, S. A., McConahey, P. J., and Dixon, F. J. (1992). Characterization of hu-PBL-SCID mice with high human immunoglobulin serum levels and graft-versus-host disease. Am J Pathol 141, 1097-1113.
67. Duchosal, M. A., McConahey, P. J., Robinson, C. A., and Dixon, F. J. (1990). Transfer of human systemic lupus erythematosus in severe combined immunodefieient (SCID) mice. J Exp Med 172, 985-988.
68. Evans, L., Moreau, J., Odehouri, K., Legg, H., Barboza, A., Cheng-Mayer, C, and Levy, J. (1988a). Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression. Science 240, 1522-1525.
69. Evans, L. A., MoHugh, T. M., Stites, D. P., and Levy, J. A. (1987). Differential ability of human immunodeficiency virus isolates to productively infect human cells. J Immunol 138, 3415-3418.
70. Evans, L. A., Moreau, J., Odehouri, K., Seto, D., Thomson-Honnebier, G., Legg, H., Barboza, A., Cheng-Mayer, C, and Levy, J. A. (1988b). Simultaneous isolation of HIV-1 and HIV-2 from an AIDS patient. Lancet 2, 1389-1391.
71. Fauci, A. S. (1988). Immunodeficiency virus: Infectivity and mechanisms of pathogenesis. Science 239, 617-622.
72. Finkel, T., Tudor-Williams, G., Banda, N., Cotton, M., Curiel, T., Monks, C, Baba, T., Ruprecht, R., and Kupfer, A. (1995). Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1, 129-134.
73. Gagnon, R., Boutin, Y., and Hebert, J. (1995). Lol p I-specific IgE and IgG synthesis by peripheral blood mononuclear cells from atopic subjects in SCID mice. J Allergy Clin Immunol 95, 1268-1275.
74. Gallo, R., Wong-Staal, F., Montagnier, L., Haseltine, W. A., and Yoshida, M. (1988). HIV/ HTLV gene nomenclature. Nature 333, 504. [Letter]
75. Gary, A., Verma, S., Barcena, A., and Spits, H. (1993). Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34: Delineation of early events in thymic development. J Exp Med 178, 391-401.
76. Gardner, M. B., and Luciw, P. A. (1989). Animal models of AIDS. FASEB J 3, 2593-3606.
77. Gartner, S., Markovits, P., Markovitz, D., Kaplan, M., Gallo, R., and Popovic, M. (1986). The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233, 215-219.
78. Gauduin, M. C, Safrit, J. T., Weir, R., Fung, M. S., and Koup, R. A. (1995). Pre- and postexposure protection against human immunodeficiency virus type 1 infection mediated by a monoclonal antibody. J Infect Dis 171, 1203-1209.
79. Gendelman, H. E., Orenstein, J. M., Baca, L. M., Weiser, B., Burger, H., Kalter, D. C, and Meltzer, M. S. (1989). The macrophage in the persistence and pathogenesis of HIV infection. Aids 3, 475-495.
80. Gendelman, H. E., Orenstein, J. M., Martin, M. A., Ferrua, C, Mitra, R., Phipps, T., Wahl, L. A., Lane, H. C, Fauci, A. S., Burke, D. S., Skillman, D., and Meltzer, M. S. (1988). Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167, 1428-1441.
81. Gibbs, J., Regier, D., and Desrosiers, R. (1994). Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res Human Retrovir 10, 343-350.
82. Goan, S. R., Fichtner, I., Just, U., Karawajew, L., Schultze, W., Krause, K. P., von Harsdorf, S., von Schilling, C., and Herrmann, F. (1995). The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: A xenotransplant model for huPBSC-initiated hematopoiesis. Blood 86, 89-100.
83. Goldsmith, M. A., Warmerdam, M. T., Atchison, R. E., Miller, M. D., and Greene, W. C. (1995). Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J Virol 69, 4112-4121.
84. Gorczyca, W., Bruno, S., Darzynkiewicz, R. J., Gong, J., and Darzynkiewicz, Z. (1992). DNA strand breaks occurring during apoptosis: Their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1, 639-648.
85. Gougeon, M. L., Colizzi, V., Dalgleish, A., and Montagnier, L. (1993). New concepts in AIDS pathogenesis. AIDS Res Hum Retroviruses 9, 287-289.
86. Grandadam, M., Cesbron, J. Y., Candotti, D., Vinatier, D., Pauchard, M., Capron, A., Debre, P., Huraux, J. M., Autran, B., and Agut, H. (1995). Dose-dependent systemic human immunodeficiency virus infection of SCID-hu mice after intraperitoneal virus injection. Res Virol 146, 101-112.
87. Graziosi, C., Pantaleo, G., Butini, L., Demarest, J., Saag, M., Shaw, G., and Fauci, A. (1993a). DNA and RNA synthesis during primary HIV-1 infection. Proc Natl Acad Sci USA 90, 6405-6409.
88. Graziosi, C., Pantaleo, G., Butini, L., Demarest, J. F., Saag, M. S., Shaw, G. M., and Fauci, A. S. (1993b). Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. Proc. Natl Acad Sci USA 90, 6405-6409.
89. Greiner, D. L., Shultz, L. D., Yates, J., Appel, M. C., Perdrizet, G., Hesselton, R. M., Schweitzer, I., Beamer, W. G., Shultz, K. L., Pelsue, S. C., Leif, J. H., and Rajan, T. V. (1995). Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am J Pathol 146, 888-902.
90. Gruters, R. A., Terpstra, F. G., De Goede, R. E., Mulder, J. W., De Wolf, F., Schellekens, P. T., Van Lier, R. A., Tersmette, M., and Miedema, F. (1991). Immunological and virological markers in individuals progressing from seroconversion to AIDS. Aids 5, 837-844.
91. Hasui, M., Miyawaki, T., Ichihara, T., Niida, Y., Iwai, K., Yachie, A., Seki, H., and Taniguchi, N. (1994). Mature helper T cell requirement for immunoglobulin production by neonatal native B cells injected intraperitoneally into severe combined immunodeficient (SCID) mice. Clin Exp Immunol 95, 357-361.
92. dc2 activity. J Virol 69, 6705-6711.
93. Heinzinger, N., Bukrinsky, M., Haggerty, S., Ragland, A., Kewalramani, V., Lee, M.-A., Gendelman, H., Ratner, L., Stevenson, M., and Emerman, M. (1994). The vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci USA 91, 7311-7315.
94. Henrard, D. R., Daar, E., Farzadegan, H., Clark, S. J., Phillips, J., Shaw, G. M., and Busch, M. P. (1995). Virologic and immunologic characterization of symptomatic and asymptomatic primary HIV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol 9, 305-310.
95. Herndier, B. G., Shiramizu, B. T., and McGrath, M. S. (1992). AIDS associated non-Hodgkin's lymphomas represent a broad spectrum of monoclonal and polyclonal lymphoproliferative processes. Curr Topics Microbiol Immunol 182, 385-394.
96. Hesselton, R. M., Koup, R. A., Cromwell, M. A., Graham, B. S., Johns, M., and Sullivan, J. L. (1993). Human peripheral blood xenografts in the SCID mouse: Characterization of immunologic reconstitution. J Infect Dis 168, 630-640.
97. Ho, D., Neumann, A., Perelson, A., Chen, W., Leonard, J., and Markowitz, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126.
98. Ho, D. D., Bredesen, D. E., Vinters, H. V., and Daar, E. S. (1989). The acquired immunodeficiency syndrome (AIDS) dementia complex. Ann Intern Med 111, 400-410.
99. Hoch, J., Lang, S., Weeger, M., Stahl-Hennig, C, Coulibaly, C, Dittmer, U., Hunsmann, G., Fuchs, D., Muller, J., Sopper, S., Fleckenstein, B., and Uberla, K. (1995). vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. J Virol 69, 4807-4813.
100. Hoffmann-Fezer, G., Gall, C., Zengerle, U., Kranz, B., and Thierfelder, S. (1993). Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice. Blood 81, 3440-3448.
101. Hoffmann-Fezer, G., Kranz, B., Gall, C, and Thierfelder, S. (1992). Peritoneal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein-Barr virus-negative donors. Eur J Immunol 22, 3161-3166.
102. Hozumi, N., Gorczynski, R., Peters, W., and Sandhu, J. S. (1994). A SCID mouse model for human immune response and disease. Res Immunol 145, 370-379.
103. Hu, S.-L., Kosowshi, S. G., and Dalrymple, J. M. (1986). Expression of AIDS virus envelope gene in recombinant vaccinia viruses. Nature 320, 537-540.
104. Hwang, S. S., Boyle, T. J., Lyerly, H. K., and Cullen, B. (1991). Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253, 71-74.
105. Ifversen, P., Martensson, C, Danielsson, L., Ingvar, C, Carlsson, R., and Borrebaeck, C. A. (1995). Induction of primary antigen-specific immune responses in SCID-hu-PBL by coupled T-B epitopes. Immunology 84, 111-116.
106. Jabbar, M. A. (1995). The human immunodeficiency virus type 1 Vpu protein: Roles in virus release and CD4 downregulation. Curr Top Microbiol Immunol 193, 107-120.
107. Jamieson, B., Aldrovandi, G., Planelles, V., Jowett, J. Gao, L., Bloch, L., Chen, I., and Zack, J. (1994). Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol 68, 3478-3485.
108. Jamieson, B., Pang, S., Aldrovandi, G., Zha, J., and Zack, J. (1995). In vivo pathogenic properties of two clonal HIV-1 i s o l a t e s. J. Virol 69, 6259-6264.
109. Jowett, J., Planelles, V., Poon, B., Shah, N., Chen, M.-L., and Chen, I. (1995). The HIV-1 vpr gene arrests infected T-cells in the G2+M phase of the cell cycle. J Virol 69, 6304-6313.
110. Kahn, J. O., Sinangil, F., Baenziger, J., Murcar, N., Wynne, D., Coleman, R. L., Steimer, K. S., Dekker, C. L., and Chernoff, D. (1994). Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gpl20 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers. J Infect Dis 170, 1288-1291.
111. Kaneshima, H., Baum, C, Chen, B., Namikawa, R., Outzen, H., Rabin, L., Tsukamoto, A., and McCune, J. M. (1990). Today's SCID-hu mouse. Nature 348, 561-562.
112. Kaneshima, H., Namikawa, R., and McCune, J. M. (1994a). Human hematolymphoid cells in SCID mice. Curr Op Immunol 6, 327-333.
113. Kaneshima, H., Shih, C. C., Namikawa, R., Rabin, L., Outzen, H., Machado, S. G., and McCune, J. M. (1991). Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Proc Natl Acad Sci USA 88, 4523-4527.
114. Kaneshima, H., Su, L., Bonyhadi, M. L., Connor, R. I., Ho, D. D., and McCune, J. M. (1994b). Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse. J Virol 68, 8188-8192.
115. Kestler, H., Ringler, D., Mori, K., Panicali, D., Sehgal, P., Daniel, M., and Desrosiers, R. (1991). Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662.
116. Khabbaz, R., Heneine, W., George, J., Parekh, B., Rowe, T., Woods, T., Switzer, W., McClure, H., Murphey-Corb, M., and Folks, T. (1994). Infection of a laboratory worker with simian immunodeficiency virus. N Engl J Med 330, 172-177.
117. Kilchherr, E., Mandak, V., Wagner, K., and Heusser, C. H. (1993). Regulation of human IgE response in hu-PBL-SCID mice. Cell Immunol 151, 241-256.
118. Kim, F. M., Kolson, D. L., Balliet, J. W., Srinivasan, A., and Collman, R. G. (1995). V3-Independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate. J Virol 69, 1755-1761.
119. Kirchhoff, F., Greenough, T. C, Brettler, D. B., Sullivan, J. L., and Desrosiers, R. C. (1995). Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N EnglJ Med 332, 228-232.
120. Koenig, S., Fuerst, T., Wood, L., Woods, R., Suzich, J., Jones, G., de la Cruz, V., Davey, R. J., Venkatesan, S., Moss, B., Biddison, W., and Fauci, A. (1990). Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein. J Immunol 145, 127-135.
121. Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C, Pezeshkpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., and Fauci, A. S. (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233, 1089-1093.
122. Kollman, T., Goldstein, M., and Goldstein, H. (1993). The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted into NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system. J Exp Med 177, 821-832.
123. Kollman, T. R., Kim, A., Pettoello-Mantovani, M., Hachamovitch, M., Rubinstein, A., Goldstein, M. M., and Goldstein, H. (1995). Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 154, 907-921.
124. Kollmann, T. R., Kim, A., Zhuang, X., Hachamovitch, M., and Goldstein, H. (1994a). Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc Natl Acad Sci USA 9 1, 8032-8036.
125. Kollmann, T. R., Pettoello-Mantovani, M., Zhuang, X., Kim, A., Hachamovitch, M., Smarnworawong, P., Rubinstein, A., and Goldstein, H. (1994b). Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 179, 513-522.
126. Koot, M., Vos, A. H., Keet, R. P., de Goede, R. E., Dercksen, M. W., Terpstra, F. G., Coutinho, R. A., Miedema, F., and Tersmette, M. (1992). HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay. AIDS 6, 49-54.
127. Korber, B., Wolinsky, S., Haynes, B., Kunstman, G., Levy, R., Furtado, M., Otto, P., and Myers, G. (1992). HIV-1 intrapatient sequence diversity in the immunogenic V3 region. AIDS Res Hum Retroviruses 8, 1461-1465.
128. Koup, R. A., Hesselton, R. M, Safrit, J. T., Somasundaran, M., and Sullivan, J. L. (1994a). Quantitative assessment of human immunodeficiency virus type 1 replication in human xenografts of acutely infected Hu-PBL-SCID mice. AIDS Res Hum Retroviruses 10, 279-284.
129. Koup, R. A., Safrit, J. T., Cao, Y., Andrews, C. A., McLeod, G., Borkowsky, W., Farthing, C, and Ho, D. D. (1994b). Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68, 4650-4655.
130. Koyanagi, Y., Miles, S., Mitsuyasu, R. T., Merrill, J. E., Vinters, H. V., and Chen, I. S. Y. (1987). Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236, 819-822.
131. Krams, S. M., Dorshkind, K., and Gershwin, M. E. (1989). Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J Exp Med 170, 1919-1930.
132. Krowka, J. F., Sarin, S., Namikawa, R., McCune, J. M, and Kaneshima, H. (1991). Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. J Immunol 146, 3751-3756.
133. Kudo, T., Saijyo, S., Saeki, H., Sato, N., Tachibana, T., and Habu, S. (1993). Production of a human monoclonal antibody to a synthetic peptide by active in vivo immunization using a SCID mouse grafted with human lymphocytes. Tohoku J Exp Med 171, 327-338.
134. Kyoizumi, S., Murray, L. J., and Namikawa, R. (1993). Preclinical analysis of cytokine therapy in the SCID-hu mouse. Blood 81, 1479-1488.
135. Ladel, C. H., Kaufmann, S. H., and Bamberger, U. (1993). Localization of human peripheral blood leukocytes after transfer to C.B-17 scid/scid mice. Immunol Lett 38, 63-68.
136. Lamhamedi-Cherradi, S., Culmann-Penciolelli, B., Guy, B., Ly, T. D., Goujard, C, Guillet, J. G., and Gomard, E. (1995). Different patterns of HIV-1-specific cytotoxic T-lymphocyte activity after primary infection. Aids 9, 421-426.
137. Lane, H. C., Depper, J. M., Greene, W. C., Whalen, G., Waldmann, T. A., and Fauci, A. S. (1985). Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med 313, 79-84.
138. Lang, S., Weeger, M., Stahl-Hennig, C, Soulibaly, C, Hunsmann, G., Muller, J., Muller-Hermelink, H., Fuchs, D., Wachter, H., Daniel, M., Desrosiers, R., and Fleckenstein, B. (1993). Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. J Virol 67, 902-912.
139. Levy, D. N., Refaeli, Y., and Weiner, D. B. (1995). The vpr regulatory gene of HIV. Curr Top Microbiol Immunol 193, 209-236.
140. Levy, J., Hoffman, A., Kramer, S., Landis, J., Shimabukuro, J., and Oshiro, L. (1984). Isolation of lymphocytotropic retroviruses from San Francisco patients with AIDS. Science 225, 840-842.
141. Levy, J. A. (1993a). HIV and host immune responses in AIDS pathogenesis. J Clin Apheresis 8, 19-28.
142. Levy, J. A. (1993b). Pathogenesis of human immunodeficiency virus infection Microbiol Rev 57, 183-289.
143. Li, S. L., Kaaya, E. E., Ordonez, C, Ekman, M., Feichtinger H., Putkonen, P., Bottiger, D., Biberfeld, G., and Biberfeld, P. (1995). Thymic immunopathology and progression of SIVsm infection in cynomolgus monkeys. J Acquir Immune Defic Syndr Hum Retroviral 9, 1-10.
144. Li, Y., Kappes, J..Conway, J., Price, R., Shaw, G., and Hahn, B. (1991). Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: Identification of replication-competent and -defective genomes. J Virol 65, 3973-3985.
145. Lipton, S. A., Gendelman, H. E., Kuiken, C. L., Goudsmit, J., Weiller, G. F., Armstrong, J. S., Hartman, S., Portegies, P., Dekker, J., and Cornelissen, M. (1995). Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome: Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex. N Engl J Med 332, 934-940.
146. Littman, D. R. (1994). Immunodeficiency viruses. Not enough sans Nef. Curr Biol 4, 618-620.
147. Liu, Z.-Q., Wood, C., Levy, J., and Chang-Mayer, C. (1990). The viral envelope gene is involved in macrophage tropism of a human immunodeficiency virus type 1 strain isolated from brain tissue. J Virol 64, 6148-6153.
148. Lukashov, V., Kuiken, C, and Goudsmit, J. (1995). Intrahost human immunodeficiency virus type 1 evolution is related to the length of the immunocompetent period. J Virol 69, 6911-6916.
149. Lusso, P., Ensoli, B., Markham, P. D., Ablashi, D. V., Zaki, S., Salahudin, S., Tschachler, E., Wong-Stall, F., and Gallo, R. C. (1989). Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337, 370.
150. Lusso, P., Malnati, M. S., Garzino-Demo, A., Crowley, R. W., Long, E. O., and Gallo, R. C. (1993). Infection of natural killer cells by human herpesvirus 6. Nature 362,458-462.
151. Lusso, P., Veronese, F. D.-M., Ensoli, B., Franchini, G., Jemma, C, DeRocco, S. E., Kalyanaraman, V. S., and Gallo, R. C. (1990). Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses. Science 247, 848-851.
152. Mackewicz, C, and Levy, J. A. (1992). CD8+ cell anti-HIV activity: Nonlytic suppression of virus replication. AIDS Res Hum Retroviruses 8, 1039-1050.
153. Mackewicz, C. E., Blackbourn, D. J., and Levy, J. A. (1995). CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription. Proc Natl Acad Sci USA 92, 2308-2312.
154. Mackewicz, C. E., Ortega, H. W., and Levy, J. A. (1991). CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest 87, 1462-1466.
155. Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., and Axel, R. (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348.
156. Maldarelli, F., Sato, H., Berthold, E., Orenstein, J., and Martin, M. (1995). Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type l.J Virol 69, 6457-6465.
157. Malkovska, V., Cigel, F., and Storer, B. E. (1994). Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumor immunity. Clin Exp Immunol 96, 158-165.
158. Martensson, C, Kristensson, K., Kalliomaki, S., Borrebaeck, C. A., and Carlsson, R. (1994). Antigen-specific human immunoglobulin production in SCID mice transplanted with human peripheral lymphocytes is dependent on CD4+ CD45RO+ T cells. Immunology 83, 171-179.
159. Martino, G., Anastasi, J., Feng, J., Mc Shan, C, DeGroot, L., Quintans, J., and Grimaldi, L. M. (1993). The fate of human peripheral blood lymphocytes after transplantation into SCID mice. Eur J Immunol 23, 1023-1028.
160. Massari, F. E., Poli, G., Schnittman, S. M., Psallidopoulos, M. C, Davey, V., and Fauci, A. S. (1990). In vivo T lymphocyte origin of macrophage-tropic strains of HIV: Role of monocytes during in vitro isolation and in vivo infection. J Immunol 144, 4628-4632.
161. McCune, J., Kaneshima, H., Krowka, J., Namikawa, R., Outzen, H., Peault, B., Rabin, L., Shih, C. C, Yee, E., Lieberman, M., Weissman, I., and Schultz, L. D. (1991a). The SCID-hu mouse: A small animal model for HIV infection and pathogenesis. Annu Rev Immunol 9, 399-429.
162. McCune, J. M. (1991). SCID mice as immune system models. Curr Op Immunol 3,224-228.
163. McCune, J. M. (1992). The SCID-hu mouse: A small animal model for the analysis of human nematolymphoid differentiation and function. Bone Marrow Transplant 9 Suppl 1, 74-76.
164. McCune, J. M., Kaneshima, H., Lieberman, M., Weissman, I. L., and Namikawa, R. (1989). The scid-hu mouse: Current status and potential applications. Curr Top Microbiol Immunol 152, 183-193.
165. McCune, J. M., Kaneshima, H., Rabin, L., Shih, C. C, and Namikawa, R. (1990a). Preclinical evaluation of antiviral compounds in the SCID-hu mouse. Ann NY Acad Sci 616,281-286.
166. McCune, J. M., Namikawa, R., Kaneshima, H., Shultz, L. D., Lieberman, M., and Weissman, I. L. (1988). The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 241, 1632-1639.
167. McCune, J. M., Namikawa, R., Shih, C.-C, Rabin, L., and Kaneshima, H. (1990b). Pseudo-types in HIV-infected mice. Science 250, 1152-1153.
168. McCune, J. M., Namikawa, R., Shih, C. C, Rabin, L., and Kaneshima, H. (1990c). Suppression of HIV infection in AZT-treated SCID-hu mice. Science 247, 564-566.
169. McCune, J. M., Peault, B., Streeter, P. R., and Rabin, L. (1991b). Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse. Immunol Rev 124, 45-62.
170. Miller, M. D., Feinberg, M. B., and Greene, W. G. (1994). The HIV-1 nef gene acts as a positive viral infectivity factor. Trends Microbiol 2, 294-298.
171. Miller, M. D., Warmerdam, M. T., Page, K. A., Feinberg, M. B., and Greene, W. C. (1995). Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gpl60 or viral entry. J Virol 69, 579-584.
172. Milman, G. (1990). HIV research in the SCID mouse: Biosafety considerations. Science 250, 1152. [Letter]
173. Mocarski, E. S., Bonyhadi, M., Salimi, S., McCune, J. M., and Kaneshima, H. (1993). Human cytomegalovirus in a SCID-hu mouse: Thymic epithelial cells are prominent targets of viral replication. Proc Natl Acad Sci USA 90, 104-108.
174. Montagnier, L., Gruest, J., Chamaret, S., Dauguet, C, Axler, C, Guetard, D., Nugeyre, M. T., Barre-Sinoussi, F., Chermann, J. C, Brunet, J. B., Klatzmann, D., and Gluckman, J. C. (1984). Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. Science 225, 63-66.
175. Moore, J. P., Cao, Y., Qing, L., Sattentau, Q. J., Pyati, J., Koduri, R., Robinson, J., Barbas III, C. F., Burton, D. R., and Ho, D. D. (1995). Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gpl20, and their neutralization is not predicted by studies with monomelic gpl20. J Virol 69, 101-109.
176. Moore, P., and Chang, Y. (1995). Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 332, 1181-1185.
177. Mosier, D., Gulizia, R., Maclsaac, P., Torbett, B., and Levy, J. (1993a). Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260, 689-692.
178. Mosier, D., and Sieburg, H. (1994). Macrophage-tropic HIV: Critical for AIDS pathogenesis? Immunol Today 15, 332-339.
179. Mosier, D. E. (1990). Immunodeficient mice xenografted with human lymphoid cells: New models for in vivo studies of human immunobiology and infectious diseases. J Clin Immunol 10, 185-191.
180. Mosier, D. E., Baird, S. M., Kirven, M. B., Gulizia, R. J., Wilson, D. B., Kubayashi, R., Picchio, G., Gamier, J. L., Sullivan, J. L., and Kipps, T. J. (1990). EBV-associated B-cell lymphomas following transfer of human peripheral blood lymphocytes to mice with severe combined immune deficiency. Curr Top Microbiol Immunol 166, 317-323.
181. Mosier, D. E., Gulizia, R. J., Baird, S. M., and Wilson, D. B. (1988). Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335, 256-259.
182. Mosier, D. E., Gulizia, R. J., Baird, S. M., Wilson, D. B., Spector, D. H., and Spector, S. A. (1991). Human immunodeficiency virus infection of human-PBL-SCID mice. Science 251, 791-794.
183. Mosier, D. E., Gulizia, R. J., Maclsaac, P., Mathieson, B. J., Smith, G., Hu, S. L., Corey, L., and Greenberg, P. (1992). Evaluation of gpl60 vaccinees in the hu-PBL-SCID mouse model. AIDS Res Hum Retroviruses 8, 1387.
184. Mosier, D. E., Gulizia, R. J., Maclsaac, P. D., Corey, L., and Greenberg, P. D. (1993b). Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gpl60 and recombinant gpl60. Proc Natl Acad Sci USA 90, 2443-2447.
185. Mosier, D. E., Stell, K. L., Gulizia, R. J., Torbett, B. E., and Gilmore, G. L. (1993c). Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177, 191-194.
186. Mullins, J. I., Hoover, E. A., Quackenbush, S. L., and Donahue, P. R. (1991). Disease progression and viral genome variants in experimental feline leukemia virus-induced immunodeficiency syndrome. JAIDS 4, 547-557.
187. Murphy, W., Bennett, M., Anver, M., Baseler, M., and Longo, D. (1992). Human-mouse lymphoid chimeras: Host vs. graft and graft vs. host reactions. Eur J Immunol 22, 1421-1427.
188. Namikawa, R., Kaneshima, H., Lieberman, M., Weissman, I. L., and McCune, J. M. (1988). Infection of the SCID-hu mouse by HIV-1. Science 242, 1684-1686.
189. Namikawa, R., Weilbaecher, K. N., Kaneshima, H., Yee, E. J., and McCune, J. M. (1990). Long-term human hematopoiesis in the SCID-hu mouse. J Exp Med 172, 1055-1063.
190. Nardelli, B., Gonzalez, C, Schecter, M., and Valentine, F. (1995). CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells. Proc Natl Acad Sci USA 92, 7312-7316.
191. Niederman, T. M., Hastings, W. R., and Ratner, L. (1993). Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix. Virology 197, 420-425.
192. Nielsen, C, Pedersen, C, Lundgren, J. D., and Gerstoft, J. (1993). Biological properties of HIV isolates in primary HIV infection: Consequences for the subsequent course of infection. Aids 7, 1035-1040.
193. Niu, M. T., Stein, D. S., and Schnittman, S. M. (1993). Primary human immunodeficiency virus type 1 infection: Review of pathogenesis and early treatment intervention in humans and animal retrovirus infections. J Infect Dis 168, 1490-1501.
194. Nonoyama, S., Smith, F. O., and Ochs, H. D. (1993). Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes. J Immunol 151, 3894-3901.
195. Numazaki, K., Bai, X. Q., Goldman, H., Wong, I., Spira, B., and Wainberg, M. A. (1989). Infection of cultured human thymic epithelial cells by human immunodeficiency virus. Clin Immunol Immunopathol 51, 185-195.
196. Palladino, G., Mozdzanowska, K., Washko, G., and Gerhard, W. (1995). Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J Virol 69, 2075-2081.
197. Pang, S., Shlesinger, Y., Daar, E. S., Moudgil, T., Ho, D. D., and Chen, I. S. (1992). Rapid generation of sequence variation during primary HIV-1 infection. Aids 6, 453-460.
198. Pantaleo, G., Graziosi, C., Demerest, J., Montroni, M., Fox, C., Orenstein, J., Kotler, D., and Fauci, A. (1993). HIV infection is active and progressive in lymphoid tissue during the clinical latent stage of disease. Nature 362, 355-358.
199. Papiernik, M., Brossard, Y., Mulliez, N., Roume, J., Brechot, C., Barin, F., Goudeau, A., Bach, J. F., Griscelli, C., Henrion, R., and Vazeux, R. (1992). Thymic abnormalities in fetuses aborted from human immunodeficiency virus type 1 seropositive women. Pediatrics 89, 297-301.
200. Park, I. W., and Sodroski, J. (1995). Functional analysis of the vpx, vpr, and nef genes of simian immunodeficiency virus. J Acquir Immune Defic Syndr Hum Retroviral 8,335-344.
201. Parren, P. W., Ditzel, H. J., Gulizia, R. J., Binley, J. M., Barbas, C. F. R., Burton, D. R., and Mosier, D. E. (1995). Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gpl20 CD4-binding site. Aids 9, Fl-6.
202. Peault, B., Weissman, I. L., Baum, C., McCune, J. M., and Tsukamoto, A. (1991). Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells. J Exp Med 174, 1283-1286.
203. Pestel, J., Jeannin, P., Delneste, Y., Dessaint, J. P., Cesbron, J. Y., Capron, A., Tsicopoulos, A., and Tonnel, A. B. (1994). Human IgE in SCID mice reconstituted with peripheral blood mononuclear cells from Dermatophagoides pteronyssinus-sensitive patients. J Immunol 153, 3804-3810.
204. Pflumio, F., Lapidot, T., Murdoch, B., Patterson, B., and Dick, J. E. (1993). Engraftment of human lymphoid cells into newborn SCID mice leads to graft-versus-host disease. Int Immunol 5, 1509-1522.
205. Piatak, M, Jr., Saag, M. S., Yang, L. C, Clark, S. J., Kappes, J. C, Luk, K. C, Hahn, B. H., Shaw, G. M., and Lifson, J. D. (1993). Determination of plasma viral load in HIV-1 infection by quantitative competitive polymerase chain reaction. Aids 7 Suppl 2, S65-71.
206. Picchio, G. R., Kobayashi, R., Kirven, M., Baird, S. M., Kipps, T. J., and Mosier, D. E. (1992). Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts. Cancer Res 52, 2468-2477.
207. Pinto, L. A., Dalgleish, A. G., Sumar, N., and Poulton, T. A. (1994). Panel of anti-gpl20 monoclonal antibodies reacts with same nuclear proteins in uninfected cells as those recognized by autoantibodies from patients with systemic lupus erythematosus. AIDS Res Hum Retroviruses 10, 823-828.
208. Pistillo, M. P., Sguerso, V., and Ferrara, G. B. (1992). High yields of anti-HLA human monoclonal antibodies can be provided by SCID mice. Hum Immunol 35, 256-259.
209. Poli, G., and Fauci, A. (1992). The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection. Pathobiology 60, 246-251.
210. Portegies, P. (1994). AIDS dementia complex: A review. J Acquir Immune Defic Syndr 7 Suppl 2, S38-48.
211. Pratt, R. D., Shapiro, J. F., McKinney, N., Kwok, S., and Spector, S. A. (1995). Virologic characterization of primary human immunodeficiency virus type 1 infection in a health care worker following needlestick injury. J Infect Dis 172, 851-854.
212. Ratner, L., and Niederman, T. M. (1995). Nef. Curr Top Microbiol Immunol 193,169-208.
213. Reason, D. C, Kitamura, M. Y., and Lucas, A. H. (1994). Induction of a protective human polysaccharide-specific antibody response in hu-PBL SCID mice by idiotypic vaccination. J Immunol 152, 5009-5013.
214. Redfield, R. R., Birx, D. L., Ketter, N., Tramont, E., Polonis, V., Davis, C, Brundage, J. F., Smith, G., Johnson, S., Fowler, A., Wierzba, T., Shafferman, A., Volvovitz, F., Oster, C, and Burke, D. S. (1991). A phase I evaluation of the safety and immunogenicity of vaccination with recombinant gpl60 in patients with early human immunodeficiency virus infection. N Engl J Med 324, 1677-1684.
215. Reinhardt, B., Torbett, B. E., Gulizia, R. J., Reinhardt, P. P., Spector, S. A., and Mosier, D. E. (1994). Human immunodeficiency virus type 1 infection of neonatal severe combined immunodeficient mice xenografted with human cord blood cells. AIDS Res Hum Retroviruses 10, 131-141.
216. Rencher, S. D., Slobod, K. S., Smith, F. S., and Hurwitz, J. L. (1994). Activity of transplanted CD8+ versus CD4+ cytotoxic T cells against Epstein-Barr virus-immortalized B cell tumors in SCID mice. Transplantation 58, 629-633.
217. Rieckmann, P., Poli, G., Kehrl, J. H., and Fauci, A. S. (1991). Activated B lymphocytes from human immunodeficiency virus-infected individuals induce virus expression in infected T cells and a promonocyte cell line, Ul. J Exp Med 173, 1-5.
218. Rochford, R., and Mosier, D. E. (1995). Differential Epstein-Barr virus gene expression in B-cell subsets recovered from lymphomas in SCID mice after transplantation of human peripheral blood lymphocytes. J Virol 69, 150-155.
219. Roder, J., and Duwe, A. (1979). The beige mutation in the mouse selectively impairs natural killer cell function. Nature 278, 271-273.
220. Roncarolo, M. G., and Vandekerckhove, B. (1992). SCID-hu mice as a model to study tolerance after fetal stem cell transplantation. Bone Marrow Transplant 9 (Suppl. 1), 83-84.
221. Rosenberg, Z. F., and Fauci, A. S. (1991). Immunopathogenesis of HIV infection. FASEB J. 5, 2382-2389.
222. Rosenzweig, M., Bunting, E. M., and Gaulton, G. N. (1994). Neonatal HIV-1 thymic infection. Leukemia 8 (Suppl. 1), S163-165.
223. Rosenzweig, M., Clark, D. P., and Gaulton, G. N. (1993). Selective thymocyte depletion in neonatal HIV-1 thymic infection. Aids 7, 1601-1605.
224. Rowe, M., Young, L. S., Crocker, J., Stokes, H., Henderson, S., and Rickinson, A. B. (1991). Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: Implications for the pathogenesis of EBV-positive lymphomas in man. J Exp Med 173, 147-158.
225. Ruprecht, R. M., Bernard, L. D., Chou, T.-C, Gamma Sosa, M. A., Fazely, F., Koch, J., Sharma, P. L., and Mullaney, S. (1990). Murine models for evaluating antiretroviral therapy. Cancer Res Suppl 50, 5618-5627.
226. Sabzevari, H., and Reisfeld, R. A. (1993). Human cytotoxic T-cells suppress the growth of spontaneous melanoma metastases in SCID/hu mice. Cancer Res 53, 4933-4937.
227. Safrit, J., Andrews, C, Zhu, T., Ho, D., and Koup, R. (1994). Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: Recognition of autologous virus sequences with a conserved immunodominant epitope. J Exp Med 179, 463-472.
228. Safrit, J. T., Fung, M. S., Andrews, C. A., Braun, D. G., Sun, W. N., Chang, T. W., and Koup, R. A. (1993). hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gpl20. Aids 7, 15-21.
229. Sandhu, J., Shpitz, B., Gallinger, S., and Hozumi, N. (1994). Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol 152, 3806-3813.
230. Sandhu, J. S., Gorczynski, R., Shpitz, B., Gallinger, S., Nguyen, H. P., and Hozumi, N. (1995). A human model of xenogeneic graft-versus-host disease in SCID mice engrafted with human peripheral blood lymphocytes. Transplantation 60, 179-184.
231. Sattentau, Q., and Moore, J. (1995). Human immunodeficiency virus 1 neutralization is determined by epitope exposure on the gpl20 oligomer. J Exp Med 182, 185-196.
232. Sawai, E. T., Baur, A., Struble, H., Peterlin, B. M., Levy, J. A., and Cheng-Mayer, C. (1994). Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc Natl Acad Sci USA 91, 1539-1543.
233. Sawai, E. T., Baur, A. S., Peterlin, B. M., Levy, J. A., and Cheng-Mayer, C. (1995). A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J Biol Chem 270, 15307-15314.
234. Saxon, A., Macy, E., Denis, K., Tary-Lehmann, M., Witte, O., and Braun, J. (1991). Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin Invest 87, 658-665.
235. Schellekens, P. T., Tersmette, M., Roos, M. T., Keet, R. P., de Wolf, F., Coutinho, R. A., and Miedema, F. (1992). Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype. Aids 6, 665-669.
236. + (T4) lymphocyte depletion. Proc Natl Acad Sci USA 87, 7727-7731.
237. Schnittman, S. M., Singer, K. H., Greenhouse, J. J., Stanley, S. K., Whichard, L. P., Le, P. T., Haynes, B. F., and Fauci, A. S. (1991). Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. J Immunol 147, 2553-2558.
238. Schols, D., Jones, D., and Roncarolo, M. G. (1995). Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration. J Immunol 154, 3204-3212.
239. Schuurman, H., Krone, W., Broekhuizen, R., Baarlen, J., van Veen, P., Goldstein, A., Huber, J., and Goudsmit, J. (1989). The thymus in acquired immune deficiency syndrome: Comparison with other types of immunodeficiency disease and presence of components of human immunodeficiency virus type 1. Am J Pathol 131, 1329-1334.
240. Scott-Algara, D., Vuillier, F., Cayota, A., and Dighiero, G. (1992). Natural killer (NK) cell activity during HIV infection: A decrease in NK activity is observed at the clonal level and is not restored after in vitro long-term culture of NK cells. Clin Exp Immunol 90, 181-187.
241. Shelton, M. W., Walp, L. A., Basler, J. T., Uchiyama, K., and Hanto, D. W. (1992). Mediation of skin allograft rejection in scid mice by CD4+ and CD8+ T cells. Transplantation 54, 278-286.
242. Shih, C. C, Kaneshima, H., Rabin, L., Namikawa, R., Sager, P., McGowan, J., and McCune, J. M. (1991). Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time-dependent manner. J Infect Dis 163, 625-627.
243. Shiroki, R., Poindexter, N. J., Woodle, E. S., Hussain, M. S., Mohanakumar, T., and Scharp, D. W. (1994). Human peripheral blood lymphocyte reconstituted severe combined immunodeficient (hu-PBL-SCID) mice. A model for human islet allograft rejection. Transplantation 57, 1555-1562.
244. Shpaer, E., Delwart, E., Kuiken, C, Goudsmit, J., Bachmann, M., and Muffins, J. (1994). Conserved V3 sequences and transmission of human immunodeficiency virus type 1. AIDS Res Hum Retrovir 10, 1679-1684.
245. Shultz, L. D., Schweitzer, P. A., Christianson, S. W., Gott, B., Schweitzer, I. B., Tennent, B., McKenna, S., Mobraaten, L., Rajan, T. V., Greiner, D. L., and Leiter, E. H. (1995). Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154, 180-191.
246. Sinicco, A., Fora, R., Sciandra, M., Lucchini, A., Caramello, P., and Gioannini, P. (1993). Risk of developing AIDS after primary acute HIV-1 infection. J Acquir Immune Defic Syndr 6, 575-581.
247. Smith, C. I., Abedi, M. R., Islam, K. B., Johansson, M. E., Christensson, B., and Hammarstrom, L. (1991). Humoral immunity in scid mice reconstituted with cells from immunoglobulin-deficient or normal humans. Immunol Rev 124, 113-138.
248. Somasundaram, R., Jacob, L., and Herlyn, D. (1995). Tetanus toxoid-specific T cell responses in severe combined immunodeficiency (SCID) mice reconstituted with human peripheral blood lymphocytes. Clin Exp Immunol 101, 94-99.
249. Spector, D. H., Wade, E., Wright, D. A., Koval, V., Clark, C, Jaquish, D., and Spector, S. A. (1990). Human immunodeficiency virus pseudotypes with expanded cellular and species tropism. J Virol 64, 2298-2308.
250. Spiegelberg, H. L., Beck, L., Kocher, H. P., Fanslow, W. C, and Lucas, A. H. (1994). Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice. J Clin Invest 93, 711-717.
251. Stanley, S., McCune, J., Kaneshima, H., Justement, J., Sullivan, M., Boone, E., Baseler, M., Adelsberger, J., Bonyhadi, M., Orenstein, J., Fox, C., and Fauci, A. (1993a). Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment of the SCID-hu mouse. J Exp Med 178, 1151-1163.
252. Stanley, S. K., McCune, J. M., Kaneshima, H., Justement, J. S., Sullivan, M., Boone, E., Baseler, M., Adelsberger, J., Bonyhadi, M., Orenstein, J., Fox, C., and Fauci, A. S. (1993b). Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 178, 1151-1163.
253. Strebel, K., Klimkait, T., Maldarelli, F., and Martin, M. (1989). Molecular and biochemical analysis of human immunodeficiency virus type 1 vpu protein. J Virol 63, 3784-3791.
254. Strieker, R. B., McHugh, T. M., Moody, D. J., Morrow, W. J., Stites, D. P., Shuman, M. A., and Levy, J. A. (1987). An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature 327, 710-713.
255. Su, L., Kaneshima, H., Bonyadi, M., Salimi, S., Kraft, D., Rabin, L., and McCune, J. (1995). HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 2, 25-36.
256. Surh, C.D., and Sprent, J. (1994). T-cell apoptosis detected in situ during positive and negative selection in the thymus [see comments J. Nature 372, 100-103.
257. Tary-Lehmann, M., Lehmann, P. V., Schols, D., Roncarolo, M. G., and Saxon, A. (1994). Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J Exp Med 180, 1817-1827.
258. Tary-Lehmann, M., and Saxon, A. (1992). Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 175, 503-516.
259. Tary-Lehmann, M., Saxon, A., and Lehmann, P. (1995). The human immune system in hu-PBL-SCID mice. Immunol Today 16, 529-533.
260. Tateno, M., and Levy, J. A. (1988). MT-4 plaque formation can distinguish cytopathic subtypes of the human immunodeficiency virus (HIV). Virology 167, 299-301.
261. Terai, C, Kornbluth, R. S., Pauza, C. D., Richman, D. D., and Carson, D. A. (1991). Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Invest 87, 1710-1715.
262. Tersmette, M., Gruters, R. A., de Wolf, F., de Goede, R. E., Lange, J. M., Schellekens, P. T., Goudsmit, J., Huisman, H. G., and Miedema, F. (1989). Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: Studies on sequential HIV isolates. J Virol 63, 2118-2125.
263. Thirdborough, S. M., Chamberlain, J. C., Swift, S. M., James, R. F., and London, N. J. (1993). The kinetics of SCID-hu reconstitution: A comparison between human splenocytes and peripheral blood leucocytes. Cell Transplant 2, 339-343.
264. Torbett, B. E., Picchio, G., and Mosier, D. E. (1991). hu-PBL-SCID mice: A model for human immune function, AIDS, and lymphomagenesis. Immunol Rev 124, 139-164.
265. Tremblay, M., Numazaki, K., Goldman, H., and Wainberg, M. A. (1990). Infection of human thymic lymphocytes by HIV-1. J Acquir Immune Defic Syndr 3, 356-360.
266. Tyor, W. R., Power, C., Gendelman, H. E., and Markham, R. B. (1993). A model of human immunodeficiency virus encephalitis in scid mice. Proc Natl Acad Sci USA 90,8658-8662.
267. Ussery, M., Broud, D., Wood, O., Kunder, S., Black, P., Dailey, P., Wilber, J., Yang, L., Piatek, M., and Lifson, J. (1995). Antiviral agents reduce viral load and delay the detection of infected cells in vivo in the HIV-infected hu-PBMC SCID mouse model. Antiviral Res 26, A238.
268. Valentin, H., Nugeyre, M. T., Vuillier, F., Boumsell, L., Schmid, M., Barre-Sinoussi, F., and Pereira, R. A. (1994). Two subpopulations of human triple-negative thymic cells are susceptible to infection by human immunodeficiency virus type 1 in vitro. J Virol 68, 3041-3050.
269. van Gemen, B., Kievits, T., Schukkink, R., van Strijp, D., Malek, L. T., Sooknanan, R., Huisman, H. G., and Lens, P. (1993). Quantification of HIV-1 RNA in plasma using NASBA during HIV-1 primary infection. J Virol Methods 43, 177-187.
270. Van Kuyk, R., and Mosier, D. E. (1995). Lack of pseudotype formation between human immunodeficiency virus type 1 and Epstein-Barr virus in productively coinfected B lymphoblastoid cell lines. Virology 209, 643-648.
271. Van Kuyk, R., Torbett, B. E., Gulizia, R. J., Leath, S., Mosier, D. E., and Koenig, S. (1994). Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism. J Immunol 153, 4826-4833.
272. Vandekerckhove, B. A., Krowka, J. F., McCune, J. M., de Vries, J. E., Spits, H., and Roncarolo, M. G. (1991). Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol 146, 4173-4179.
273. Veugelers, P. J., Schechter, M. T., Tindall, B., Moss, A. R., Page, K. A., Craib, K. J., Cooper, D. A., Coutinho, R. A., Charlebois, E., Winkelstein, W., Jr., and van Griensven, G. J. P. (1993). Differences in time from HIV seroconversion to CD4+ lymphocyte end-points and AIDS in cohorts of homosexual men. Aids 7, 1325-1329.
274. Wain-Hobson, S. (1989). HIV genome variability in vivo. AIDS 3 (Suppl. 1), S13-S18.
275. Walker, C. M., Erickson, A. L., Hsueh, F. C, and Levy, J. A. (1991a). Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism. J Virol 65, 5921-5927.
276. Walker, C. M., Moody, D. J., Stites, D. P., and Levy, J. A. (1989). CD8 T lymphocyte control of HIV replication in cultured CD4 cells varies among infected individuals. Cell Immunol 119, 470-475.
277. Walker, C. M., Thomson-Honnebier, G. A., Hsueh, F. C, Erickson, A. L., Pan, L. Z., and Levy, J. A. (1991b). CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses. Cell Immunol 137, 420-428.
278. Walker, W., and Gallagher, G. (1994). The in vivo production of specific human antibodies by vaccination of human-PBL-SCID mice. Immunology 83, 163-170.
279. Walker, W., and Gallagher, G. (1995). The development of a novel immunotherapy model of human ovarian cancer in human PBL-severe combined immunodeficient (SCID) mice. Clin Exp Immunol 101, 494-501.
280. Wecker, H., Grusby, M. J., and Auchincloss, H., Jr. (1995). Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation 59, 1223-1227.
281. Wei, X., Ghosh, S., Taylor, M, Johnson, V., Emini, E., Deutsch, P., Lifson, J., Bonhoeffer, S., Nowak, M., Harm, B., Saag, M., and Shaw, G. (1995). Viral dynamics in human immunodeficiency virus type I infection. Nature 373, 117-122.
282. Westervelt, P., Trowbridge, D., Epstein, L., Blumberg, B., Li, Y., Hahn, B., Shaw, G., Price, R., and Ratner, L. (1992). Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol 66, 2577-2582.
283. Willey, R. L., Maldarelli, F., Martin, M. A., and Strebel, K. (1992). Human immunodeficiency virus type 1 vpu protein regulates the formation of intracellular gpl60-CD4 complexes. J Virol 66, 226-234.
284. York-Higgins, D., Cheng-Mayer, C, Bauer, D., Levy, J., and Dina, D. (1990). Human immunodeficiency virus type 1 cellular host range, replication and cytopathicity are linked to the envelope region of the viral genome. J Virol 64, 4016-4020.
285. Yu, X., McLane, M. F., Ratner, L., O'Brien, W., Collman, R., Essex, M., and Lee, T. H. (1994). Killing of primary CD4+ T cells by non-syncytium-inducing macrophage-tropic human immunodeficiency virus type 1. Proc Natl Acad Sci USA 91, 10237-10241.
286. Zaunders, J., Carr, A., McNally, L., Penny, R., and Cooper, D. A. (1995). Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes. Aids 9, 561-566.
287. Zhang, L. Q., MacKenzie, P., Cleland, A., Holmes, E. C, Brown, A. J., and Simmonds, P. (1993). Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary i n f e c t i o n. J. Virol 67, 3345-3356.
288. Zhu, T., Mo, H., Wang, N., Nam, D. S., Cao, Y., Koup, R. A., and Ho, D. D. (1993). Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261, 1179-1181.