Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7549-7560

  Kovelman, Robert ^a   Bilter, Graham K ^a   Glezer, Emilia ^a   Tsou, Amy Y ^a   Barbosa, Miguel S ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN POLYMORPHISM; UTERINE CERVIX CARCINOMA; VIRUS CARCINOGENESIS; VIRUS GENE; VIRUS STRAIN; VIRUS TRANSCRIPTION; VULVA CARCINOMA; WART VIRUS;

EID: 0029795272     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7549-7560.1996     Document Type: Article

References (63)

1. Androphy, E. J., D. R. Lowy, and J. T. Schiller. 1987. Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Nature (London) 325:70-73.
2. Barbosa, M. S., and R. Schlegel. 1989. The E6 and E7 genes of HPV-18 arc sufficient for inducing two-stage in vitro transformation of human keratinocytes. Oncogene 4:1529-1532.
3. Barbosa, M. S., W. C. Vass, D. L. Lowy, and J. T. Schiller. 1991. In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J. Virol. 65:292-298.
4. Bedrosian, C. L., and D. Bastia. 1990. The DNA-binding domain of HPV-16 E2 protein interaction with the viral enhancer: protein-induced DNA bending and role of the nonconserved core sequence in binding site affinity. Virology 174:557-575.
5. Bernard, B. A., C. Bailly, M. C. Lenoir, M. Darmon, F. Thierry, and M. Yaniv. 1989. The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. J. Virol. 63:4317-4324.
6. Bouvard, V., A. Storey, D. Pim, and L. Banks. 1994. Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. EMBO J. 13:5451-5459.
7. Brewer, C. B., and M. G. Roth. 1991. A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin. J. Cell Biol. 114:413-421.
8. Chiang, C. M., M. Ustav, A. Stenlund, T. F. Ho, T. R. Broker, and L. T. Chow. 1992. Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins. Proc. Natl. Acad. Sci. USA 89: 5799-5803.
9. Chin, M. T., R. Hirochika, H. Hirochika, T. R. Broker, and L. T. Chow. 1988. Regulation of human papillomavirus type 11 enhancer and E6 promoter by activating and repressing proteins from the E2 open reading frame: functional and biochemical studies. J. Virol. 62:2994-3002.
10. Choe, J., P. Vaillancourt, A. Stenlund, and M. Botchan. 1989. Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs. J. Virol. 63:1743-1755.
11. Chow, L. T., M. Nasseri, S. M. Wolinski, and T. R. Broker. 1987. Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J. Virol. 61:2581-2588.
12. Cole, S. T., and O. Danos. 1987. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome: phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. J. Mol. Biol. 193:599-608.
13. Cripe, T. P., T. H. Haugen, J. P. Turk, F. Tahatabai, P. G. Schmid, M. Durst, L. Gissmann, A. Roman, and L. P. Turek. 1987. Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. EMBO J. 6:3745-3753.
14. Del Vecchio, A. M., H. Romanczuk, P. M. Howley, and C. C. Baker. 1992 Transicnt replication of human papillomavirus DNAs. J. Virol. 66:5949-5958.
15. Dostatni, N., P. F. Lambert, R. Sousa, J. Ham, P. M. Howley, and M. Yaniv. 1991. The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex. Genes Dev. 5:1657-1671.
16. Gauthier, J. M., N. Dostatni, M. Lusky, and M. Yaniv. 1991. Two DNA-bound E2 dimers are required for strong transcriptional activation and for cooperation with cellular factors in most cells. New Biol. 3:498-509.
17. Giri, I., and M. Yaniv. 1988. Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains. EMBO J. 7:2823-2829.
18. Giri, I., and M. Yaniv. 1988. Study of the E2 gene product of the cottontail rabbit papillomavirus reveals a common mechanism of transactivation among papillomaviruses. J. Virol. 62:1573-1581.
19. Gopalakrishnan, V., and S. A. Khan. 1994. E1 protein of human papillomavirus type la is sufficient for initiation of viral DNA replication. Proc. Natl. Acad. Sci. USA 91:9597-9601.
20. Grossel, M. J., F. Sverdrup, U. E. Breiding, and E. J. Androphy. 1996 Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2. J. Virol. 70:7264-7269.
21. Guan, K. L., and J. E. Dixon. 1991. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192:262-267.
22. Ham, J., N. Dostatni, F. Arnos, and M. Yaniv. 1991. Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein. EMBO J. 10:2931-2940.
23. Ham, J., N. Dostatni, J. M. Gauthier, and M. Yaniv. 1991. The papillomavirus E2 protein: a factor with many talents. Trends Biochem. Sci. 16:440-444.
24. Ham, J., G. Steger, and M. Yaniv. 1994. Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure. EMBO J. 13:147-157.
25. Haugen, T. H., T. P. Cripe, G. D. Ginder, M. Karin, and L. P. Turek. 1987. Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J. 6:145-152.
26. Haugen, T. H., L. P. Turek, F. M. Mercurio, T. P. Cripe, B. J. Olson, R. D. Anderson, D. Seidl, M. Karin, and J. Schiller. 1988. Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain. EMBO J. 7:4245-4253.
27. Hawley-Nelson, P., E. J. Androphy, D. R. Lowy, and J. T. Schiller. 1988. The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer. EMBO J. 7:525-531.
28. Hermonat, P. L., B. A. Spalholz, and P. M. Howley. 1988. The bovine papillomavirus P2443 promoter is E2 trans-responsive: evidence for E2 autoregulation. EMBO J. 7:2815-2822.
29. Hirochika, H., T. R. Broker, and L. T. Chow. 1987. Enhancers and trans-acting E2 transcriptional factors of papillomaviruses. J. Virol. 61:2599-2606.
30. Hirochika, H., R. Hirochika, T. R. Broker, and L. T. Chow. 1988. Functional mapping of the human papillomavirus type 11 transcriptional enhancer and its interaction with the trans-acting E2 proteins. Genes Dev. 2:54-67.
31. Hubbert, N. L., J. T. Schiller, D. R. Lowy, and E. J. Androphy. 1988. Bovine papilloma virus-transformed cells contain multiple E2 proteins. Proc. Natl. Acad. Sci. USA 85:5864-5868.
32. Hummel, M., J. B. Hudson, and L. A. Laimins. 1992. Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. J. Virol. 66:6070-6080.
33. Lambert, P. F., N. L. Hubbert, P. M. Howley, and J. T. Schiller. 1989. Genetic assignment of multiple E2 gene products in bovine papillomavirus-transformed cells. J. Virol. 63:3151-3154.
34. Lambert, P. F., B. A. Spalholz, and P. M. Howley. 1987. A transcriptional represser encoded by BPV-I shares a common carboxy-terminal domain with the E2 transactivator. Cell 50:69-78.
35. Li, R., J. D. Knight, S. P. Jackson, R. Tjian, and M. R. Botchan. 1991. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell 65:493-505.
36. McBride, A. A., H. Romanczuk, and P. M. Howley. 1991. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266:18411-18414.
37. McBride, A. A., R. Schlegel, and P. M. Howley. 1988. The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity. EMBO J. 7:533-539.
38. Morrissey, L. C, J. Barsoum, and E. J. Androphy. 1989. trans activation by the bovine papillomavirus E2 protein in Saccharomyces cererisiae. J. Virol. 63:4422-4425.
39. Moskaluk, C. A., and D. Bastia. 1988. Interaction of the bovine papillomavirus type 1 E2 transcriptional control protein with the viral enhancer: purification of the DNA-binding domain and analysis of its contact points with DNA. J. Virol. 62:1925-1931.
40. Phelps, W. C., and P. M. Howley. 1987. Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product. J. Virol. 61:1630-1638.
41. Prakash, S. S., B. H. Horwitz, T. Zibello, J. Settleman, and D. DiMaio. 1988. Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J. Virol. 62:3608-3613.
42. Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature (London) 335:683-689.
43. Rank, N. M., and P. F. Lambert. 1995. Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB. J. Virol. 69:6323-6334.
44. Romanczuk, H., F. Thierry, and P. M. Howley. 1990. Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J. Virol. 64:2849-2859.
45. Scheffner, M., K. Münger, J. Byrne, and P. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88:5523-5527.
46. Schwarz, E., U. K. Freese, L. Gissman, W. Mayer, B. Roggenbuck, A. Stremlau, and H. zur Hausen. 1985. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (London) 314:111-114.
47. Sedman, S. A., M. S. Barbosa, W. C. Vass, N. L. Hubbert, J. A. Haas, D. R. Lowy, and J. T. Schiller. 1991. The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. J. Virol. 65:4860-4866.
48. Seedorf, K., G. Kraemmer, M. Duerst, S. Suhai, and W. G. Roewekamp. 1985. Human papillomavirus type 16 DNA sequence. Virology 145:181-185.
49. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
50. Smotkin, D., H. Prokoph, and F. O. Wettstein. 1989. Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J. Virol. 63:1441-1447.
51. Smotkin, D., and F. O. Wettstein. 1986. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680-4684.
52. Spalholz, B. A., J. C. Byrne, and P. M. Howley. 1988. Evidence for cooperativity between E2 binding sites in E2 trans-regulation of bovine papillomavirus type 1. J. Virol. 62:3143-3150.
53. Steger, G., J. Ham, O. Lefebvre, and M. Yaniv. 1995. The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding. EMBO J. 14:329-340.
54. Stenlund, A., and M. R. Botchan. 1990. The E2 trans-activator can act as a repressor by interfering with a cellular transcription factor. Genes Dev. 4:123-136.
55. Stoler, M. H., S. M. Wolinsky, A. Whitbeck, T. R. Broker, and L. T. Chow. 1989. Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology 172:331-340.
56. Storey, A., K. Osborn, and L. Crawford. 1990. Co-transformation by human papillomavirus types 6 and 11. J. Gen. Virol. 71:165-171.
57. Sverdrup, F., and S. A. Khan. 1994. Replication of human papillomavirus (HPV) DNAs supported by the HPV type 18 E1 and E2 proteins. J. Virol. 68:505-509.
58. Thierry, F., J. M. Heard, K. Dartmann, and M. Yaniv. 1987. Characterization of a transcriptional promoter of human papillomavirus type 18 and modulation of its expression by simian virus 40 and adenovirus early antigens. J. Virol. 61:134-142.
59. Thierry, F., and P. M. Howley. 1991. Functional analysis of E2-mediated repression of the HPV18 P105 promoter. New Biol. 3:90-100.
60. Thierry, F, and M. Yaniv. 1987. The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J. 6:3391-3397.
61. Ushikai, M., M. J. Lace, Y. Yamakawa, M. Kono, J. Anson, T. Ishiji, S. Parkkinen, N. Wicker, M. E. Valentine, I. Davidson, L. P. Turek, and T. H. Haugen. 1994. Transactivation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors. J. Virol. 68:6655-6666.
62. Vande Pol, S. B., and P. M. Howley. 1990. A bovine papillomavirus constitutive enhancer is negatively regulated by the E2 repressor through competitive binding for a cellular factor. J. Virol. 64:5420-5429.
63. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.