Contractile responses of rat duodenum caused by transmural nerve stimulation: Interaction between tachykininergic and cholinergic mechanisms

Acta Physiologica Scandinavica

Volumn 158, Issue 2, 1996, Pages 135-142

  Tolessa, T ^a   Lordal M ^a   Hellstrom P M ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Gastrointestinal motility; Neurokinins; Senktide; Smooth muscle; Substance P methyl ester; Tachykinins; Ala8 neurokinin A(4 10)

Indexed keywords

ATROPINE; MEN 10627; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR; NEUROKININ A [4-10][8 BETA ALANINE]; SENKTIDE; SUBSTANCE P METHYL ESTER; TACHYKININ RECEPTOR AGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM; GASTROINTESTINAL MOTILITY; IN VITRO STUDY; MALE; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029795219     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1996.539297000.x     Document Type: Article

References (33)

1. Al-Saffar, A., Rahman, M. & Hellström, P.M. 1993. Neurokinin receptors in motor responses to neuropeptide γ and transmural nerve stimulation. Surg Res Communication 14, 13-21.
2. Barthó, L. & Holzer, P. 1985. Search for a physiological role of substance P in gastrointestinal motility. Neuroscience 16, 1-32.
3. Buck, S.H., Burcher, E., Shults, C.W., Lovenberg, W. & O'Donohue, T.L. 1984. Novel pharmacology of substance K-binging sites: a third type of tachykinin receptor. Science 226, 987-989.
4. Delbro, D., Fändriks, L., Rosell, S. & Folkers, K. 1983. Inhibition of antidromically induced stimulation of gastric motility by substance P receptor blockade. Acta Physiol Scand 118, 309-316.
5. Edin, R., Lundberg, J.M., Lidberg, P., Dahlström, A. & Ahlman, H. 1980. Atropine sensitive contractile motor effects of substance P on the feline pylorus and stomach in vivo. Acta Physiol Scand 110, 207-209.
6. Fändriks, L. & Delbro, D. 1983. Cholinergic excitatory motor responses of the feline colon elicited by high-strength sympathetic nerve stimulation or by intra-arterial infusion of substance P. Acta Physiol Scand 117, 473-475.
7. Gates, T.S., Zimmerman, R.P., Mantyh, C.R., Vigna, S.R., Maggio, J.E., Welton, M.L., Passaro, Jr, E.P. & Mantyh, P.W. 1989. Substance P and substance K receptor binding sites in the human gastrointestinal tract: Localization by autoradiography. Peptides 9, 1207-1219.
8. Grady, E.F., Baluk, P., Wong, H., Böhm, S., Gamp, P., Payan, D., McDonald, D.M. & Bunnett, N.W. 1995. Localization of NK1, NK2 and NK3 receptors by immunofluorescence and confocal microscopy. Tachykinins'95, abstract, Florence, Italy, October 16-18, p. 208.
9. ++ signaling pathways in intestinal muscle cells. J Pharm Exp Ther 270, 236-243.
10. Hellström, P.M., Söder, O. & Theodorsson, E. 1991. Occurrence, release and effects of multiple tachykinins in cat colonic tissues and nerves. Gastroenterology 100, 431-440.
11. Holzer, P. 1982. Different contractile effects of substance P on the intestine of mammals. Naunyn-Schmiedeberg's Arch Pharmacol 297, 127-136.
12. Holzer, P. & Lembeck, F. 1980. Neurally mediated contraction of ileal longitudinal muscle by substance P. Neurosci Lett 17, 101-105.
13. Holzer, P., Lembeck, F. & Donnerer, J. 1980. Caerulein, substance P, serotonin and cholinomimetics induce rhythmic contractions of the intestinal circular muscle. Naunyn-Schmiedeberg's Arch Pharmacol 312, 131-137.
14. Holzer, P. & Maggi, C.A. 1994. Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis. Naunyn-Schmiedeberg's Arch Pharmacol 349, 194-201.
15. Holzer, P., Schluet, W. & Maggi, C.A. 1993. Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation. J Pharm Exp Ther 264, 391-396.
16. Holzer, P., Schluet, W. & Maggi, C.A. 1995. Substance P stimulates and inhibits intestinal peristalsis via distinct receptors. J Pharm Exp Ther 274, 322-328.
17. Kim, Y.C. & Hellström, P.M. 1993. Identification of mechanisms for duodenal contraction induced by tachykinins in the rat. J Gastrointest Mot 5, 97-106.
18. Lidberg, P., Dahlström, A., Lundberg, J.M. & Ahlman, H. 1983. Different modes of action of substance P in the motor control of the feline stomach and pylorus. Regul Peptides 7, 41-52.
19. Lördal, M., Johansson, C. & Hellström, P.M. 1993. Myoelectric pattern and effects on small bowel transit induced by the tachykinins neurokinin A, neurokinin B, substance P and neuropeptide K in the rat. J Gastrointest Mot 5, 33-40.
20. Maggi, C.A., Astolfi, M., Giuliani, S., Goso, C., Manzini, S., Meini, S., Patacchini, R., Pavone, V., Pedone, C., Quartara, L., Renzetti, A.R. & Giachetti, A. 1994c. MEN 10627, a novel polycyclic peptide antagonist at tachykinin NK2 receptor. J Pharmacol Exp Ther 271, 1489-1500.
21. Maggi, C.A., Giuliani, S., Ballati, L., Lecci, A., Manzini, S., Patacchini, R., Renzetti, A.R., Rovero, P., Quartara, L. & Giachetti, A. 1991. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther 257, 1172-1178.
22. Maggi, C.A., Giuliani, S., Mangini, S., Santicioli, P. & Meli, A. 1986. Motor effects of neurokinins on the rat duodenum: Evidence for the involvement of substance K and substance P receptors. J Pharmacol Exp Ther 238, 341-351.
23. Maggi, C.A., Holzer, P. & Giuliani, S. 1994b. Effect of ω-conotoxin on cholinergic and tachykininergic excitatory neurotransmission to the circular muscle of guinea-pig colon. Naunyn-Schmiedeberg's Arch Pharmacol 350, 529-536.
24. Maggi, C.A., Patacchini, R., Meini, S. & Giuliani, S. 1994a. Effect of longitudinal muscle myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum. J Auton Pharmacol 14, 49-60.
25. Mantyh, P.W., Gates, T., Mantyh, C.R. & Maggio, J.E. 1989. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci 9, 258-279.
26. Osakada, F., Kubo, K., Goto, K., Kanazawa, I. & Munekata, E. 1986. The contractile activities of neurokinin A, B and related peptides on smooth muscles. Eur J Pharmacol 120, 201-208.
27. Patacchini, R., De Giorgio, R., Giachetti, A. & Maggi, C.A. 1991a. Different mechanism of tachykinin NK2 receptor blockade by SR 48968 and MEN 10,627 in the guinea-pig isolated gallbladder and colon. Eur J Pharmacol 271, 111-119.
28. Rahman, M., Lördal, M., Al-Saffar, A. & Hellström, P.M. 1994. Intestinal motility responses to neuropeptide γ in vitro and in vivo in the rat: comparison with neurokinin 1 and neurokinin 2 receptor agonists. Acta Physiol Scand 151, 497-505.
29. Regoli, D., Drapeau, G., Dion, S. & d'Orleans-Juste, P. 1989. Receptors for substance P and relatied neurokinins. Pharmacology 38, 1-15.
30. Regoli, D., Nantel, F., Tousignant, C., Jukic, D., Rouissi, N., Rhaleb, N.-E., Télémaque, S., Drapeau, G. & d'Orleans-Juste, P. 1991. Neurokinin agonists and antagonists. Ann NY Acad Sci 632, 170-173.
31. Souquet, J.C., Grider, J.R., Bitar, K.N. & Makhlouf, G.M. 1985. Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells. Am J Physiol 249, G533-G538.
32. Tramontana, M., Maggi, C.A. & Evangelista, S. 1994. Spasmolytic effect of the NK2-receptor-selective antagonist MEN 10,627 in rat small intestine. Eur J Pharmacol 6, 281-283.
33. Watson, S.P., Sandberg, B.E.B., Hanky, M.R. & Iversen, L.L. 1983. Tissue selectivity of substance P alkyl esters: suggesting multiple receptors. Eur J Pharmacol 87, 77-84.