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Volumn 16, Issue 20, 1996, Pages 6612-6623

An opioidergic cortical antinociception triggering site in the agranular insular cortex of the rat that contributes to morphine antinociception

Author keywords

analgesia; cerebral cortex; descending inhibition; formalin test; Fos; limbic system; pain; systemic opioids; opioid receptor

Indexed keywords

17 METHYLNALOXONE; MORPHINE SULFATE; MU OPIATE RECEPTOR;

EID: 0029794861     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-20-06612.1996     Document Type: Article
Times cited : (105)

References (56)
  • 1
    • 0018129407 scopus 로고
    • Analgesia produced by electrical stimulation of limbic structures and its relation to epileptiform after-discharges
    • Abbott FV, Melzack R (1978) Analgesia produced by electrical stimulation of limbic structures and its relation to epileptiform after-discharges. Exp Neurol 62:720-734.
    • (1978) Exp Neurol , vol.62 , pp. 720-734
    • Abbott, F.V.1    Melzack, R.2
  • 2
    • 0026637561 scopus 로고
    • Analgesia induced by morphine injected into the pallidum
    • Anagnostakis Y, Zis V, Spyraki C (1992) Analgesia induced by morphine injected into the pallidum. Behav Brain Res 48:135-143.
    • (1992) Behav Brain Res , vol.48 , pp. 135-143
    • Anagnostakis, Y.1    Zis, V.2    Spyraki, C.3
  • 6
    • 0021288912 scopus 로고
    • Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
    • Basbaum AI, Fields HL (1984) Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338.
    • (1984) Annu Rev Neurosci , vol.7 , pp. 309-338
    • Basbaum, A.I.1    Fields, H.L.2
  • 7
    • 0017050770 scopus 로고
    • Opiate and stimulus-produced analgesia: Functional anatomy of a medullospinal pathway
    • Basbaum AI, Clanton CH, Fields HL (1976) Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proc Natl Acad Sci USA 73:4685-4688.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 4685-4688
    • Basbaum, A.I.1    Clanton, C.H.2    Fields, H.L.3
  • 8
    • 0026443162 scopus 로고
    • Biotin-dextran: A sensitive anterograde tracer for neuroanatomic studies in rat and monkey
    • Brandt HM, Apkarian AV (1992) Biotin-dextran: a sensitive anterograde tracer for neuroanatomic studies in rat and monkey. J Neurosci Methods 45:35-40.
    • (1992) J Neurosci Methods , vol.45 , pp. 35-40
    • Brandt, H.M.1    Apkarian, A.V.2
  • 9
    • 0019944834 scopus 로고
    • Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat
    • Carstens E, MacKinnon JD, Guinan MJ (1982) Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat. J Neurophysiol 48:981-991.
    • (1982) J Neurophysiol , vol.48 , pp. 981-991
    • Carstens, E.1    MacKinnon, J.D.2    Guinan, M.J.3
  • 10
    • 0023181826 scopus 로고
    • Evidence for a viscerotopic representation in the cortex and thalamus in the rat
    • Cechetto DF, Saper CB (1987) Evidence for a viscerotopic representation in the cortex and thalamus in the rat. J Comp Neurol 262:27-45.
    • (1987) J Comp Neurol , vol.262 , pp. 27-45
    • Cechetto, D.F.1    Saper, C.B.2
  • 11
    • 0027156210 scopus 로고
    • The formalin test: A validation of the weighted-scores method of behavioural pain rating
    • Coderre TJ, Fundytus ME, McKenna JE, Dalal S, Melzack R (1993) The formalin test: a validation of the weighted-scores method of behavioural pain rating. Pain 54:43-50.
    • (1993) Pain , vol.54 , pp. 43-50
    • Coderre, T.J.1    Fundytus, M.E.2    McKenna, J.E.3    Dalal, S.4    Melzack, R.5
  • 12
    • 0021139973 scopus 로고
    • Unilateral analgesia produced by intraventricular morphine
    • Cohen SR, Abbott FV, Melzack R (1984) Unilateral analgesia produced by intraventricular morphine. Brain Res 303:277-287.
    • (1984) Brain Res , vol.303 , pp. 277-287
    • Cohen, S.R.1    Abbott, F.V.2    Melzack, R.3
  • 13
    • 0026337337 scopus 로고
    • Antinociceptive action of opiates and opioid peptides after unilateral microinjection into Area Tempestas in rats
    • d'Amore A, Lorenzini P, Massotti M (1991) Antinociceptive action of opiates and opioid peptides after unilateral microinjection into Area Tempestas in rats. J Pharmacol Exp Ther 259:1308-1315.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 1308-1315
    • Amore, A.1    Lorenzini, P.2    Massotti, M.3
  • 14
    • 0028239559 scopus 로고
    • Expression of mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level
    • Delfs JM, Kong H, Mestek A, Chen Y, Yu L, Reisine T, Chesselet M-F (1994) Expression of mu opioid receptor mRNA in rat brain: an in situ hybridization study at the single cell level. J Comp Neurol 345:46-68.
    • (1994) J Comp Neurol , vol.345 , pp. 46-68
    • Delfs, J.M.1    Kong, H.2    Mestek, A.3    Chen, Y.4    Yu, L.5    Reisine, T.6    Chesselet, M.-F.7
  • 15
    • 0023162253 scopus 로고
    • Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat
    • Lond
    • Dickenson AH, Le Bars D (1987) Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat. J Physiol (Lond) 384:81-107.
    • (1987) J Physiol , vol.384 , pp. 81-107
    • Dickenson, A.H.1    Le Bars, D.2
  • 16
    • 0017643233 scopus 로고
    • The formalin test: A quantitative study of the analgesic effects of morphine, nieperidine, and brain stem stimulation in rats and cats
    • Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, nieperidine, and brain stem stimulation in rats and cats. Pain 4:161-174.
    • (1977) Pain , vol.4 , pp. 161-174
    • Dubuisson, D.1    Dennis, S.G.2
  • 17
    • 70449177837 scopus 로고
    • A note on a simple apparatus for detecting neurological deficit in rats and mice
    • Dunham NW, Miya TS (1957) A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc 46:208-209.
    • (1957) J Am Pharm Assoc , vol.46 , pp. 208-209
    • Dunham, N.W.1    Miya, T.S.2
  • 18
    • 0021049145 scopus 로고
    • Evidence that disinhibition of brain stem neurones contributes to morphine analgesia
    • Fields HL, Vanegas H, Hentall ID, Zorman G (1983) Evidence that disinhibition of brain stem neurones contributes to morphine analgesia. Nature 306:684-686.
    • (1983) Nature , vol.306 , pp. 684-686
    • Fields, H.L.1    Vanegas, H.2    Hentall, I.D.3    Zorman, G.4
  • 19
    • 0028926310 scopus 로고
    • Antinociception produced by an ascending spino-supraspinal pathway
    • Gear RW, Levine JD (1995) Antinociception produced by an ascending spino-supraspinal pathway. J Neurosci 15:3154-3161.
    • (1995) J Neurosci , vol.15 , pp. 3154-3161
    • Gear, R.W.1    Levine, J.D.2
  • 20
    • 0025882073 scopus 로고
    • The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: Correlation of nociceptive behavior and c-fos expression
    • Gogas KR, Presley RW, Levine JD, Basbaum AI (1991) The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression. Neuroscience 42:617-628.
    • (1991) Neuroscience , vol.42 , pp. 617-628
    • Gogas, K.R.1    Presley, R.W.2    Levine, J.D.3    Basbaum, A.I.4
  • 21
    • 0028229190 scopus 로고
    • The rotarod test: An evaluation of its effectiveness in assessing motor deficits following traumatic brain injury
    • Hamm RJ, Pike BR, O'Dell DM, Lyeth BG, Jenkins LW (1994) The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma 11:187-196.
    • (1994) J Neurotrauma , vol.11 , pp. 187-196
    • Hamm, R.J.1    Pike, B.R.2    O'Dell, D.M.3    Lyeth, B.G.4    Jenkins, L.W.5
  • 22
    • 0027968011 scopus 로고
    • Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla
    • Heinricher MM, Morgan MM, Tortorici V, Fields HL (1994) Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience 63:279-288.
    • (1994) Neuroscience , vol.63 , pp. 279-288
    • Heinricher, M.M.1    Morgan, M.M.2    Tortorici, V.3    Fields, H.L.4
  • 23
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody procedure
    • Hsu S-U, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody procedure. J Histochem Cytochem 29:577-580.
    • (1981) J Histochem Cytochem , vol.29 , pp. 577-580
    • Hsu, S.-U.1    Raine, L.2    Fanger, H.3
  • 24
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632-634.
    • (1987) Nature , vol.328 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 25
    • 0015909767 scopus 로고
    • Morphine action at central nervous system sites in rat: Analgesia or hyperalgesia depending on site and dose
    • Jacquet YF, Lajtha A (1973) Morphine action at central nervous system sites in rat: analgesia or hyperalgesia depending on site and dose. Science 182:490-492.
    • (1973) Science , vol.182 , pp. 490-492
    • Jacquet, Y.F.1    Lajtha, A.2
  • 26
    • 0027979335 scopus 로고
    • Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat
    • Jasmin L, Gogas KR, Ahlgren SC, Levine JD, Basbaum AI (1994) Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat. Neuroscience 58:275-286.
    • (1994) Neuroscience , vol.58 , pp. 275-286
    • Jasmin, L.1    Gogas, K.R.2    Ahlgren, S.C.3    Levine, J.D.4    Basbaum, A.I.5
  • 27
    • 0026041886 scopus 로고
    • Hyperalgesia during acute opioid abstinence: Evidence for a nociceptive facilitating function of the rostral ventromedial medulla
    • Kaplan H, Fields HL (1991) Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla. J Neurosci 11:1433-1439.
    • (1991) J Neurosci , vol.11 , pp. 1433-1439
    • Kaplan, H.1    Fields, H.L.2
  • 28
    • 0023359832 scopus 로고
    • Behavioral assessment of functional deficit in rats with contusive spinal injury
    • Kerasidis H, Wrathall JR, Gale K (1987) Behavioral assessment of functional deficit in rats with contusive spinal injury. J Neurosci Methods 20:167-189.
    • (1987) J Neurosci Methods , vol.20 , pp. 167-189
    • Kerasidis, H.1    Wrathall, J.R.2    Gale, K.3
  • 29
    • 0023835233 scopus 로고
    • Visceral cortex: Integration of the mucosal senses with limbic information in the rat agranular insular cortex
    • Krushel AA, van der Kooy D (1988) Visceral cortex: integration of the mucosal senses with limbic information in the rat agranular insular cortex. J Comp Neurol 270:39-54.
    • (1988) J Comp Neurol , vol.270 , pp. 39-54
    • Krushel, A.A.1    Van Der Kooy, D.2
  • 30
    • 0026674125 scopus 로고
    • Complete penetration of antibodies into vibratome sections after glutaraldehyde fixation and ethanol treatment: Light and electron microscopy for neuropeptides
    • Llewellyn-Smith IJ, Minson JB (1992) Complete penetration of antibodies into vibratome sections after glutaraldehyde fixation and ethanol treatment: light and electron microscopy for neuropeptides. J Histochem Cytochem 40:1741-1749.
    • (1992) J Histochem Cytochem , vol.40 , pp. 1741-1749
    • Llewellyn-Smith, I.J.1    Minson, J.B.2
  • 31
    • 0028807729 scopus 로고
    • The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test
    • Manning BH, Mayer DJ (1995a) The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test. Pain 63:141-152.
    • (1995) Pain , vol.63 , pp. 141-152
    • Manning, B.H.1    Mayer, D.J.2
  • 32
    • 0029617652 scopus 로고
    • The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test
    • Manning BH, Mayer DJ (1995b) The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test. J Neurosci 15:8199-8213.
    • (1995) J Neurosci , vol.15 , pp. 8199-8213
    • Manning, B.H.1    Mayer, D.J.2
  • 33
    • 0028178510 scopus 로고
    • Muopioid receptor mRNA expression in the rat CNS: Comparison to mu-receptor binding
    • Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ (1994) Muopioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding. Brain Res 643:245-265.
    • (1994) Brain Res , vol.643 , pp. 245-265
    • Mansour, A.1    Fox, C.A.2    Thompson, R.C.3    Akil, H.4    Watson, S.J.5
  • 34
    • 10144241318 scopus 로고
    • Antinociception induced by morphine in the cortex acts through descending inhibition on spinal transmission
    • Marchand S, Carstens E, Burkey A, Jasmin L (1995) Antinociception induced by morphine in the cortex acts through descending inhibition on spinal transmission. Soc Neurosci Abstr 552:13.
    • (1995) Soc Neurosci Abstr , vol.552 , pp. 13
    • Marchand, S.1    Carstens, E.2    Burkey, A.3    Jasmin, L.4
  • 35
    • 0028968621 scopus 로고
    • Effects of partial decortication on opioid analgesia in the formalin test
    • Matthies BK, Franklin KB (1995) Effects of partial decortication on opioid analgesia in the formalin test. Behav Brain Res 67:59-66.
    • (1995) Behav Brain Res , vol.67 , pp. 59-66
    • Matthies, B.K.1    Franklin, K.B.2
  • 36
    • 0017344097 scopus 로고
    • An analysis of response properties of spinal cord dorsal horn neurones to nonnoxious and noxious stimuli in the spinal rat
    • Menétrey D, Giesler GJJ, Besson JM (1977) An analysis of response properties of spinal cord dorsal horn neurones to nonnoxious and noxious stimuli in the spinal rat. Exp Brain Res 27:15-33.
    • (1977) Exp Brain Res , vol.27 , pp. 15-33
    • Menétrey, D.1    Giesler, G.J.J.2    Besson, J.M.3
  • 37
    • 0024371525 scopus 로고
    • Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation
    • Menétrey D, Gannon A, Levine JD, Basbaum AI (1989) Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol 285:177-195.
    • (1989) J Comp Neurol , vol.285 , pp. 177-195
    • Menétrey, D.1    Gannon, A.2    Levine, J.D.3    Basbaum, A.I.4
  • 38
    • 0028224864 scopus 로고
    • Serotonin and pain: Evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice
    • Milan MJ (1994) Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. Pain 58:45-61.
    • (1994) Pain , vol.58 , pp. 45-61
    • Milan, M.J.1
  • 39
    • 0023258149 scopus 로고
    • The origin of corticospinal projection neurons in rat
    • Miller MW (1987) The origin of corticospinal projection neurons in rat. Exp Brain Res 67:339-351.
    • (1987) Exp Brain Res , vol.67 , pp. 339-351
    • Miller, M.W.1
  • 40
    • 0021711550 scopus 로고
    • The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord
    • Molander C, Xu O, Grant G (1984) The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol 230:133-141.
    • (1984) J Comp Neurol , vol.230 , pp. 133-141
    • Molander, C.1    Xu, O.2    Grant, G.3
  • 41
    • 0027946186 scopus 로고
    • Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine
    • Olmstead MC, Franklin K (1994) Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine. Brain Res 662:134-140.
    • (1994) Brain Res , vol.662 , pp. 134-140
    • Olmstead, M.C.1    Franklin, K.2
  • 43
    • 0025137135 scopus 로고
    • Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord
    • Presley RW, Menétrey D, Levine JD, Basbaum AI (1990) Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci 10:323-335.
    • (1990) J Neurosci , vol.10 , pp. 323-335
    • Presley, R.W.1    Menétrey, D.2    Levine, J.D.3    Basbaum, A.I.4
  • 44
    • 76949120541 scopus 로고
    • The cytoarchitectonic atlas of the spinal cord in the cat
    • Rexed B (1952) The cytoarchitectonic atlas of the spinal cord in the cat. J Comp Neurol 96:415-495.
    • (1952) J Comp Neurol , vol.96 , pp. 415-495
    • Rexed, B.1
  • 45
    • 0026088478 scopus 로고
    • Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injections
    • Schroeder RL, Weinger MB, Vakassian L, Koob GF (1991) Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injections. Neurosci Lett 121:173-177.
    • (1991) Neurosci Lett , vol.121 , pp. 173-177
    • Schroeder, R.L.1    Weinger, M.B.2    Vakassian, L.3    Koob, G.F.4
  • 46
    • 0019500462 scopus 로고
    • Functional properties of neurons in cat trigeminal subnucleus caudalis (medullary dorsal horn). II. Modulation of responses to noxious and nonnoxious stimuli by periaqueductal gray, nucleus raphe magnus, cerebral cortex, and afferent influences, and effects of naloxone
    • Sessle BJ, Hu JW, Dubner R, Lucier GE (1981) Functional properties of neurons in cat trigeminal subnucleus caudalis (medullary dorsal horn). II. Modulation of responses to noxious and nonnoxious stimuli by periaqueductal gray, nucleus raphe magnus, cerebral cortex, and afferent influences, and effects of naloxone. J Neurophysiol 45:193-207.
    • (1981) J Neurophysiol , vol.45 , pp. 193-207
    • Sessle, B.J.1    Hu, J.W.2    Dubner, R.3    Lucier, G.E.4
  • 47
    • 0026530940 scopus 로고
    • The representation of prolonged and intense, noxious somatic and visceral stimuli in the ventrolateral orbital cortex of the cat
    • Snow PJ, Lumb BM, Cervero F (1992) The representation of prolonged and intense, noxious somatic and visceral stimuli in the ventrolateral orbital cortex of the cat. Pain 48:89-99.
    • (1992) Pain , vol.48 , pp. 89-99
    • Snow, P.J.1    Lumb, B.M.2    Cervero, F.3
  • 48
    • 0028301968 scopus 로고
    • Inhibition of morphine tolerance and dependence by diazepam and its relation to the CNS Met-enkephalin levels
    • Sribanditmongkol P, Sheu MJ, Tejwani GA (1994) Inhibition of morphine tolerance and dependence by diazepam and its relation to the CNS Met-enkephalin levels. Brain Res 645:1-12.
    • (1994) Brain Res , vol.645 , pp. 1-12
    • Sribanditmongkol, P.1    Sheu, M.J.2    Tejwani, G.A.3
  • 49
    • 0015318666 scopus 로고
    • Cytoarchitecture of the rat spinal cord
    • Lond
    • Steiner TJ, Turner LM (1972) Cytoarchitecture of the rat spinal cord. J Physiol (Lond) 222:123P-125P.
    • (1972) J Physiol , vol.222
    • Steiner, T.J.1    Turner, L.M.2
  • 51
    • 0026633275 scopus 로고
    • Forebrain sites differentially sensitive to beta-endorphine and morphine for analgesia and release of Met-enkephalin in the pentobarbital-anesthetized rat
    • Tseng LF, Wang Q (1992) Forebrain sites differentially sensitive to beta-endorphine and morphine for analgesia and release of Met-enkephalin in the pentobarbital-anesthetized rat. J Pharmacol Exp Ther 261: 1028-1036.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 1028-1036
    • Tseng, L.F.1    Wang, Q.2
  • 52
    • 0027943291 scopus 로고
    • Descending modulation of central neural plasticity in the formalin pain test
    • Vaccarino AL, Chorney DA (1994) Descending modulation of central neural plasticity in the formalin pain test. Brain Res 666:104-108.
    • (1994) Brain Res , vol.666 , pp. 104-108
    • Vaccarino, A.L.1    Chorney, D.A.2
  • 53
    • 10144239976 scopus 로고
    • The analgesic effect of morphine in the piriform cortex (PC) may be mediated through the descending inhibitory control as evidence by correlation of nociceptive behavior and c-fos expression in the formalin test
    • Wenniger J, Proctor M, Gale K, Jasmin L (1994) The analgesic effect of morphine in the piriform cortex (PC) may be mediated through the descending inhibitory control as evidence by correlation of nociceptive behavior and c-fos expression in the formalin test. Soc Neurosci Abstr 318:18.
    • (1994) Soc Neurosci Abstr , vol.318 , pp. 18
    • Wenniger, J.1    Proctor, M.2    Gale, K.3    Jasmin, L.4
  • 54
    • 0017089254 scopus 로고
    • Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray
    • Yaksh TL, Yeung JC, Rudy TA (1976) Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Res 114:83-103.
    • (1976) Brain Res , vol.114 , pp. 83-103
    • Yaksh, T.L.1    Yeung, J.C.2    Rudy, T.A.3
  • 55
    • 0027985016 scopus 로고
    • Characterization of the foot withdrawal response to noxious radiant heat in the rat
    • Yeomans DC, Proudfit HK (1994) Characterization of the foot withdrawal response to noxious radiant heat in the rat. Pain 59:85-94.
    • (1994) Pain , vol.59 , pp. 85-94
    • Yeomans, D.C.1    Proudfit, H.K.2
  • 56
    • 0019132654 scopus 로고
    • Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine
    • Yeung JC, Rudy TA (1980) Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine. J Pharmacol Exp Ther 215: 633-642.
    • (1980) J Pharmacol Exp Ther , vol.215 , pp. 633-642
    • Yeung, J.C.1    Rudy, T.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.