New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 18, 1996, Pages 3431-3434

  Kim, C U ^a   McGee, L R ^a   Krawczyk, S H ^a   Harwood, E ^a   Harada, Y ^a   Swaminathan, S ^a   Bischofberger, N ^a   Chen, M S ^a   Cherrington, J M ^a   Xiong, S F ^a   Griffin, L ^a   Cundy, K C ^a   Lee, A ^a   Yu, B ^a   Gulnik, S ^a   Erickson, J W ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL DERIVATIVE; PROTEINASE INHIBITOR; SULFONE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; ENZYME BINDING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR INTERACTION; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; HIV PROTEASE INHIBITORS; HIV-1; MALE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 0029794741     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960340o     Document Type: Article

References (0)