Double-blind, parallel, comparative multicentre study of a new combination of diltiazem and hydrochlorothiazide with individual components in patients with mild or moderate hypertension

Journal of Human Hypertension

Volumn 10, Issue 7, 1996, Pages 443-448

  Manning, G ^a   Joy, A ^a   Mathias, C J ^b   McDonald, C J ^c   Millar Craig, M W ^a  

^a DERBYSHIRE ROYAL INFIRMARY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Napp Laboratories   (United Kingdom)

Author keywords

Ambulatory blood pressure monitoring; Diltiazem; Hydrochlorothiazide

Indexed keywords

DILTIAZEM; HYDROCHLOROTHIAZIDE;

ADULT; AGED; AMBULATORY MONITORING; ARTICLE; BLOOD PRESSURE MEASUREMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MIXTURE; DRUG TOLERABILITY; ESSENTIAL HYPERTENSION; HEADACHE; HUMAN; LEG CRAMP; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA; ORAL DRUG ADMINISTRATION; PATIENT CARE; RANDOMIZED CONTROLLED TRIAL; SUPINE POSITION; TREATMENT OUTCOME; VOMITING;

ADOLESCENT; ADULT; AGED; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CALCIUM CHANNEL BLOCKERS; DIASTOLE; DILTIAZEM; DIURETICS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; MIDDLE AGED; SODIUM CHLORIDE SYMPORTER INHIBITORS; SUPINE POSITION; SYSTOLE;

EID: 0029794592     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Pool PE et al. Sustained release diltiazem: duration of antihypertensive effect. J Clin Pharmacol 1989; 29: 533-537.
2. Pool PE, Salel AF. Sustained release diltiazem in hypertension: clinical safety and efficacy. Pract Cardial 1990; 16: 53.
3. Nikkila MT et al. Antihypertensive effect of diltiazem in a slow release formulation for mild to moderate essential hypertension. Am J Cardiol 1989; 63: 1227-1230.
4. Coulter DM. Trial of slow release diltiazem for essential hypertension in general practice. NZ Med J 1991; 104 (Suppl 905): 37-38.
5. Myburgh DP. Long term efficacy and safety of sustained release diltiazem in the treatment of hypertension. S Afr Med J 1990; 78: 456-457.
6. Sawai K. Effects of long term administration of diltiazem hydrochloride in hypertensive patients. Clin Ther 1983; 5 (4): 424-435.
7. Djian J et al. Effects of sustained release diltiazem on blood pressure and serum lipids; a multi-centre, randomised, placebo controlled study. J Cardiovasc Pharmacol 1990; 16 (Suppl 1): S38-S45.
8. Inouye IK et al. Antihypertensive therapy with diltiazem and comparison with hydrochlorothiazide. Am J Cardiol 1984; 53: 1588-1592.
9. Moser M, Lunn J, Materson BJ. Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension. Am J Cardiol 1985; 56: 101H-104H.
10. Frishman WH et al. Diuretics vs calcium-channel blockers in systemic hypertension: a preliminary multi-centre experience with hydrochlorothiazide and sustained-release diltiazem. Am J Cardiol 1985; 56: 92H-96H.
11. Zawada ET et al. Renal-metabolic consequences of antihypertensive therapy with diltiazem versus hydrochlorothiazide. Mineral, Electrolyte Metab 1987; 13: 72-77.
12. Leehey DJ, Hartman E. Comparison of diltiazem and hydrochlorothiazide for treatment of patients 60 years of age or older with systemic hypertension. Amer J Cardiol 1988; 62: 1218-1223.
13. Frishman WH et al. Comparison of hydrochlorothiazide and sustained release diltiazem for mild to moderate systemic hypertension. Am J Cardiol 1987; 59: 615-623.
14. Burris JF et al. An assessment of diltiazem and hydrochlorothiazide in hypertension. JAMA 1990; 263: 1507-1512.
15. Weir MR et al. A dose escalation trial comparing the combination of diltiazem SR and hydrochlorothiazide with the monotherapies in patients with essential hypertension. J Hum Hypertens 1992; 6: 133-138.
16. Pool PE et al. A randomised, controlled trial comparing diltiazem, hydrochlorothiazide, and their combination in the therapy of essential hypertension. Pharmacotherapy 1993; 13(5): 487-493.
17. Data on file. Napp Laboratories, Cambridge.
18. O'Brien E et al. Ambulatory blood pressure monitoring in the evaluation of drug efficacy. Am Heart J 1991; 121: 999-1006.
19. Conway J, Coats A. Value of ambulatory blood pressure monitoring in clinical pharmacology. J Hypertens 1989; 7 (Suppl 3): S29-S32.
20. Pickering TG. The clinical significance of diurnal blood pressure variations; dippers and non-dippers. Circulation 1990; 81: 700-702.
21. Verdecchia P et al. Circadian blood pressure changes in left ventricular hypertrophy in essential hypertension. Circulation 1990; 81: 528.
22. O'Brien E, O'Malley K. Twenty-four hour ambulatory blood pressure monitoring: a review of the validation data. J Hypertens 1990; 8 (Suppl 6): S11-S16.
23. White WB, Morganroth J. Usefulness of ambulatory monitoring of blood pressure in assessing antihypertensive therapy. Am J Cardiol 1989; 63: 94-98.
24. Sever P et al. Management guidelines in essential hypertension: report of the second working party of the British Hypertension Society. Br Med J 1993; 306: 983-987.