Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites

Journal of Virology

Volumn 70, Issue 10, 1996, Pages 6716-6722

  Biswas, Siddhartha K ^a   Nayak, Debi P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; INFLUENZA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 0029793810     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.6716-6722.1996     Document Type: Article

References (38)

1. Akkina, K. R., J. C. Richardson, M. C. Aguilera, and C. M. Yang. 1991. Heterogeneous form of polymerase proteins exist in influenza A virus-infected cells. Virus Res. 19:17-30.
2. Akkina, R. K., T. M. Chambers, D. R. Londo, and D. P. Nayak. 1987. Intracellular localization of the viral polymerase proteins in cells infected with influenza virus and cells expressing PB1 protein from cloned cDNA. J. Virol. 61:2217-2224.
3. Ball, L. A. 1992. Cellular expression of a functional nodavirus RNA replicon from vaccinia virus vectors. J. Virol. 66:2335-2345.
4. Biswas, S. K., and D. P. Nayak. 1994. Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1. J. Virol. 68:1819-1826.
5. Cianci, C, L. Tiley, and M. Krystal. 1995. Differential activation of the influenza virus polymerase via template RNA binding. J. Virol. 69:3995-3999.
6. de la Luna, S., J. Martin, A. Portela, and J. Ortin. 1993. Influenza virus naked RNA can he expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from SV 40 recombinant viruses. J. Gen. Virol. 74:535-539.
7. Detjen, B. M., C. St. Angelo, M. G. Katze, and R. M. Krug. 1987. The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complex. J. Virol. 61:16-22.
8. Fodor, E., D. C. Pritlove, and G. G. Brownlee. 1994. The influenza virus panhandle is involved in the initiation of transcription. J. Virol. 68:4092-4096.
9. Fodor, E., B. L. Seong, and G. G. Brownlee. 1993. Photochemical cross-linking of influenza a polymerase to its virion RNA promoter defines a polymerase binding site at residues 9 to 12 of the promoter. J. Gen. Virol. 74:1327-1333.
10. Fuerst, T. R., A. L. Earl, and B. Moss. 1987. Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes. Mol. Cell. Biol. 7:2538-2544.
11. Hagen, M., T. D. Y. Chung, J. A. Butcher, and M. Krystal. 1994. Recombinant influenza virus polymerase: requirement of both 5′ and 3′ viral ends for endonuclease activity. J. Virol. 68:1509-1515.
12. Hizi, A., A. Barber, and S. H. Huges. 1989. Effects of small insertions on the RNA-dependent DNA polymerase activity of HIV-1 reverse transcriptase. Virology 170:326-329.
13. Horikami, S. M., J. Curran, D. Kolakofsky, and S. A. Moyer. 1992. Complexes of Sendai virus NP-P and P-L proteins are required for defective interfering particle genome replication in vitro. J. Virol. 66:4901-4908.
14. Hsu, M., J. D. Parvin, S. Gupta, M. Krystal, and P. Palese. 1987. Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc. Natl. Acad. Sci. USA 84: 8140-8144.
15. Huang, T.-S., P. Palese, and M. Krystal. 1990. Determination of influenza virus proteins required for genome replication. J. Virol. 64:5669-5673.
16. Kimura, N., M. Nishida, K. Nagata, A. Ishihama, K. Oda, and S. Nakada. 1992. Transcription of a recombinant influenza virus RNA in cells that can express the influenza virus RNA polymerase and nucleoprotein genes. J. Gen. Virol. 73:1321-1328.
17. Krug, R. M., F. V. Aloso-Caplen, I. Julkunen, and M. G. Katze. 1989. Expression and replication of the influenza virus genome, 89-152. In R. M. Krug (ed.), The influenza viruses. Plenum Press, New York.
18. Luytjes, W., M. Krystal, M. Enami, J. D. Parvin, and P. Palese. 1989. Amplification, expression and packaging of a foreign gene by influenza virus. Cell 59:1107-1113.
19. Mena, I., S. de la Luna, C. Alba, J. Martin, A. Nieto, J. Ortin, and A. Portela. 1994. Synthesis of biologically active influenza virus core proteins using a vaccinia-T7 RNA polymerase expression system. J. Gen. Virol. 75:2109-2114.
20. Mena, I., S. de la Luna, J. Martin, C. Albo, B. Perales, A. Nieto, A. Portela, and J. Ortin. 1995. Systems to express recombinant RNA molecules by the influenza A virus polymerase in vivo, p. 329-342. In K. W. Adolph (ed.). Methods in molecular genetics, Molecular virology techniques, part B. Academic Press, Inc., Orlando, Fla.
21. Mukaigawa, J., and D. P. Nayak. 1991. Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. J. Virol. 65:245-253.
22. Nakagawa, Y., N. Kimura, T. Toyoda, K. Mizumoto, A. Ishihama, K. Oda, and S. Nakada. 1995. The RNA polymerase PB2 subunits is not required for replication of the influenza virus genome but is involved in capped mRNA synthesis. J. Virol. 69:728-733.
23. Nath, S. T., and D. P, Nayak. 1990. Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1). Mol. Cell. Biol. 10:4139-4145.
24. Neumann, G., A. Zobel, and G. Hobom. 1994. RNA polymerase I-mediated expression of influenza viral RNA molecules. Virology 202:477-479.
25. Nieto, A., S. de la Luna, J. Barcena, A. Portela, J. Valcarcel, J. A. Melero, and J. Ortin. 1992. Nuclear transport of influenza virus polymerase PA protein. Virus Res. 24:65-75.
26. Parks, G. D. 1994. Mapping of a region of the paramyxovirus L protein required for the formation of a stable complex with the viral phosphoprotcin P. J. Virol. 68:4862-4872.
27. Perales, B., S. de la Luna, I. Palacios, and J. Ortin. 1996. Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. J. Virol. 70:1678-1686.
28. Perez, D. R., and R. O. Donis. 1995. A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA. J. Virol. 69:6932-6939.
29. 28a.Pleschka, S., S. R. Jaskunas, O. G. Engelhardt, T. Zucher, P. Palese, and A. Garcia-Sastre. 1996. Plasmid-based reverse genetics system for influenza A virus. J. Virol. 70:4188-4192.
30. Poch, O., I. Sauvaget, M. Delarue, and N. Tordo. 1989. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 8:3867-3874.
31. Prasad, V. R., and S. P. Goff. 1989. Linker-insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain. Proc. Natl. Acad. Sci. USA 86:3104-3108.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning of laboratory mammal, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
33. Sanz-Ezquerro, J. J., S. de la Luna, J. Ortin, and A. Nieto. 1995 Individual expression of influenza virus PA protein induces degradation of expression proteins. J. Virol. 69:2420-2426.
34. Sivasubramanian, N., and D. P. Nayak. 1982. Sequence analysis of the polymerase 1 gene and secondary structure prediction of polymerase 1 protein of human influenza virus A/WSN/33. J. Virol. 44:321-329.
35. St. Angelo, C., G. E. Smith, M. D. Summers, and R. M. Krug. 1987. Two of the three influenza viral polymerase proteins expressed by using baculovirus vectors form a complex in insect cells. J. Virol. 61:361-365.
36. Tiley, L. S., M. Hagen, J. T. Matthews, and M. Krystal. 1994. Sequence specific binding of the influenza virus RNA polymerase to sequences located at the 5′ ends of the viral RNAs. J. Virol. 68:5108-5116.
37. Yamashita, M., M. Krystal, and P. Palese. 1989. Comparison of the three large polymerase proteins of influenza A, B, and C viruses. Virology 171: 458-466.
38. Zhang, H., and G. M. Air. 1994. Expression of functional influenza virus polymerase proteins and template cloned from cDNAs in recombinant vaccinia virus-infected cells. Biochem. Biophys. Res. Commun. 200:95-101.