The zinc finger of nucleocapsid protein of Friend murine leukemia virus is critical for proviral DNA synthesis in vivo

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 5791-5798

  Yu, Qiang ^a   Darlix, Jean Luc ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; DNA SYNTHESIS; MURINE LEUKEMIA VIRUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVIRUS; REVERSE TRANSCRIPTION; RNA ANALYSIS; RNA BINDING; RNA REPLICATION; VIRION; VIRUS ASSEMBLY; VIRUS INFECTIVITY; VIRUS NUCLEOCAPSID;

EID: 0029793362     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.5791-5798.1996     Document Type: Article

References (46)

1. Aldovini, A., and R. A. Young. 1990. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J. Virol. 64:1920-1926.
2. Allain, B., M. Lapadat-Tapolsky, C. Berlioz, and J. L. Darlix. 1994. Transactivation of the minus strand DNA transfer by nucleocapsid protein during reverse transcriplion of the retroviral genome. EMBO J. 13:973-981.
3. Bender, M. A., T. D. Palmer, R. E. Gelinas, and A. D. Miller. 1987. Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region. J. Virol. 61:1639-1646.
4. Berkowitz, R. D., J. Luban, and S. P. Goff. 1993. Specific binding of human immunodeficiency virus type 1 Gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays. J. Virol. 67:7190-7200.
5. Berlioz, C., and J. L. Darlix. 1995. An internal ribosomal entry mechanism promotes translation of murine leukemia virus Gag polyprotein precursors. J. Virol. 69:2214-2222.
6. Bess, J. W., P. J. Powell, H. J. Issaq, L. J. Schumack, M. K. Grimes, L. E. Henderson, and L. O. Arthur. 1992. Tightly bound zinc in human immunodeficiency virus type 1, human T-cell leukemia virus type 1, and other retroviruses. J. Virol. 66:840-847.
7. Bowles, N. E., P. Damay, and P.-F. Spahr. 1993. Effect of rearrangements and duplications of the Cis-His motifs of Rous sarcoma virus nucleocapsid protein. J. Virol. 67:623-631.
8. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
9. Cornille, F., Y. Mely, D. Ficheux, I. Salvignol, D. Gérard, J. L. Darlix, M.-C. Fournié-Zaluski, and B. Roques. 1990. Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukemia virus and related zinc-fingers in free SH forms: influence of zinc chelation on structural and biochemical properties. Int. J. Pep. Protein Res. 36:551-558.
10. Covey, S. N. 1986. Amino acid sequence homology in GAG region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus. Nucleic Acids Res. 14:623-633.
11. Darlix, J.-L, M. Lapadat-Tapolsky, H. de Rocquigny, and B. Roques. 1995. First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses. J. Mol. Biol. 254:532-537.
12. Darlix, J. L., A. Vincent, C. Gabus, H. de Rocquigny, and B. Roques. 1993. Transactivation of the 5′ to 3′ viral DNA strand transfer by nucleocapsid protein during reverse transcription of HIV-1 RNA. C. R. Acad. Sci. Ser. III Sci. Vie 316:763-771.
13. Démené, H., N. Jullian, N. Morellet, H. de Rocquigny, F. Cornille, B. Maigret, and B. P. Roques. 1994. Three dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus. J. Biol. NMR 4:153-170.
14. De Rocquigny, H., D. Ficheux, C. Gabus, B. Allain, M. C. Fournie-Zaluski, J. L. Darlix, and B. P. Roques. 1993. Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity. Nucleic Acids Res. 21:823-829.
15. Dorfman, T., J. Luban, S. P. Goff, W. A. Haseltine, and H. G. Göttlinger. 1993. Mapping of functionally important residues of a cysteine-histeinc box in the human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 67:6159-6169.
16. Dupraz, P., S. Oertle, C. Méric, P. Damay, and P.-F. Spahr. 1990. Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein. J. Virol. 64:4978-4987.
17. Goff, S., P. Traktman, and D. Baltimore. 1981. Isolation and properties of Moloney murine leukemia virus mutants: use of rapid assay for release of virion reverse transcriptase. J. Virol. 38:239-248.
18. Gorelick, R. J., D. J. Chabot, A. Rein, L. E. Henderson, and L. O. Arthur. 1993. The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent. J. Virol. 67:4027-4036.
19. Gorelick, R. J., L. E. Henderson, J. P. Hanser, and A. Rein. 1988. Point mutations of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific recognition by a zinc finger-like protein sequence. Proc. Natl. Acad. Sci. USA 85:8420-8424.
20. Gorelick, R. J., S. M. Nigida, Jr., J. W. Bess, Jr., L. O. Arthur, L. E. Henderson, and A. Rein. 1990. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 46:3207-3211.
21. Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365-369.
22. Housset, V., H. de Rocquigny, B. P. Roques, and J. L. Darlix. 1993. Basic amino acids flanking the zinc finger of Moloney murine leukemia virus nucleocapsid protein NCp10 are critical for virus infectivity. J. Virol. 67: 2537-2545.
23. Hu, W., and H. Temin. 1990. Retroviral recombination and reverse transcription. Science 250:1227-1233.
24. Kalnins, A., K. Otto, U. Rüter, and B. Müller-Hill. 1983. Sequence of the lacZ gene of Escherichia coli. EMBO J. 2:593-597.
25. Kunkel, T. A. 1985. Rapid and efficient site-directed mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
26. Landau, N., and D. R. Littman. 1992. Packaging system for rapid production of murine leukemia virus vectors with variable tropism. J. Virol. 66:5110-5113.
27. Lapadat-Tapolsky, M., H. de Rocquigny, D. van Gent, B. P. Roques, R. Plasterk, and J. L. Darlix. 1993. Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle. Nucleic Acids Res. 21:831-839.
28. Méric, C., and S. Goff. 1989. Characterization of Moloney murine leukemia virus mutants with single amino acid substitutions in the Cys-His box of the nucleocapsid protein. J. Virol. 63:1558-1568.
29. Méric, C., E. Gouilloud, and P. F. Spahr. 1988. Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): deletions of Cys-His boxes. J. Virol. 62:3328-3333.
30. Méric, C., and P. F. Spahr. 1986. Rous sarcoma virus nucleic acid-binding protein p12 is necessary for viral 70S RNA dimer formation and packaging. J. Virol. 60:450-459.
31. Morellet, N., N. Jullian, H. de Rocquigny, B. Maigret, J. L. Darlix, and B. P. Roques. 1992. Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by H-1 NMR. EMBO J. 11:3059-3065.
32. Oroszlan, S., C. L. Fisher, T. B. Stanley, and R. V. Gilden. 1970. Protein of the murine C-type RNA tumour viruses: isolation of a group-specific antigen by isoelectric focusing. J. Gen. Virol. 8:1-10.
33. Ottmann, M., C. Gabus, and J. L. Darlix. 1995. The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity. J. Virol. 69:1778-1784.
34. Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392-8396.
35. Prats, A. C., V. Housset, G. de Billy, F. Cornille, B. Roques, and J. L. Darlix. 1991. Viral annealing activities of the nucleocapsid protein of Moloney murine leukemia virus arc zinc independent. Nucleic Acids Res. 19:3533-3541.
36. Prats, A. C., C. Roy, P. Wang, M. Erard, V. Housset, C. Gabus, C. Paoletti, and J. L. Darlix. 1990. cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA. J. Virol. 64:774-783.
37. Prats, A. C., L. Sarih, C. Gabus, S. Litvak, G. Keith, and J. L. Darlix. 1988. Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA. EMBO J. 7:1777-1783.
38. Rein, A., D. P. Harvin, J. Mirro, S. M. Ernst, and R. J. Gorelick. 1994. Evidence that a central domain of nucleocapsid protein is required for RNA packaging in murine leukemia virus. J. Virol. 68:6124-6129.
39. Schiff, L. A., M. L. Nibert, and B. N. Fields. 1988. Characterization of a zinc blotting technique: evidence that a retroviral gag protein binds zinc. Proc. Natl. Acad. Sci. USA 85:4195-4199.
40. Sitbon, M., B. Sola, L. Evans, J. Nishio, S. F. Hayes, K. Nathanson, C. F. Garon, and B. Chesebro. 1986. Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: mapping of the effects to different regions of the viral genome. Cell 47:851-859.
41. Soneoka, Y., P. M. Cannon, E. E. Ramsdale, J. C. Griffiths, G. Romano, S. M. Kingsman, and A. J. Kingsman. 1995. A transient three-plasmid expression system for the production of high liter retroviral vectors. Nucleic Acids Res. 23:628-633.
42. Summers, M. F., L. E. Henderson, M. R. Chance, J. W. Bess, Jr., T. L. South, P. R. Blake, I. Sagi, G. Perez-Alvarado, R. C. Sowder III, D. R. Hare, and L. O. Arthur. 1992. Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1. Protein Sci. 1:563-574.
43. Torrent, C., C. Berlioz, and J. L. Darlix. Stable MLV-VL30 dicistronic retroviral vectors with a VL30 or MoMLV sequence promoting both packaging of genomic RNA and expression of the 3′ cistron. Submitted for publication.
44. Torrent, C., C. Gabus, and J. L. Darlix. 1994. A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer. J. Virol. 68:661-667.
45. Tsuchihashi, Z., and P. O. Brown. 1994. DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 68:5853-5870.
46. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.