Toward an integrated phenotype in Pre-NIDDM

Diabetic Medicine

Volumn 13, Issue SUPPL. 6, 1996, Pages

  Bergman, R N ^a   Watanabe, R ^a   Rebrin, K ^a   Ader, M ^a   Steil, G ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Diposition index; Genetics; Glucose effectiveness; Insulin action; Insulin secretion

Indexed keywords

INSULIN;

CONFERENCE PAPER; HUMAN; LIPOLYSIS; LIVER METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE;

EID: 0029793137     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/dme.1996.13.s6.67     Document Type: Conference Paper

References (37)

1. Hamman, RF. Genetic and environmental determinants of non-insulin dependent diabetes mellitus (NIDDM). Diabetes Metab Rev 1992; 8: 287-338.
2. Knowler WC, Pettitt DJ, Saad MF, et al. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Revs 1990; 6: 1-27.
3. Ader M, Pacini G, Yang YJ, et al. Importance of glucose per se to intravenous glucose tolerance: comparison of the minimal model prediction with direct measurements. Diabetes 1985; 34: 1092-1103.
4. Martin BC, Warram JH, Krolewski AS, et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992; 340: 925-929.
5. Ryan EA, O'Sullivan MJ, Skyler JS. Insulin action during pregnancy: studies with the euglycemic clamp technique. Diabetes 1985; 34: 380-389.
6. DeFronzo RA. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1987; 37: 667-687.
7. Lillioja S, Mott DM, Spraul M, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 1993; 329: 1988-1992.
8. Taniguchi A, Nakai Y, Fukushima M, et al. Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 1992; 41: 1540-1546
9. Chaiken RL, Banerji MA, Huey H, et al. Do blacks have an insulin-resistance syndrome? Diabetes 1994; 43: 741-745.
10. Pyrola K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two studies in Finland. Diabetes Care 1979; 2: 131-141.
11. Ferrannini E, Buzzigoli G, Bonadonna RC, et al. Insulin resistance in essential hypertension. New Engl J Med 1987; 317: 350-357.
12. DeFronzo RA, Tobin JD, Anders R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-E223.
13. Wagenknecht PH, Mayer EJ, Rewers MD, et al. The insulin resistance atherosclerosis study (IRAS): objectives, design and recruitment results. Annal Epidem (in press).
14. Bergman RN, Ider YZ, Bowden CR, et al. Quantitative estimation of insulin sensitivity. Am J Physiol 1979; 236: E667-E677.
15. Bergman RN, Phillips ES, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 1981; 68: 1456-1467.
16. Bergman RN, Prager R, Vølund A, Olefsky JM. Equivalence of the insulin sensitivity index in man derived by the minimal model and the euglycemic glucose clamp. J Clin Invest 1987; 79: 790-800.
17. Bergman RN. Toward physiological understanding of glucose tolerance: Minimal-model approach. Diabetes 1989; 38: 1512-1527.
18. Shen SW, Reaven GM, Farquhar JW. Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest 1970; 49: 2151-2160.
19. Yalow RS, Glick SM, Roth J, et al. Plasma insulin and growth hormone levels in obesity and diabetes. Ann NY Acad Sci 1965; 131: 357-373.
20. Pei D, Jones CN, Bhargava R, et al. Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test [Letter]. Diabetologia 1994; 37: 843-845.
21. Alzaid AA, Dinneen SF, Turk DJ, et al. Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest 1994; 94: 2341-2348.
22. Yang JJ, Hope ID, Ader M, et al. Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest 1989; 84: 1620-1628.
23. Steil GM, Murray J, Bergman RN, et al. Repeatability of insulin sensitivity and glucose effectiveness from the minimal model: Implications for study design. Diabetes 1994; 43: 1365-1371.
24. Ferrari P, Alleman Y, Riesen W, et al. Reproducibility of insulin sensitivity measured by the minimal model method. Diabetologia 1991; 34: 527-530.
25. Velho G, Froguel P, Clement K, et al. Primary pancreatic β-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity-onset diabetes of the young. Lancet 1992; 340: 444-448.
26. Watanabe RM, Laws A, Rewers M, et al. Impaired glucose tolerant subjects exhibit a β-cell defect despite normal fasting glycemia (Abstract). Diabetes 1995; 44: 10.
27. Eaton RP, Allen RC, Schade DS, et al. Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behaviour. J Clin Endocrinol Metab 1980; 51: 520-528.
28. O'Meara NM, Blackman JD, Sturis J, et al. Alterations in kinetics of C-peptide and insulin secretion in hyperthyroidism. J Clin Endocrinol Metab 1993; 76: 79-84.
29. Cobelli C, Pacini G. Insulin secretion and hepatic extraction in humans by minimal modeling of C-peptide and insulin kinetics. Diabetes 1988; 37: 223-231.
30. Buchanan TA, Metzger BE, Freinkel N, et al. Insulin sensitivity and β-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 1990; 162: 1008-1014.
31. Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 1993; 42: 1663-1672.
32. Kahn SE, Beard JC, Schwartz MW, et al. Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic-acid-induced insulin resistance. Diabetes 1989; 38: 562-568.
33. Quon MJ, Cochran C, Taylor SI, et al. Non-insulin-mediated glucose disappearance in subjects with IDDM. Discordance between experimental results and minimal model analysis. Diabetes 1994; 43: 890-896.
34. Ader M, Bergman RN. Peripheral effects of insulin dominate supression of fasting hepatic glucose production. Am J Physiol 1990; 258: E1020-E1032.
35. Giacca A, Fisher SJ, Shi ZQ, et al. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 1992; 90: 1769-1777.
36. Rebrin K, Steil GM, Getty L, et al. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 1995; 44: 1038-1045.
37. Rebrin K, Steil GM, Mittelman S, Bergman RN. Causal linkage between insulin regulation of lipolysis and liver glucose output in dogs. J Clin Invest (in press).