Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266

AIDS

Volumn 10, Issue 11, 1996, Pages 1205-1209

  Winslow, Dean L ^a,b   Garber, Sena ^a   Reid, Carol ^a   Scarnati, Helen ^a   Baker, David ^a   Rayner, Marlene M ^a   Anton, Elizabeth D ^a  

^a Molecular Biology Division   (United States)

^b AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

HIV 1; Non nucleoside reverse transcriptase inhibitor; Resistance

Indexed keywords

EFAVIRENZ; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; GENE AMPLIFICATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONONUCLEAR CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS CULTURE; VIRUS GENE; VIRUS RESISTANCE;

EID: 0029792465     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199609000-00005     Document Type: Article

References (8)

1. Saag MS, Emini EA, Laskin OL, et al.: A short clinical trial of L-607,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. N Engl J Med 1993, 329:1065-1072.
2. Young SD, Britcher SF, Tran LO, et al.: L743,726 (DMP266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type I reverse transcriptase. Antimicrob Agents Chemother 1995, 39:2602-2605.
3. Mellors JW, Larder BA, Schinazi RF: Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. Int Antiviral News 1995, 3:8-13.
4. Smallheer JM, Otto MJ, Amaral-Ly CA, et al.: Synthesis and anti-HIV activity of a series of 2-indolinones and related analogues. Antiviral Chem Chemother 1993, 4:27-40.
5. Japour AJ, Mayers DL, Johnson VA: A standardized peripheral blood mononuclear cell culture assay for the determination of drug susceptibility of clinical human immunodeficiency virus-1 (HIV-1) isolates. Antimicrob Agents Chemother 1993, 34:11095-11012.
6. Otto MJ, Garber S, Winslow DL, et al.: In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease. Proc Natl Acad Sci USA 1993, 90:7543-7547.
7. De Wolf F, Hogervorst E, Goudsmit J, et al.: Syncytium-inducing and non-syncytium inducing capacity of human immunodeficiency virus type I subtypes other than B: phenotypic and genotypic characteristics. AIDS Res Hum Retroviruses 1994, 10:1383-1396.
8. Lukashov VV, Goudsmit J: Increasing genotypic and phenotypic selection from the original genomic RNA populations of HIV-1 strains LAI and MN (NM) by peripheral blood mononuclear cell culture, B-cell-line propagation and T-cell-line adaptation. AIDS 1995, 9:1307-1311.