Augmented thermic effect of amino acids under general anaesthesia occurs predominantly in extra-splanchnic tissues

Clinical Science

Volumn 91, Issue 4, 1996, Pages 431-439

  Selldén, Eva ^a   Bränström, Robert ^a   Brundin, Tomas ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Amino acids; Anaesthesia; Blood temperature; Hypometabolism; Hypothermia; Splanchnic oxygen uptake; Thermogenesis

Indexed keywords

ALANINE; AMINO ACID MIXTURE; ARGININE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLYCINE; HISTIDINE; ISOFLURANE; ISOLEUCINE; KETOBEMIDONE; LEUCINE; LORAZEPAM; LYSINE; METHIONINE; OXYGEN; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRYPTOPHAN; TYROSINE; VALINE; VAMIN;

ABDOMINAL SURGERY; AEROBIC METABOLISM; ARTICLE; BLOOD FLOW; BODY TEMPERATURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GENERAL ANESTHESIA; HEART OUTPUT; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW; THERMOGENESIS;

EID: 0029792358     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0910431     Document Type: Article

References (26)

1. Rubner M. Die Gesetze des Energieverbrauchs bei der Ernährung. Leipzig: Deuticker, 1902: 1-426.
2. Jéquier E. The influence of nutrient administration on energy expenditure in man. Clin Nutr 1986; 5: 181-6.
3. Brundin T, Wahren J. Effects of i.v. amino acids on human splanchnic and whole-body oxygen consumption, blood flow, and blood temperatures. Am J Physiol 1994; 266: E396-402.
4. Brundin T, Wahren J. Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man. Am J Physiol 1994; 267: E648-55.
5. Brundin T, Wahren J. Influence of protein ingestion on human splanchnic and whole-body oxygen consumption, blood flow, and blood temperature. Metab Clin Exp 1994; 43: 626-32.
6. Brundin T, Wahren J. Whole-body and splanchnic oxygen consumption and blood flow after oral ingestion of fructose or glucose. Am J Physiol 1993; 264: E504-13.
7. Brundin T, Bränström R, Wahren J. Effects of oral vs intravenous glucose administration on splanchnic and extra-splanchnic oxygen uptake and blood flow. Am J Physiol (In press).
8. Selldén E, Bränström R, Brundin T. Pre-operative infusion of amino acids prevents postoperative hypothermia. Br J Anaesth 1996; 96: 227-34.
9. Selldén E, Brundin T, Wahren J. Augmented thermic effect of amino acids under general anaesthesia. A mechanism useful for prevention of anaesthesia-induced hypothermia. Clin Sci 1994; 86: 611-18.
10. Brundin T, Söderberg R, Wahren J. A versatile technique for multichannel, digital blood temperature recording in man. Clin Physiol 1987; 7: 481-91.
11. Fick A. Über die messung des Blutquantums in den Herzventrikeln. In: Sitzungsberichte der phys.-med. Ges. zu Würzburg; XIV Sitzung am 9 Juli 1870, p.9.
12. Bradley SE, Ingelfinger GP, Curry JJ. The estimation of hepatic blood flow in man. J Clin Invest 1945; 24: 890-7.
13. Rowell LB, Blackmon JR, Bruce RA. Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man. J Clin Invest 1964; 43: 1677-90.
14. Mendlowitz M. The specific heat of human blood. Science (Washington) DC 1948; 107: 97-8.
15. Van Slyke DD, Phillips RA, Dole VP, Hamilton PB, Archibald RM, Plazin J. Calculation of haemoglobin from blood specific gravities. J Biol Chem 1959; 183: 349-60.
16. Minard D. Body heat content. In: Hardy JD, Gagge AP, Stolwijk JA, ed. Physiological and behavioral temperature regulation. Springfield, IL, U.S.A.: Charles C Thomas, 1970: 345-57.
17. Viby-Mogensen J. Clinical assessment of neuromuscular transmission. Br J Anaesth 1982; 54: 209-23.
18. Scheffé HA. A method for judging all contrasts in the analysis of variance. Biometrika 1953; 40: 87-104.
19. Harris JA, Benedict FG. A biometric study of basal metabolism in man. Washington DC: Carnegie Institution of Washington, 1919: Publication no. 279.
20. Brundin T, Wahren J. Mechanisms for protein-induced thermogenesis in man. FASEB J 1995; 9: A 439.
21. Wahren J, Felig P, Hagenfeldt L. Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 1976; 57: 987-99.
22. Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol 1985; 249: G549-56.
23. Parks DA, Gelman S, Maze M. Hepatic physiology. In: Miller RD, ed. Anesthesia, 4th edn. New York: Churchill Livingstone, 1994: 649-62.
24. Gelman S, Fowler KC, Smith LR. Liver circulation and function during isoflurane and halothane anesthesia. Anesthesiology 1984; 61: 726-30.
25. Carli F, Gabrielczyk M, Clark MM, Aver VR. An investigation of factors affecting postoperative rewarming of adult patients. Anaesthesia 1986; 41: 363-9.
26. Frank SM, Beattle C, Christopherson R, et al. Unintentional hypothermia is associated with postoperative myocardial ischemia. Anesthesiology 1993; 78: 468-76.