Conjugates of minor groove DNA binders with oligodeoxynucleotides: Synthesis and properties

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 2, 1996, Pages 75-85

  Levina, Asya S ^a,b   Metelev, Valeri G ^a   Cohen, Aharon S ^c   Zamecnik, Paul C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^c HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CONGOCIDINE; DISTAMYCIN A; DNA BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DNA BINDING; DRUG STABILITY; DRUG SYNTHESIS; ION EXCHANGE CHROMATOGRAPHY; PRIORITY JOURNAL; THERMOSTABILITY;

EID: 0029792335     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.75     Document Type: Article

References (6)

1. AMIRKHANOV, N.V., and ZARYTOVA, V.F. (1995). Synthesis of the 3′-derivatives of phosphorothioate oligonucleotide analogues. Nucleosides Nucleotides 14, 935-937.
2. ARCAMONE, F., ROEZZI, P.C., BARBIERI, W., NICOLELLA, V., and PENCO, S. (1967). Distamycin A. Nota I. Isolamento e struttura dell'agente antivirale distamycin A. Gazz. Chim. Ital. 97, 1097-1109.
3. 1H NMR spectroscopy and molecular modeling. Proc. Natl. Acad. Sci. USA 90, 10018-10022.
4. BOGER, D.L., and JOHNSON, D.S. (1995). CC-1065 and the duocarmycins: Unraveling the keys to a new class of naturally derived DNA alkylating agents. Proc. Natl. Acad. Sci. USA 92, 3642-3649.
5. GEIERSTANGER, B.H., JACOBSEN, J.P., MRKSICH, M., DERVAN, P.B., and WEMMER, D.E. (1994). Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA. Biochemistry 33, 3055-3062.
6. ZIMMER, C., and WAHNERT, U. (1986). Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material. Prog. Biophys. Molec. Biol. 47, 31-112.