Multiple regulatory steps are involved in the control of lipoprotein lipase activity in brown adipose tissue

Journal of Lipid Research

Volumn 37, Issue 8, 1996, Pages 1685-1695

  Klingenspor, Martin ^a,b   Ebbinghaus, Carsten ^a   Hülshorst, Guido ^a   Stöhr, Sigrid ^a   Spiegelhalter, Frank ^a   Haas, Kirsten ^a   Heldmaier, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

cold acclimation; nonshivering thermogenesis; noradrenaline; posttranslational regulation; surgical denervation; sympathetic innervation; translational regulation; uncoupling protein; white adipose tissue

Indexed keywords

CYCLOHEXIMIDE; DACTINOMYCIN; DNA; LIPOPROTEIN LIPASE; MESSENGER RNA; NORADRENALIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; DENERVATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; NONHUMAN; NONSHIVERING THERMOGENESIS; PHODOPUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SYMPATHETIC INNERVATION; TRANSLATION REGULATION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; COLD; CRICETINAE; CYCLOHEXIMIDE; DACTINOMYCIN; DENERVATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; LIPOPROTEIN LIPASE; MALE; NOREPINEPHRINE; NUCLEIC ACID SYNTHESIS INHIBITORS; PHODOPUS; PROTEIN SYNTHESIS INHIBITORS; RNA, MESSENGER; SYMPATHOMIMETICS; TIME FACTORS;

EID: 0029791998     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Heldmaier, G., S. Steinlechner, and J. Rafael. 1982. Non-shivering thermogenesis and cold resistance during seasonal acclimatization in the Djungarian hamster. J. Comp. Physiol. B. 149: 1-9.
2. Rafael, J., P. Vsiansky, and G. Heldmaier. 1985. Increased contribution of brown adipose tissue to nonshivering thermogenesis in the Djungarian hamster during cold acclimation. J. Comp. Physiol. B. 155: 521-528.
3. Braun, J. E. A., and D. L. Severson. 1992. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem. J. 287: 337-347.
4. Radomski, M. W., and T. Orme. 1971. Response of lipoprotein lipase in various tissues to cold exposure. Am. J. Physiol. 220: 1852-1856.
5. Goubern, M., and R. Portet. 1981. Circadian rhythm and hormonal sensitivity of lipoprotein lipase activity in cold acclimated rats. Horm. Metab. Res. 13: 73-77.
6. Carneheim, C., J. Nedergaard, and B. Cannon. 1984. Beta-adrenergic stimulation of lipoprotein lipase in rat brown adipose tissue during acclimation to cold. Am. J. Physiol. 246: E327-E333.
7. Matsushita, H., K. Kobayashi, and H. Kutsumi. 1980. Effect of cold exposure on lipoprotein lipase activity in brown adipose tissue of mice. Adv. Physiol. Sci. 32: 523-526.
8. Klingenspor, M., S. Klaus, H. Wiesinger, and G. Heldmaier. 1989. Short photoperiod and cold activate brown fat lipoprotein lipase in the Djungarian hamster. Am. J. Physiol. 257: R1123-R1127.
9. Klaus, S., L. Casteilla, F. Bouillaud, and D. Ricquier. 1991. The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int. J. Biochem. 23: 791-801.
10. Carneheim, C., J. Nedergaard, and B. Cannon. 1988. Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription. Am. J. Physiol. 254: E155-E161.
11. Mitchell, J. R., A. Jacobsson, T. G. Kirchgessner, M. C. Schotz, B. Cannon, and J. Nedergaard. 1992. Regulation of expression of the lipoprotein lipase gene in brown adipose tissue. Am. J. Physiol. 263: E500-E506.
12. Giralt, M., I. Martin, S. Vilaro, F. Villarroya, T. Mampel, R. Iglesias, and O. Vinas. 1990. Lipoprotein lipase mRNA expression in brown adipose tissue: translational and/or posttranslational events are involved in the modulation of enzyme activity. Biochim. Biophys. Acta. 1048: 270-273.
13. Cameron, I. L., and R. E. Smith. 1964. Cytological responses of brown fat tissue in cold-exposed rats. J. Cell Biol. 23: 89-100.
14. Bukowiecki, L., A. J. Collet, N. Follea, G. Guay, and L. Jahjah. 1982. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am. J. Physiol. 242: E353-E359.
15. Ailhaud, G., P. Grimaldi, and R. Négrel. 1992. Cellular and molecular aspects of adipocyte development. Annu. Rev. Nutr. 12: 207-233.
16. Marie, V., F. Dupuy, and R. Bazin. 1994. Acute injection of a β-adrenoceptor agonist BRL 35135 corrects both impaired uncoupling protein and lipoprotein lipase gene expression but not hypercapacity of lipogenesis in brown adipose tissue of suckling fa/fa rats. Int. J. Obes. 18: 273-279.
17. Hamilton, J. M., T. J. Bartness, and G. N. Wade. 1989. Effects of norepinephrine and denervation on brown adipose tissue in Syrian hamsters. Am. J. Physiol. 257: R396-R404.
18. Heldmaier, G., and S. Steinlechner. 1981. Seasonal control of energy requirements for thermoregulation in the Dungarian hamster (Phodopus sungorus), living in natural photoperiod. J. Comp. Physiol. 142: 429-437.
19. Böckler, H., S. Steinlechner, and G. Heldmaier. 1982. Complete cold substitution of noradrenaline-induced thermogenesis in the Djungarian hamster, Phodopus sungorus. Experientia. 38: 261-262.
20. Klingenspor, M., A. Meywirth, S. Stöhr, and G. Heldmaier. 1994. Effect of unilateral denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrome-c-oxidase activity in the Djungarian hamster. J. Comp. Physiol. B. 163: 664-670.
21. Labarca, C., and K. Paigen. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352.
22. Chomzynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
23. Kirchgessner, T. G., K. L. Svenson, and A. J. Lusis. 1987. The sequence of cDNA encoding lipoprotein lipase. J. Biol. Chem. 262: 8463-8466.
24. Bouillaud, F., D. Ricquier, J. Thibault, and J. Weissenbach. 1985. Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc. Natl Acad Sci. USA. 82: 445-448.
25. Liu, G., and T. Olivecrona. 1992. Synthesis and transport of lipoprotein lipase in perfused guinea pig hearts. Am. J. Physiol. 263: H438-H446.
26. Socorro, L., and R. L. Jackson. 1985. Monoclonal antibodies to bovine milk lipoprotein lipase: evidence for proteolytic degradation of the native enzyme. J. Biol. Chem. 260: 6324-6328.
27. Klingenberg, M., and C. S. Lin. 1986. Isolation and characterization of the uncoupling protein from brown adipose tissue. Methods Enzymol. 126: 490-498.
28. Ong, J. M., and P. A. Kern. 1989. The role of glucose and glycosylation in the regulation of lipoprotein lipase synthesis and secretion in rat adipose. J. Biol. Chem. 264: 3177-3182.
29. Saffari, B., J. M. Ong, and P. A. Kern. 1992. Regulation of adipose tissue lipoprotein lipase gene expression by thyroid hormone in rats. J. Lipid Res. 33: 241-249.
30. Ong, J. M., B. Saffari, R. B. Simsolo, and P. A. Kern. 1992. Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing. Mol. Endocrinol. 6: 61-69.
31. Ranganathan, G., J. M. Ong, A. Yukht, M. Saghizadeh, R. B. Simsolo, A. Pauer, and P. A. Kern. 1995. Tissue-specific expression of human lipoprotein lipase: effect of the 3′-untranslated region on translation. J. Biol. Chem. 270: 7149-7155.
32. Yukht, A., R. C. Davis, J. M. Ong, G. Ranganathan, and P. A. Kern. 1995. Regulation of lipoprotein lipase translation by epinephrine in 3T3-L1 cells: importance of the 3′ untranslated region. J. Clin. Invest. 96: 2438-2444.
33. Ottosson, M., K. Vikman-Adolfsson, S. Enerbäck, G. Olivecrona, and P. Bjorntorp. 1994. The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue. J. Clin. Endocrinol. Metab. 79: 820-825.
34. Fried, S. K., C. D. Russell, N. L. Grauso, and R. E. Brolin. 1993. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J. Clin. Invest. 92: 2191-2198.
35. Semb, H., and T. Olivecrona. 1989. Two different mechanisms are involved in nutritional regulation of lipoprotein lipase in guinea-pig adipose tissue. Biochem. J. 262: 505-511.
36. Doolittle, M. H., O. Ben-Zeev, J. Elovson, D. Martin, and T. G. Kirchgessner. 1990. The response of lipoprotein lipase to feeding and fasting: evidence for posttranslational regulation. J. Biol. Chem. 265: 4570-4577.
37. Rehnmark, S., P. Antonson, K. G. Xanthopoulos, and A. Jacobsson. 1993. Differential adrenergic regulation of C/EBPα and C/EBPβ in brown adipose tissue. FEBS Lett. 318: 235-241.
38. Foster, D. O., F. Depocas, and G. Zaror-Behrens. 1982. Unilaterality of the sympathetic innervation of each pad of interscapular brown adipose tissue. Can. J. Physiol. Pharmacol. 57: 257-270.