메뉴 건너뛰기




Volumn 37, Issue 8, 1996, Pages 1812-1822

Effect of hypocholesterolemic doses of 17α-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues

Author keywords

4 aminopyrazolo(3,4 d)pyrimidine; cholesterol metabolism; cholesterol synthesis; low density lipoprotein transport

Indexed keywords

4 AMINOPYRAZOLO[3,4 D]PYRIMIDINE; CHOLESTEROL; CHOLESTEROL ESTER; ETHINYLESTRADIOL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA;

EID: 0029791656     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (40)
  • 1
    • 0002681759 scopus 로고
    • The metabolism and excretion of cholesterol by the liver
    • I. M. Arias, W. B. Jakoby, H. Popper, D. Schachter and D. A. Shafritz, editors. Raven Press, Ltd., New York, NY
    • Turley, S. D., and J. M. Dietschy. 1988. The metabolism and excretion of cholesterol by the liver. In The Liver: Biology and Pathobiology. 2nd ed. I. M. Arias, W. B. Jakoby, H. Popper, D. Schachter and D. A. Shafritz, editors. Raven Press, Ltd., New York, NY. 617-641.
    • (1988) The Liver: Biology and Pathobiology. 2nd Ed. , pp. 617-641
    • Turley, S.D.1    Dietschy, J.M.2
  • 2
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 0027501003 scopus 로고
    • Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
    • Dietschy, J. M., S. D. Turley, and D. K. Spady. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34: 1637-1659.
    • (1993) J. Lipid Res. , vol.34 , pp. 1637-1659
    • Dietschy, J.M.1    Turley, S.D.2    Spady, D.K.3
  • 4
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein, J. L., and M. S. Brown. 1990. Regulation of the mevalonate pathway. Nature. 343: 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 5
    • 3242823479 scopus 로고
    • Receptor-mediated endocytosis: Insights from the lipoprotein receptor system
    • Brown, M. S., and J. L. Goldstein. 1979. Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proc. Natl. Acad. Sci. USA. 76: 3330-3337.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 3330-3337
    • Brown, M.S.1    Goldstein, J.L.2
  • 6
    • 0026525973 scopus 로고
    • Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo
    • Rudling, M. 1992. Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo. J. Lipid Res. 33: 493-501.
    • (1992) J. Lipid Res. , vol.33 , pp. 493-501
    • Rudling, M.1
  • 7
    • 0021054875 scopus 로고
    • Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium
    • Stange, E. F., and J. M. Dietschy. 1983. Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium. Proc. Natl. Acad. Sci. USA. 80: 5739-5743.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 5739-5743
    • Stange, E.F.1    Dietschy, J.M.2
  • 8
    • 0021091742 scopus 로고
    • Dissociation of hepatic cholesterol synthesis from hepatic low-density lipoprotein uptake and biliary cholesterol saturation in female and male hamsters of different ages
    • Spady, D. K., S. D. Turley, and J. M. Dietschy. 1983. Dissociation of hepatic cholesterol synthesis from hepatic low-density lipoprotein uptake and biliary cholesterol saturation in female and male hamsters of different ages. Biochim. Biophys. Acta. 753: 381-392.
    • (1983) Biochim. Biophys. Acta. , vol.753 , pp. 381-392
    • Spady, D.K.1    Turley, S.D.2    Dietschy, J.M.3
  • 9
    • 0021950499 scopus 로고
    • Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver
    • Spady, D. K., S. D. Turley, and J. M. Dietschy. 1985. Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver. J. Lipid Res. 26: 465-472.
    • (1985) J. Lipid Res. , vol.26 , pp. 465-472
    • Spady, D.K.1    Turley, S.D.2    Dietschy, J.M.3
  • 10
    • 0018607971 scopus 로고
    • Hepatic catabolism of rat and human lipoproteins in rats treated with 17α-ethinyl estradiol
    • Chao, Y-S., E. E. Windier, G. C. Chen, and R. J. Havel. 1979. Hepatic catabolism of rat and human lipoproteins in rats treated with 17α-ethinyl estradiol. J. Biol. Chem. 254: 11360-11366.
    • (1979) J. Biol. Chem. , vol.254 , pp. 11360-11366
    • Chao, Y.-S.1    Windier, E.E.2    Chen, G.C.3    Havel, R.J.4
  • 11
    • 0018607973 scopus 로고
    • Increased binding of low density lipoprotein to liver membranes from rats treated with 17α-ethinyl estradiol
    • Kovanen, P. T., M. S. Brown, and J. L. Goldstein. 1979. Increased binding of low density lipoprotein to liver membranes from rats treated with 17α-ethinyl estradiol. J. Biol. Chem. 254:11367-11373.
    • (1979) J. Biol. Chem. , vol.254 , pp. 11367-11373
    • Kovanen, P.T.1    Brown, M.S.2    Goldstein, J.L.3
  • 12
    • 0019174823 scopus 로고
    • The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that mediates the uptake of rat lipoproteins containing apoproteins B and E
    • Windler, E. E. T., P. T. Kovanen, Y-S. Chao, M. S. Brown, R. J. Havel, and J. L. Goldstein. 1980. The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that mediates the uptake of rat lipoproteins containing apoproteins B and E. J. Biol. Chem. 255: 10464-10471.
    • (1980) J. Biol. Chem. , vol.255 , pp. 10464-10471
    • Windler, E.E.T.1    Kovanen, P.T.2    Chao, Y.-S.3    Brown, M.S.4    Havel, R.J.5    Goldstein, J.L.6
  • 13
    • 0020378382 scopus 로고
    • Correlation of low and high density lipoprotein in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin
    • Koelz, H. R., B. C. Sherrill, S. D. Turley, and J. M. Dietschy. 1982. Correlation of low and high density lipoprotein in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin. J. Biol. Chem. 257: 8061-8072.
    • (1982) J. Biol. Chem. , vol.257 , pp. 8061-8072
    • Koelz, H.R.1    Sherrill, B.C.2    Turley, S.D.3    Dietschy, J.M.4
  • 14
    • 0015121275 scopus 로고
    • Effect of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat
    • Shiff, T. S., P. S. Roheim, and H. A. Eder. 1971. Effect of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat. J. Lipid Res. 12: 596-603.
    • (1971) J. Lipid Res. , vol.12 , pp. 596-603
    • Shiff, T.S.1    Roheim, P.S.2    Eder, H.A.3
  • 15
    • 0016686060 scopus 로고
    • Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat
    • Mjøs, O. D., O. Faergeman, R. L. Hamilton, and R. J. Havel. 1975. Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. J. Clin. Invest. 56: 603-615.
    • (1975) J. Clin. Invest. , vol.56 , pp. 603-615
    • Mjøs, O.D.1    Faergeman, O.2    Hamilton, R.L.3    Havel, R.J.4
  • 16
    • 0019481094 scopus 로고
    • Rates of sterol synthesis and uptake in the major organs of the rat in vivo
    • Turley, S. D., J. M. Andersen, and J. M. Dietschy. 1981. Rates of sterol synthesis and uptake in the major organs of the rat in vivo. J. Lipid Res. 22: 551-569.
    • (1981) J. Lipid Res. , vol.22 , pp. 551-569
    • Turley, S.D.1    Andersen, J.M.2    Dietschy, J.M.3
  • 18
    • 0346842693 scopus 로고
    • Tissue sites of degradation of low density lipoprotein: Application of a method for determining the fate of plasma proteins
    • Pittman, R. C., D. Attie, T. E. Carew, and D. Steinberg. 1979. Tissue sites of degradation of low density lipoprotein: application of a method for determining the fate of plasma proteins. Proc. Natl. Acad. Sci. USA. 76:5345-5349.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 5345-5349
    • Pittman, R.C.1    Attie, D.2    Carew, T.E.3    Steinberg, D.4
  • 19
    • 3142662216 scopus 로고
    • Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster
    • Spady, D. K., D. W. Bilheimer, and J. M. Dietschy. 1983. Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster. Proc. Natl. Acad. Sci. USA. 80: 3499-3503.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3499-3503
    • Spady, D.K.1    Bilheimer, D.W.2    Dietschy, J.M.3
  • 20
    • 76949121427 scopus 로고
    • A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity
    • Abell, L. L., B. B. Levy, B. B. Brodie, and F. E. Kendall. 1952. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357-366.
    • (1952) J. Biol. Chem. , vol.195 , pp. 357-366
    • Abell, L.L.1    Levy, B.B.2    Brodie, B.B.3    Kendall, F.E.4
  • 21
    • 0003100802 scopus 로고
    • The estimation of cholesterol in serum: A classification and clinical review of methods
    • Tonks, D.B. 1967. The estimation of cholesterol in serum: a classification and clinical review of methods. Clin. Biochem. 1: 12-29.
    • (1967) Clin. Biochem. , vol.1 , pp. 12-29
    • Tonks, D.B.1
  • 22
    • 0026775156 scopus 로고
    • Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7α-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor
    • Spady, D. K., and J. A. Cuthbert. 1992. Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7α-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor. J. Biol. Chem. 267: 5584-5591.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5584-5591
    • Spady, D.K.1    Cuthbert, J.A.2
  • 23
    • 0027291387 scopus 로고
    • Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels
    • Horton, J. D., J. A. Cuthbert, and D. K. Spady. 1993. Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels. J. Clin. Invest. 92: 743-749.
    • (1993) J. Clin. Invest. , vol.92 , pp. 743-749
    • Horton, J.D.1    Cuthbert, J.A.2    Spady, D.K.3
  • 24
    • 0029064549 scopus 로고
    • Regulatory effects of n-3 polyunsaturated fatty acids on hepatic LDL uptake in the hamster and rat
    • Spady, D. K., J. D. Horton, and J. A. Cuthbert. 1995. Regulatory effects of n-3 polyunsaturated fatty acids on hepatic LDL uptake in the hamster and rat. J. Lipid Res. 36: 1009-1020.
    • (1995) J. Lipid Res. , vol.36 , pp. 1009-1020
    • Spady, D.K.1    Horton, J.D.2    Cuthbert, J.A.3
  • 25
    • 0020478759 scopus 로고
    • Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight
    • Schneider, W. J., U. Beisiegel, J. L. Goldstein, and M. S. Brown. 1982. Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight. J. Biol. Chem. 257: 2664-2673.
    • (1982) J. Biol. Chem. , vol.257 , pp. 2664-2673
    • Schneider, W.J.1    Beisiegel, U.2    Goldstein, J.L.3    Brown, M.S.4
  • 26
    • 33947481699 scopus 로고
    • Rigorous least squares adjustment. Application to some non-linear equations
    • Wentworth, W. E. 1965. Rigorous least squares adjustment. Application to some non-linear equations. J. Chem. Educ. 42: 96-103.
    • (1965) J. Chem. Educ. , vol.42 , pp. 96-103
    • Wentworth, W.E.1
  • 27
    • 0022483764 scopus 로고
    • Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster
    • Spady, D. K., J. B. Meddings, and J. M. Dietschy. 1986. Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster. J. Clin. Invest. 77: 1474-1481.
    • (1986) J. Clin. Invest. , vol.77 , pp. 1474-1481
    • Spady, D.K.1    Meddings, J.B.2    Dietschy, J.M.3
  • 28
    • 0023192557 scopus 로고
    • Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17α-ethinylestradiol-treated rat
    • Rudling, M. J. 1987. Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17α-ethinylestradiol-treated rat. Biochim. Biophys. Acta. 919: 175-180.
    • (1987) Biochim. Biophys. Acta. , vol.919 , pp. 175-180
    • Rudling, M.J.1
  • 29
    • 0024418329 scopus 로고
    • Effects of estrogen on low density lipoprotein metabolism in males. Short-term and long-term studies during hormonal treatment of prostatic carcinoma
    • Eriksson, M., L. Berglund, M. Rudling, P. Henriksson, and B. Angelin. 1989. Effects of estrogen on low density lipoprotein metabolism in males. Short-term and long-term studies during hormonal treatment of prostatic carcinoma. J. Clin. Invest. 84: 802-810.
    • (1989) J. Clin. Invest. , vol.84 , pp. 802-810
    • Eriksson, M.1    Berglund, L.2    Rudling, M.3    Henriksson, P.4    Angelin, B.5
  • 30
    • 0027301849 scopus 로고
    • In vivo regulation of low-density lipoprotein receptors by estrogens differs at the post-transcriptional level in rat and mouse
    • Srivastava, R. A. K., D. Baumann, and G. Schonfeld. 1993. In vivo regulation of low-density lipoprotein receptors by estrogens differs at the post-transcriptional level in rat and mouse. Eur. J. Biochem. 216: 527-538.
    • (1993) Eur. J. Biochem. , vol.216 , pp. 527-538
    • Srivastava, R.A.K.1    Baumann, D.2    Schonfeld, G.3
  • 31
    • 0022456499 scopus 로고
    • Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17α-ethinyl estradiol
    • Ma, P. T. S., T. Yamamoto, J. L. Goldstein, and M. S. Brown. 1986. Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17α-ethinyl estradiol. Proc. Natl Acad. Sci. USA. 83: 792-796.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 792-796
    • Ma, P.T.S.1    Yamamoto, T.2    Goldstein, J.L.3    Brown, M.S.4
  • 33
    • 0028256391 scopus 로고
    • Lack of effect on the low density lipoprotein receptor in hamsters treated with 17α-ethinyl estradiol
    • Himber, J., B. Missano, and H. Kuhl. 1994. Lack of effect on the low density lipoprotein receptor in hamsters treated with 17α-ethinyl estradiol. Biochim. Biophys. Acta. 1211:359-363.
    • (1994) Biochim. Biophys. Acta. , vol.1211 , pp. 359-363
    • Himber, J.1    Missano, B.2    Kuhl, H.3
  • 35
    • 0023234483 scopus 로고
    • Effect of 17α-ethinylestradiol on the catabolism of high-density lipoprotein apolipoprotein A-I in the rat
    • Van't Hooft, F. M., T. Van Gent, and A. Van Tol. 1987. Effect of 17α-ethinylestradiol on the catabolism of high-density lipoprotein apolipoprotein A-I in the rat. Atherosclerosis. 67: 23-31.
    • (1987) Atherosclerosis , vol.67 , pp. 23-31
    • Van't Hooft, F.M.1    Van Gent, T.2    Van Tol, A.3
  • 36
    • 0023446056 scopus 로고
    • Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters
    • Rinninger, F., and R. C. Pittman. 1987. Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters. J. Lipid Res. 28: 1313-1325.
    • (1987) J. Lipid Res. , vol.28 , pp. 1313-1325
    • Rinninger, F.1    Pittman, R.C.2
  • 37
    • 0026459464 scopus 로고
    • Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools
    • Daumerie, C. M., L. A. Woollett, and J. M. Dietschy. 1992. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc. Natl Acad. Sci. USA. 89: 10797-10801.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 10797-10801
    • Daumerie, C.M.1    Woollett, L.A.2    Dietschy, J.M.3
  • 38
    • 0003042048 scopus 로고
    • Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proc
    • Ma, P. T. S., G. Gil, T. C. Südhof, D. W. Bilheimer, J. L. Goldstein, and M. S. Brown. 1986. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proc. Natl. Acad. Sci. USA. 83: 8370-8374.
    • (1986) Natl. Acad. Sci. USA , vol.83 , pp. 8370-8374
    • Ma, P.T.S.1    Gil, G.2    Südhof, T.C.3    Bilheimer, D.W.4    Goldstein, J.L.5    Brown, M.S.6
  • 39
    • 0028965725 scopus 로고
    • Regulation of hepatic cholesterol metabolism in the rat in vivo: Effect of a synthetic fat-free diet on sterol synthesis and low density lipoprotein transport
    • Bertolotti, M., D. K. Spady, and J. M. Dietschy. 1995. Regulation of hepatic cholesterol metabolism in the rat in vivo: effect of a synthetic fat-free diet on sterol synthesis and low density lipoprotein transport. Biochim. Biophys. Acta. 1255: 293-300.
    • (1995) Biochim. Biophys. Acta. , vol.1255 , pp. 293-300
    • Bertolotti, M.1    Spady, D.K.2    Dietschy, J.M.3
  • 40
    • 0025830753 scopus 로고
    • Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels
    • Ness, G. C., R. K. Keller, and L. C. Pendleton. 1991. Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels. J. Biol Chem. 266: 14854-14857.
    • (1991) J. Biol Chem. , vol.266 , pp. 14854-14857
    • Ness, G.C.1    Keller, R.K.2    Pendleton, L.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.