The internalization of a short acyl chain analogue of ganglioside GM1 in polarized neurons

Journal of Cell Science

Volumn 109, Issue 8, 1996, Pages 2111-2119

  Sofer, Anat ^a   Schwarzmann, Güenter ^b   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Endocytosis; Ganglioside; Neuron

Indexed keywords

GANGLIOSIDE GM1;

ANIMAL CELL; ARTICLE; DENDRITE; EMBRYO; ENDOSOME; HIPPOCAMPUS; INTERNALIZATION; LYSOSOME; NERVE CELL; NERVE CELL CULTURE; NERVE FIBER; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

4-CHLORO-7-NITROBENZOFURAZAN; 6-AMINOCAPROIC ACID; ANIMALS; AXONS; CARBOHYDRATE SEQUENCE; CELLS, CULTURED; DENDRITES; ENDOCYTOSIS; FLUORESCENT DYES; G(M1) GANGLIOSIDE; HIPPOCAMPUS; MEMBRANE LIPIDS; MOLECULAR SEQUENCE DATA; NEURONS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0029791263     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Antes, P., Schwarzmann, G. and Sandhoff, K. (1992). Detection of protein mediated glycosphingolipid clustering by the use of resonance energy transfer between fluorescent labelled lipids - a method established by applying the system ganglioside GM1 and cholera toxin-B subunit. Chem. Phys. Lipids 62, 269-280.
2. Augenbraun, E., Maxfield, F. R., Stjules, R., Setlik, W. and Holtzman, E. (1993). Properties of acidified compartments in hippocampal neurons. Eur. J. Cell Biol. 61, 34-43.
3. Cameron, P. L., Südhof, T. C., Jahn, R. and De Camilli, P. (1991). Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis. J. Cell Biol. 115, 151-164.
4. Dotti, C. G., Sullivan, C. A. and Banker, G. A. (1988). The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8, 1454-1468.
5. Fishman, P. H., Pacuszka, T. and Orlandi, P. A. (1993). Gangliosides as receptors for bacterial enterotoxins. In Advan. Lipid Res. 25, 165-187.
6. Fletcher, T. L., Cameron, P., de Camilli, P. and Banker, G. (1991). The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture. J. Neurosci. 11, 1617-1626.
7. Furuya, S., Irie, F., Hashikawa, T., Nakazawa, K., Kozakai, A., Hasegawa, A., Sudo, K. and Hirabayashi, Y. (1994). Ganglioside GD1α in cerebellar Purkinje cells: its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long term desensitization. J. Biol. Chem. 269, 32418-32425.
8. Furuya, S., Hashikawa, T., Irie, F., Hasegawa, A., Nakao, T. and Hirabayashi, Y. (1995). Neuronal expression of a minor monosialosyl ganglioside GM1b in rat brain: immunochemical characterization using a specific monoclonal antibody. Neurosci. Res. 22, 411-421.
9. Futerman, A. H., Hirschberg, K., Meivar-Levy, I., Rapaport, E., Schwarz, A., Sofer, A. and Zisling, R. (1995). Vesicle transport during cell growth and in the maintenance of cell polarity. Biochem. Soc. Trans. 23, 530-534.
10. Futerman, A. H. and Banker, G. A. (1996). The economics of neurite growth - the addition of new membrane to the growing axon. Trends Neurosci. 19, 144-149.
11. Goslin, K. and Banker, G. (1991). Rat hippocampal neurons in low density culture. In Culturing Nerve Cells, pp. 251-281. Cambridge, MA: MIT Press.
12. Hamprecht, B., Glaser, T., Reiser, G., Bayer, E. and Propst, F. (1985). Culture and characteristics of hormone responsive neuroblastoma X glioma hybrid cells. Meth. Enzymol. 109, 316-341.
13. Harel, R. and Futerman, A. H. (1993). Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. J. Biol. Chem. 268, 14476-14481.
14. Hirschberg, K., Zisling, R., van Echten-Deckert, G. and Futerman, A. H. (1996). Ganglioside synthesis during the development of neuronal polarity: major changes occur during axonogenesis and axon elongation, but not during dendrite growth or during synaptogenesis. J. Biol. Chem. 271 (in press).
15. Hoekstra, D. and Kok, J. W. (1992). Trafficking of glycosphingolipids in eukaryotic cells - sorting and recycling of lipids. Biochim. Biophys. Acta 1113, 277-294.
16. Koval, M. and Pagano, R. E. (1989). Lipid recycling between the plasma membrane and intracellular compartments: Transport and metabolism of sphingomyelin analogs in cultured fibroblasts. J. Cell Biol. 108, 2169-2181.
17. Ledeen, R. W. and Yu, G. (1992). Ganglioside function in the neuron. Trends Glycosci. Glycotechnol. 4, 174-187.
18. Lencer, W. I., Constable, C., Moe, S., Jobling, M. G., Webb, H. M., Ruston, S., Madara, J. L., Hirst, T. R. and Holmes, R. K. (1995). Targeting of cholera toxin and Esherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL. J. Cell Biol. 131, 951-962.
19. Martin, O. C. and Pagano, R. E. (1994). Internalization and sorting of a fluorescent analogue of glucosylceramide to the Golgi apparatus of human skin fibroblasts: utilization of endocytic and nonendocytic mechanisms. J. Cell Biol. 125, 769-781.
20. Matteoli, M., Takei, K., Perin, M. S., Südhof, T. C. and de Camilli, P. (1992). Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons. J. Cell Biol. 117, 849-861.
21. Mayor, S., Presley, J. F. and Maxfield, F. R. (1993). Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. J. Cell Biol. 121, 1257-1269.
22. McIntyre, J. C. and Sleight, R. G. (1991). Fluorescence assay for phospholipid membrane asymmetry. Biochemistry 30, 11819-11827.
23. Mundigl, O., Matteoli, M., Daniell, L., Thomasreetz, A., Metcalf, A., Jahn, R. and Decamilli, P. (1993). Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons - differential effects of Brefeldin-A in axon and dendrites. J. Cell Biol. 122, 1207-1221.
24. Neuenhofer, S., Schwarzmann, G., Egge, H. and Sandhoff, K. (1985). Synthesis of lysogangliosides. Biochemistry 24, 525-532.
25. Pagano, R. E. and Sleight, R. G. (1985). Defining lipid transport pathways in animal cells. Science 229, 1051-1057.
26. Pagano, R. E., Martin, O. C., Kang, H. C. and Haugland, R. P. (1991). A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: Accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor. J. Cell Biol. 113, 1267-1279.
27. Pagano, R. E. and Martin, O. (1994). Use of fluorescent analogs of ceramide to study the Golgi apparatus of animal cells. In Cell Biology: A Laboratory Handbook (ed. J. E. Cerlis), pp. 387-393. Academic Press, NY.
28. Parton, R. G., Dotti, C. G., Bacallao, R. B., Kurtz I., Simons, K. and Prydz, K. (1991). pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells. J. Cell Biol. 113, 261-274.
29. Parton, R. G., Simons, K. and Dotti, C. G. (1992). Axonal and dendritic endocytic pathways in cultured neurons. J. Cell Biol. 119, 123-137.
30. Parton, R. G. and Dotti, C. G. (1993). Cell biology of neuronal endocytosis. J. Neurosci. Res. 36, 1-9.
31. Parton, R. G. (1994). Ultrastructural localization of gangliosides - GM(1) is concentrated in caveolae. J. Histochem. Cytochem. 42, 155-166.
32. Raub, T. J., Koroly, M. J. and Roberts, R. M. (1990). Rapid endocytosis and recycling of wheat germ agglutinin binding sites on CHO cells: evidence for two compartments in an nondegradative pathway. J. Cell. Physiol. 144, 52-61.
33. Riboni, L. and Tettamanti, G. (1991). Rapid internalization and intracellular metabolic processing of exogenous ganglioside by cerebellar granule cells differentiated in culture. J. Neurochem. 57, 1931-1939.
34. Riboni, L., Bassi, R., Sonnino, S. and Tettamanti, G. (1992). Formation of free sphingosine and ceramide from exogenous ganglioside GM1 by cerebellar granule cells in culture. FEBS Lett. 300, 188-192.
35. Riboni, L., Bassi, R., Conti, M. and Tettamanti, G. (1993). Metabolism of exogenous ganglioside GM1 in cultured cerebellar granule cells - the fatty acid and sphingosine moieties formed during degradation are re-used for lipid biosynthesis. FEBS Lett. 322, 257-260.
36. Schwarz, A., Rapaport, E., Hirschberg, K. and Futerman, A. H. (1995). A regulatory role for sphingolipids in neuronal growth: inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching. J. Biol. Chem. 270, 10990-10998.
37. Schwarz, A. and Futerman, A. H. (1996). The use of anti-ganglioside antibodies to localize gangliosides in neurons of the central nervous system. Biochim. Biophys. Acta in press.
38. Schwarzmann, G. (1978). A simple and novel method for tritium labelling of gangliosides. Biochim. Biophys. Acta 529, 106-114.
39. Schwarzmann, G., Marsh, D., Herzog, V. and Sandhoff, K. (1987). In Gangliosides and Modulation of Neuronal Function (ed. H. Rahmann), pp. 217-229. Berlin: Springer-Verlag.
40. Schwarzmann, G. and Sandhoff, K. (1987). Lysogangliosides: Synthesis and use in preparing labeled gangliosides. Meth. Enzymol. 138, 319-341.
41. Schwarzmann, G. and Sandhoff, K. (1990). Metabolism and intracellular transport of glycosphingolipids. Biochemistry 29, 10865-10871.
42. Sofer, A. and Futerman, A. H. (1995). Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. J. Biol. Chem. 270, 12117-12122.
43. van Echten, G. and Sandhoff, K. (1993). Ganglioside metabolism. Enzymology, topology and regulation. J. Biol. Chem. 268, 5341-5344.
44. van Genderen, I. and van Meer, G. (1995). Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells. J. Cell Biol. 131, 645-654.
45. van Meer, G. (1989). Lipid traffic in animal cells. Annu. Rev. Cell Biol. 5, 247-275.
46. 18 cartridges during the isolation of gangliosides. J. Neurochem. 35, 266-269.