Anal canal cancer: Current treatment and results

Annals of the Academy of Medicine Singapore

Volumn 25, Issue 3, 1996, Pages 460-467

  Cummings, B J ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

chemotherapy; combined modality therapy; radiation therapy

Indexed keywords

CISPLATIN; FLUOROURACIL; MITOMYCIN C;

ANUS CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; HUMAN; LYMPH NODE METASTASIS; PELVIS CANCER; REVIEW;

ANAL CANAL; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; CISPLATIN; COMBINED MODALITY THERAPY; FLUOROURACIL; HUMANS; LYMPHATIC METASTASIS; MITOMYCIN; NEOPLASM RECURRENCE, LOCAL; PELVIC NEOPLASMS; PROGNOSIS; RECTUM; SURVIVAL RATE;

EID: 0029790837     PISSN: 03044602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. American Joint Committee on Cancer. Manual for Staging of Cancer In: Beahrs O H, Henson D E, Hutter, R V P, Myers M H, editors. 3rd ed Philadelphia. JB Lippincott, 1988:81-3.
2. Union Internationale Contre le Cancer. TNM Classification of Malignant Tumors. In: Hermanek P, Sobin L H, editors. 4th ed Berlin: Springer-Verlag, 1987:50-2
3. Jass J R, Sobin L H Histological Typing of Intestinal Tumors. 2nd ed. Berlin: Springer Verlag, 1989.41-4.
4. Hardcastle J D, Bussey H J R. Results of surgical treatment of squamous cell carcinoma of the anal canal and anal margin seen at St Mark's Hospital 1928-66. Proc R Soc Med 1968; 61 629-30.
5. Greenall M J, Quan S H Q, Stearns M W, Urmacher C, DeCosse J J Epidermoid cancer of the anal margin. Am J Surg 1985, 149 95-101.
6. Greenall M J, Quan S H Q, Urmacher C, DeCosse J J Treatment of epidermoid carcinoma of the anal canal Surg Gynecol Obstet 1985, 161:509-17
7. Boman B M, Moertel C G, O'Connell M J, Scott N, Weiland L H, Beart R W, et al Carcinoma of the anal canal A clinical and pathologic study of 188 cases. Cancer 1984; 54 114-25.
8. Dougherty B G, Evans H L Carcinoma of the anal canal, a study of 79 cases. Am J Clin Pathol 1985, 83:159-64
9. Frost D B, Richards P X, Montague E D, Giacco G G, Marrin R G Epidermoid cancer of the anorectum. Cancer 1984; 53:1285-93.
10. Cummings BJ. The place of radiation therapy in the treatment of carcinoma of the anal canal. Cancer Treat Rev 1982, 9 124-47.
11. Touboul E, Schlienger M, Buffatt L, Lefkopoulos D, Pené F, Parc R, et al Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients. Cancer 1994; 73:1569-79.
12. Touboul E, Schlienger M, Buffatt L, Ozsahin M, Belkacemi Y, Pené F, et al. Conservative versus nonconservative treatment of epidermoid carcinoma of the anal canal for tumours longer than or equal to 5 centimeters Cancer 1995; 75:786-93.
13. Doggett S W, Green J P, Cantril S T. Efficacy of radiation therapy alone for limited squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 1988; 15:1069-72.
14. Steel G. The search for therapeutic gain in the combination of radiotherapy and chemotherapy Radiother Oncol 1988; 11:31-53.
15. Cummings B J. Epidermoid cancer of the anal canal. In: Horwich A, editor. Combined Radiotherapy and Chemotherapy in Clinical Oncology. London: Edward Arnold, 1992:127-37
16. Nigro N D, Vaitkevicius V K, Considine B. Combined therapy for cancer of the anal canal: A preliminary report. Dis Colon Rectum 1974; 17:354-6.
17. Buroker T R, Nigro N, Bradley G. Combined therapy for cancer of the anal canal: a follow up report. Dis Colon Rectum 1977; 20:677-8.
18. Roeloffson F, Bossett J F, Eschwege F, Pjeiffer M, van Glabbeke M, Bartelink H. Concomitant radiotherapy and chemotherapy superior to radiotherapy alone in the treatment of locally advanced anal cancer Results of a phase III randomized trial of the EORTC Radiotherapy and Gastrointestinal Cooperative Groups [abstract]. Proc ASCO 1995, 14:194.
19. UKCCCR Anal Canal Cancer Trial Newsletter. CRC Clinical Trials Centre, London March 1994.
20. Leichman L, Nigro N, Vaitkevicius V K, Considine B, Buroker T, Bradley G, et al Cancer of the anal canal: Model for preoperative adjuvant combined modality therapy. Am J Med 1985; 78:211-5.
21. Sischy B, Doggett R L S, Krall J M, Taylor D G, Sause W T, Lipsett J A, et al. Definitive irradiation and chemotherapy for radiosensitization in management of anal carcinoma, interim report on Radiation Therapy Oncology Group Study No. 8314. J Natl Cancer Inst 1989, 81:850-6
22. Cummmgs B J, Keane T J, O'Sullivan B, Wong C S, Catton C N Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys 1991; 21:1115-25.
23. Papillon J, Montbarbon J F. Epidermoid carcinoma of the anal canal. A series of 276 cases Dis Colon Rectum 1987; 30:324-33.
24. Tanum G, Tveit K, Karlsen K O, Hauer-Jensen M. Chemotherapy and radiation therapy for anal carcinoma. Survival and late morbidity. Cancer 1991, 67:2462-6.
25. Nigro N D An evaluation of combined therapy for squamous cell cancer of the anal canal Dis Colon Rectum 1984; 27:763-6.
26. Flam M S, John M, Pajak T, Petrelli N, Myerson R, Doggett S, et al. Radiation and 5-fiuorouracil vs radiation, 5FU, mitomycin C in the treatment of anal carcinoma. Results of a phase III randomized RTOG-ECOG intergroup trial [abstract]. Proc ASCO 1995; 14 191.
27. Flam M S, John M J, Mowry P A, Lovalo L J, Ramalho L D, Wade J. Definitive combined modality therapy of carcinoma of the anus Dis Colon Rectum 1987; 30.495-502.
28. Papillon J. Rectal and Anal Cancers. Conservative Treatment by irradiation - an Alternative to Radical Surgery. Berlin: Springer-Verlag, 1982:107-77.
29. Cummings B J. Carcinoma of the anal canal In: Perez C A, Brady L, editors Principles and Practice of Radiation Oncology. 2nd ed. Philadelphia Lippincott, 1992:1015-24.
30. Miller E J, Quan S H Q, Thaler H T. Treatment of squamous cell carcinoma of the anal canal. Cancer 1991; 67:2038-41.
31. Wagner J P, Mane M A, Romestaing P, Rocher F P, Berger C, Trillet-Lenoir V, et al. Radiation therapy in the conservative treatment of carcinoma of the anal canal Int J Radiat Oncol Biol Phys 1994; 29:17-23.
32. Martenson J A, Lipsitz S R, Wagner H, Kaplan E H, Ottoman L A, Schuchter L M, et al. Initial results of a phase II trial of radiation therapy, 5-fluorouracil, and cisplatin for patients withanal cancer [abstract]. Proc ASTRO, Int J Radiat Oncol Biol Phys 1995, 32 (Suppl 1):158.
33. Rich T A, Ajani J A, Morrison W H, Ola D, Levin B. Chemoradiation therapy for anal cancer radiation plus continuous infusion of 5-fluorouracil with or without cisplatin. Radiother Oncol 1993; 27:209-15
34. Brunet R, Bécouarn Y, Figneux J, Revaud A, Faivre J, Jeandroz V. Cisplatine et fluorouracile en chimiothéraoue neoadjuvante des carcinomas épidermoides du canal anal. Lyon Chir 1990; 87:77-8.
35. Svensson C, Goldman S, Friberg B. Radiation treatment of pidermoid cancer of the anus. Int J Radiat Oncol Biol Phys 1993; 27:67-73
36. Roca E, De Simone G, Barugel M, De Simone G, Sardi M, Graziano A. A phase II study of alternating chemo-radiotherapy including cisplatin in anal canal carcinoma [abstract]. Proc ASCO 1990; 9:128.
37. Byfield J E, Barone R M, Sharp T R, Frankel S S. Conservative management without alkylating agents of squamous cell anal cancer using cyclical 5-FU alone and x-ray therapy. Cancer Treat Rep 1983; 67:709-12.
38. Tanum G, Tveit K, Karlsen K O. Chemoradiotherapy of anal carcinoma. tumour response and acute toxicity. Oncology 1993; 50:14-7.
39. Herrera L, Luna P, Garcia C. Surgical therapy of recurrent epidermoid carcinoma of the anal canal. In: Cohen A M, Winawer S J, editors. Cancer of the Colon, Rectum and Anus. New York: McGraw-Hill Inc, 1995:1043-50.
40. Golden G T, Horsley J S. Surgical management of epidermoid carcinoma of the anus. Am J Surg 1976; 131:275-80.
41. Stearns M W, Urmacher C, Sternberg S S, Woodruff J, Attiyeh F. Cancer of the anal canal Curr Probl Cancer 1980; 4:1-44.
42. Greenall M J, Quan S H, Decosse J J. Epidermoid cancer of the anus. Br J Surg 1985; 72(suppl) S97-103.
43. Tanum G. Treatment of relapsing anal carcinoma. Acta Oncologica 1993; 32:33-5.
44. Flam M S Chemotherapy of persistent, recurrent, or metastatic cancer. In: Cohen A M, Winawer S J, editors. Cancer of the Colon, Rectum and Anus. New York: McGraw-Hill Inc, 1995:1051-60
45. Michaelson R A, Magill G B, Quan S H Q, Leaming R, Nikrui M, Stearns M Preoperative chemotherapy and radiation therapy in the management of anal epidermoid carcinoma. Cancer 1983; 51:390-5.