Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome

British Journal of Haematology

Volumn 94, Issue 3, 1996, Pages 507-509

  Beguin, Yves ^a   Collignon, Joelle ^a   Laurent, Christian ^a   Fillet, Georges ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Bone marrow transplantation; Cytomegalovirus infection; Graft versus leukaemia effect; Myelodysplastic syndrome

Indexed keywords

AMPHOTERICIN B; ANTINEOPLASTIC AGENT; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; GANCICLOVIR; IMMUNOGLOBULIN; METHOTREXATE;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CASE REPORT; CYTOMEGALOVIRUS; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIESIS; HUMAN; HUMAN CELL; MALE; MYELODYSPLASTIC SYNDROME; NEUTROPENIA; PRIORITY JOURNAL; VIRUS INFECTION;

EID: 0029790635     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1824.x     Document Type: Article

References (11)

1. Antin, J.H. (1993) Graft-versus-leukemia: no longer an epiphenomenon, (Editorial). Blood, 82, 2273-2277.
2. Benaim, E., Hvizdala, E.V., Papenhausen, P. & Moscinski, L.C. (1995) Spontaneous remission in monosomy 7 myelodysplastic syndrome. British Journal of Haematology, 89, 947-948.
3. Cheson, B.D. (1992) Chemotherapy and bone marrow transplantation for myelodysplastic syndromes. Seminars in Oncology, 19, 85-94.
4. Collins, R.H., Jr. Rogers, Z.R., Bennett, M., Kumar, V., Nikein, A. & Fay, J.W. (1992) Hematologic relapse of chronic myelogenous leukemia following allogeneic bone marrow transplantation: apparent graft-versus-leukaemia effect following abrupt discontinuation of immunosuppression. Bone Marrow Transplantation, 10, 391-395.
5. Ganser, A. & Hoelzer, D. (1992) Clinical course of myelodysplastic syndromes. Hematology and Oncology Clinics of North America, 6, 607-618.
6. Giralt, S.A. & Champlin, R.E. (1994) Leukemia relapse after allogeneic bone marrow transplantation: a review. Blood, 84, 3603-3612.
7. Horowitz, M.M., Gale, R.P., Sondel, P.M., Goldman, J.M., Kersey, J., Kolb, H.J., Rimm, A.A., Ringden, O., Rozman, C., Speck, B., Truitt, R.L., Swaan, F. & Bortin, M.M. (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood, 75, 555-562.
8. Jacobsen, N., Badsberg, J.H., Lonnqvist, B., Ringden, O., Volin, L., Rajantie, J., Nikoskelainen, N. & Keiding, N. (1990) Graft-versus-leukemia activity associated with CMV-seropositive donor, post-transplant CMV infection, young donor age and chronic graft-versus-host disease in bone marrow allograft recipients. Bone Marrow Transplantation, 5, 413-418.
9. Loffler, H., Schmitz, N. & Gassmann, W. (1992) Intensive chemotherapy and bone marrow transplantation for myelodysplastic syndromes. Hematology and Oncology Clinics of North America, 6, 619-631.
10. Roux, E., Helg, C., Chapuis, B., Jeannet, M. & Roosnek, E. (1992) Evolution of mixed chimerism after allogeneic bone marrow transplantation as determined on granulocytes and mononuclear cells by the polymerase chain reaction. Blood, 79, 2775-2783.
11. Weiden, P.L., Flournoy, N., Thomas, E.D., Prentice, R., Fefer, A., Buckner, C.D. & Storb, R. (1979) Antileukemic effect of graft-versus-host disease in human recipients of allogeneic marrow grafts. New England Journal of Medicine, 300, 1068-1073.