The Escherichia coli MutS DNA mismatch binding protein specifically binds O6-methylguanine DNA lesions

Carcinogenesis

Volumn 17, Issue 9, 1996, Pages 2085-2088

  Rasmussen, Lene Juel ^a   Samson, Leona ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 O METHYLTHYMINE; 6 O METHYLGUANINE; ALKYLATING AGENT; CYTOSINE; DNA BINDING PROTEIN; DNA METHYLTRANSFERASE; THYMINE;

ARTICLE; BASE MISPAIRING; CELL TYPE; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DRUG CYTOTOXICITY; DRUG RESISTANCE; ESCHERICHIA COLI; EUKARYOTIC CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

EID: 0029790568     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.9.2085     Document Type: Article

References (42)

1. Baker, S.M. et al. (1995) Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell, 82, 309-319.
2. Fishel, R., Lescoe, M.K., Rao, M.R.S., Copeland, N.G., Jenkins, N.A., Garber, J., Kane, M. and Kolodner, R.D. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis cancer. Cell, 75, 1027-1038.
3. Leach, F.S. et al. (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75, 1215-1225.
4. de Wind, N., Dekker, M., Berns, A., Radman, M and te Riele, H. (1995) Inactivation of the mouse MSH2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell, 82, 321-330.
5. 6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions. Cancer Res., 52, 6471-6475.
6. MacKay, W.J., Han, S. and Samson, L.D. (1994) DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J. Bacteriol., 176, 3224-3230.
7. 4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis. Proc. Natl Acad. Sci. USA. 83, 8501-8505.
8. 6-methylguanine DNA repair methyltransferase. J. Bacteriol., 173, 2068-2076.
9. 6-methylguanine in template DNA during in vitro DNA replication. J. Biol. Chem., 259, 8095-8100.
10. 6-position of dGTP. Carcinogenesis, 4, 1591-1597.
11. Xiao, W. and Samson, L. (1993) In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl Acad. Sci. USA, 90, 2117-2121.
12. Samson, L.D. (1992) The repair of DNA alkylation damage by methyltransferases and glycosylases. Essays Biochem., 27, 69-78.
13. Friedberg, E.C., Walker, G.C. and Siede, W. (1995) DNA Repair and Mutagenesis. ASM Press, Washington, DC.
14. Brennand, J. and Margison, G.P. (1986) Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the E. coli alkyltransferase gene. Proc. Natl Acad. Sci. USA, 83, 6292-6296.
15. Day, R.S., Ziolowski, C.H.J., Scudiero, D.A., Meyer, S.A., Lubiniecki, A.S., Girardi, A.J., Galloway, S.M. and Bynum, G.D. (1980) Defective repair of alkylated DNA by human tumor and SV40-transformed human cell strains. Nature, 288, 724-727.
16. 6-methylguanine-DNA methyltransferase. J. Biol. Chem., 265, 9563-9569.
17. Samson, L., Derfler, B. and Waldstein, E.A. (1986) Suppression of human DNA alkylation repair defects by Escherichia coli DNA-repair genes. Proc. Natl Acad. Sci. USA, 83, 5607-5610.
18. 6-methylguanine-DNA methyltransferase. Carcinogenesis, 13, 289-296.
19. 6-alkylguanine. Proc. Natl Acad. Sci. USA, 87, 686-690.
20. Jones, M. and Wagner, R. (1981) N-methyl-N′-nitro-N′-nitrosoguanine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair. Mol. Gen. Genet., 184, 562-563.
21. 6-methyl-guanine residues in E. coli DNA. Nature, 296, 868-869.
22. Harris, G., Lawley, P.D. and Olsen, I. (1981) Mode of action of methylating carcinogens: comparative studies of murine and human cells. Carcinogenesis, 2, 403-411.
23. Lawley, P.D. and Thatcher, C.J. (1970) Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. Biochem. J., 116, 693-707.
24. 6-methylguanine built into a unique site in a viral genome. Proc. Natl Acad. Sci. USA, 81, 6271-6275.
25. 6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used. Proc. Natl Acad. Sci. USA, 86, 8271-8274.
26. - human cells. Cancer Res., 52, 5257-5263.
27. Kataoka, H., Hall, J. and Karran, P. (1986) Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene. EMBO J., 5, 3195-3200.
28. Pieper, R.O., Costello, J.F., Kroes, R.A., Futscher, B.W., Marathi, U. and Erickson, L.C. (1991) Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. Cancer Commun., 3, 241-253.
29. Branch, P., Aquilina, G., Bignami, M. and Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature, 362, 652-654.
30. Goldmacher, V.S., Cuzick, R.A. and Thilly, W.G. (1986) Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitro-nitrosoguanidine. J. Biol. Chem., 261, 12462-12471.
31. Kat, A., Thilly, W.G., Fang, W.-H., Longley, M.J., Li, G.-M. and Modrich, P. (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl Acad. Sci. USA, 90, 6424-6428.
32. Drummond, J.T., Li, G.-M., Longley, M.J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science, 268, 1909-1912.
33. Palombo, F., Gallinari, P. Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo A., Truong, O., Hsuan, J.J. and Jiricny, J. (1995) GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science, 268, 1912-1914.
34. Papadopoulos, N. et al. (1995) Mutations of GTPB in genetically unstable cells. Science, 268, 1915-1917.
35. Parker, B.O. and Marinus, M.G. (1992) Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli. Proc. Natl Acad. Sci. USA, 89, 1730-1734.
36. Jiricny, J., Su, S.-S., Wood, S.G. and Modrich, P. (1988) Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. Nucleic Adds Res., 16, 7843-7853.
37. Wood, S.G., Ubasawa, A., Martin, D. and Jiricny, J. (1986) Guanine and adenine analogues as tools in the investigation of the mechanisms of mismatch repair in E.coli. Nucleic Adds Res., 14, 6591-6602.
38. 2-methylthymine DNA glycosylase. Biochem. Biophys. Res. Commun., 120, 1-8.
39. + gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage. EMBO J., 3, 2151-2157.
40. 6-methylguanine thymine base pairs to guanine thymine base pairs in DNA. Carcinogenesis, 5, 1733-1735.
41. 6-methylguanine-DNA methyltransferase (MGMT) activity in mammalian cells: a pre-molecular view. Mutat. Res., 233, 139-150.
42. 6-Methylguanine residues elicit DNA repair synthesis by human cell extracts. J. Biol. Chem., 268, 15878-15886.