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Volumn 239, Issue 3, 1996, Pages 624-631

Nuclear factor κB (NF-κB), nuclear factor interleukin-6 (NFIL-6 or C/EBPβ) and nuclear factor interleukin-6β (NFIL6-β or C/EBPδ) are not sufficient to activate the endogenous interleukin-6 gene in the human breast-carcinoma cell line MCF-7. Comparative analysis with MDA-MB-231 cells, an interleukin-6-expressing human breast carcinoma cell line

Author keywords

CAAT enhancer binding protein; Cytokine; Gene expression; Interleukin 6; Nuclear factor B

Indexed keywords

CYCLOHEXIMIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 0029790317     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0624u.x     Document Type: Article
Times cited : (28)

References (38)
  • 1
    • 0006891447 scopus 로고
    • 46th Forum in immunology: Molecular biology and immunology of interleukin-6
    • Hirano, T. & Kishimoto, T. (1992) 46th Forum in immunology: Molecular biology and immunology of interleukin-6. Res. Immunol. 143, 722-783.
    • (1992) Res. Immunol. , vol.143 , pp. 722-783
    • Hirano, T.1    Kishimoto, T.2
  • 2
    • 0028095919 scopus 로고
    • The acute phase response
    • Baumann, H. & Gauldie, J. (1994) The acute phase response, Immun. Today 15, 74-80.
    • (1994) Immun. Today , vol.15 , pp. 74-80
    • Baumann, H.1    Gauldie, J.2
  • 3
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • Akira, T., Taga, T. & Kishimoto, T. (1993) Interleukin-6 in biology and medicine. Adv. Immun. 54, 1-78.
    • (1993) Adv. Immun. , vol.54 , pp. 1-78
    • Akira, T.1    Taga, T.2    Kishimoto, T.3
  • 4
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IkBa: A mechanism for NF-kB activation
    • Beg, A. A., Finco, T. S., Nantermet, P. V. & Baldwin, A. S. Jr (1993) Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IkBa: a mechanism for NF-kB activation. Mol. Cell. Biol. 13, 3301-3310.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3301-3310
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin Jr., A.S.4
  • 5
    • 0025283377 scopus 로고
    • IL-1 and Tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA
    • Elias, J. A. & Lentz, V. (1990) IL-1 and Tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA, J. Immunol. 145, 161-166.
    • (1990) J. Immunol. , vol.145 , pp. 161-166
    • Elias, J.A.1    Lentz, V.2
  • 6
    • 0026056120 scopus 로고
    • Regulation of cytokine production in the human thymus: Epidermal growth factor and Transforming growth factor α regulate mRNA levels of interleukin Iα (IL-Iα), IL-1β, and IL-6 in human thymic epithelial cells at a post-transcriptional level
    • Le, P. T., Lazorick, S., Whichard, L. P., Haynes, B. F. & Singer, K. H. (1991) Regulation of cytokine production in the human thymus: Epidermal growth factor and Transforming growth factor α regulate mRNA levels of interleukin Iα (IL-Iα), IL-1β, and IL-6 in human thymic epithelial cells at a post-transcriptional level, J. Exp. Med. 174, 1147-1157.
    • (1991) J. Exp. Med. , vol.174 , pp. 1147-1157
    • Le, P.T.1    Lazorick, S.2    Whichard, L.P.3    Haynes, B.F.4    Singer, K.H.5
  • 7
    • 0026613061 scopus 로고
    • 4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: Transcriptional and posttranscriptional mechanisms
    • 4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Blood 80, 1004-1011.
    • (1992) Blood , vol.80 , pp. 1004-1011
    • Rola-Pleszczynski, M.1    Stankova, J.2
  • 8
    • 0025370224 scopus 로고
    • Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene
    • Isshiki, H., Akira, S., Tanabe, O., Nakajima, T., Shimamoto, T., Hirano, T. & Kishimoto, T. (1990) Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene, Mol. Cell. Biol. 10, 2757-2764.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2757-2764
    • Isshiki, H.1    Akira, S.2    Tanabe, O.3    Nakajima, T.4    Shimamoto, T.5    Hirano, T.6    Kishimoto, T.7
  • 9
    • 0025343895 scopus 로고
    • Activation of interleukin-6 gene expression through the NF-κB transcription factor
    • Libermann, T. A. & Baltimore, D. (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor, Mol. Cell. Biol. 10, 2327-2334.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2327-2334
    • Libermann, T.A.1    Baltimore, D.2
  • 10
    • 0347333807 scopus 로고
    • 2-interferon/hepatocyte-stimulating factor/interleukin-6' promoter by cytokines, viruses and second messenger agonists
    • 2-interferon/hepatocyte-stimulating factor/interleukin-6' promoter by cytokines, viruses and second messenger agonists, Proc. Natl Acad. Sci. USA 85, 6701-6705.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 6701-6705
    • Ray, A.1    Tatter, S.B.2    May, L.T.3    Sehgal, P.B.4
  • 11
    • 0024355425 scopus 로고
    • A multiple cytokine- And second messenger-responsive element in the enhancer of the human interleukin-6 gene: Similarities with c-fos gene regulation
    • Ray, A., Sassone-Corsi, P. & Sehgal, P. B. (1989) A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation, Mol. Cell. Biol. 9, 5537-5547.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5537-5547
    • Ray, A.1    Sassone-Corsi, P.2    Sehgal, P.B.3
  • 12
    • 0025138248 scopus 로고
    • Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
    • Shimizu, H., Mitomo, K., Watanabe, T., Okamoto, S. & Yamamoto, K. (1990) Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol. Cell. Biol. 10, 561-568.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 561-568
    • Shimizu, H.1    Mitomo, K.2    Watanabe, T.3    Okamoto, S.4    Yamamoto, K.5
  • 13
    • 0025280023 scopus 로고
    • Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblast involves activation of a nuclear factor binding to a κB-like sequence
    • Zhang, Y., Lin, J. & Vilcek, J. (1990) Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblast involves activation of a nuclear factor binding to a κB-like sequence, Mol. Cell. Biol. 10, 3818-3823.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3818-3823
    • Zhang, Y.1    Lin, J.2    Vilcek, J.3
  • 15
    • 0026580335 scopus 로고
    • A member of the C/EBP family, NFIL6β, forms a heterodimer and transcriptionally synergizes with NFIL6
    • Kinoshita, S., Akira, S. & Kishimoto, T. (1992) A member of the C/EBP family, NFIL6β, forms a heterodimer and transcriptionally synergizes with NFIL6, Proc. Natl Acad. Sci. USA 89, 1473-1476.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 1473-1476
    • Kinoshita, S.1    Akira, S.2    Kishimoto, T.3
  • 16
    • 0028678794 scopus 로고
    • Transcription factors 1-bZIP Proteins
    • Hurst, H. C. (1994) Transcription factors 1-bZIP Proteins, Protein Profile 1, 123-168.
    • (1994) Protein Profile , vol.1 , pp. 123-168
    • Hurst, H.C.1
  • 17
    • 0025941621 scopus 로고
    • CAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription
    • Metz, R. & Ziff, E. (1991) cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription, Genes & Dev. 5, 1754-1766.
    • (1991) Genes & Dev. , vol.5 , pp. 1754-1766
    • Metz, R.1    Ziff, E.2
  • 18
    • 0027499295 scopus 로고
    • Phosphorylation at threonine235 by a ras-dependent mitogen-activated protein kinasc cascade is essential for transcription factor NF-IL6
    • Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T. & Akira, S. (1993) Phosphorylation at threonine235 by a ras-dependent mitogen-activated protein kinasc cascade is essential for transcription factor NF-IL6, Proc. Natl Acad. Sci. USA 90, 2207-2211.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2207-2211
    • Nakajima, T.1    Kinoshita, S.2    Sasagawa, T.3    Sasaki, K.4    Naruto, M.5    Kishimoto, T.6    Akira, S.7
  • 19
    • 0027186357 scopus 로고
    • Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
    • Trautwein, C., Caelles, C., Van der Geer, P., Hunter, T., Karin, M. & Chojkler, M. (1993) Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain, Nature 364, 544-547.
    • (1993) Nature , vol.364 , pp. 544-547
    • Trautwein, C.1    Caelles, C.2    Van Der Geer, P.3    Hunter, T.4    Karin, M.5    Chojkler, M.6
  • 20
    • 0026516073 scopus 로고
    • Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ
    • Wegner, M., Cao, Z. & Rosenfeld, M. G. (1992) Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ, Science 256, 370-373.
    • (1992) Science , vol.256 , pp. 370-373
    • Wegner, M.1    Cao, Z.2    Rosenfeld, M.G.3
  • 21
    • 0028271005 scopus 로고
    • Expression of the gene encoding α1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of βand δ CCAAT-enhancer-binding proteins
    • Ray, B. K. & Ray, A. (1994) Expression of the gene encoding α1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of βand δ CCAAT-enhancer-binding proteins, Eur. J. Biochem. 222, 891-900.
    • (1994) Eur. J. Biochem. , vol.222 , pp. 891-900
    • Ray, B.K.1    Ray, A.2
  • 22
    • 0027332498 scopus 로고
    • The IκB proteins: Multifunctional regulators of Rel/NF-κB transcription factors
    • Beg, A. A. & Baldwin, A. S. Jr (1993) The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors, Genes & Dev. 7, 2064-2070.
    • (1993) Genes & Dev. , vol.7 , pp. 2064-2070
    • Beg, A.A.1    Baldwin Jr., A.S.2
  • 23
    • 0027618650 scopus 로고
    • Regulation of the NF-κB/rel transcription factor and IκB inhibitor system
    • Liou, H.-C. & Baltimore, D. (1993) Regulation of the NF-κB/rel transcription factor and IκB inhibitor system, Cell Biol. 5, 477-487.
    • (1993) Cell Biol. , vol.5 , pp. 477-487
    • Liou, H.-C.1    Baltimore, D.2
  • 24
    • 0025865317 scopus 로고
    • The inducible transcription activator NF-κB: Regulation by distinct protein subunits
    • Baeuerle, P. A. (1991) The inducible transcription activator NF-κB: regulation by distinct protein subunits, Biochim. Biophys. Acta 1072, 63-80.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 63-80
    • Baeuerle, P.A.1
  • 25
    • 0027232067 scopus 로고
    • NF-κB and Rel: Partecipants in a multiform transcriptional regulatory system
    • Grilli, M., Chiu, J. J.-S. & Lenardo, M. J. (1993) NF-κB and Rel: partecipants in a multiform transcriptional regulatory system, Int. Rev. Cyt. 143, 1-62.
    • (1993) Int. Rev. Cyt. , vol.143 , pp. 1-62
    • Grilli, M.1    Chiu, J.J.-S.2    Lenardo, M.J.3
  • 26
    • 0027453552 scopus 로고
    • Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
    • Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T. & Akira, S. (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8, Proc. Natl Acad. Sci. USA 90, 10193-10197.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10193-10197
    • Matsusaka, T.1    Fujikawa, K.2    Nishio, Y.3    Mukaida, N.4    Matsushima, K.5    Kishimoto, T.6    Akira, S.7
  • 27
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto, T., Taga, T. & Akira, S. (1994) Cytokine signal transduction, Cell 76, 253-262.
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T.1    Taga, T.2    Akira, S.3
  • 28
    • 0028281708 scopus 로고
    • Interleukin-10 inhibits interleukin-8 production in human neutrophils
    • Wang, P., Wu, P., Anthes. J. C., Siegel, M. I., Egan, R. W. & Billah, M. M. (1994) Interleukin-10 inhibits interleukin-8 production in human neutrophils, Blood 83, 2678-2683.
    • (1994) Blood , vol.83 , pp. 2678-2683
    • Wang, P.1    Wu, P.2    Anthes, J.C.3    Siegel, M.I.4    Egan, R.W.5    Billah, M.M.6
  • 29
    • 0342742310 scopus 로고
    • Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB
    • Osborn, L., Kunkel, S. & Nabel, G. J. (1989) Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB, Proc. Natl Acad. Sci. USA 86, 2336-2340.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2336-2340
    • Osborn, L.1    Kunkel, S.2    Nabel, G.J.3
  • 31
    • 0024530685 scopus 로고
    • Regulation of the acute phase und immune response: Interleukin-6
    • Sehgal, P. B., Grieninger, G. & Tosato, G. (1988) Regulation of the acute phase und immune response: interleukin-6, Ann. NY Acad. Sci. 557, 1-583.
    • (1988) Ann. NY Acad. Sci. , vol.557 , pp. 1-583
    • Sehgal, P.B.1    Grieninger, G.2    Tosato, G.3
  • 33
    • 0026605150 scopus 로고
    • Review: Transcriptional and post-transcriptional regulation of interleukin 1 gene expression
    • Fenton, M. J. (1992) Review: transcriptional and post-transcriptional regulation of interleukin 1 gene expression, Int. J. Immuno-pharmac. 14, 401-411.
    • (1992) Int. J. Immuno-pharmac. , vol.14 , pp. 401-411
    • Fenton, M.J.1
  • 34
    • 0028365116 scopus 로고
    • Differential induction of the interleukin-6 gene by Tumor necrosis factor and interleukin-1
    • Ng, S. B., Tan, Y. H. & Guy, G. R. (1994) Differential induction of the interleukin-6 gene by Tumor necrosis factor and interleukin-1, J. Biol. Chem. 269, 19021-19027.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19021-19027
    • Ng, S.B.1    Tan, Y.H.2    Guy, G.R.3
  • 35
    • 0027474913 scopus 로고
    • Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells
    • Hsu, W. & Chen-Kiang, S. (1993) Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells, Mol. Cell. Biol. 13, 2515-2523.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2515-2523
    • Hsu, W.1    Chen-Kiang, S.2
  • 36
    • 0025936177 scopus 로고
    • A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein. LIP, are translated from the same mRNA
    • Descombes, P. & Schibler, U. (1991) A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein. LIP, are translated from the same mRNA, Cell 67, 569-579.
    • (1991) Cell , vol.67 , pp. 569-579
    • Descombes, P.1    Schibler, U.2
  • 37
    • 0027217386 scopus 로고
    • The two C/EBP isoforms, IL-6BP/NF-IL6 and C/ebpδ/NF-IL6β, arc induced by IL-6 to promote acute phase gene transcription via different mechanisms
    • Ramji, D. P., Vitelli, A., Tronche, F., Cortese, R. & Ciliberto, G. (1993) The two C/EBP isoforms, IL-6BP/NF-IL6 and C/ebpδ/NF-IL6β, arc induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acid Res. 21, 289-294.
    • (1993) Nucleic Acid Res. , vol.21 , pp. 289-294
    • Ramji, D.P.1    Vitelli, A.2    Tronche, F.3    Cortese, R.4    Ciliberto, G.5
  • 38
    • 0027451924 scopus 로고
    • In vivo control of NF-κB activation by 1κBα
    • Rice, N. R. & Ernst, M. K. (1993) In vivo control of NF-κB activation by 1κBα. EMBO J. 12, 4685-4695.
    • (1993) EMBO J. , vol.12 , pp. 4685-4695
    • Rice, N.R.1    Ernst, M.K.2


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