Sequential activation of TH1 and TH2 cells in the immunopathogenesis of atopic eczema;Sequentielle Aktivierung von TH1- und TH2-Zellen in der Immunpathogenese des atopischen Ekzems: Das 2-Phasen-Modell

Allergologie

Volumn 19, Issue 10, 1996, Pages 449-451

  Krutmann, J ^a,b   Grewe, M ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE   (Germany)

Author keywords

atopic eczema; interferon ; interleukin 12; interleukin 4

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ATOPIC DERMATITIS; HELPER CELL; HUMAN; IMMUNOPATHOLOGY; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0029789966     PISSN: 03445062     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (21)

1. Bos J.D., E.A. Wierenga, J.H.S. Smitt, F.L. van der Heijden, M.L. Kapsenberg: Immune dysregulation in atopic eczema. Arch. Dermatol. 128, 1509-1512 (1992).
2. Braathen L.R. O. Forre, J.B. Narvig, T. Eeg-Larsen: Predominance of T-lymphocytes in the dermal infiltrate of atopic dermatitis Br. J Dermatol. 100, 168-511 (1979).
3. Bruynzeel-Koomen C.A.F.M., D.F. van Wichen, C.J.F. Spry, P. Venge, P.L.B. Bruynzeel: Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis. Br. J. Dermatol. 118, 229-238 (1988).
4. Del Prete G., M. De Carli, F. Almerigogna, M.G Giudizi, R. Biagotti, S. Ramagnani: IL-10 is procuced by both type 1 helper (TH1) and type 2 helper (TH2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150, 353-360 (1993).
5. Grewe M., K. Gyufko, E. Schöpf, J. Krutmann: Lesional expression of interferon-γ in atopic eczema. Lancet 343, 25-26 (1994).
6. Grewe M., S. Walther, K. Gyufko, W. Czech, E. Schöpf, J. Krutmann: Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reaction of atopic dermatitis patients J. Invest. Dermatol. 105, 407-410 (1995).
7. Grewe M., W. Czech, A. Mortia, A Busse, T. Ruzicka, T. Werfel, A. Kapp, J. Krutmann: Eosinophile granulocytes produce biologically active IL-12. J. Invest. Dermatol. 107 (in press).
8. Hamid Q., M. Boguniewicz, D.Y.M. Leung: Differential in situ cytokine gene expression in acute versus chronic atopic dermatitits. J. Clin. Invest. 94, 870-876 (1994).
9. Hanifin J.M.: Atopic dermatitis. J. Allergy Clin. Immunol. 73, 211-222 (1984).
10. Krutmann J.: Phototherapy for atopic dermatitis. Dermatol. Therapy (in press).
11. Maggi E., G. Del Prete, D. Maccina, P. Parronchi, A. Tiri, I. Chretien, M. Ricci, S. Romagnani: Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur. J Immunol. 18, 1045-1052 (1988).
12. Mosmann T.R., H. Cherwinski, M.W. Bond: Two types of murine helper T cell clones. Definition according to profiles of lymphokine activites and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
13. Ohmen J.D., J.M. Hanifin, B.J. Nickoloff, T.H. Rea. R. Wyzykowski, J. Kim, D. Jullien, T. McHugh, A.S. Nassif, S.C. Chan, R.L Modlin: Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. J. Immunol. 154, 1956-1963 (1995).
14. Romagnani S.: Human TH1 and TH2 subsets: doubt no more. Immunol. Today 12, 256-257 (1991).
15. Sager N., A. Felmann, G. Schilling, P. Kreitsch, C. Neumann: House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J. Allergy Clin. Immunol 4, 801-810 (1992).
16. Scott P.: IL-12: initiation cytokine for cell-mediated immunity. Science 260, 496-498 (1993).
17. Thepen T., E.G. Langeveld-Wildschut, J.C. Bihari, D.F. van Wichen, F.C. van Reijsen, G.C. Mudde, C.A.F.M. Bruynzeel-Koomen: Biphasic response against aeroallergen in atopic dermatitis showing a swich from an initial TH2 response in situ: an immunocytochemical study. J Allergy Clin. Immunol. 97, 828-838 (1996).
18. Umetsu D.T., H.H. Jabara, R.H. de Kruyff, A.K. Abbas, J S. Abrams, R.F Geha: Functional heterogeneity among human inducer T cell clones. J. Immunol. 67, 68-75 (1988)
19. + allergen specific T lymphocytes in atopic dermatitis lesional skin. J. Invest. Dermatol. 97, 389-394 (1991).
20. Werfel T., A. Morita, M. Grewe, H. Renz, U Wahn, J. Krutmann, A Kapp: Analysis of the phenotype and cytokine pattern of allergen-specific T cell from chronic skin lesions of atopic dermatitis. J. Invest. Dermatol 107 (in press).
21. Zachary C.B., M.H. Allen, D.M. Macdonald: In situ quantification of T-lymphocyte subsets and Langerhans cells in the inflammatory infiltrate of atopic eczema. Br. J. Dermatol. 112, 149-156 (1985).