Penetration of azithromycin into middle ear effusions in acute and secretory otitis media in children

Journal of Antimicrobial Chemotherapy

Volumn 37, Issue SUPPL. C, 1996, Pages 53-61

  Pukander, J ^a   Rautianen, M ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; MACROLIDE;

ABDOMINAL PAIN; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DRUG BLOOD LEVEL; DRUG PENETRATION; FEMALE; FLATULENCE; HUMAN; MALE; MIDDLE EAR EFFUSION; OTITIS MEDIA; PRESCHOOL CHILD; SECRETORY OTITIS MEDIA; TYMPANOSTOMY TUBE;

EID: 0029789055     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/37.suppl_c.53     Document Type: Article

References (40)

1. Baldwin, D. R., Wise, R., Andrews, J. M., Ashby, J. P. & Honeybourne, D. (1990). Azithromycin concentrations at the sites of pulmonary infection. European Respiratory Journal 3, 886-90.
2. Baron, S. & Bégué, P. (1991). Traitement antibiotique de l'otite moyenne aigue. Annales de Pediatrie 38, 549-55.
3. Barry, A. L., Jones, R. N. & Thornsberry, C. (1988). In vitro activities of azithromycin (CP-62,993), clarithromycin (A-56268; TE 031), erythromycin, roxithromycin, and clindamycin. Antimicrobial Agents and Chemotherapy 32, 752-4.
4. Bérézin, A., Bergogne-Bérézin, E., Martin, P. & Berthelot, G. (1985). Etude des concentrations d'antibiotiques (josamycine, trioleandotnycine et amoxicilline) dans les secretion d'oreille de sinus et dans les vegetations adenoides. Annales d'Oto-laryngologie et de Chirurgie Cervico-Faciale 102, 499-502.
5. Bluestone, C. D. (1982) Otitis media in children: to treat or not to treat? New England Journal of Medicine 306, 1399-404.
6. Bluestone, C. D. (1989). Role of sulbactam/ampicillin and sultamicillin in the treatment of bacterial infections of the upper respiratory tract of children. Acta Pathologica Microbiologica et Immunologica Scandinavica 97, Suppl. 5, 35-40.
7. Chan, K. H., Swarts, J. D., Doyle, W. J., Tanpowpong, K. & Kardatzke, D. R. (1988). Efficacy of a new macrolide (azithromycin) for acute otitis media in the chinchilla model. Archives of Otolaryngology - Head and Neck Surgery 114, 1266-9.
8. Chirgwin, K., Roblin, P. M. & Hammerschlag, M. R. (1989). In vitro susceptibilities of Chlamydia pneumoniae (Chtamydia sp. strain TWAR). Antimicrobial Agents and Chemotherapy 33, 1634-5.
9. Daniel, R. R. (1993). Comparison of azithromycin and co-amoxiclav in the treatment of otitis media in children. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 65-71.
10. Dunkin, K. T., Jones, S. & Howard, A. J. (1988). The in-vitro activity of CP-62, 993 against Haemophilus influenzae, Branhamella catarrhalis, staphylococci and streptococci. Journal of Antimicrobial Chemotherapy 21, 405-11.
11. Felstead, S., Daniel, R. & the European Azithromycin Study Group. (1991). Short-course treatment of sinusitis and other upper respiratory tract infections with azithromycin: a comparison with erythromycin and amoxicillin. Journal of International Medical Research 19, 363-72.
12. Fernandes, P. B. & Hardy, D. J. (1988). Comparative in vitro potencies of nine new macrolides. Drugs under Experimental and Clinical Research 14, 445-51.
13. Foulds, G., Chan, K. H., Johnson, J. T., Shepard, R. M. & Johnson, R. B. (1991). Concentrations of azithromycin in human tonsillar tissue. European Journal of Clinical Microbiology and Infectious Diseases 10, 853-6.
14. Foulds, G. & Johnson, R. B. (1993). Selection of dose regimens of azithromycin. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 39-50.
15. Foulds, G., Shepard, R. M. & Johnson, R. B. (1990). The pharmacokinetics of azithromycin in human serum and tissues. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 73-82.
16. Fraschini, F., Scaglione, F., Falchi, M., Nebuloni, R., Zampella, K., Saedelli, M. et al. (1991). Kinetic profile of miocamycin in middle ear fluid and mucosa. Acta Otolarvngologica 111, 756-61.
17. Girard, A. E., Girard, D. & Retsema, J. A. (1990). Correlation of the extravascular pharmacokinetics of azithromycin with in-vivo efficacy in models of localized infection. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 61-71.
18. Hardy, D. J., Hensey, D. M., Beyer, J. M., Vojtko, C., McDonald, E. J. & Fernandes, P. B. (1988). Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Antimicrobial Agents and Chemotherapy 32, 1710-9.
19. Karma, P., Luotonen, J., Timonen, M., Pontynen, S., Pukander, J., Herva, E. et al. (1980). Efficacy of pneumococcal vaccination against recurrent otitis media. Annals of Otology Rhinology and Laryngology 89, Suppl. 68, 357-62.
20. Kusmiesz, H., Shelton, S., Brown, O., Manning, S. & Nelson, J. D. (1990). Loracarbef concentrations in middle ear fluid. Antimicrobial Agents and Chemotherapy 34, 2030-1.
21. McCracken, G. H. (1987). Selection of antimicrobial agents for treatment of acute otitis media with effusion. Pediatric Infectious Diseases Journal 6, 985-8.
22. Maskell, J. P., Sefton, A. M. & Williams, J. D. (1990). Comparative in-vitro activity of azithromycin and erythromycin against Gram-positive cocci, Haemophilus influenzae and anaerobes. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 19-24.
23. Mohs, E., Rodriguez-Solares, A., Rivas, E. & El Hoshy, Z. (1993). A comparative study of azithromycin and amoxycillin in paediatric patients with acute otitis media. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 73-90.
24. Morris, D. L., De Souza, A., Jones, J. A. & Morgan, W. E. (1991). High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose. European Journal of Clinical Microbiology and Infectious Diseases 10, 859-61.
25. Müller, O. (1993). Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 137-46.
26. Nelson, J. D. (1984). State of the art: microbiology of acute otitis media with effusion. In Recent Advances in Otitis Media with Effusion (Lim, D. J., Bluestone, C. D., Klein, J. O. & Nelson, J. D., Eds), pp. 105-6. B. C. Decker Inc., Burlington, Ontario.
27. Ogawa, H., Hashiguchi, K. & Kazuyama, Y. (1992). Recovery of Chlamydia pneumoniae, in six patients with otitis media with effusion. Journal of Laryngology and Otology 106, 490-2.
28. Peltola, H. (1982). Contribution of infectious diseases to a normal paediatric walk-in population. Journal of Infection 4, 199-209.
29. Pestalozza, G., Cioce, C. & Facchini, M. (1992). Azithromycin in upper respiratory tract infections: a clinical trial in children with otitis media. Scandinavian Journal of Infectious Diseases 83, 22-5.
30. Poole, M. D. (1993). The emerging epidemic of resistant pneumococci. Ear, Nose and Throat Journal 72, 6-7.
31. Pukander, J., Karma, P. & Sipilä, M. (1982). Occurrence and recurrence of acute otitis media among children. Acta Otolaryngologica 94, 479-86.
32. Reichler, M. R., Allphin, A. A., Breiman, R. F., Schreiber, J. R., Arnold, J. E., McDonald, L. K. et al. (1992). The spread of multiple resistant Streptococcus pneumoniae at a day care center in Ohio. Journal of Infectious Diseases 166, 1346-53.
33. Retsema, J. A., Girard, A. E., Girard, D. & Milisen, W. B. (1990). Relationship of high tissue concentrations of azithromycin to bactericidal activity and efficacy in vivo. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 83-9.
34. Retsema, J. A., Girard, A., Schelkly, W., Manousos, M., Anderson, M., Bright, G. M. et al. (1987). Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered macrolide with improved potency against Gram-negative organisms. Antimicrobial Agents and Chemotherapy 31, 1939-47.
35. Schaad, U. B. (1993). Multicentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 81-8.
36. Shepard, R. M. (1987). High pressure liquid chromatography (HPLC) assay for azithromycin (CP-62,993/XZ-450) in serum and tissues. In Program and Abstracts of the Twenty-Seventh Interscience Conference on Antimicrobial Agents and Chemotherapy. New York, 1987. Abstract 238, p. 138. American Society for Microbiology, Washington, DC.
37. Sunderberg, L. & Cederberg, A. (1994). Penetration of clarithromycin and its 14-hydroxy metabolite into middle ear effusion in children with secretory otitis media. Journal of Antimicrobial Chemotherapy 33, 299-307.
38. Treadway, G. & Pontani, D. (1994). Worldwide pediatric safety experience of azithromycin. In Program and Abstracts of the Second International Conference on the Macrolides, Azalides and Streptogramins, Venice, 1994. Abstract 212. Wallace Communications, Atlanta.
39. van Buchem, F. L., Dunk, J. H. M. & van't Hof, M. A. (1981). Therapy of acute otitis media: myringotomy, antibiotics, or neither? Lancet ii, 883-7.
40. Van Hare, G. F., Shurin, P. A., Marchant, C. D., Cartelli, N. A., Johnson, C. E., Fulton, D. et al. (1987). Acute otitis media caused by Branhamella catarrhalis: biology and therapy. Reviews of Infectious Diseases 9, 16-27.